Human immunodeficiency virus type 1 disease progression, CCR5 genotype, and specific immune responses

Clinical and Diagnostic Laboratory Immunology

Volumn 5, Issue 4, 1998, Pages 463-466

  Visco Comandini, Ubaldo ^a,b   Hultgren, Catharina ^a   Broström, Christina ^a   Birk, Markus ^a   Kim, Soo ^a   Sällberg, Matti ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR 5; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; GENE DELETION; GENOTYPE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HUMORAL IMMUNITY; PRIORITY JOURNAL; SEROCONVERSION; VIRUS NEUTRALIZATION;

EID: 0031858846     PISSN: 1071412X     EISSN: None     Source Type: Journal    
DOI: 10.1128/cdli.5.4.463-466.1998     Document Type: Article

References (29)

1. Alkhatib, G., C. Combadiere, C. C. Broder, Y. Feng, P. E. Kennedy, P. M. Murphy, and E. A. Berger. 1996. CC-CKR5: a RANTES, MIP1alpha, MIP1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272:1955-1958.
2. Ansari-Lari, M. A., X. M. Liu, M. L. Metzker, A. R. Rut, and R. A. Gibbs. 1997. The extent of genetic variation in the CCR5 gene. Nat. Genet. 16:221-222.
3. Bleul, C. C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T. A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry. Nature 382:829-833.
4. Broström, C., A. Sönnerborg, and M. Sällberg. 1995. HIV-1 infected patients with no disease progression display a maintained high avidity antibody production to autolugous V3 sequences. J. Infect. Dis. 172:897-898.
5. Broström, C., A. Sönnerborg, S. Kim, and M. Sällberg. 1996. Site directed serology of HIV-1 subtype B infection: relation between virus specific antibody levels and disease progression. Clin. Exp. Immunol. 106:35-39.
6. Cocchi, F., A. L. DeVico, A. Garzino-Demo, A. Cara, R. C. Gallo, and P. Lussu. 1996. The V3 domain of the HIV-1 gp 120 envelope glycoprotein is critical for chemokine-mediated blockade of infection. Nat. Med. 2:1244-1247.
7. Connor, R. I., K. E. Sheridan, D. Ceradini, S. Choe, and N. R. Landau. 1997. Change in coreceptor use correlates with disease progression in HIV-1-infected individuals. J. Exp. Med. 185:621-628.
8. Dean, M., M. Carrington, C. Winkler, G. A. Huttley, M. W. Smith, R. Allikmets, J. J. Goedert, S. P. Buchbinder, E. Vittinghoff, E. Gomperts, S. Donfield, D. Vlahov, R. Kaslow, A. Saah, C. Rinaldo, R. Detels, and S. J. Obrien. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allelc of the CKR5 structural gene. Science 273:1856-1862.
9. Deng, H. K., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R. E. Sutton, C. M. Hill, C. B. Davis, S. C. Peiper, T. J. Schall, D. R. Littman, and N. R. Landau. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature 381:661-666.
10. Dragic, T., V. Litwin, G. P. Allaway, S. R. Martin, Y. X. Huang, K. A. Nagashima, C. Cayanan, P. J. Maddon, R. A. Koup, J. P. Moore, and W. A. Paxton. 1996. HIV-1 entry into CD4(+) cells is mediated by the chemokine receptor CC-CKR-5. Nature 381:667-673.
11. Eugen-Olsen, J., A. K. N. Iversen, P. Garred, U. Koppelhus, C. Pedersen, T. L. Benfield, A. M. Sorensen, T. Katzenstein, E. Dickmeiss, J. Gerstoft, P. Skinhoj, A. Svejgaard, J. O. Nielsen, and B. Hofmann. 1997. Heterozygosity for a deletion in the CKR-5 gene leads to prolonged AIDS-free survival and slower CD4 T-cell decline in a cohort of HIV-seropositive individuals. AIDS 11:305-310.
12. Galli, M., C. Balotta, M. Violin, M. C. Colombo, L. Papagno, P. Bagnarelli, and the Resistant Host Perspective Study (R-HoPeS). 1997. Prevelance of CCR5 w1/D32 phenotype in long-term non progressors (LTNP), abstr. 117, p. 11. In Abstracts of the Sixth European Conference on Clinical Aspects and Treatment of HIV-Infection, 1997, Hamburg, Germany.
13. Garred, P., J. Eugen-Olsen, A. K. N. Iversen, T. L. Benfield, A. Svejgaard, B. Hofmann, and the Copenhagen AIDS Study Group. 1997. Dual effect of CCR5 Δ32 gene deletion in HIV-1-infected patients. Lancet 349:1884.
