Identification of human tumour suppressor genes by monochromosome transfer: Rapid growth-arrest response mapped to 9p21. Is mediated solely by the cyclin-D-dependent kinase inhibitor gene, CDKN2A (p16(INK4A))

Carcinogenesis

Volumn 17, Issue 8, 1996, Pages 1567-1575

  England, Nicole L ^a   Cuthbert, Andrew P ^a   Trott, Deborah A ^a   Jezzard, Sarah ^a   Nobori, Tsutomu ^b   Carson, Dennis A ^b   Newbold, Robert F ^a  

^a BRUNEL UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE; TRANSFERASE INHIBITOR;

ANIMAL CELL; ARTICLE; CHROMOSOME 9P; CONTROLLED STUDY; DELETION MUTANT; GENE MAPPING; GROWTH INHIBITION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0029741033     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/17.8.1567     Document Type: Article

References (62)

1. Sano, T., Tsujino, T., Yoshida, K., Nakayama, H., Haruma, K., Ito, H., Nakamura, Y., Kajiyama, G. and Tahara, E. (1991) Frequent loss of heterozygosity on chromosomes 1q, 5q, and 17p in human gastric carcinomas. Cancer Res., 51, 2926-2931.
2. Saito, H., Inazawa, J., Saito, S., Kasumi, F., Koi, S., Sagae, S., Kudo, R., Saito, J., Noda, K. and Nakamura, Y. (1993) Detailed deletion mapping of chromosome 17q in ovarian and breast cancers: 2cM region on 17q21.3 often and commonly deleted in tumors. Cancer Res., 53, 3382-3385.
3. Olopade O.I., Buchhagen, D.L., Malik, K., Sherman, J., Nobori, T., Bader, S., Nau, M.M., Gazdar, A.F., Minna, J.D. and Diaz, M.O. (1993) Homozygous loss of interferon genes defines the critical region on 9p that is deleted in lung cancers. Cancer Res., 53, 2410-2415.
4. Knowles, M.A., Elder, P.A., Williamson, M., Cairns, J.P., Shaw, M.E. and Law, M.G. (1994) Allelotype of human bladder cancer. Cancer Res., 54, 531-538.
5. Van der Riet, P., Nawroz, H., Hruban, R.H., Corio, R., Tokino, K., Koch, W. and Sidransky, D. (1994) Frequent loss of chromosome 9p21-22 early in head and neck cancer. Cancer Res., 54, 1156-1158.
6. Radford, D.M., Fair, K.L., Phillips, N.J., Ritter, J.H., Steinbrueck, T., Holt, M.S. and Donis-Keller, H. (1995) Allelotyping of ductal carcinoma in situ of the breast: Deletion of loci on 8p, 13q, 17p and 17q. Cancer Res., 55, 3399-3405.
7. Marshall, C.J. (1991) Tumour suppressor genes. Cell, 64, 313-326.
8. Hatakeyama, M., Herrera, R.A., Makela, T., Dowdy, S.F., Jacks, T. and Weinberg, R.A. (1994) The cancer cell and the cell cycle clock. Cold Spring Harbor. Symp. Quantit. Biol., 59, 1-10.
9. Hedrick, L., Cho, K.R. and Vogelstein, B (1993). Cell adhesion molecules as tumor suppressors. Trends Cell Biol., 3, 36-39.
10. Hedrick, L., Cho, K.R., Fearon, E.R., Wu, T., Kinzler, K.W. and Vogelstein, B. (1994) The DCC gene product in cellular differentiation and colorectal tumorigenesis. Genes and Development, 8, 1174-1183.
11. Newbold, R.F., Overell, R.W. and Connell, J.R. (1982) Induction of immortality is an early event in malignant transformation of mammalian cells by carcinogens. Nature, 299, 633-635.
12. Newbold, R.F. and Overell, R.W. (1983) Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature, 304, 648-651.
13. Newbold, R.F., Cuthbert, A.P., Themis, M., Trott, D.A., Blair, A.L. and Wei, Li. (1993) Cell immortalization as a key, rate-limiting event in malignant transformation: approaches toward a molecular genetic analysis. Toxicology Letts, 67, 211-230.
