Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia

Endocrinology

Volumn 137, Issue 6, 1996, Pages 2397-2405

  Moller, David E ^a,d   Chang, Pi Yun ^a   Yaspelkis III, Benedict B ^b   Flier, Jeffrey S ^a   Wallberg Henriksson, Harriet ^c   Ivy, John L ^b  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^c KAROLINSKA INSTITUTE   (Sweden)

^d MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLGLUCOSE; FATTY ACID; GLYCOGEN; INSULIN; INSULIN RECEPTOR; LACTIC ACID; TRIACYLGLYCEROL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DYSLIPIDEMIA; FATTY ACID BLOOD LEVEL; GLUCOSE HOMEOSTASIS; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; LACTATE BLOOD LEVEL; MOUSE; MUSCLE METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; SKELETAL MUSCLE; TRANSGENIC MOUSE; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 0029902593     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.6.8641192     Document Type: Article

References (67)

1. DeFronzo RA, Jacot E, Jequier E, Maeder E, Wahren J, Felber JP 1981 The effect of insulin on the disposal of intravenous glucose: results from indirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30:1000-1007
2. Kraegen EW, James DE, Jenkins AB, Chisholm DJ 1985 Dose-response curves for in vivo insulin sensitivity in individual tissues in rats. Am J Physiol 248:E353-E362
3. DeFronzo RA, Bonadonna RC, Ferannini E 1992 Pathogenesis of NIDDM: a balanced overview. Diabetes Care 15:318-368
4. Alzaid A, Rizza RA 1993 Insulin resistance and its role in the pathogenesis of impaired glucose tolerance and non-insulin-dependent diabetes mellitus: perspectives gained from in vivo studies. In: Moller DE (ed) Insulin Resistance. Wiley and Sons, Chichester, pp 143-186
5. Jackson RA, Perry G, Rogers J, Pilkington TR 1973 Relationship between the basal glucose concentration, glucose tolerance and forearm glucose uptake in maturity-onset diabetes. Diabetes 22:751-761
6. DeFronzo RA, Gunnarsson R, Bjorkman O, Olsson M, Wahren J 1985 Effects of insulin on peripheral and splanchnic glucose metabolism in noninsulin-dependent (type II) diabetes mellitus. J Clin Invest 76:149-155
7. Baron AD, Laakso M, Brechtel G, Edelman SV 1991 Reduced capacity and affinity of skeletal muscle for insulin-mediated glucose uptake in noninsulin-dependent diabetic subjects. Effects of insulin therapy. J Clin Invest 87:1186-1194
8. Laakso M, Edelman SV, Olefsky JM, Brechtel G, Wallace P, Baron AD 1990 Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity. Diabetes 39:965-974
9. 13C nuclear magnetic resonance spectroscopy. N Engl J Med 322:223-228
10. Rothman DL, Shulman RG, Shulman GI 1992 31-P Nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest 89:1069-1075
11. Gerich JE 1991 Is muscle the major site of insulin resistance in type 2 (non-insulin-dependent) diabetes mellitus? Diabetologia 34:607-610
12. Taylor SI, Accili D, Imai Y 1994 Insulin resistance or insulin deficiency. Which is the primary cause of NIDDM? Diabetes 43:735-740
13. O'Rahilly S, Hattersley A, Vaag A, Gray H 1994 Insulin resistance as the major cause of impaired glucose tolerance: a self-fulfilling prophesy? Lancet 344:585-589
14. Dohm GL, Tapscott EB, Pories WJ, Dabbs DJ, Flickinger EG, Meelheim D, Fushiki T, Atkinson SM, Elton CW, Caro JF 1988 An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 82:486-494
15. Thorburn AW, Gumbiner B, Bulacan F, Brechtel G, Henry RR 1991 Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus. J Clin Invest 87:489-495
16. Bogardus C, Lillioja S, Stone K, Mott D 1984 Correlation between muscle glycogen synthase activity and in vivo insulin action in man. J Clin Invest 73:1185-1190
17. Taylor SI, Moller DE 1993 Mutations of the insulin receptor gene. In: Moller DE (ed) Insulin Resistance. Wiley and Sons, Chichester, pp 83-111
