The dopamine D4 receptor gene (DRD4) is not associated with alcoholism in three taiwanese populations: Six polymorphisms tested separately and as haplotypes

Biological Psychiatry

Volumn 41, Issue 4, 1997, Pages 394-405

  Chang, Fong Ming ^a,b   Ko, Huei Chen ^b   Lu, Ru Band ^c   Pakstis, Andrew J ^a   Kidd, Kenneth K ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c TRI SERVICE GENERAL HOSPITAL   (Taiwan)

Author keywords

Alcoholism; Association; Dopamine D4 receptor gene (DRD4); Molecular genetics; Population

Indexed keywords

DOPAMINE RECEPTOR;

ADULT; ALCOHOLISM; ARTICLE; CONTROLLED STUDY; GENETIC POLYMORPHISM; GENETICS; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; TAIWAN;

EID: 0031568860     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-3223(96)00248-X     Document Type: Article

References (53)

1. American Psychiatric Association (1987): Diagnostic and Statistical Manual of Mental Disorder, 3rd edition-Revised. Washington, DC.
2. Barr CL, Kidd KK (1993): Population frequencies of the A1 allele at the dopamine D2 receptor locus. Biol Psychiatry 34:204-209.
3. Blum K, Noble P, Sheridan PJ, Montgomery A, Ritchie T, Jagadeeswaran P, Nogami H, Briggs AH, Cohn JB (1990): Allelic association of human dopamine D2 receptor gene in alcoholism. JAMA 263:2055-2060.
4. Blum K, Noble EP, Sheridan PJ, Montgomery A, Ritchie T, Ozkaragoz T, Fitch RJ, Wood R, Finley O, Sadlack F (1993): Genetic predisposition in alcoholism: association of the D2 dopamine receptor TaqI B1 RFLP with severe alcoholics. Alcohol 10:59-67.
5. Bolos AM, Dean M, Lucas-Derse S, Ramsburg M, Brown GL, Goldman D (1990): Population and pedigree studies reveal a lack of association between the dopamine D2 receptor gene in alcoholism. JAMA 264:3156-3160.
6. Castiglione CM, Deinard AS, Speed WC, Sirugo G, Rosenbaum HC, Zhang Y, Grandy DK, Grigorenko EL, Bonne-Tamir B, Kidd JR, Kidd KK (1995): Evolution of Haplotypes at the DRD2 Locus. Am J Hum Genet 57:1445-1456.
7. Catalano M, Nobile M, Novelli E, Nothen MM, Smeraldi E (1993): Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients. Biol Psychiatry 34:459-464.
8. Chang FM, Kidd KK (in press): Rapid molecular haplotyping of the first exon of the human dopamine D4 receptor gene by heteroduplex analysis. (Neuropsy Genet) Am J Med Gen
9. Chang FM, Kidd JR, Livak KJ, Pakstis AJ, Kidd KK (1996): The world-wide distribution of allele frequencies at the human dopamine D4 receptor locus. Hum Genet 98:91-101.
10. Cheng TA (1993): Epidemiology of alcoholism among four aboriginal groups in Taiwan. Proceedings of the Symposium on Drink and Health Problems among Aboriginal Groups in Taiwan. pp 9-19.
11. Crabb DW, Edenberg HJ, Bosron WF, Li TK (1989): Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH 2(2) allele is dominant. J Clin Invest 83:314-316.
12. DiLella AG, Marvit J, Brayton K, Woo SL (1987): An amino-acid substitution involved in phenylketonuria is in linkage disequilibrium with DNA haplotype 2. Nature 327:333-336.
13. Estivill X, Scambler PJ, Wainwright BJ, Hawley K, Frederick P, Schawrtz M, Baiget M, Kere J, Williamson R, Farrall M (1987): Patterns of polymorphism and linkage disequilibrium for cystic fibrosis. Genomics 1:257-263.
14. Falk CT, Rubenstein P (1987): Haplotype relative risks: an easy reliable way to construct a proper control sample for risk calculations. Ann Hum Genet 51:227-233.