14. Newbold, R.F. (1985) Multistep malignant transformation of mammalian cells by carcinogens: induction of immortality as a key event. In Barrett, J.C. and Tennant, R.W. (eds) Carcinogenesis: A Comprehensive Survey, vol 9.Raven Press, New York, pp. 17-28.
15. Trott, D.A., Cuthbert, A.P., Overell, R.W., Russo, I. and Newbold, R.F. (1995). Mechanisms involved in the immortalization of mammalian cell by ionizing radiation and chemical carcinogens. Carcinogenesis, 16, 193-204.
16. Vogelstein, B., Fearon, E.R., Kern, S.E., Hamilton, S.R., Preisinger, A.C., Nakamura, Y. and White, R. (1989) Allelotype of colorectal carcinomas. Science, 244, 207-211.
17. Polakis, P. (1995) Mutations in the APC gene and their implications for protein structure and function. Curr. Opinion Genet. Devel., 5, 66-71.
18. Cuthbert, A.P., Trott, D.A., Ekong, R.M., Jezzard, S., England, N.L., Themis, M., Todd, C.M. and Newbold, R.F. (1995) Construction and characterization of a highly stable human:rodent monochromosome hybrid panel for genetic complementation and genome mapping studies. Cytogenet. Cell Genet., 71, 68-76.
19. Newbold, R.F. and Cuthbert, A.P. (1996) Mapping human senescence genes using interspecific monochromosome transfer. In Freshney, I.R. (ed.) Culture of Immortalized Cells. Wiley-Liss, in press.
20. Trott, D.A., Cuthbert, A.P., Todd, C.M., Themis, M. and Newbold, R.F. (1995) Novel use of a selectable fusion gene as an 'in-out' marker for studying genetic loss in mammalian cells. Mol. Carcinogenesis, 12, 213-224.
21. Lupton, S.D., Brunton, L.L., Kalberg, V.A. and Overell, R.W (1991). Dominant positive and negative selection using a hygromycin phosphotransferase-thymidine kinase fusion gene. Mol Cell Biol., 11, 3374-3378.
22. Killary, A.M., Wolf, M.E., Giambernardi, T.A. and Naylor, S.L. (1992) Definition of a tumour suppressor locus within human chromosome 3p21-p22. Proc. Natl Acad. Sci. USA, 89, 10877-10881.
23. Warburton, D., Gershen, S., Yu, M., Jackson, C., Handelin, B., and Houseman, D. (1990) Monochromosomal rodent-human hybrids from microcell fusion of human lymphoblastoid cells containing an inserted dominant selectable marker. Genomics, 6, 358-366.
24. Larizza, L., Doneda, L., Rodolfo, M. and Fossati, G. (1989) High incidence of chromosomal lesions involving C-heterochromatin in four human melanoma cell lines. Clin. Expl. Metast., 7, 633-644.
25. Easty, D.J., Guthrie, B.A., Maung, K., Farr, C.J., Lindberg, R.A., Toso, R.J., Herlyn, M. and Bennett, D.C. (1995) Protein B61 as a new growth factor: Expression of B61 and upregulation of its receptor during melanoma progression. Cancer Res., 55, 2528-2532.
26. Bobrow, M. and Cross, J. (1974) Differential staining of human and mouse chromosomes in interspecific cell hybrids. Nature, 251, 77-79.
27. Nobori, T., Muira, K., Wu, D.J., Lois, A., Takabayashi, K. and Carson, D.A. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756.
28. Serrano, M., Gomez-Lahoz, E., DePinho, R.A., Beach, D. and BarSagi, D. (1995) Inhibition of Ras-induced proliferation and cellular transformation by p16 (INK4). Science, 267, 249-252.
