Functions of the GTPase Ran in RNA export from the nucleus

Current Opinion in Cell Biology

Volumn 10, Issue 3, 1998, Pages 400-408

  Dahlberg, James E ^a   Lund, Elsebet ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATE; MEMBRANE RECEPTOR; MESSENGER RNA;

CELL NUCLEUS; CELL NUCLEUS MEMBRANE; CYTOPLASM; EUKARYOTIC CELL; HYDROLYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; RNA TRANSPORT;

EUKARYOTA;

EID: 0031805069     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(98)80017-3     Document Type: Article

References (69)

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16. of special interest Fornerod M, Ohno M, Yoshida M, Mattaj IW. CRM1 is an export receptor for leucine-rich nuclear export signals. of outstanding interest Cell. 90:1997;1051-1060 The human CRM1 protein (see Formerod 1997 [26]) is shown to be the target for leptomycin B (Wolff 1997 [23]), a cytotoxin that blocks Rev-dependent RNA export as well as export of snRNAs. Overexpression of CRM1 in oocytes reverses leptomycin-B-induced inhibition of Rev export and stimulates Rev and U snRNA export. In vitro, CRM1 binds co-operatively to both Ran-GTP and leucine-rich Rev (or protein kinase A inhibitor) NES peptides. Formation of this ternary complex is prevented in the presence of leptomycin B, supporting the conclusion that CRM1 or exportin 1 is an export receptor for leucine rich NESs.
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