A tryptophan hydroxylase gene marker for suicidality and alcoholism

Archives of General Psychiatry

Volumn 55, Issue 7, 1998, Pages 593-602

  Nielsen, David A ^a   Virkkunen, Mutti ^b   Lappalainen, Jaakko ^a   Eggert, Monica ^b   Brown, Gerald L ^a   Long, Jeffrey C ^a   Goldman, David ^a   Linnoila, Markku ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; FAMILY STUDY; FEMALE; FINLAND; GENETIC LINKAGE; GENETIC MARKER; GENETIC POLYMORPHISM; HUMAN; MAJOR CLINICAL STUDY; MALE; OFFENDER; SIBLING; SUICIDAL BEHAVIOR; SUICIDE ATTEMPT;

ADULT; ALCOHOLISM; FAMILY; FINLAND; GENETIC MARKERS; GENOTYPE; HUMANS; IMPULSE CONTROL DISORDERS; INTRONS; LINKAGE (GENETICS); MALE; MODELS, GENETIC; PERSONALITY; POLYMORPHISM, GENETIC; PRISONERS; REGRESSION ANALYSIS; SEROTONIN; SUICIDE, ATTEMPTED; TRYPTOPHAN HYDROXYLASE; VARIATION (GENETICS);

EID: 0031872284     PISSN: 0003990X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archpsyc.55.7.593     Document Type: Article

References (67)

