Transcriptional control of cytokine genes

International Reviews of Immunology

Volumn 16, Issue 5-6, 1998, Pages 581-616

  Tsuruta, Lisako ^a   Arai, Naoko ^b   Arai, Ken Ichi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Coordinated expression; Cytokine genes; Differential expression; Helper T cells; NF AT; Transcriptional regulation

Indexed keywords

EID: 0031803991     PISSN: 08830185     EISSN: None     Source Type: Journal    
DOI: 10.3109/08830189809043010     Document Type: Article

References (157)

1. Abe, E., De Waal-Malefyt, R., Matsuda, I., Arai, K. and Arai, N. An 11 base-pair DNA sequence motif apparently unique to the human interleukin 4 gene confers responsiveness to T-cell activation signals. Proc. Natl. Acad. Sci. USA 89 (1992) 2864-2868.
2. Angel, P. and Karin, M. The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation, Biochem. Biophys. Acta 1072 (1991) 129-157.
3. Arai, K.I., Lee, F., Miyajima, A., Miyatake, S., Arai, N. and Yokota, T. Cytokines: coordinators of immune and inflammatory responses. Annu. Rev. Biochem. 59 (1990) 783-836.
4. Bach, E.A., Szabo, S.J., Dighe, A.S., Ashkenazi, A , Aguer, M., Murphy, K.M. and Shreiber, R.D. Ligand-induced autoregulation of IFN-gamma receptor beta chain expression in T helper cell subsets. Science 270 (1995) 1215-1218.
5. Baeuerle, P.A. and Henkel, T. Function and activation of NF-κB in the immune system. Annu. Rev. Immunol. 12 (1994) 141-179.
6. Baldwin, A.S. The NF-κB and IκB proteins: new discoveries and insights. Annu. Rev. Immunol. 14 (1996) 649-681.
7. Beg, A.A. and Baldwin, A.S., Jr. The IκB proteins: multifunctional regulators of Rel/ NF-κB transcription factors. Genes Dev. 7 (1993) 2064-2070.
8. Betz, M. and Fox, B.S. Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines. J. Immunol. 146 (1991) 108-113.
9. Brorson, K.A., Beverly, B., Kang, S.M., Lenard, M. and Schwarz, R.H. Transcriptional regulation of cytokine genes in nontransformed T cells. Apparent constitutive signals in run-on assays can be caused by repeated sequences. J. Immunol. 147 (1991) 3601-3609.
10. Boulay, J.-L. and Paul, W.E. The interleukin-4 family of lymphokines. Curr. Opin. Immunol. 4 (1992) 294-298.
11. Briegel, K., Hentsch, B , Pfeuffer, I. and Serfling, E. One base pair change abolishes the T cell-restricted activity of a κB-like proto-enhancer element from the interleukin 2 promoter. Nucleic Acids Res. 19 (1991) 5929-5936.
12. Broide, D.H., Paine, M-M. and Friestein, G.S. Eosinophils express interleukin-5 and granulocyte macrophage-colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J. Clin. Invest. 90 (1992) 1414-1424.
13. Bruhn, K.W., Nelms, K., Boulay, J.-L., Paul, W.E. and Lenardo, M.J. Molecular dissection of the mouse interleukin-4 promoter. Proc. Natl. Acad. Sci. USA 90 (1993) 9707-9711.
14. Burgering, B.M.T., Pronk, G. J., van Weeren, P. C., Chardin, P. and Bos, J.L. cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor. EMBO J. 12 (1993) 4211-4220.
15. Campbell, P.M., Pimm, J., Ramassar, V. and Halloran, P.F. Identification of a calcium-inducible, cyclosporin-sensitive element in the IFN-γ promoter that is a potential NFAT binding site. Transplantation 61 (1996) 933-939.
16. Cantrell, D. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14 (1996) 259-274.
17. + T cells. Science 271 (1996) 1272-1275.
18. Casolaro, V., Georas, S.N., Song, Z., Zurakoff, I.D., Abdulkadir, S.A., Thanos, D and Ono, S.J. Inhibition of NF-AT-dependent transcription by NF-κB: Implications for differential gene expression in T helper cell subsets. Proc. Natl. Acad. Sci. USA 92 (1995) 11623-11627.