29. Harrison, G.S., Wang, Y., Tomczak, J., Hogan, C., Shpall, E.J., Curiel, T.J. and Felgner, P.L. (1995) Optimization of gene transfer using cationic lipids in cell lines and primary human CD4+ and CD34+ hematopoietic cells. Biotechniques, 19, 816-823.
30. Jen, J., Harper, J.W., Bigner, S.H., Bigner, D.D., Papadopoulos, N., Markowitz, S., Willson, J.K.V., Kinzler, K.W. and Vogelslein, B. (1994) Deletion of p 16 and p15 genes in brain tumors. Cancer Res., 54, 6353-6358.
31. Jackson, C.L., Britt, D.E., Graw, S.L., Potts, A., Santoro, K., Buckler, A.J., Houseman, D.E. and Mark, H.F.L. (1992). Construction and characterization of radiation hybrids for chromosome 9, and their use in mapping cosmid probes on the chromosome. Somatic Cell Mol. Genet., 18, 285-301.
32. Koi, M., Shimizu, M., Morita, H., Yamada, H. and Oshimura, M. (1989) Construction of mouse A9 clones containing a single human chromosome tagged with neomycin resistance gene via microcell fusion. Jpn J. Cancer Res., 80, 413-418.
33. Yamada, H., Wake, N., Fujimoto, S., Barrett, J.C. and Oshimura, M. (1990) Multiple chromosomes carrying tumopur suppressor activity for a uterine endometrial carcinoma cell line identified by microcell-mediated monochromosome transfer. Oncogene, 5, 1141-1147
34. Louis, D.N., Von Diemling, A. and Seizinger, B.R. (1992). A (CA)(n) dinucleotide repeat assay for evaluating loss of allelic heterozygosity in small and archival human brain tumour specimens. Am. J. Pathol., 141, 777-782.
35. Kamb, A. (1994) Role of a cell cycle regulator in hereditary and sporadic cancer. Cold Spring Harbor Symp. Quantit. Biol., 59, 39-47.
36. Kamb, A. (1995) Cell cycle regulators and cancer. Trends Genetics, 11, 136-140.
37. Spruck, C.H., Gonzales-Zulueta, M., Shibata, A., Simoneau, A.R., Lin, M.F., Gonzales, F., Tsai, Y.C. and Jones, P.A. (1994) p16 gene in uncultured tumours. Nature, 370, 183-184.
38. Quelle, D.E., Zindy, F., Ashmun, R.A. and Sherr, C.J. (1995) Alternative reading frames of the INK4a tumor suppressor geneencode two unrelated proteins capable of inducing cell cycle arrest. Cell, 83, 993-1000.
39. Giani, C. and Finocchiaro, G. (1994) Mutation rate of the CDKN2 gene in malignant gliomas. Cancer Res., 54, 6338-6339.
40. Ohta, M., Nagai, H., Shimizu, M., Rasio, D., Berd, D., Mastrangelo, M., Singh, A.D., Shields, J.A., Shields, C.L., Croce, C.M. and Huebner, K. (1994) Rarity of somatic and germline mutations of the cyclin-dependent kinase 4 inhibitor gene, CDK41, in melanoma. Cancer Res., 54, 5269-5272.
41. Liu, Q., Neuhausen, S., McClure, M., Frye, C., Weaver-Feldhaus, J., Gruis, N.A., Eddington, K., Allalunis-Turner, M.J., Skolnick, M.H., Fujimura, F.K. and Kamb, A. (1995) CDKN2 (MTS1) tumour suppressor gene mutations in human tumor cell lines. Oncogene, 10, 1061-1067.
42. Suzuki, H., Zhou, X., Yin, J., Lei, J., Jiang, H., Suzuki, Y. Chan, T., Hannon, G., Mergner, W.J., Abraham, J.M. and Meltzer, S.J. (1995) Intragenic mutations of CDKN2B and CDKN2A in primary human esophageal cancers. Human Mol. Genet., 4, 1883-1887.
43. Li, Y., Hoang-Xuan, K., Delattre, J., Poisson, M., Thomas, G. and Hamelin, R. (1995) Frequent loss of heterozygosity of cyclin-dependent kinase inhibitors p15 (MTS2) and p16 (MTS1) genes in gliomas. Oncogene, 11, 597-600.
