Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region

Genes Chromosomes and Cancer

Volumn 23, Issue 2, 1998, Pages 123-133

  Tanaka, Hiromi ^a   Shimizu, Motoyuki ^a   Horikawa, Izumi ^b   Kugoh, Hiroyuki ^a   Yokota, Jun ^c   Barrett, J Carl ^b   Oshimura, Mitsuo ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; RNA; TELOMERASE;

ANIMAL CELL; ARTICLE; CHROMOSOME 3P; CHROMOSOME DELETION; CHROMOSOME MAP; CLONE; ENZYME ACTIVITY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE; HETEROZYGOSITY LOSS; HUMAN; HUMAN CELL; HYBRID CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; REPRESSOR GENE; RESTRICTION FRAGMENT; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; TELOMERE;

CARCINOMA, RENAL CELL; CHROMOSOMES, HUMAN, PAIR 3; CLONE CELLS; HUMANS; HYBRID CELLS; KIDNEY NEOPLASMS; REPRESSOR PROTEINS; RESTRICTION MAPPING; TELOMERASE; TUMOR CELLS, CULTURED;

EID: 0031710737     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2264(199810)23:2<123::AID-GCC5>3.0.CO;2-4     Document Type: Article

References (41)

1. Barrett JC (1993) Cell senescence and apoptosis. In Levine AJ, Schmideck HH (eds): Molecular Genetics of Nervous System Tumors. New York: John Wiley & Sons, Inc., pp 61-72.
2. Chen F, Kishida T, Duh FM, Renbaum P, Orcutt ML, Schmidt L, Zbar B (1995) Suppression of growth of renal carcinoma cells by the von Hippel-Lindau tumor suppressor gene. Cancer Res 55:4804-4807.
3. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S (1992) Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11:1921-1929.
4. Counter CM, Hirte HW, Bacchetti S, Harley CB (1994) Telomerase activity in human ovarian carcinoma. Proc Natl Acad Sci USA 91:2900-2904.
5. Dimri GP, Lee X, Basile G, Acosta M, Scott G, Roskelley C, Medrano EE, Linskens M, Rubelj I, Pereira-Smith O, Peacocke M, Campisi J (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci USA 92:9363-9367.
6. Dowdy SF, Scanlon DJ, Fasching CL, Casey G, Stanbridge EJ (1990) Irradiation microcell-mediated chromosome transfer (XMMCT): The generation of specific chromosomal arm deletions. Genes Chromosomes Cancer 2:318-327.
7. Feng J, Funk WD, Wang SS, Weinrich SL, Avilion AA, Chiu CP, Adams RR, Chang E, Allsopp RC, Yu J, Le S, West MD, Harley CB, Andrews WH, Greider CW, Villeponteau B (1995) The RNA component of human telomerase. Science 269:1236-1241.
8. Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten during ageing of human fibroblasts. Nature 345:458-460.
9. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Bass MB, Arruda I, Robinson MO (1997) A mammalian telomerase-associated protein. Science 275:973-977.
10. Hayflick L (1976) The cell biology of human aging. N Engl J Med 295:1302-1308.
11. Henslet PJ, Annab LA, Barrett JC , Pereira-Smith OM (1994) A gene involved in control of human cellular senescence on human chromosome 1q. Mol Cell Biol 14:2291-2297.
12. Hiyama E, Hiyama K, Yokoyama T, Matsuura Y, Piatyszek MA, Shay JW (1995) Correlating telomerase activity levels with human neuroblastoma outcomes. Nat Med 1:249-255.
13. Holt SE, Wright WE, Shay JW (1996) Regulation of telomerase activity in immortal cell line. Mol Cell Biol 16:2932-2939.
14. Iliopoulos O, Kibel A, Gray S, Kaelin WG Jr (1995) Tumour suppression by the human von Hippel-Lindau gene product. Nat Med 1:822-826.
15. Kagiyama N, Yoshida K, Hamabata T, Joni N, Awasaki T, Fujita S, Momiyama M, Kondoh Y, Yoshida MC, Hori SH (1993) A novel fluorescent method for in situ hybridization. Acta Histochem Cytochem 26:441-445.
16. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PL, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994) Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
17. Kohno T, Sekine T, Tobisu K, Oshimura M, Yokota J (1993) Chromosome 3p deletion in a renal cell carcinoma cell line established from a patient with von Hippel-Lindau disease. Jpn J Clin Oncol 23:226-231.
18. Koi M, Morita H, Yamada H, Satoh H, Barrett JC, Oshimura M (1989a) Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa. Mol Carcinog 2:12-21.
19. Koi M, Shimizu M, Morita H, Yamada H, Oshimura M (1989b) Construction of mouse A9 clones containing a single human chromosome tagged with neomycin-resistance gene via microcell fusion. Jpn J Cancer Res 80:413-418.