19. Chen, D. and Rothenberg, E.V. Interleukin 2 transcription factors as molecular targets of cAMP inhibition: delayed inhibition kinetics and combinatorial transcription roles, J. Exp. Med. 179 (1994) 931-942.
20. Chen, Z., Parent, L. and Maniatis, T. Site-specific phosphorylation of IκB-α by a novel ubiquitin-dependent kinase activity. Cell 84 (1996) 853-862.
21. Chiu, R., Angel, P. and Karin, M. Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 59 (1989) 979-986.
22. Chrivia, J.C., Wedrychowicz, T., Young, H.A. and Hardy, K.J. A model of human cytokine regulation based on transfection of g interferon gene fragments directly into isolated peripheral blood T lymphocytes. J. Exp. Med. 172 (1990) 661-664.
23. Chuvpilo, S., Schomberg, C., Gerwig, R., Heinfling, A., Reeves, R., Grummt, F. and Serfling, E. Multiple closely-linked NFAT/octamer and HMG I(Y) binding sites are part of the interleukin-4 promoter. Nucleic Acids Res. 21 (1993) 5694-5704.
24. Ciccarone, V.C., Chrivia, J., Hardy. K.J. and Young, H.A. Identification of enhancer-like elements in human IFN-γ genomic DNA. J. Immunol. 144 (1990) 725-730.
25. Cockerill, P.N., Shannon, M.F., Bert, A.G., Ryan, G.R. and Vadas, M.A. The granulocyte-macropharge colony-stimulating factor/interleukin 3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc. Natl. Acad. Sci. USA 90 (1993) 2466-2470.
26. Cook, S.J. and McCormick, F. Inhibition by cAMP of Ras dependent activation of Raf. Science 262 (1993) 1069-1072.
27. Crabtree, G.R. Contingent genetic regulatory events in T lymphocyte activation. Science 243 (1989) 355-361.
28. Crabtree, G.R. and Clipstone, N.A. Signal transmission between the plasma membrane and nucleus of T lymphocytes. Annu. Rev. Biochem. 63 (1994) 1045-1083.
29. Davies, K., TePas, E.C., Nathan, D.G. and Mathey-Prevot, B. Interleukin-3 expression by activated T cells involves an inducible, T-cell-specific factor and octamer binding protein. Blood 81 (1993) 928-934.
30. Dent, J.W.P., Wolfman, J.A., Weber, M.J. and Sturgill, T.W. Inhibition of the EGF-activated MAP Kinase signalling pathway by adenosine 3′,5′-monophosphate. Science 262 (1993) 1065-1069.
31. Derijard, B., Hibi, M., Wu, I.-H., Barret, T., Su, B., Deng, T., Karin, M. and Davis, R.J. A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76 (1994) 1025-1037.
32. ras upon T cell activation. Nature 346 (1990) 719-723.
33. Durand, D.B., Bush, M.R., Morgan, J.G., Weiss, A. and Crabtree, G.R. A 275 basepair fragment at the 5′ end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor. J. Exp. Med. 165 (1987) 395-407.
34. Durand, D.B., Shaw, J. P., Bush, M. R., Replogle, R.E., Belageje, R. and Crabtree, G.R. Characterization of antigen receptor response elements within the interleukin 2 enhancer. Mol. Cell. Biol. 8 (1988) 1715-1724.
35. Farrer, M.A. and Shreiber, R.D. The molecular cell biology of interferon-g and its receptor. Annu. Rev. Immunol. 11 (1993) 571-611.
36. Fields, P.E., Gajewski, T.F. and Fitch, F.W. Blocked Ras activation in anergic CD4+T cells. Science 271 (1996) 1276-1278.
37. Finco, T.S. and Baldwin, A.S. Mechanistic aspects of NF-κB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3 (1995) 263-272.
38. Flanagan, W.M., Corthesy, B., Bram, R.J. and Crabtree, G.R. Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A. Nature 352 (1991) 803-807.