15. Gelernter J, O'Malley S, Risch N, Kranzler HR, Krystal J, Merikangas KM, Kennedy JL, Kidd KK (1991): No association between an allele at the D2 dopamine receptor gene (DRD2) and alcoholism. JAMA 266:1801-1807.
16. Gelernter J, Kennedy JL, Van Tol HHM, Civelli O, Kidd KK (1992): The D4 dopamine receptor (DRD4) maps to distal 11p close to HRAS. Genomics 13:208-210.
17. George SR, Cheng R, Nguyen T, Israel Y, O'Dowd BF (1993): Polymorphisms of the D4 dopamine receptor alleles in chronic alcoholism. Biochem Biophys Res Comm 196:107-114.
18. Hauge XY, Grandy DK, Eubanks JH, Evans GA, Civelli O, Litt M (1991): Detection and characterization of additional DNA polymorphisms in the dopamine D2 receptor gene. Genomics 10:527-530.
19. Hawley ME, Kidd KK (1995): HAPLO: A program using the EM algorithm to estimate the frequencies of multi-site haplotypes. J Hered 86:409-411.
20. Helzer JE, Canino GJ, Yeh EK, Bland RC, Lee CK, Hwu HG, Newman S (1990): Alcoholism - North America and Asia. A comparison of population surveys with the Diagnostic Interview Schedule. Arch Gen Psychiatry 47:313-319.
21. Hwu HG, Yeh EK, Yeh YL (1990a): Risk factors of alcoholism in Taiwan Chinese: An epidemiological approach. Acta Psychiatrica Scand 82:295-298.
22. Hwu HG, Yeh YL, Wang JD, Yeh EK (1990b): Alcoholism among Taiwan aborigines defined by the Chinese Diagnostic Interview Schedule: A comparison with alcoholism among Chinese. Acta Psychiatrica Scand 82:374-380.
23. Hwu HG, Yeh YL, Wang JD (1991): Risk factors of alcoholism among Taiwan aborigines: Implications for etiological models and the nosology of alcoholism. Acta Psychiatrica Scand 83:267-272.
24. Hwu HG, Chen CC, Yeh LL (1992): A typology of alcoholism in Taiwan aborigines: A study of evolving process of community cases. Psychopathology 25:311-318.
25. Inoue A, Ihara H, Kon T, Nakamura M, Suzuki J, Aoki T, Hemmi H, Shimatake H (1993): Polymorphism in the human dopamine D4 receptor gene (DRD4) in Japanese detected by PCR. Hum Mol Genet 2:2197.
26. Iversen LL (1992): Dopamine receptors. Which D4 do you have? Nature 358:109.
27. Kidd KK (1987): Phenylketonuria. Population genetics of a disease. Nature 327:282-283.
28. Kidd KK (1993): Association of disease with genetic markers: Deja vu all over again. Am J Med Genet 48:71-73.
29. Kidd KK, Pakstis AJ, Castiglione CM, Kidd JR, Speed WC, Goldman D, Knowler WC, Lu R-B, Bonne-Tamir B (1996): Alcoholism and DRD2 haplotypes containing the TaqI A1 allele. Alc Clin Exp Res 20:697-705.
30. Lichter JB, Livak KJ, Rogers J, Kennedy JL, Van Tol HHM (1992): Echoes of D4 receptor repeats. Nature 360:424.
31. Lichter JB, Barr CL, Kennedy JL, Van Tol HHM, Kidd KK, Livak KJ (1993): A hypervariable segment in the human dopamine receptor (DRD4) gene. Hum Mol Genet 2:767-773.
32. Livak KJ, Rogers J, Lichter JB (1995): Variability of dopamine D4 receptor (DRD4) gene sequence within and among non-human primates species. Proc Natl Acad Sci USA 92:427-431.
33. Lu RB, Ko HC, Chang FM, Castiglione CM, Schoolfield G, Pakstis AJ, Kidd JR, Kidd KK (1996): No association between alcoholism and multiple polymorphisms at the dopamine D2 receptor gene (DRD2) in three distinct Taiwanese populations. Biol Psychiatry 39:419-429.
34. MacDonald ME, Lin C, Srinidhi L, Bates G, Altherr M, Whaley WL, Lehrach H, Wasmuth J, Gusella JF (1991): Complex patterns of linkage disequilibrium in Huntington's disease region. Am J Hum Genet 49:723-734.