14. Ho, D. D., A. U. Neumann, A. S. Perelson, W. Chen, J. M. Leonard, and M. Markowitz. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
15. Huang, Y. X., W. A. Paxton, S. M. Wolinsky, A. U. Neumann, L. Q. Zhang, T. He, S. Kang, D. Ceradini, Z. Q. Jin, K. Yazdanbakhsh, K. Kunstman, D. Erickson, E. Dragon, N. R. Landau, J. Phair, D. D. Ho, and R. A. Koup. 1996. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nat. Med. 2:1240-1243.
16. Keet, I. P., A. Krol, M. R. Klein, P. Veugelers, J. de Wit, M. Roos, M. Koot, J. Goudsmit, F. Miedema, and R. A. Coutinho. 1994. Characteristics of long-term asymptomatic infection with human immunodeficiency virus type 1 in men with normal and low CD4+ cell counts. J. Infect. Dis. 169:1236-1243.
17. Liu, R., W. A. Paxton, S. Choe, D. Ceradini, S. R. Martin, R. Horuk, M. E. Macdonald, H. Stuhlmann, R. A. Koup, and N. R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86:367-377.
18. Martinson, J. J., N. H. Chapman, D. C. Rees, Y. T. Liu, and J. B. Clegg. 1997. Global distribution of the CCRr5 gene 32-basepair deletion. Nat. Genet. 16: 100-103.
19. Michael, N. L., G. Chang, L. G. Louie, J. R. Mascola, D. Dondero, D. L. Birx, and H. W. Sheppard. 1997. The role of viral phenotype and CCR5 gene defects in HIV-1 transmission and disease progression. Nat. Med. 3:338-340.
20. Raport, C. J., J. Gosling, V. L. Schweickart, P. W. Gray, and I. F. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for Rantes, Mip-1-beta, and Mip-1-alpha, J. Biol. Chem. 271:17161-17166.
21. Rappaport, J., Y. Y. Cho, H. Hendel, E. J. Schwartz, F. Schachter, and J. F. Zagury. 1997. 32 Bp CCR5 gene deletion and resistance to fast progression in HIV-1 infected heterozygotes. Lancet 349:922-923.
22. Rowe, P. M. 1996. CKR-5 deletion heterozygotes progress slower to AIDS. Lancet 348:947.
23. Samson, M., F. Libert, B. J. Doranz, J. Rucker, C. Liesnard, C. M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille, G. Muyldermans, C. Verhofstede, G. Burtonboy, M. Georges. T. Imai, S. Rana, Y. J. Yi, R. J. Smyth, R. G. Collman, R. W. Doms, G. Vassart, and M. Parmentier. 1996. Resistance to HIV-1 infection in Caucasian individuals bearing mutant allcles of the CCR5 chemokine receptor gene. Nature 382:722-772.
24. Samuelsson, A., C. Broström, N. van Dijk, A. Sönnerborg, and F. Chiodi. 1997. Apoptosis of CD4+ and CD19+ cells during human immunodeficiency virus type 1 infection - correlation with clinical progression, viral load, and loss of humoral immunity. Virology 238:180-188.
25. Simmons, G., P. R. Clapham, L. Picard, R. E. Offord, M. M. Rosenkilde, T. W. Schwartz, R. Buser, T. N. C. Wells, and A. E. I. Proudfoot. 1997. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist. Science 276:276-279.
26. Theodorou, I., L. Meyer, M. Magierowska, C. Katlama, and C. Rouzioux. 1997. HIV-1 infection in an individual homozygous for CCR5-delta-32. Lancet 349:1219-1220.
27. Wei, X., S. K. Ghosh, M. E. Taylor, V. A. Johnson, E. A. Emini, P. Deutsch, J. D. Lifson, S. Bonhoeffer, M. A. Nowak, and B. H. Hahn. 1995. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373: 117-122.
28. Wong, M. T., R. Q. Warren, S. A. Anderson, M. J. Dolan, C. W. Hendrix, S. P. Blatt, G. P. Melcher, R. N. Boswell, and R. C. Kennedy. 1993. Longitudinal analysis of the humoral immune response to human immunodeficiency virus type 1 (HIV-1) gp160 epitopes in rapidly progressing and nonprogressing HIV-1-infected subjects. J. Infect. Dis. 168:1523-1527.
29. Wu, L. J., W. A. Paxton, N. Kassam, N. Ruffing, J. B. Rottman, N. Sullivan, H. Choe, J. Sodroski, W. Newman, R. A. Koup, and C. R. Mackay. 1997. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro. J. Exp. Med. 185:1681-1691.