39. Fraser, J.D., Irving, B.A., Crabtree, G.R. and Weiss, A. Regulation of interleukin-2 gene enhancer activity by the T cell accessory molecule CD28. Science 251 (1991) 313-316.
40. Fraser, J.D. and Weiss, A. Regulation of T-cell lymphokine gene transcription by the accessory molecule CD28. Mol. Cell Biol. 12 (1992) 4357-4363.
41. Frolova, E.I., Dolganov, G.M., Mazo, I.A., Smirnov, D.V., Copeland, P., Stewart, C., O'Brien, S.J. and Dean, M. Linkage mapping of the human CSF2 and IL3 genes. Proc. Natl. Acad. Sci. USA 88 (1991) 4821-4824.
42. Fujita, T., Shibuya, H., Ohashi, T., Yamanishi, K. and Taniguchi, T. Regulation of human interleukin-2 gene: functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes. Cell 46 (1986) 401-405.
43. Garrity, P.A., Chen, D., Rothenberg, E.V. and Wold, B.J. Interleukin-2 transcription is regulated in vivo at the level of coordinated binding of both constitutive and regulated factors. Mol. Cell Biol. 14 (1994) 2159-2169.
44. Ghosh, P., Tan, T.-H., Rice, N.R., Sica, A. and Young, H.A. The interleukin 2 CD28-responsive complex contains at least three members of the NF-κB family: c-Rel, p50, and p65. Proc. Natl. Acad. Sci. USA 90 (1993) 1696-1700.
45. Gottschalk, L.R., Giannola, D.M. and Emerson, S.G. Molecular regulation of the human IL-3 gene: inducible T cell-restricted expression requires intact AP-1 and Elf-1 nuclear protien binding sites. J. Exp. Med. 178 (1993) 1681-1692.
46. Gray, P. and Goeddel, D.V. Nature 298 (1982) 859.
47. Grimaldi, J.C. and Meeker, T.C. The t(5;I4) chromosomal translocation in a case of acute lymphocytic leukemia joins the interleukin-3 gene to the immunogloblin heavy chain gene. Blood 73 (1989) 2081-2085.
48. Guba, S.C., Stella, G., Turka, L.A., June, C.H., Thompson, C.B. and Emerson, S.G. Regulation of interleukin 3 gene induction in normal human T cells. J. Clin. Invest. 84 (1989) 1701-1706.
49. Gupta, S., Gollob, K.J., Garfein, E., Coffman, R.L., Schindler, C. and Rothman, P. Lack of interferon gamma receptor beta chain and the prevention of interferon gamma signaling in Th1 cells. Science 269 (1995) 245-247.
50. Hardy, K.J., Peterlin, R.E., Atchison, R.F. and Stobo, J.P. Regulation of expression of the human IFN-γ gene. Proc. Natl. Acad. Sci. USA 82 (1985) 8173-8177.
51. Hardy, K.J., Manger, B., Newton, M. and Stobo, J.D. Molecular events involved in regulating human interferon-g gene expression during T cell activation. J. Immunol. 138 (1987) 2353-2358.
52. Henkel, G., Weiss, D.L., McCoy, R., Deloughery, T., Tara, D. and Brown, M.A. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J. Immunol. 149 (1992) 3239-3246.
53. Ho, I.-C., Hodge, M.R. and Rooney, J.W. The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 85 (1996) 973-983.
54. Hoey, T., Sun, Y.L., Williamson, K. and Xu, X. Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins. Immunity 2 (1995) 461-472.
55. Hsueh, Y.-P. and Lai, M.-Z. c-Jun N-terminal kinase but not mitogen-activated protein kinase is sensitive to inhibition in T lymphocytes. J. Biol. Chem. 270 (1995) 18094-18098.
56. ras regulatory pathways coexist in T cells. Mol. Cell Biol. 12 (1992) 3305-3312.
57. Jam, J., McCaffrey, P.G., Valge, A.V. and Rao, A. Nuclear factor of activated T cells contains Fos and Jun. Nature 356 (1992) 801-804.
