A dominant mechanism coordinately suppresses the expression of T(h)2 lymphokines

International Immunology

Volumn 9, Issue 9, 1997, Pages 1347-1353

  Weiss, Angela ^a   Waiser, Johannes ^a   Serfling, Edgar ^b   Nebl, Gabriele ^c   Samstag, Yvonne ^c   Jáck, Hans Martin ^d   Gessner, Andre ^a   Röllinghoff, Martin ^a   Lohoff, Michael ^a  

^a UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^b UNIVERSITY OF WÜRZBURG   (Germany)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^d UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

IL 4; Lymphokine regulation; T(h)1 T(h)2

Indexed keywords

CELL DNA; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; LYMPHOKINE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL FUSION; CELL LINE; CELL SECRETION; CONTROLLED STUDY; DNA SEQUENCE; HELPER CELL; HYBRIDOMA; LYMPHOCYTE CLONE; MOUSE; NONHUMAN; NORTHERN BLOTTING; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; THYMOMA; TRANSCRIPTION REGULATION;

EID: 0030813311     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.9.1347     Document Type: Article

References (41)

1. Mosmann, T. R., Cherwinsky, H., Bond, M. W., Giedlin, M. A. and Coffman, R. L. 1986. Two types of murine helper T-cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
2. Swain, S. L., Bradley, L. M., Croft, M., Tonkonogy, S., Atkins, G., Weinberg, A. D., Duncan, D. D., Dedrick, S. M., Durron, R. W. and Huston, W. 1991. Helper T-cell subsets: phenotype, function and the role of lymphokines in regulating their development, Immunol. Rev. 123:115.
3. Street, N. E and Mosmann, T. R. 1991. Functional diversity of T lymphocytes due to secretion of different cytokine patterns. FASEB J. 5:171.
4. Hsieh, C. S., Macatonia, S. E., Wolf, S. F., O'Garra, A. and Murphy, K. M. 1993. Development of TH1 cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
5. + T cells from T cell receptor transgenic mice. J. Exp. Med. 176:1091.
6. Todd, M. D., Grusby, M. J., Lederer, J. A., Lacy, E., Lichtman, A. H. and Glimcher, L. H. 1993. Transcription of the interleukin 4 gene is regulated by multiple promoter elements. J. Exp. Med. 177:1663.
7. Szabo, S. S., Gold, J. S., Murphy, T. L and Murphy, K. M. 1993. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells: role for NF-Y and NF-ATc. Mol. Cell. Biol. 13:4793.
8. h2 cell subsets. I. Induction of IL-2 transcription by up-regulation of transcription factors with the protein synthesis initiation factor 4E. J. Immunol. 152:1171.
9. Lederer, J. A., Liou, J. S., Todd, M. D., Glimcher, L. H. and Lichtman, A. H. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77.
10. Brombacher, F., Schäfer, Th., Weissenstein, U., Tschopp, C., Andersen, E., Bürki, K. and Baumann, G. 1994. IL-2 promoter driven lacZ expression as a monitoring tool for IL-2 expression in primary T cells of transgenic mice. Int. Immunol. 6:189.
11. Chuvpilo, S., Schomberg, Ch., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F. and Serfling, E 1993. Multiple closely-linked NF-AT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 24:5694.
12. + T-cells in experimental leishmaniasis. Infect. Immunol. 56:2120.
13. Kaye, J. S., Gillis, S. B., Mizel, S. B., Shevach, E. M., Malek, T. R., Dinarello, C. A., Lachman, L. B. and Janeway, C. A. 1984. Growth of a cloned helper T cell line induced by a monoclonal antibody specific for the antigen receptor: Interleukin 1 is required for the expression of receptors for Interleukin 2. J. Immunol. 133:1339.
14. + T cells but is not a general T cell growth factor. Eur. J. Immunol. 19:2167.
15. Lohoff, M., Steinert, M., Weiss, A., Röllinghoff, M., Balderas, R. S. and Theophilopoulos, A. N. N. A. 1994. Vβ gene repertoires in T cells expanded in local self- healing and lethal systemic murine leishmaniasis. Eur. J. Immunol. 24:492 .
16. Solbach W., Forberg, K., Kammerer, E., Bogdan, C. and Röllinghoff, M. 1986. Suppressive effect of cyclosporin A on the development of Leishmania mayor-induced lesions in genetically susceptible BALB/c mice. J. Immunol. 137:702.
17. Harwell, L., Skidmore, B., Marrack, P. and Kappler, J. 1980. Concanavalin A inducible, interleukin-2-producing T-cell hybridoma. J. Exp. Med. 152:893.