20. Koi M, Johnson LA, Kalikin LM, Little PF, Nakamura Y, Feinberg AP (1993) Tumor cell growth arrest caused by subchromosomal transferable DNA fragments from chromosome 11. Science 260: 361-364.
21. Lengauer C, Green ED, Cremer T (1992) Fluorescence in situ hybridization of YAC clones after Alu-PCR amplification. Genomics 13:826-828.
22. Loughran O, Clark LJ, Bond J, Baker A, Berry IJ, Edington KG, Ly I-S, Simmons R, Haw R, Black DM, Newbold RF, Parkinson EK (1997) Evidence for the inactivation of multiple replicative life span genes in immortal human squamous cell carcinoma keratinocytes. Oncogene 14:1955-1964.
23. Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddele SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA (1997) hEST2, the putative human telomerase catalytic subunit gene, is upregulated in tumor cells and during immortalization. Cell 90:785-795.
24. Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR (1997) Telomerase catalytic subunit homologues from fission yeast and human. Science 277:955-959.
25. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F (1997) TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88:875-884.
26. Ning Y, Weber JL, Killary AM, Ledbetter DH, Smith JR, Pereira-Smith OM (1991) Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci USA 88:5635-5639.
27. Ogata T, Ayusawa D, Namba M, Takahashi E, Oshimura M, Oishi M (1993) Chromosome 7 suppresses indefinite division of nontumorigenic immortalized human fibroblast cell lines KMST-6 and SUSM-1. Mol Cell Biol 13:6036-6043.
28. Ohmura H, Tahara H, Suzuki M, Ide T, Shimizu M, Yoshida MA, Tahara E, Shay JW, Barrett JC, Oshimura M (1995) Restoration of the cellular senescence program and repression of telomerase by human chromosome 3. Jpn J Cancer Res 86:899-904.
29. Ohta M, Inoue H, Cotticelli MG, Kastury K, Baffa R, Palazzo J, Siprashvili Z, Mori M, McCue P, Druck T, Croce CM, Huebner K (1996) The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers. Cell 84:587-597.
30. Oshimura M, Barrett JC (1997) Multiple pathways to cellular senescence: Role of telomerase repressors. Eur J Cancer 33:710-715.
31. Pereira-Smith OM, Smith JR (1983) Evidence for the recessive nature of cellular immortality. Science 221:964-966.
32. Sandhu AK, Hubbard K, Kaur GP, Jha KK, Ozer HL, Athwal RS (1994) Senescence of immortal human fibroblasts by the introduction of normal human chromosome 6. Proc Natl Acad Sci USA 91:5498-5502.
33. Sasaki M, Honda T, Yamada H, Wake N, Barrett JC, Oshimura M (1994) Evidence for multiple pathways to cellular senescence. Cancer Res 54:6090-6093.
34. Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM (1996) The FHIT gene 3p14.2 is abnormal in lung cancer. Cell 85:17-26.
35. Steenbergen RDM, Walboomers JMM, Meijer CJLM, van der Raaij-Helmer EMH, Parker JN, Chow LT, Broker TR, Snijders PJF (1996) Transition of human papillomavirus type 16 and 18 transfected human foreskin keratinocytes towards immortality: Activation of telomerase and allele losses at 3p, 10p, 11q and/or 18q. Oncogene 13:1249-1257.
36. Sugawara O, Oshimura M, Koi M, Annab LA, Barrett JC (1990) Induction of cellular senescence in immortalized cells by human chromosome 1. Science 247:707-710.
37. Uejima H, Mitsuya K, Kugoh H, Horikawa I, Oshimura M (1995) Normal human chromosome 2 induces cellular senescence in the human cervical carcinoma cell line SiHa. Genes Chromosomes Cancer 14:120-127.
38. Vojta PJ, Barrett JC (1995) Genetic analysis of cellular senescence. Biochim Biophys Acta 1242:29-41.
39. Wright WE, Shay JW, Piatyszek MA (1995) Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 23:3794-3795.
40. Yamada H, Wake N, Fujimoto S, Barrett JC , Oshimura M (1990) Multiple chromosomes carrying tumor suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated chromosome transfer. Oncogene 5:1141-1147.
41. Yoshida MA, Shimizu M, Ikeuchi T, Tonomura A, Yokota J, Oshimura M (1994) In vitro growth suppression and morphological change in a human renal cell carcinoma cell line by the introduction of normal chromosome 3 via microcell fusion. Mol Carcinog 9:114-121.