58. Jain, J., Burgeon, E., Badalian, T.M., Hogan, P.G. and Rao, A. A similar DNA binding motif in NFAT family proteins and the Rel homology region. J. Biol. Chem. 270 (1995a) 4138-4145.
59. Jain, J., Loh, C. and Rao, A. Transcriptional regulation of the IL-2 gene. Curr. Opin. Immunol. 7 (1995b) 333-342.
60. Jenkins, M.K. The ups and downs of T cell costimulation. Immunity 1 (1994) 443-446.
61. Kamps, M.P., Corcoran, L., LeBowitz, J. H. and Baltimore, D. The promoter of the human interleukin-2 gene contains two octamer binding sites and is partially activated by the expression of oct-2. Mol. Cell Biol. 10 (1990) 5464-5472.
62. + T lymphocytes. Science 256 (1992a) 1452-1456.
63. Kang, S.M., Beverly, B., Tran, A.C., Brorson, K., Schwartz, R.H. and Lenardo, M.J. Transactivation by AP-1 is a molecular target of T cell clonal energy. Science 257 (1992b) 1134-1138.
64. Kaplan, M.H., Schindler, U., Smiley, S.T. and Grusby, M.J. Stat6 is required for mediating responses to IL-4 and for the development of Th2 cells. Immunity 4 (1996) 313-319.
65. Karin, M. and Smeal, T. Control of transcription factors by signal transduction pathways: the beginning of the end. TIBS 17 (1992) 418-422.
66. Karin, M. Signal transduction from the cell surface to the nucleus through the phosphorylation of transcription factors. Curr. Opin. Cell Biol. 6 (1994) 415-424.
67. Karin, M. and Hunter, T. Transcriptional control by phosphorylation: signal transmission from the cell surface to the nucleus. Curr. Biol. 5 (1995) 747-756.
68. Kerppola, T.K. and Curran, T. Transcription factor interactions: basics on zippers. Curr. Opin. Struct. Biol. 1 (1991) 71-79.
69. Koyano-Nakagawa, N., Nishida, J., Baldwin, D., Arai, K. and Yokota, T. Molecular cloning of a novel human cDNA encoding a zinc finger protein that binds to the interleukin-3 promoter. Mol. Cell Biol. 14 (1994) 5009-5107.
70. 2+/calmodulin-activated, phosphoprotein phosphatase calcineurin is sufficient for positive transcriptional regulation of the mouse IL-4 gene. Int. Immunol. 6 (1994) 179-188.
71. Lai, J.-H. and Tan, T.-H. CD28 signaling causes a sustained downregulation of IκBα which can be prevented by immunosuppressant rapamycin. J. Biol. Chem. 269 (1994) 30077-30080.
72. Lederer, J.A., Liou, J.S., Todd, M.D., Glimcher, L.H. and Lichtman, A.H. Regulation of cytokine gene expression in T helper cell subsets. J. Immunol. 152 (1994) 77-86.
73. Lederer, J. A., Liou, J.S., Kim, S., Rice, N. and Lichtman, A.H. Regulation of NF-κB activation in T helper 1 and T helper 2 cells. J. Immunol. 156 (1996a) 56-63.
74. Lederer, J.A., Perez, V.L., DesRoches, L., Kim, S.M., Abbas, A.K. and Lichtman, A. Cytokine transcriptional events during helper T cell subset differentiation. J. Exp. Med. 184 (1996b) 397-406.
75. Lee, H.J., Koyano-Nakagawa, N., Naito, Y., Nishida, J., Arai, N., Arai, K. and Yokota, T. cAMP activates the IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J. Immunol. 151 (1993) 6135-6142.
76. Lee, H.J., Masuda, E.S., Arai, N., Arai, K. and Yokota, T. Definition of cis-regulatory elements of the mouse interleukin-5 gene promoter. Involvement of nuclear factor of activated T cell-related factors in interleukin-5 expression. J. Biol. Chem. 270 (1995) 17541-17550.
77. Lenschow, D.J., Walunas, T.L. and Bluestone, J.A. CD28/B7 system of T cell costimulation. Annu. Rev. Immunol. 14 (1996) 233-258.
