Agonist-promoted down-regulation and functional desensitization in two naturally occurring variants of the human serotonin(1A) receptor

Neuropsychopharmacology

Volumn 17, Issue 1, 1997, Pages 18-26

  Rotondo, Alessandro ^a   Nielsen, David A ^a   Nakhai, Bita ^a   Hulihan Giblin, Bridget ^a   Bolos, Annabel ^a   Goldman, David ^a  

^a NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM   (United States)

Author keywords

5 HT(1A) receptor; 5 Hydroxytryptamine; Desensitization; Down regulation; Polymorphisms; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; CYCLIC AMP; FORSKOLIN; GLYCINE; ISOLEUCINE; N TERT BUTYL 3 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL] 2 PHENYLPROPIONAMIDE; RADIOLIGAND; SERINE; SEROTONIN; SEROTONIN 1A AGONIST; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; VALINE;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL LINE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DESENSITIZATION; DRUG ANTAGONISM; DRUG RECEPTOR BINDING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN VARIANT; RECEPTOR DOWN REGULATION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; CHO CELLS; CRICETINAE; DOWN-REGULATION; HUMANS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN AGONISTS;

EID: 0030947520     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0893-133X(97)00021-3     Document Type: Article

References (35)

1. 1A receptor: Signaling, desensitization and gene transcription. Neuropsychopharmacology 14:19-25
2. Artigas F, Perez V, Alvarez E (1994): Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. Arch Gen Psychiatry 51:248-251
3. 1A structural variants with allele-specific amplification and electrochemiluminescent detection. Hum Mutat 7:135-143
4. Blier P, De Montigny C (1994): Current advances and trends in the treatment of depression. Trends Pharmacol Sci 15:220-226
5. Blier P, and Bergeron R (1995): Effectiveness of pindolol with selected antidepressant drugs in treatment of major depression. J Clin Psychopharmacol 15:217-222
6. Boess FG, Martin IL (1994):Molecular biology of 5-HT receptors. Neuropharmacology 33:275-317
7. Bradford MM (1976): A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254
8. 1A receptor variant with the Ile28Val substitution in the extracellular domain. Naunyn-Schmiedeberg's Arch Pharmacol 352:455-458
9. 2A receptor mRNA in human brain. Brain Res 676:157-168
10. 1A serotonin receptor. Mol Pharmacol 43:516-520
11. Collins S, Caron MG, Lefkowitz RJ (1992): From ligand binding to gene expression: New insights into the regulation of G-protein-coupled receptors.Trends Biochem Sci 17:37-39
12. De Vivo M, Maayani S (1986): Characterization of the 5-hydroxytryptamine1A receptor-mediated inhibition of forskolin-stimulated adenylate cyclase activity in guinea pig and rat hippocampal membranes. J Pharmacol Exp Ther 238:248-253
13. De Vry J (1995): Receptor agonists: recent developments and controversial issues. Psychopharmacology 121:1-26
14. Dixon RAF, Sigal IS, Candelore MR, Register RB, Scattergood W, Rands E, Strader C (1987): Structural features required for ligand binding to the β-adrenergic receptor. EMBO J 6:3269-3275
15. Dohlman HG, Thorner J, Caron MG, Lefkowitz RJ (1991): Model system for the study of seven-transmembrane-segment receptor. Annu Rev Biochem 60:635-688
16. Dumuis A, Sebben M, Bockaert J (1988): Pharmacology of 5-hydroxytryptamine-1A receptors which inhibit cAMP production in hippocampal and cortical neurons in primary culture. Mol Pharmacol 33:178-186
17. 1A gene. Am J Med Genet 60:393-399
18. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry 33:9414-9419
19. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol 13:25-33
20. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 345:1213-1214
21. Harada S, Okubo T, Muramatsu T (1996): Genetic variations of CCKRB, HT1AR, and MT-DNA deletion in alcoholics. Alcoholism 20 (Suppl):67A
22. 1B recognition sites. Brain Res 376:85-96
23. Kobilka BK, Frielle I, Collins S, Yang-Feng T, Kobilka TS, Francke U, Lefkowitz RJ, Caron MG (1987): An intronless gene encoding a potential member of the family of receptors coupled to guanine nucleotide regulatory proteins. Nature 329:75-79
24. Kunkel TA (1985): Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 82:488-492
25. Mak C, Avalos M, Randall PK, Kwan SW, Abell CW, Nëumeyci JL, Whisennand R, and Wilcox RE (1996): Improved models for pharmacological null experiments: Calculation of drug efficacy at recombinant D1A dopamine receptors stably expressed in clonal cell lines. Neuropharmacology (in press)
26. Marazziti D, Marracci S, Palego L, Rotondo A, Mazzanti C, Nardi I, Ladinsky H, Giraldo F, Borsini F, Cassano GB (1994): Localization and gene expression of serotonin 1A receptor in post-mortem human brain. Brain Res 658:55-59
27. 1A receptor: glycine 22 to serine 22 and isoleucine 28 to valine 28. Biochem Biophys Res Commun 210:530-536
28. 1A receptor-mediated effects of antidepressants. Prog Neuro-Psychopharmacol and Biol Psychiatr 17:1-19
29. 1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells. Biochem J 285:933-938
30. Peroutka SJ (1994): Molecular biology of serotonin (5-HT) receptors. Synapse 18:241-260
31. 1A receptor. J Biol Chem 266:14747-14753
32. 1A receptors and different coupling to second messengers in CHO cells. Naunyn-Schmiedeberg's Arch Pharmacol 346:127-137
33. 2-adrenergic receptor in normal and asthmatic subjects. Am J Respir Cell Mol Biol 8: 334-339
34. Sambrook J, Fritsch EF, Maniatis T (1989): Molecular Cloning: A Laboratory Manual. Cold Spring Harbor, NY, Cold Spring Harbor Laboratory Press
35. Zifa E, Fillon G (1992): 5-hydroxytryptamine receptors. Pharmacol Rev 44:401-458