1. Roy A, Segal NL, Centerwall BS, Robinette CD. Suicide in twins. Arch Gen Psychiatry. 1991;48:29-32.
2. Brent DA, Bridge J, Johnson BA, Connolly J. Suicidal behavior runs in families: a controlled family study of adolescent suicide victims. Arch Gen Psychiatry. 1996;53:1145-1152.
3. Bohman M, Cloninger CR, von Knorring AL, Sigvardsson S, An adoption study of somatoform disorders, III: cross-fostering analysis and genetic relationship to alcoholism and criminality. Arch Gen Psychiatry. 1984;41:872-878.
4. Cloninger CR, Bohman M, Sigvardsson S, Inheritance of alcohol abuse: crossfostering analysis of adopted men. Arch Gen Psychiatry. 1981;38:861-868.
5. Linnoila M, De Jong J, Virkkunen M. Family history of alcoholism in violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989;46:613-616.
6. Murphy GE, Wetzel RD. The lifetime risk of suicide in alcoholism. Arch Gen Psychiatry. 1990;47:383-392.
7. Roy A, Linnoila M. Alcoholism and suicide, Suicide Life Threat Behav. 1986;16: 162-191.
8. Rosenthal NE, Davenport Y, Cowdry RW, Webster MH, Goodwin FK. Monoamine metabolites in cerebrospinal fluid of depressive subgroups. Psychiatry Res. 1980;2:113-119.
9. Asberg M, Traskman L, Thoren P. 5-HIAA in the cerebrospinal fluid; a biochemical suicide predictor? Arch Gen Psychiatry. 1976;33:1193-1197.
10. Virkkunen M, De Jong J, Bartko J, Linnoila M. Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters. Arch Gen Psychiatry. 1989;46:604-606.
11. Roy A, De Jong J, Linnoila M. Cerebrospinal fluid monoamine metabolites and suicidal behavior in depressed patients. Arch Gen Psychiatry. 1989;46: 609-612.
12. Ballenger JC, Goodwin FK, Major LF, Brown GL. Alcohol and central serotonin metabolism in man. Arch Gen Psychiatry. 1979;36:224-227.
13. Fils-Aime ML, Eckardt MJ, George DT, Brown GL, Mefford I, Linnoila M. Earlyonset alcoholics have lower cerebrospinal fluid 5-hydroxyindoleacetic acid levels than late-onset alcoholics. Arch Gen Psychiatry. 1996;53:211-216.
14. Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW, Scanlan JM, Suomi SJ, Linnoila M. Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry. 1993;50:615-623.
15. Brunner HG, Nelen M, Breakefield XO, Ropers HH, van Oost BA. Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A. Science. 1993;262:578-580.
16. Nielsen DA, Dean M, Goldman D. Genetic mapping of the human tryptophan hydroxylase gene on chromosome 11, using an intronic conformational polymorphism. Am J Hum Genet. 1992;51:1366-1371.
17. Ichinose H, Ohye T, Takahashi E, Seki N, Hori T, Segawa M, Nomura Y, Endo K, Tanaka H, Tsuji S, Fujlta K, Nagatsu T. Hereditary progressive dystonia with marked diurnal fluctuation caused by mutations in the GTP cyclohydrolase I gene. Nat Genet. 1994;8:236-242.
18. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science. 1996;274: 1527-1531.
19. Ogilvie AD, Battersby S, Bubb VJ, Fink G, Harmar AJ, Goodwin GM, Smith CA, Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 1996;347:731-733.
20. Nakhai B, Nielsen DA, Linnoila M, Goldman D. Two naturally occurring amino acid substitutions in the human 5-HT1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochem Biophys Res Commun. 1995;210: 530-536.
21. 1A receptor. Neuropsychopharmacology. 1997;17:18-26.
22. Erdmann J, Shimron-Abarbanell D, Cichon S, Albus M, Maier W, Lichtermann D, Minges J, Reuner U, Franzek E, Ertl MA, Hebebrand J, Remschmidt H, Lehmkuhl G, Poustka F, Schmidt M, Flmmers R, Körner J, Rietschel M, Propping P, Nöthen M. Systematic screening for mutations in the promoter and the coding region of the 5-HT1A gene. Am J Med Genet. 1995;60:393-399,
23. Ozaki N, Lappalainen J, Dean M, Virkkunen M, Linnoila M, Goldman D. Mapping of the serotonin 5-HT1D alpha autoreceptor gene (HTR1D) on chromosome 1 using a silent polymorphism in the coding region. Am J Med Genet. 1995;60: 162-164.
24. Lappalainen J, Dean M, Charbonneau L, Virkkunen M, Linnoila M, Goldman D. Mapping of the serotonin 5-HT1D beta autoreceptor gene on chromosome 6 and direct analysis for sequence variants. Am J Med Genet. 1995;60: 157-161.
25. Nothen MM, Erdmann J, Shimron-Abarbanell D, Propping P. Identification of genetic variation in the human serotonin 1D beta receptor gene. Biochem Biophys Res Commun. 1994;205:1194-1200.
26. Shimron-Abarbanell D, Harms H, Erdmann J, Albus M, Maier W, Rietschel M, Korner J, Weigelt B, Franzek E, Sander T, Knapp M, Propping P, Nothen MM. Systematic screening for mutations in the human serotonin 1F receptor gene in patients with bipolar affective disorder and schizophrenia. Am J Med Genet. 1996;67:225-228.
27. Ozaki N, Manji H, Lubierman V, Lu SJ, Lappalainen J, Rosenthal NE, Goldman D. A naturally occurring amino acid substitution of the human serotonin 5-HT2A receptor influences amplitude and timing of intracellular calcium mobilization. Biol Psychiatry. 1996;40:1267-1272.
28. Erdmann J, Shimron-Abarbanell D, Rietschel M, Albus M, Maier W, Korner J, Bondy B, Chen K, Shih JC, Knapp M, Propping P, Nothen MM. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet. 1996;97:614-619.
29. Lappalainen J, Zhang L, Dean M, Oz M, Ozaki N, Yu DH, Virkkunen M, Weight F, Linnoila M, Goldman D. Identification, expression, and pharmacology of a Cys23-Ser23 substitution in the human 5-HT2c receptor gene (HTR2C). Genomics. 1995;27:274-279.
30. Gelernter J, Rao PA, Pauls DL, Hamblin MW, Sibley DR, Kidd KK. Assignment of the 5HT7 receptor gene (HTR7) to chromosome 10q and exclusion of genetic linkage with Tourette syndrome. Genomics. 1995;26:207-209.
31. Cooper JR, Melcer I. The enzymatic oxidation of tryptophan to 5-hydroxytryptophan in the bjosynthesis of serotonin. J Pharmacol Exp Ther. 1961;132:265-268.
32. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry. 1994;51: 34-38.
33. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D. Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol Brain Res. 1997;45:145-148.