78. Li-Weber, M., Eder, A., Krafft-Czepa, H. and Krammer, P.H. T cell specific negative regulation of transcription of the human cytokine IL-4. J. Immunol. 148 (1992) 1913-1918.
79. Liu, J., Koyano-Nakagawa, N., Amasaki, Y., Saito-Ohara, F., Ikeuchi, T., Imai, S., Takano, T., Arai, N., Yokota, T and Arai, K. Calcineurin dependent nuclear translocation of a murine transcripton factor NFATx: Molecular cloning and functional characterization. Mol. Biol. Cell 18 (1997) 157-170.
80. Lindsten, T., June, C.M., Ledbetter, J.A. and Thompson, C.B. Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 244 (1989) 339-343.
81. Linsley, P.S. and Ledbetter, J.A. The role of the CD28 receptor during T cell responses to antigen. Annu. Rev. Immunol. 11 (1993) 191-212.
82. Loh, C., Shaw, T.-Y., Carew, J., Viola. J.P.B., Luo, C., Perrino, B.A. and Rao, A. Calcineurin binds the transcription factor NFAT1 and reversibly regulates its activity. J. Biol. Chem. 271 (1996) 10884-10891.
83. Masuda, E.S., Tokumitsu, H., Tsuboi, A., Shlomai, J., Hung, P., Arai, K. and Arai, N. The granulocyte-macrophage colony-stimulating factor promoter cis-acting elment CLE0 mediates induction signals in T cells and is recognized by factors related to AP1 and NFAT. Mol. Cell Biol. 13 (1993) 7399-7407.
84. Masuda, E.S., Naito, Y., Arai, K. and Arai, N. Expression of lymphokine genes in T cells. Immunologist 1 (1993) 198-203.
85. Masuda, E.S., Yamaguchi-Iwai, Y., Tsuboi, A., Hung, P., Arai, K. and Arai, N. The transcription factor Sp1 is required for induction of the murine GM-CSF promoter in T cells. Biochem. Biophys. Res. Comm. 205 (1994) 1518-1525.
86. Masuda, E.S., Naito, Y., Tokumitsu, H., Campbell, D., Saito, F., Hannum, K., Arai, K. and Arai, N. NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus. Mol. Cell Biol. 15 (1995) 2697-2706.
87. Masuda, E.S., Liu, J., Imamura, R., Imai, S., Arai, K. and Arai, N. NFATx1 nuclear translocation control by a calcineurin-regulated inhibitory domain. Mol. Cell Biol. 17 (1997) 2066-2075.
88. Mathey-Prevot, B., Andrews, N.C., Murphy, H.S., Kreissman, S.G. and Nathan, D.G. Positive and negative elements regulate human interleukin 3 expression. Proc. Natl. Acad. Sci. USA 87 (1990) 5046-5050.
89. McCaffrey, P.G., Luo, C., Kerppola, T.K , Jain, J., Badalian, T. M., Ho, A.M., Burgeon, E., Lane, W.S., Lambert, J.N., Curran, T., Verdine, G. L., Rao, A. and Hogan, P.G.' Isolation of the cyciosponn-sensitive T cell transcription factor NFATp. Science 262 (1993) 750-754.
90. McCaffrey, P.G., Goldfeld, A.E. and Rao, A. The role of NFATp in cyclosporin A-sensitive tumor necrosis factor- α gene transcription. J. Biol. Chem. 269 (1994) 30045-30450.
91. McKenzie, A.N., Li, X., Largaespada, D.A., Sato, A., Kaneda, A., Zurawski, S.M., Doyle, E.L., Milatovich, A., Francke, U. and Copeland, N.G. Structural comparison and chromosomal localization of the human and mouse IL-13 genes. J. Immunol. 15 (1993) 5436-5444.
92. Miyatake, S., Shlomai, J., Arai, K.-i. and Arai, N., Characterization of the mouse GM-CSF promoter: Nuclear factors that interact with an element shared by three lymphokine genes; GM-CSF, IL-4 and IL-5. Mol. Cell. Biol. 11 (1991) 5894-5901.
93. Mosmann, T.R., Cherwinski, H., Bond, M.W., Giedlin, M.A. and Coffman, R.L. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136 (1986) 2348-2357.
