Proapoptotic ICE/ced3 cysteine proteases: Future prospects for pharmacological inhibition;LES CASPASES, LES PROTEASES A CYSTEINE DE L'APOPTOSE: UN ENJEU THERAPEUTIQUE POUR DEMAIN?

Medecine/Sciences

Volumn 14, Issue 1, 1998, Pages 9-17

  Mignon, Alexandre ^a   Rouquet, Nicolas ^a   Joulin, Virginie ^a  

^a INSTITUT COCHIN   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CYSTEINE PROTEINASE; DIPEPTIDYL CARBOXYPEPTIDASE; INTERLEUKIN 1;

APOPTOSIS; ENZYME ANALYSIS; ENZYME SPECIFICITY; REVIEW;

MAMMALIA;

EID: 0031983013     PISSN: 07670974     EISSN: None     Source Type: Journal    
DOI: 10.4267/10608/878     Document Type: Review

References (49)

1. Ellis RE, Yuan JY, Horvitz HR. Mechanisms and functions of cell death. Annu Rev Cell Biol 1991 ; 7 : 663-98.
2. Steller H. Mechanisms and genes of cellular suicide. Science 1995 ; 267 : 1445-9.
3. Denis H, Mignotte B. L'apoptose dérive-telle de la mort nucléaire programmée mise en œuvre par les protistes ? Med Sci 1994 ; 10 : 687-95.
4. White E. Life, death, and the pursuit of apoptosis. Genes Dev 1996 ; 10 : 1-15.
5. Martin SJ, Green DR. Protease activation during apoptosis : death by a thousand cuts ? Cell 1995 ; 82 : 349-52.
6. Henkart PA, Grinstein S. Apoptosis : mitochondria resurrected ? [comment]. J Exp Med 1996 ; 183 : 1293-5.
7. Susin SA, Zamzami N, Castedo M, et al. The central executioner of apoptosis : Multiple connections between protease activation and mitochondria in Fas/APO-1/CD95- and ceramide-induced apoptosis. J Exp Med 1997 ; 186 : 25-37.
8. Nicholson DW. ICE/CED3-like proteases as therapeutic targets for the control of inappropriate apoptosis. Nat Biotechnol 1996 ; 14 : 297-301.
9. Thompson CB. Apoptosis in the pathogenesis and treatment of disease. Science 1995 ; 267 : 1456-62.
10. Labouesse M. C. elegans, les promesses d'un petit animal intelligent : « small is beautiful ». Med Sci 1994 ; 10 : 337-41.
11. Reed JC. Bcl-2 and the regulation of programmed cell death. J Cell Biol 1994 ; 124 : 1-6.
12. Vaux DL, Weissman IL, Kim SK. Prevention of programmed cell death in Caenorhabditis elegans by human bcl-2. Science 1992 ; 258 : 1955-7.
13. Zou H, Henzel WJ, Liu X, Lutschg A, Wang X. Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3. Cell 1997 ; 90 : 405-13.
14. Chinnaiyan AM, Chaudhary D, O'Rourke K, Koorin EV, Dixit VM. Role of CED-4 in the activation of CED-3. Nature 1997 : 388 ; 728-9.
15. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 1993 ; 75 : 641-52.
16. Nicholson DW, Ali A, Thornberry NA, et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 1995 ; 376 : 37-43.
17. Alnemri ES, Livingston DJ, Nicholson DW, et al. Human ICE/CED-3 protease nomenclature. Cell 1996 ; 87 : 171.
18. Fraser A, Evan G. A license to kill. Cell 1996 ; 85 : 781-4.
19. Nagata S. Apoptosis by death factor. Cell 1997 ; 88 : 355-65.
20. Gueydan C, Coessens E. Avancées et perspectives de la recherche sur le facteur de nécrose tumorale (TNF). Med Sci 1997 ; 13 : 83-8.
21. Liu XS, Zou H, Slaughter C, Wang XD. DFF, a heterodimeric protein that functions downstream of caspase-3 to trigger DNA fragmentation during apoptosis. Cell 1997 ; 89 : 175-84.
22. Kuida K, Lippke JA, Ku G, et al. Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme. Science 1995 ; 267 : 2000-3.
23. Li P, Allen H, Banerjee S, et al. Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell 1995 ; 80 : 401-11.
24. Kuida K, Zheng TS, Na S, et al. Decreased apoptosis in the brain and premature lethafity in CPP32-deficient mice. Nature 1996 ; 384 : 368-72.
25. Kroemer G. The proto-oncogenc Bcl-2 and its role in regulating apoptosis. Nat Med 1997 ; 3 : 614-20.
26. Chinnaiyan AM, Orth K, O'Rourke K, Duan H, Poirier GG, Dixit VM. Molecular ordering of the cell death pathway. J Biol Chem 1996 ; 271 : 4573-6.