18. Geering, G., Old, L. J. and Boyse, E. A. 1969. Antigens of leukemias induced by naturally occuring murine leukemia virus: their relation to the antigen gross virus and other murine leukemia viruses. J. Exp. Med. 124:753.
19. Leo, O., Foo, M., Sachs, D. H., Samelson, L. E. and Bluestone, J. A. 1987. Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc. Natl Acad. Sci. USA 84:1374.
20. Lohoff, M., Dirks, M., Rohwer, P. and Röllinghoff, M. 1989. Studies on the mechanism of polyclonal B cell stimulation by TH2 cells. Eur. J. Immunol. 19:77.
21. Watson, J. 1979. Continuous proliferation of murine antigen-specific T lymphocytes in culture. J. Exp. Med. 150:1510.
22. Lohoff, M., Sommer, F., Solbach, W. and Röllinghoff, M. 1989. Coexistence of antigen-specific TH1 and TH2 cells in genetically susceptible BALB/c Mice infected with Leishmania major, Immunobiology 179:412.
23. 2-terminal amino acid sequence of a T-cell derived lymphokine with growth factor activity for B-cell hybridomas. Proc. Natl Acad. Sci. USA 83:9679.
24. Vink, A., Coulie, P. G., Wauters, P., Nordan, R. P. and van Snick, J. V. 1988. B cell growth and differentiation activity of interleukin-HP1 and related murine plasmocytoma growth factors. Synergy with interleukin 1. Eur. J. Immunol. 18:607.
25. Gessner, A., Drjupin, R., Löhler, J., Lother, H. and Lehmann-Grube, F. 1990. IFN-γ production in tissues of mice during acute infection with Lymphocytic Choriomeningitis Virus. J. Immunol. 144:3160.
26. Gessner, A., Schröppel, K., Will, A., Enssle, K.-H., Lauffer, L. and Röllinghoff, M. 1994. Recombinant soluble interleukin-4 (IL-4) receptor acts as an antagonist of IL-4 in murine cutaneous Leishmaniasis. Infect. Immun. 62:4117.
27. Krug, M. S. and Berger, S. L. 1987. First strand cDNA synthesis primed with oligo(dT). Methods Enzymol. 152:316.
28. Montgomery, R. A. and Dallman M. J. 1991 Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction. J. Immunol. 147:554.
29. Serfling, E., Barthelmäs, R., Pfeuffer, I., Schenk, B., Zarius, S., Swoboda, R., Mercurio, R. and Karin, M. 1989. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO J. 8:46529
30. h2 populations. Int. Immunol. 7:869.
31. h2 lineage by extinction of IL-12 signaling. Immunity 2:665.
32. Munoz, E., Zubiga, A., Olson, D. and Huber, B. T. 1989. Control of lymphokine expression in T helper 2 cells. Proc. Natl Acad. Sci. USA 86:9461.
33. Bill, O., Garlisi, C. G., Grove, D. S., Holt, G. E. and Mastro, A. M. 1994. IL-2 mRNA levels and degradation rates change with mode of stimulation and phorbol ester treatment of lymphocytes. Cytokine 6:101.
34. Gerez, L., Arad, G., Efrat, S., Ketzinel, M. and Kaempfer, R. 1995. Post-transcriptional regulation of human interleukin-2 gene expression at processing of precursor transcripts. J. Biol. Chem 270:19569.
35. Fox, F. E., Chernajovsky, Y. and Platsoucas, C. D. 1994. Inhibition of interleukin 2 production and alteration of interleukin 2 mRNA processing by human T-T cell hybridoma-derived suppressor factors. Hybridoma 13:343.
36. Li-Weber, M., Eder, A., Krafft-Czepa, H. and Krammer, P. H. 1992. T cell-specific negative regulation of transcription of the human cytokine IL-4. J. Immunol, 148:1913.
37. Tara, D., Weiss, D. L. and Brown, M. A. 1993. An activation responsive element in the murine IL-4 gene is the site of an inducible DNA-protein interaction. J. Immunol. 151:3617.
38. Lederer, J. A., Liou, J. S., Todd, M. D., Glimcher, L. H. and Lichtman, A. H. 1994. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152:77.
39. h2 cytokine response. Nature 362:245.
40. Cockerill, P. N., Shannon, M., F., Bert, A. G., Ryan, G. R. and Vadas, M. A. 1993. The granulocyte-macrophage colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl Acad. Sci. USA 90:2466.
41. Siebenlist, U., Durand, D. B., Bressler, P., Holbrook, M. J., Norris, C. A., Kamoun, M., Kant, J. A. and Crabtree, G. R. 1986. Promoter region of the IL-2 gene undergoes chromatin structure changes and confers inducibility on chloramphenicol acetyltransferase gene during activation of T cells. Mol. Cell. Biol. 6:3042.