94. Mosmann, T R. and Coffman, R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu. Rev. Immunol. 7 (1989b) 145-173.
95. Munoz, E., Zubiaga, A.M., Merrow, M., Sauter, N.P. and Huber, B.T. Cholera toxin discriminates between T helper 1 and 2 cells in T cell receptor-mediated activation: role of cAMP in T cell proliferation. J. Exp. Med. 172 (1990) 95-103.
96. Murphy, E., Shibuya, K., Hosken, N., Openshaw, P., Maino, V., Davis, K., Murphy, K. and O'Garra, A. Reversibility of T helper 1 and 2 population is lost after long-term stimulation. J. Exp. Med. 183 (1996) 901-913.
97. 2 may reside downstream of the PKC-dependent pathway. Cytokine 8 (1996) 346-356.
98. Naora, H., van Leeuwen, B.H., Bourke, P.F. and Young, I.G. Functional role and signal-induced modulation of proteins recognizing the conserved TCATTT-containing promoter elements in the murine IL-5 and GM-CSF genes in T lymphocytes. J. Immunol. 153 (1994) 3466-3475.
99. Neumann, M., Grieshammer, T , Chuvpilo, S., Kneitz, B., Lohoff, M., Schimpl, A., Franza, B.R. Jr and Serfling, E. RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A. EMBO. J. 14 (1995) 1991-2004
100. Niemeyer, C.M., Sieff, C.A., Mathey-Prevot, B., Wimperis, J.Z., Bierer, B.E., Clark, S.C. and Nathan, D.G. Expression of human interleukin-3 (multi-CSF) is restricted to human lymphocytes and T-cell tumor lines. Blood 73 (1989) 945-951.
101. Nishida, J., Yoshida, M., Arai, K. and Yokota, T. Definition of a GC-rich motif as regulatory sequence of the human IL-3 gene by CLE2/GC box of the GM-CSF gene in T cell activation. Int. Immunol. 3 (1991) 245-254.
102. Northrop, J.P., Ho, S.N., Chen, L., Thomas, D.J., Timmerman, L.A., Nolan, G.P., Admon, A. and Crabtree, G.R. NF-AT components define a family of transcription factors targeted in T-cell activation. Nature 369 (1994) 497-502.
103. Novak, T.J. and Rothenberg, E.V. cAMP inhibits induction of interleukin 2 but not of interleukin 4 in T cells. Proc. Natl. Acad. Sci. USA 87 (1990) 9353-9357.
104. Novak, T.J., White, P.M. and Rothenberg, E.V. Regulatory anatomy of the murine interleukin-2 gene. Nucl. Acids. Res. 18 (1990) 4523-4533.
105. Osborne, C.S., Vadas, M.A. and Cockerill, P.N. Transcriptional regulation of mouse granulocyte-macropharge colony-stimulating factor/IL-3 locus. J. Immunol. 155 (1995) 226-235.
106. Park, D.J., Min, H.K. and Rhee, S.G. Inhibition of CD3-linked phospholipase C by phorbol ester and by cAMP is associated with decreased phosphotyrosine and increased phosphoserine contents of PLC-gamma 1. J. Biol. Chem. 267 (1992) 1496-1501.
107. Park, J., Yaseen, N.R., Hogan, P.G., Rao, A. and Sharma, S. Phosphorylation of the transcription factor NFATp inhibits its DNA binding activity in cyclosporin A-treated human B and T cells. J. Biol. Chem. 270 (1995) 20653-20659.
108. Paul, W.E. and Seder, R.A. Lymphocyte responses and cytokines. Cell 76 (1994) 241-251.
109. Penix, L., Weaver, W.M., Pang, Y., Young, H.A. and Wilson, C.B. Two essential regulatory elements in the human interferon-γ promoter confer activation specific expression in T cells. J. Exp. Med. 178 (1993) 1483-1496.
110. Pfeuffer, I., Klein-Hessling, S., Heinfling, A., Chuvpilo, S., Escher, C., Brabletz, T., Hentsch, B., Schwarzenbach, H., Matthias, P. and Serfling, E. Octamer factors exert a dual effect on the IL-2 and IL-4 promoters. J. Immunol. 153 (1994) 5572-5585.