27. Minn AJ, Velez P, Schendel SL, et al. Bcl-x(L) forms an ion channel in synthetic lipid membranes. Nature 1997 ; 385 : 353-7.
28. Chinnaiyan AM, Orourke K, Lane BR, Dixit VM. Interaction of CED-4 with CED-3 and CED-9 : a molecular framework for cell death. Science 1997 ; 275 : 1122-6.
29. Wu DY, Wallen HD, Nunez G. Interaction and regulation of subcellular localization of CED-4 by CED-9. Science 1997 ; 275 : 1126-9.
30. Liu X, Kim CN, Yang J, Jemmerson R, Wang X. Induction of apoptotic program in cell-free extracts : requirement for dATP and cytochrome c. Cell 1996 ; 86 : 147-57.
31. Yang J, Liu XS, Bhalla K, et al. Prevention of apoptosis by Bcl-2 : release of cytochrome c from mitochondria blocked. Science 1997 ; 275 : 1129-32.
32. Kluck RM, Bossy-Wetzel E, Green DR, Newmeyer DD. The release of cytochrome c from mitochondria : a primary site for Bcl-2 regulation of apoptosis. Science 1997 ; 275 : 1132-6.
33. Reed JC. Double identity for proteins of the Bcl-2 family. Nature 1997 ; 361 : 773-6.
34. Golstein P. Controlling cell death [comment]. Science 1997 ; 275 : 1081-2.
35. Han J, Sabbatini P, Perez D, Rao L, Mohda D, White E. The E1B 19K protein functions as an apoptosis inhibitor by interacting with and inhibiting the p53-inducible and death promoting Bax protein. Genes Dev 1996 ; 10 : 461-77.
36. Bump NJ, Hackett M, Hugunin M, et al. Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 1995 ; 269 : 1085-8.
37. Ray CA, Black RA, Kronheim SR, et al. Viral inhibition of inflammation : cowpox virus encodes an inhibitor of the interleukin-1b converting enzyme. Cell 1992 ; 69 : 597-604.
38. Thome M, Schneider P, Hofmann K, et al. Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors. Nature 1997 ; 386 : 517-21.
39. Miossec C, Dutilleul V, Fassy F, Diu-Hercend A. Evidence of CPP32 activation in the absence of apoptosis during T lymphocyte stimulation. J Biol Chem 1997 ; 272 : 13459-62.
40. McCarthy NJ, Whyte MK, Gilbert CS, Evan GI. Inhibition of Ced-3/ICE-related proteases does not prevent cell death induced by oncogenes, DNA damage, or the Bc1-2 homologue Bak. J Cell Biol 1997 ; 136 : 215-27.
41. Xiang J, Chao DT, Korsmeyer SJ. BAX-induced cell death may not require interleukin 1 beta-converting enzyme-like proteases. Proc Natl Acad Sci USA 1996 ; 93 : 14559-63.
42. Buttke TM, Sandstrom PA. Oxidative stress as a mediator of apoptosis. Immunol Today 1994 ; 15 : 7-10.
43. Hara H, Friedlander RM, Gagliardini V, et al. Inhibition of interleukin 1 beta converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage. Proc Natl Acad Sci USA 1997 ; 94 : 2007-12.
44. Kajstura J, Cheng W, Reiss K, et al. Apoptotic and necrotic myocyte cell deaths are independent contributing variables of infarct size in rats. Lab Invest 1996 ; 74 : 86-107.
45. Saraste A, Pulkki K, Kallajoki M, Henriksen K, Parvinen M, Voipio-Pulkki LM. Apoptosis in human acute myocardial infarction. Cirulation 1997 ; 95 : 320-3.
46. Golstein P. Deux mécanismes moléculaires pour la cytotoxixité T : perforine/ granzymes et Fas. Med Sci 1995 ; 11 : 99-104.
47. Shi L, Mai S, Israels S, Browne K, Trapani JA, Greenberg AH. Granzyme B (GraB) autonomously crosses the cell membrane and perform initiates apoptosis and GraB nuclear localization. J Exp Med 1997 ; 185 : 855-66.
48. Rouquet N, Pages JC, Molina T, Briand P, Joulin V. ICE inhibitor YVAD-cmk is potent against liver apoptosis in vivo. Curr Biol 1996 ; 6 : 1192-5.
49. Rodriguez I, Matsuura K, Ody C, Nagata S, Vassalli P. Systemic injection of a tripeptide inhibits the intracellular activation of CPPS2-like proteases in vivo and fully protects mice against Fas-mediated fulminant liver destruction and death. J Exp Med 1996 ; 184 : 2067-72.