Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 272, Issue 2 35-2, 1997, Pages

  Vannucci, Susan J ^a   Gibbs, E Michael ^b   Simpson, Ian A ^c  

^a PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

cerebral glucose utilization; diabetes; leptin

Indexed keywords

DEOXYGLUCOSE; GLUCOSE; GLUCOSE TRANSPORTER;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN GROWTH; BRAIN METABOLISM; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FRONTAL CORTEX; GLUCOSE TRANSPORT; GLUCOSE UTILIZATION; HYPOTHALAMUS; MOUSE; NONHUMAN; PRIORITY JOURNAL; THALAMUS; TRANSPORT KINETICS;

EID: 0030951430     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1997.272.2.e267     Document Type: Article

References (34)

1. Bondy, C. A., W. Lee, and J. Zhou. Ontogeny and cellular distribution of brain glucose transporter gene expression. Mol. Cell. Neurosci. 3: 305-314, 1992.
2. Chen, H., O. Charlat, L. A. Tartaglia, E. A. Woolf, X. Weng, S. J. Ellis, N. D. Lakey, J. Culpepper, K. J. Moore, R. E. Breihart, G. M. Duyk, R. I. Tepper, and J. P. Morgenstern. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 84: 491-495, 1996.
3. Coleman, D. L. Diabetes-obesity syndromes in mice. Diabetes 31, Suppl. 1: 1-6, 1982.
4. Duckrow, R. B. Glucose transfer into rat brain during acute and chronic hyperglycemia. Metab. Brain Dis. 3: 201-209, 1988.
5. Duckrow, R. B., and R. M. Bryan. Regional cerebral glucose utilization during hyperglycemia. J. Neurochem. 48: 989-993, 1987.
6. Garris, D. R., S. K. Williams, and D. L. Coleman. Glucose utilization by the mouse brain: influence of age and diabetes. Dev. Brain Res. 15: 141-146, 1984.
7. Gjedde, A., and C. Crone. Blood-brain glucose transfer: repression in chronic hyperglycemia. Science Wash. DC 214: 456-457, 1981.
8. Harik, S. I., S. A. Gravina, and R. N. Kalraia. Glucose transporter of the blood-brain barrier and brain in chronic hyperglycemia. J. Neurochem. 51: 1930-1934, 1988.
9. Harik, S. I., and J. C. LaManna. Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia. J. Neurochem. 51: 1924-1929, 1988.
10. Hawkins, R. A., D. H. Williamson, and H. A. Krebs. Ketone-body utilization by adult and suckling rat brain in vivo. Biochem. J. 122: 13-18, 1971.
11. Jakobsen, J., M. Nedergaard, M. Aarslew-Jensen, and N. H. Diemer. Regional brain glucose metabolism and blood flow in streptozotocin-induced diabetic rats. Diabetes 39: 437-440, 1990.
12. Lowry, O. H., and J. V. Passonneau. A Flexible System of Enzymatic Analysis. New York: Academic, 1972.
13. Lyons, D. T., F. Vasta, and R. C. Vannucci. Autoradiographic determination of regional cerebral blood flow in the immature rat. Pediatr. Res. 21: 471-476, 1987.
14. Maher, F., S. J. Vannucci, and I. A. Simpson. Glucose transporter isoforms in the brain: absence of GLUT3 from the blood-brain barrier. J. Cereb. Blood Flow Metab. 13: 342-345, 1993.
15. Maher, F., S. J. Vannucci, and I. A. Simpson. Glucose transporter proteins in brain. FASEB J. 8: 1003-1011, 1994.
16. Mans, A. W., R. DeJoseph, D. W. Davis, and R. A. Hawkins. Brain energy metabolism in streptozotocin-diabetes. Biochem. J. 249: 57-62, 1988.