18. Caro JF, Sinha MK, Raju SM, Ittoop O, Pories WJ, Flickinger EG, Meelheim D, Dohm GL 1987 Insulin receptor kinase in human skeletal muscle from obese subjects with and without non-insulin dependent diabetes. J Clin Invest 79:1330-1337
19. Maegawa H, Shigeta Y, Egawa K, Kobayashi M 1991 Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in non-obese subjects with NIDDM. Diabetes 40:815-819
20. Freidenberg GR, Suter S, Henry RR, Nolan J, Reichart D, Olefsky JM 1994 Delayed onset of insulin activation of the insulin receptor kinase in vivo in human skeletal muscle. Diabetes 43:118-126
21. Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM 1994 Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 78:471-477
22. Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL 1995 Insulin receptor autophosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95:2195-2204
23. Maeda R, Raz I, Zurlo F, Sommercorn J 1991 Activation of skeletal muscle casein kinase II by insulin is not diminished in subjects with insulin resistance. J Clin Invest 87:1017-1022
24. Kolterman OG, Insel J, SaeRow M, Olefsky JM 1980 Mechanism of insulin resistance in human obesity. Evidence for receptor and post receptor defects. J Clin Invest 65:1272-1284
25. Moller DE, Flier JS 1991 Insulin resistance: mechanisms, syndromes, and implications. N Engl J Med 325:938-948
26. Odeleye OE, De Courten M, Ravussin E 1995 Insulin resistance as a predictor of body weight gain in 5-10 year old Pima Indians. Diabetes [Suppl 1] 44:7A
27. Caro JF, Dohm LG, Pories WJ, Sinha MK 1989 Cellular alterations in liver, skeletal muscle, and adipose tissue responsible for insulin resistance in obesity and type II diabetes. Diabetes Metab Rev 5:665-689
28. Arner P 1988 Control of lipolysis and its relevance to development of obesity in man. Diabetes Metab Rev 4:507-515
29. Felig P 1984 Insulin is the mediator of feeding-related thermogenesis: insulin resistance and/or deficiency results in a thermic defect which contributes to the pathogenesis of obesity. Clin Physiol 4:267-273
30. Cooney GJ, Storlien LH 1994 Insulin action, thermogenesis and obesity. Bailliere Clin Endocrinol Metab 8:481-507
31. Jeanrenaud B 1988 Neuroendocrine and metabolic basis of type II diabetes as studied in animal models. Diabetes Metab Rev 4:603-614
32. Chang P-Y, Benecke H, Le Marchand-Brustel Y, Lawitts J, Moller DE 1994 Expression of a dominant-negative mutant human insulin receptor in the muscle of transgenic mice. J Biol Chem 269:16034-16040
33. Chang P-Y, Goodyear LJ, Benecke H, Markuns JS, Moller DE 1995 Impaired insulin signaling in skeletal muscles from transgenic mice expressing kinase-deficient insulin receptors. J Biol Chem 270: 12593-12600
34. Ruderman NB, Houghton CR, Hems R 1971 Evaluation of the isolated perfused rat hindquarter for the study of muscle metabolism. Biochem J 124:639-651
35. Ivy JL, Brozinick Jr JT, Torgan CE, Kastello GM 1989 Skeletal muscle glucose transport in obese Zucker rats after excercise training. J Appl Physiol 66:2635-2641
36. Hohorst HJ, Arese P, Bartels H, Stratmann D, Talke H 1965 L(+) lactic acid and the steady state of cellular red/ox-systems. Ann NY Acad Sci 119:974-994
37. Lo S, Russell JC, Taylor AW 1970 Determination of glycogen in small tissue samples. J Appl Physiol 28:234-236
38. Benecke H, Flier JS, Rosenthal N, Siddle K, Klein HH, Moller DE 1993 Muscle-specific expression of human insulin receptor in transgenic mice. Diabetes 42:206-212
39. Warden CH, Fisler JS, Pace MJ, Svenson KL, Lusis AJ 1993 Coincidence of genetic loci for plasma cholesterol levels and obesity in a multifactorial mouse model. J Clin Invest 92:773-779
40. Salmon DMV, Flatt JP 1985 Effect of dietary fat content on the incidence of obesity among ad libitum fed mice. Int J Obesity 9:443-449
41. Brooke MH, Kaiser KK 1970 Three myosin ATPase systems: the nature of their pH lability and sulphydryl dependence. J Histochem Cytochem 18:670-672
42. Andersen P, Henriksson J 1977 Capillary supply of the quadriceps femoris muscle of man: adaptive response to exercise. J Physiol 270:677-690