34. Abbar M, Courtet P, Amadeo S, Caer Y, Mallet J, Baldy-Moulinier M, Castelnau D, Malafosse A. Suicidal behaviors and the tryptophan hydroxylase gene. Arch Gen Psychiatry. 1995;52:846-849.
35. Virkkunen M, Eggert M, Rawlings R, Linnoila M. A prospective follow-up study of alcoholic violent offenders and fire setters. Arch Gen Psychiatry. 1996;53: 523-529.
36. American Psychiatric Association, Committee on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders, Revised Third Edition. Washington, DC: American Psychiatric Association; 1987.
37. American Psychiatric Association, Committee on Nomenclature and Statistics. Diagnostic and Statistical Manual of Mental Disorders, Third Edition. Washington, DC: American Psychiatric Association; 1987.
38. Schalling D, Asberg M. Biological and psychological correlation of impulsiveness and monotony avoidance. In: Strelau J, Farlay FM, Gale A, eds. The Biological Foundations of Personality and Behavior. New York, NY: Hemisphere Press; 1981:181-194.
39. Schalling D. Psychopathy related personality variables and the psychophyslology of socialization. In: Hare RD, Schalling D, eds. Psychopathic Behaviour: Approaches to Research. Chicester, England: Wiley; 1987:85-106.
40. Schalling D, Asberg M, Edman G, Oreland L. Markers for vulnerability to psyche-pathology: temperament traits associated with platelet MAO activity. Acta Psychiatr Scand. 1987;76:172-182.
41. Rosen A-S, Schalling D. On the validity of the CPI socialization scale. J Consult Clin Psychol. 1974;42:757-765.
42. Gough HG. Theory and measurement of socialization. J Consult Clin Psychol. 1960;74:23-30.
43. Nielsen DA, Novoradovsky A, Goldman D. SSCP primer design based on single-strand DNA structure predicted by a DNA folding program. Nucleic Acids Res. 1995;23:2287-2291.
44. SAGE: Statistical Analysis for Genetic Epidemiology, Release 2.2. New Orleans, La: Department of Biometry and Genetics, LSU Medical Center: 1994.
45. Elston RC. 1996 William Allan Award Address: algorithms and inferences; the challenge of multifactorial diseases. Am J Hum Genet. 1997;60:255-262.
46. Haseman JK, Elston RC. The investigation of linkage between a quantitative trait and a marker locus. Behav Genet. 1972;2:3-19.
47. Zhang H, Risch N, Mapping quantitative-trait loci in humans by use of extreme concordant sib pairs: selected sampling by parental phenotypes. Am J Hum Genet. 1996;59:951-957.
48. Risch NJ, Zhang H. Mapping quantitative trait loci with extreme discordant sib pairs: sampling considerations. Am J Hum Genet. 1996;58:836-843.
49. Scheinin M, Chang WH, Kirk KL, Linnoila M. Simultaneous determination of 3-methoxy-4-hydroxyphenylglycol, 5-hydroxyindoleacetic acid, and homovanillic acid in cerebrospinal fluid with high-performance liquid chromatography using electrochemical detection. Anal Biochem. 1983;131:246-253.
50. Sigvardsson S, Bohman M, Cloninger CR. Replication of the Stockholm Adoption Study of alcoholism: confirmatory cross-fostering analysis. Arch Gen Psychiatry. 1996;53:681-687.
51. Fry JC. Biological data analysis: a practical approach. In: Fry JC, ed. Practical Approach Series. Oxford, England: Oxford University Press; 1996:102.
52. Mann JJ, Malone KM, Nielsen DA, Goldman D, Erdos J, Gelernter J. Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients. Am J Psychiatry. 1997;154:1451-1453.
53. Nieisen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M. TPH replication study: not! Arch Gen Psychiatry. 1996;53:964-965.
54. Gottfries CG, von Knorring L, Oreland L. Platelet monoamine oxidase activity in mental disorders, 2: affective psychoses and suicidal behavior. Prog Neuropsychopharmacol. 1980;4:185-192.
55. Prasad AJ. Neuroendocrine differences between violent and non-violent parasuicides. Neuropsychobiology. 1985;13:157-159.
56. Nordstrom P, Gustavsson P, Edman G, Asberg M. Temperamental vulnerability and suicide risk after attempted suicide. Suicide Life Threat Behav. 1996;26:380-394.
57. Thomasson HR, Crabb DW, Edenberg HJ, Li TK, Hwu HG, Chen CC, Yeh EK, Yin SJ. Low frequency of the ADH2*2 allele among Atayal natives of Taiwan with alcohol use disorders. Alcohol Clin Exp Res. 1994;18:640-643.
58. Thomasson HR, Edenberg HJ, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin YT, Lu RB, Yin SJ. Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet. 1991;48:677-681.
59. Nakamura K, Iwahashi K, Matsuo Y, Miyatake R, IchikawaY, Suwakl H. Characteristics of Japanese alcoholics with the atypical aldehyde dehydrogenase 2*2, I: a comparison of the genotypes of ALDH2, ADH2, ADH3, and cytochrome P-4502E1 between alcoholics and nonalcoholics. Alcohol Clin Exp Res. 1996;20: 52-55.
60. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB. Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA. 1990;263:2055-2060.
61. Lawford BR, Young RM, Rowell JA, Gibson JN, Feeney GFX, Ritchie TL, Syndulko K, Noble EP. Association of the D2 dopamine receptor A1 allele with alcoholism: medical severity of alcoholism and type of controls. Biol Psychiatry. 1997;41:386-393.
62. Gelernter J, Goldman D, Risen N, The A1 allele at the D2 dopamine receptor gene and alcoholism: a reappraisal, JAMA. 1993;269:1673-1677.
63. Lester D. The availability of firearms and the use of firearms for suicide; a study of 20 countries. Acts Psychiatr Scano. 1990;81:146-147.
64. Eronen M, Hakola P, Tiihonen J. Mental disorders and homicidal behavior in Finland. Arch Gen Psychiatry. 1996;53:497-501.
65. Geijer T, Jonsson E, Neiman J, Persson M-L, Brene S, Gyllander A, Sedvall G, Rydberg U, Wasserman D, Terenius L. Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics. Alcohol Clin Exp Res. 1997;21:39-39.
66. Adamson MD, Kennedy J, Petronis A, Dean M, Virkkunen M, Linnoila M, Goldman D. DRD4 dopamine receptor genotype and CSF monoamine metabolites in Finnish alcoholics and controls. Am J Med Genet. 1995;60:199-205.
67. Chang F-M, Ko H-C, Lu R-B, Pakstis AJ, Kidd KK. The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three Taiwanese populations: six polymorphisms tested separately and as haplotypes. Biol Psychiatry. 1997;41:393-405.