17. Matthei, S., R. Horuk, and J. M. Olefsky. Blood-brain glucose transfer in diabetes mellitus: decreased number of glucose transporters at blood-brain barrier. Diabetes 35: 1181-1184, 1986.
18. McCall, A. M. The impact of diabetes on the CNS. Diabetes 41: 557-570, 1992.
19. McCall, A. M., W. R. Millington, and R. J. Wurtman. Metabolic fuel and amino acid transport into the brain in experimental diabetes mellitus. Proc. Natl. Acad. Sci. USA 79: 5406-5410, 1982.
20. Nagamatsu, S., J. M. Kornhauser, C. F. Burant, S. Seino, K. E. Mayo, and G. I. Bell. Glucose transporter expression in brain. J. Biol. Chem. 267: 467-472, 1992.
21. Pardridge, W. M., D. Triguero, and C. F. Farrell. Downregulation of blood-brain barrier glucose transporter in experimental diabetes. Diabetes 39: 1040-1044, 1990.
22. Pelligrino, D. A., M. D. Lipa, and R. F. Albrecht. Regional blood-brain glucose transfer and glucose utilization in chronically hyperglycemic, diabetic rats following acute normalization. J. Cereb. Blood Flow Metab. 10: 774-780, 1990.
23. Schuier, F., F. Orzi, S. Suda, G. Lucignani, C. Kennedy, and L. Sokoloff. Influence of plasma glucose concentration on lumped constant of the deoxyglucose method: effects of hyperglycemia in the rat. J. Cereb. Blood Flow Metab. 10: 765-773, 1990.
24. Simpson, I. A., K. R. Chundu, T. Davies-Hill, W. G. Honer, and P. Davies. Decreased concentrations of GLUT1 and GLUT3 glucose transporters in the brains of patients with Alzheimer's disease. Ann. Neurol. 35: 546-551, 1994.
25. 14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J. Neurochem. 28: 897-916, 1977.
26. Timmers, K. I., M. Palkovits, and D. L. Coleman. Unique alterations of neuropeptide content in median eminence, amygdala, and dorsal vagal complex of 3- and 6-week-old diabetes mutant mice. Metab. Clin. Exp. 39: 1158-1164, 1990.
27. van der Kroon, P. H. W., and G. J. A. Seeijers. Brain deviations in adult obese-hyperglycemia mice (ob/ob). Metab. Clin. Exp. 28: 1-3, 1979.
28. Vannucci, R. C., M. A. Christensen, and D. T. Stein. Regional cerebral glucose utilization in the immature rat: effect of hypoxia-ischemia. Pediatr. Res. 26: 208-214, 1989.
29. Vannucci, R. C., and T. E. Duffy. Influence of birth on carbohydrate and energy metabolism in rat brain. Am. J. Physiol. 226: 933-940, 1974.
30. Vannucci, S. J. Developmental regulation of GLUT1 and GLUT3 glucose transporters in rat brain. J. Neurochem. 62: 240-246, 1994.
31. Vannucci, S. J., F. Maher, E. Koehler, and I. A. Simpson. Altered expression of GLUT-1 and GLUT-3 glucose transporters in neurohypophysis of water-deprived or diabetic rats. Am. J. Physiol. 267 (Endocrinol. Metab. 30): E605-E611, 1994.
32. Vannucci, S. J., L. B. Seaman, and R. C. Vannucci. Effects of hypoxia-ischemia on GLUT1 and GLUT3 glucose transporters in immature rat brain. J. Cereb. Blood Flow Metab. 16: 77-81, 1996.
33. Werner, H., M. Adamo, W. L. Lowe, C. T. Roberts, and D. Le Roith. Developmental regulation of rat brain/Hep G2 glucose transporter gene expression. Mol. Endocrinol. 3: 273-279, 1989.
34. Zhang, Y., R. Proenca, M. Maffei, M. Barone, L. Leopold, and J. M. Friedman. Positional cloning of the mouse obese gene and its human homologue. Nature Lond. 372: 425-431, 1994.