43. Wallberg-Henriksson H 1987 Glucose transport into skeletal muscle. Acta Physiol Scand [Suppl 1] 564:1-80
44. Sherman WM, Katz A, Cutler CL, Withers WT, Ivy JL 1988 Glucose transport: locus of muscle insulin resistance in the obese Zucker rat. Am J Physiol 255:E374-E382
45. Le Marchand-Brustel Y, Gremeaux T, Ballotti R, Van Obberghen E 1985 Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice. Nature 315:676-679
46. Benecke H, Hamann A, Lowell BB, Flier JS 1994 Transgenic mice with brown fat deficiency develop insulin resistant diabetes. Diabetes [Suppl 1] 43:132A
47. DeFronzo RA 1988 The triumvirate: beta-cell, muscle, liver: a collusion responsible for NIDDM. Diabetes 37:667-687
48. Lillioja S, Mott DM, Zawadzki JK, Young AA, Abbott WG, Bogardus C 1986 Glucose storage is a major determinant of in vivo "insulin resistance" in subjects with normal glucose tolerance. J Clin Endocrinol Metab 62:922-977
49. Erikkson J, Franssila-Kallunki A, Ekstrand A, Saloranta C, Widen E, Schalin C, Groop L 1989 Early metabolic defects in persons at increased risk for non-insulin-dependent diabetes mellitus. N Engl J Med 321:337-343
50. Bogardus C, Lillioja S, Mott D, Reaven GR, Kashiwagi A, Foley JE 1984 Relationship between obesity and maximal insulin-stimulated glucose uptake in vivo in Pima Indians. J Clin Invest 73:800-805
51. Scheen AJ, Castillo M, Lefebvre PJ 1988 Insulin sensitivity in anorexia nervosa: a mirror image of obesity? Diabetes Metab Rev 4:681-690
52. Narimiya M, Azhar S, Dolkas CB, Mondon CE, Sims C, Wright DW, Reaven GM 1984 Insulin resistance in older rats. Am J Physiol 246:E397-E404
53. Jackson RA 1990 Mechanisms of age-related glucose intolerance. Diabetes Care 13:9-19
54. Torbay N, Bracco EF, Geliebeter A, Stewart IM, Hashim SA 1985 Insulin increases body fat despite control of food intake and physical activity. Am J Physiol 248:R120-R124
55. Jequier E, Schutz Y 1988 Energy expenditure in obesity and diabetes. Diabetes Metab Rev 4:583-593
56. Eberhart GP, West DB, Boozer CN, Atkinson RL 1994 Insulin sensitivity of adipocytes from inbred mouse strains resistant or sensitive to diet-induced obesity. Am J Physiol 266:R1423-R1428
57. Shepherd PR, Gnudi L, Tozzo E, Yang H, Kahn BB 1993 Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue. J Biol Chem 268:22243-22246
58. Swinburn BA, Nyomba BL, Saad MF, Zurlo F, Raz I, Knowler WC, Lillioja S, Bogardus C, Ravussin E 1991 Insulin resistance is associated with lower rates of weight gain in Pima Indians. J Clin Invest 88:168-173
59. Neel JV 1962 Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress." Am J Hum Genet 14:353-362
60. Wendorf M, Goldfine ID 1991 Archaeology of NIDDM: excavation of the "thrifty" genotype. Diabetes 40:161-165
61. Eckel RH 1992 Insulin resistance: an adaptation for weight maintenance. Lancet 340:1452-1453
62. Barrett EJ, Gelfand RA 1995 The in vivo study of cardiac and skeletal muscle protein turnover. Diabetes Metab Rev 5:133-148
63. Moller DE, O'Rahilly S 1993 Syndromes of severe insulin resistance: clinical and pathophysiological features. In: Moller DE (ed) Insulin Resistance. Wiley and Sons, Chichester, pp 49-82
64. Burkholder TJ, Fingado B, Baron B, Lieber RL 1994 Relationship between muscle fiber types and sizes and muscle architectural properties in the mouse hindlimb. J Morphol 221:177-190
65. Reaven GM 1988 Banting Lecture 1988: role of insulin resistance in human disease. Diabetes 37:1595-1607
66. Stout RW 1993 Insulin resistance, hyperlipidemia and atherosclerosis. In: Moller DE (ed) Insulin Resistance. Wiley and Sons, Chichester, pp 355-375
67. Zavaroni I, Bonora E, Pagliara M, Dall'Aglio MD, Luchetti L, Buonanno G, Bonati PA, Bergonzani M, Gnudi L, Passcei M, Reaven G 1989 Risk factors for coronary artery disease in healthy persons with hyperinsulinemia and normal glucose tolerance. N Engl J Med 320:702-706