111. Plaut, M., Pierce, J.H., Watson, C.J., Hanley-Hyde, J., Nordan, R.P. and Paul, W.E. Mast cell lines produce lymphokines in response to cross-linkage of FceRI or to calcium ionophores. Nature 339 (1989) 64-67.
112. Ransone, L.J. and Verma, I.M. Nuclear proto-oncogenes FOS and JUN. Annu. Rev. Cell. Biol. 6 (1991) 539-557.
113. Rennick, D., Yang, G., Gemmell, L. and Lee, F. Control of hemopoiesis by a bone marrow stromal cell clone: lipopolysaccharide- and interleukin-1-inducible production of colony-stimulating factors. Blood 69 (1987) 682-691.
114. Rincon, M. and Flavell, R.A. AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO. J. 13 (1994) 4370-4381.
115. Rooney, J.W., Hoey, T. and Glimcher, L.H. Coordinate and cooperative roles for NF-AT and AP-1 in the regulation of the murine IL-4 gene. Immunity 2 (1995a) 473-483.
116. Rooney, J.W., Sun, Y.-L., Glimcher, L.H. and Hoey, T. Novel NFAT sites that mediate activation of the interleukin-2 promoter in response to T-cell receptor stimulation. Mol. Cell. Biol. 15 (1995b) 6299-6310.
117. Rudd, C.E. Upstream-downstream: CD28 cosignaling pathways and T cell function. Immunity 4 (1996) 527-534.
118. Ruff, V.A. and Leach, K.L. Direct demonstration of NFATp dephosphorylation and nuclear translocation in activated HT-2 cells using a specific. NFATp polyclonal antibody. J. Biol. Chem. 270 (1995) 22602-22607.
119. Sanderson, C.J. Interleukin-5, eosinophiles, and disease. Blood 79 (1992) 3101-3109.
120. Schindler, C., Kashleva, H., Pernis, A., Pine, R. and Rothman, P. STF-IL-4: A novel IL-4 induced signal transducing factor. EMBO J. 13 (1994) 1350-1356.
121. Schwartz, R.H. Models of T cell anergy: Is there a common molecular mechanism? J. Exp. Med. 184 (1996) 1-8.
122. + T cells. Annu. Rev. Immunol. 12 (1994) 635-673.
123. Serfling, E., Barthelmas, R., Pfeuffer, I., Schenk, B., Zarius, S., Swoboda, R., Mercurio, F. and Karin, M. Ubiquitous and lymphocyte-specific factors are involved in the induction of the mouse interleukin 2 gene in T lymphocytes. EMBO. J. 8 (1989) 465-473.
124. Sevetson, B.R., Kong, X. and Lawrence, J.C. Increasing cAMP attenuates activation of mitogen-activated protein kinase. Proc. Natl. Acad. Sci. USA 90 (1993) 10305-10309.
125. Shaw, J., Meerovitch, K., Elliott, J.F., Bleackley, R.C. and Paetkau, V. Induction, suppression and superinduction of lymphokine mRNA in T lymphocytes. Mol. Immunol. 24 (1987) 409-419.
126. Shaw, J.-P., Utz, P.J., Durand, D.B., Toole, J.J., Emmel, E.A. and Crabtree, G.R. Identification of a putative regulator of early T cell activation genes. Science 241 (1988) 202-205.
127. Shaw, K.T., Ho, A.M., Raghavan, A., Kim, J., Jain, J., Park, J., Sharma, S., Rao, A. and Hogan, P.G. Immunosupressive drugs prevent a rapid dephosphorylation of transcription factor NFAT1 in stimulated immune cells. Proc. Natl. Acad. Sci. USA 92 (1995) 11205-11209.
128. Shibasaki, F., Price, E.R., Milan, D. and McKeon, F. Role of kinases and the phosphatase calcineurin in the nuclear shutteling of transcription factor NF-AT4. Nature 382 (1996) 370-373.