44. Puig, S., Ruiz, A., Lazaro, C., Castel, T., Lynch, M., Palou, J., Vilata, A., Weissenbach, J., Mascaro, J. and Estivill, X. (1995) Chromosome 9p deletions in cutaneous malignant melanoma tumours: The minimal deleted region involves markers outside the p16 (CDKN2) gene. Am. J. Hum. Genet., 57, 395-402.
45. Merlo, A., Herman, J.G., Mao, L., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B. and Sidransky, D. (1995) 5 CpG island methylation is associated with transcriptional silencing of the tumour suppressor p161 CDKN2/MTS1 in human cancers. Nature Med., 1, 686-692.
46. Herman, J.G., Merlo, A., Mao, L., Lapidus, R.G., Issa, J., Davidson, N.E., Sidransky, D. and Baylin, S.B. (1995) Inactivation of the CDKN2/p16/ MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers. Cancer Res., 55, 4525-4530.
47. Porterfield, B.W., Diaz, M.O., Rowley, J.D. and Olopade, O.I. (1992) Induction of senescence in two human neoplastic cell lines by microcell transfer of human chromosome 9. Proc. Am. Assoc. Cancer Res., 33, 73 (abstract).
48. Medema, R.H., Herrera, R.E., Lam, F. and Weinberg, R.A. (1995) Growth suppression by p16 (INK4) requires functional retinoblastoma protein. Proc. Natl Acad. Sci. USA, 92, 6289-6293.
49. Lukas, J., Parry, D., Aagaard, L., Mann, D.J., Bartkova, J., Strauss, M., Peters, G. and Bartek, J. (1995) Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature, 375, 503-506.
50. Marx, J. (1994) A challenge to p16 gene as a major tumor suppressor. Science, 264, 1846.
51. Bonetta, L. (1994) Open questions on p16. Nature, 370, 180.
52. Kamb, A., Gruis, N.A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S.V., Stockert, E., Day, R.S., Johnson, B.E. and Skolnick, M.H. (1994) A cell cycle regulator potentially involved in the genesis of many tumor types. Science, 264, 436.
53. Cairns, P., Polascik, T.J., Eby, Y. et al. (1995) Frequency of homozygous deletion at p16/CDKN2 in primary human tumours. Nature Genet., 11, 210-212.
54. Lois, A.F., Cooper, L.T., Geng, Y., Nobori, T. and Carson, D. (1995) Expression of the p16 and p15 cyclin-dependent kinase inhibitors in lymphocyte activation and neuronal differentiation. Cancer Res., 55, 4010-4013
55. Skapek, S.X., Rhee, J., Spicer, D.B. and Lassar, A.B. (1995) Inhibition of myogenic differentiation in proliferating myoblasts by cyclin-D1-dependent kinase. Science, 267, 1022-1024.
56. Stein, G.H. and Dulic, V. (1995) Origins of Gl arrest in senescent human fibroblasts. Bioessays, 17, 537-543.
57. INK4A with human head and neck keratinocyte replicative senescence: Relationship of dysfunction to immortality and neoplasia. Oncogene, in press.
58. INK4 in human cancer. Proc Natl Acad. Sci. USA. 91, 11045-11049.
59. CDKN2 expression and its implications for cell immortalization and senescence. Mol. Cell Biol., 16, 859-867.
60. Wynford-Thomas, D., Bond, J.A., Wyllie, F.S. and Jones, C.J. (1995) Does telomere shortening drive selection for p53 mutation in human cancer. Mol. Carcinogenesis, 12, 119-123.
61. Marx, J. (1995) Cell cycle inhibitors may help brake growth as cells develop. Science, 267, 963-964.
62. Smith, J.R. and Whitney, R.J. (1980) Intraclonal variation in proliferative potential of human diploid fibroblasts: Stochastic mechanism for cellular aging. Science, 207, 82-84.