35. Merikangas KR (1990): The genetic epidemiology of alcoholism. Psycho Med 20:11-22.
36. Nanko S, Hattori M, Ikeda K, Sasaki T, Kazamatsuri H, Kuwata S (1993): Dopamine D4 receptor polymorphism and schizophrenia. Lancet 341:689-690.
37. Nothen MM, Cichon S, Hemmer S, Hebebrand J, Remschmidt H, Lehmkuhl G, Poustka F, et al. (1994): Human dopamine D4 receptor gene: frequent occurrence of a null allele and observation of homozygosity. Hum Mol Genet 3:2207-2212.
38. Petronis A, Van Tol HHM, Livak KJ, Siderberg DG, Macciardi FM, Kennedy JL (1992): Genetic analysis of variable repeat sequence in DRD4 gene exon. Am J Hum Genet (Abstract) A198:779.
39. Petronis A, Van Tol HHM, Lichter JB, Livak KJ, Kennedy JL (1993): The D4 dopamine receptor gene maps on 11p proximal to HRAS. Genomics 18:161-163.
40. Petronis A, Van Tol HHM, Kennedy JL (1994a): A SmaI PCR-RFLP in the 5′ noncoding region of the human D4 dopamine receptor gene (DRD4). Hum Hered 44:58-60.
41. n-mononucleotide polymorphism in the human D4 dopamine receptor (DRD4) gene. Hum Genet 93:719.
42. Seeman P, Ulpian C, Chouinard G, Van Tol HHM, Dwosh H, Liberman JA, Siminovitch K, Liu JS, Waye J, Voruganti P, et al. (1994): Dopamine D4 receptor variant, D4glycine194, in Africans, but not in Caucasians: No association with schizophrenia. Am J Med Genet 54:384-390.
43. Shaikh S, Collier D, Kerwin RW, Pilowsky LS, Gill M, Xu WM, Thornton A (1993): Dopamine D4 receptor subtypes and response to clozapine. Lancet 341:116.
44. Shaikh S, Collier DA, Sham P, Pilowsky L, Sharma T, Lin LK, Crocq MA, Gill M, Kerwin R (1995): Analysis of clozapine response and polymorphisms of the dopamine D4 receptor gene (DRD4) in schizophrenic patients. Am J Med Gen (Neuropsy Genet) 60:541-545.
45. Sibley DR, Monsma FJ Jr, Shen Y (1993): Molecular neurobiology of dopaminergic receptors. Int Rev Neurobiol 35:391-415.
46. Sommer SS, Lind TJ, Heston LL, Sobell JL (1993): Dopamine D4 receptor variants in unrelated schizophrenic cases and controls. Am J Med Gen 48:90-93.
47. Tanaka T, Igarashi S, Onodera O, Tanaka H, Kameda K, Takahashi K, Tsuji S, and Ihda S (1995): Lack of association between dopamine D4 receptor gene and schizophrenia. Am J Med Gen (Neuropsy Genet) 60:580-582.
48. Thomasson HR, Edenberg H, Crabb DW, Mai XL, Jerome RE, Li TK, Wang SP, Lin TT, Lu RB, Yin SJ (1991): Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men. Am J Hum Genet 48:677-681.
49. Van Tol HHM, Bunzow JR, Guan HC, Sunahara RK, Seeman P, Niznik HB, Civelli O (1991): Cloning of the gene for a human dopamine receptor with high affinity for the antipsychotic clozapine. Nature 350:610-614.
50. Van Tol HHM, Wu CM, Guan HC, Ohara K, Bunzow JR, Civelli O, Kennedy J, Seeman P, Niznik HB, Jovanovic V (1992): Multiple dopamine D4 receptor variants in the human population. Nature 358:149-152.
51. Wall TL, Thomasson HR, Schuckit MA, Ehlers CL (1992): Subjective feelings of alcohol intoxication in Asians with genetic variations of ALDH2 alleles. Alcohol Clin Exp Res 16:991-995.
52. Workman PL, Niswander JD (1970): Population studies on southwestern Indian tribes. II. Local genetic differentiation in the Papago. Am J Hum Gen 22:24-49.
53. Xu Y, Carr LG, Bosron WF, Li TK, Edenberg HJ (1988): Genotyping of human alcohol dehydrogenase at the ADH2 and ADH3 loci following DNA sequence amplification. Genomics 2:209-214.