Possible association of a polymorphism of the tryptophan hydroxylase gene with suicidal behavior in depressed patients

American Journal of Psychiatry

Volumn 154, Issue 10, 1997, Pages 1451-1453

  John Mann, J ^b   Malone, Kevin M ^b   Nielsen, David A ^b   Goldman, David ^b   Erdos, Joseph ^b   Gelernter, Joel ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

5 HYDROXYINDOLEACETIC ACID; DNA; SEROTONIN; TRYPTOPHAN HYDROXYLASE;

ADULT; ARTICLE; DEPRESSION; FEMALE; GENE; GENETIC POLYMORPHISM; GENOTYPE; HAMILTON SCALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RISK; SUICIDAL BEHAVIOR;

EID: 0030770598     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.154.10.1451     Document Type: Article

References (18)

1. Mann JJ, Underwood MD, Arango V, Postmortem studies of suicide victims, in Biology of Schizophrenia and Affective Disease. Edited by Watson SJ. Washington, DC, American Psychiatric Press, 1996, pp 197-220
2. Mann JJ, Malone KM, Sweeney JA, Brown RP, Linnoila M, Stanley B, Stanley M. Attempted suicide characteristics and cerebrospinal fluid amine metabolites in depressed inpatients. Neuropsychopharmacology 1996; 15:576-586
3. Cooper SJ, Kelly CB, King DJ: 5-Hydroxyindoleacetic acid in cerebrospinal fluid and prediction of suicidal behaviour in schizophrenia. Lancet 1992; 340:940-941
4. Träskman-Bendz L, Asberg M, Schalling D: Serotonergic function and suicidal behavior in personality disorders. Ann NY Acad Sei 1986; 487:168-174
5. Roy A: Family history of suicide. Arch Gen Psychiatry 1983; 40: 971-974
6. Nielsen DA, Dean M, Goldman D: Genetic mapping of the human tryptophan hydroxylase gene on chromosome II, using an intronic conformational polymorphism. Am J Hum Genet 1992; 51:1366-1371
7. Spitzer RL, Williams JEW, Gibbon M, First MB: Instruction Manual for the Structured Clinical Interview for DSM-III-R (SCID). New York, New York State Psychiatric Institute, Biometrics Research, 1989
8. Loranger AW, Lenzenweger MF, Gärtner AF, Lehmann-Susman V, Herzig J, Zammit GK, Gärtner JD, Abrams RC, Young RC: Trait-state artifacts and the diagnosis of personality disorders. Arch Gen Psychiatry 1991; 48:720-728
9. Beck AT, Kovacs M, Weissman A: Assessment of suicidal intention: the Scale for Suicide Ideation. J Consult Clin Psychol 1979; 47:343-352
10. Lahiri DK, Nürnberger JI Jr, A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res 1991; 19:5444
11. Nielsen DA, Jenkins GL, Stefanisko KM, Jefferson KK, Goldman D: Sequence, splice site and population frequency distribution analyses of the polymorphic human tryptophan hydroxylase intron 7. Mol Brain Res (in press)
12. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo MD, Mieczkowski T, Myers JE, Stanley M: Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 1992; 49: 442-446
13. Egeland JA, Sussex JN: Suicide and family loading for affective disorders. JAMA 1985; 254:915-918
14. Schulsinger F, Kety SS, Rosenthal D, Wender PH: A family study of suicide, in Origin, Prevention and Treatment of Affective Disorders. Edited by Schou M, Stromgren E. New York, Academic Press, 1979, pp 277-287
15. Higley JD, Thompson WW, Champoux M, Goldman D, Hasert MF, Kraemer GW, Scanlan JM, Suomi SJ, Linnoila M: Paternal and maternal genetic and environmental contributions to cerebrospinal fluid monoamine metabolites in rhesus monkeys (Macaca mulatta). Arch Gen Psychiatry 1993; 50:615-623
16. Asberg M, Träskman L, Thorén P: 5-HIAA in the cerebrospinal fluid: a biochemical suicide predictor? Arch Gen Psychiatry 1976; 33:1193-1197
17. Nielsen DA, Goldman D, Virkkunen M, Tokola R, Rawlings R, Linnoila M: Suicidality and 5-hydroxyindoleacetic acid concentration associated with a tryptophan hydroxylase polymorphism. Arch Gen Psychiatry 1994; 51:34-38
18. Abbar M, Court P, Amadéo S, Caer Y, Mallet J, Baldy-Moulinier M, Castelnau D, Malafosse A: Suicidal behaviors and the tryptophan hydroxylase gene. Arch Gen Psychiatry 1995; 52: 846-849