129. Shoemaker, S.G., Hromas, R. and Kaushansky, K. Transcriptional regulation of interleukin 3 gene expression in T lymphocytes. Proc. Natl. Acad. Sci. USA 87 (1990) 9650-9654.
130. Siebenlist, U., Franzoso, G. and Brown, K. Structure, regulation and function of NF-κB. Annu. Rev. Cell. Biol. 10 (1994) 405-455.
131. Siegel, M.D., Zhang, D.-H., Ray, P. and Ray, A. Activation of the interleukin-5 promoter by cAMP in murine EL-4 cells requires the GATA-3 and CLEO elements. J. Biol. Chem. 270 (1995) 24548-24555.
132. Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M. and Ben-Neriah, Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77 (1994) 727-736.
133. Su, B. and Karin, M. Mitogen-activated protein kinase cascades and regulation of gene expression. Curr. Opin. Immunol. 8 (1996) 402-411.
134. Suzuki, T., Okuno, H., Yoshida, T., Endo, T., Nishina, H. and Iba, H. Difference in transeriptional regulatory function between c-Fos and Fra-2. Nucleic. Acids. Res. 19 (1991) 5537-5542.
135. Szabo, S.J., Gold, J.S., Murphy, T.L. and Murphy, K.M. Identification of cis-acting regulatory elements controlling interleukin-4 gene expression in T cells; roles for NF-Y and NF-ATc. Mol. Cell. Biol. 13 (1993) 4793-4805.
136. Szabo, S.J., Jacobson, N.G., Dighe, A.S., Gubler, U. and Murphy, K.M. Developmental commitment to the Th2 lineage by extinction of IL-12 signaling. Cell 2 (1995) 665-675.
137. Tamir, A. and Isakov, N. Cyclic AMP inhibits phosphatidylinositol-coupled and - uncoupled mitogenic signals in T lymphocytes, J. Immunol. 152 (1994) 3391-3399.
138. Tamir, A., Granot, Y. and Isakov, N. Inhibition of T lymphocyte activation by cAMP is associated with down regulation of two parallel mitogen-activated protein kinase pathways, the extracellular signal-related kinase and c-Jun N-terminal kinase. J. Immunol. 157 (1996) 1514-1522.
139. Tamura, T., Yanagida, T. and Nariuchi, H. Difference in signal transduction pathway in IL-2 and IL-4 Production in T Helper 1 and T Helper 2 cell clones in response to anti-CD3. J. Immunol. 151 (1993) 6051-6061.
140. Tamura, T., Nakano, H., Nagase, H., Morokata, T., Igarashi, O., Oshimi, Y., Miyazaki, S. and Nariuchi, H. Early activation signal transduction pathways of Th1 and Th2 cell clones stimulated with anti-CD3. J. Immunol. 155 (1995) 4692-4701.
141. Thompson, C.B., Lindsten, T., Ledbetter, J.A., Kunkel, S.L., Young, H.A., Emerson, S.G., Leiden, J.M. and June, C.H. CD28 activation pathway regulates the production of multiple T-cell-derived lymphokine/cytokines. Proc. Natl. Acad. Sci. USA 86 (1989) 1333-1337.
142. Thompson, J.E., Phillips, R.J., Erdjument-Bromage, H., Tempst, P. and Ghosh, S. IκB-β regulates the persistent response in a biphasic activation of NF-κB. Cell 80 (1995) 573-582.
143. Tocci, M.J., Matkovich, D.A., Collier, K.A., Kwok, P., Dumount, S., Lin, S , DeGudicibus, S., Siekierka, J.J., Chin, J. and Hutchinson, N.I. The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes. J. Immunol. 143 (1993) 718-726.
144. Todd, M.D-, Grusby, M.J., Lederer, J.A., Lacy, E., Lichtman, A.H. and Glimcher, L.H. Transcriptiona of the interleukin 4 gene is regulated by multiple promoter elements. J. Exp. Med. 177 (1993) 1663-1674.
145. Tsuboi, A., Sugimoto, K., Yodoi, J., Miyatake, S., Arai, K. and Arai, N. A nuclear factor NF-GM2 that interacts with a regulatory region of the GM-CSF gene essential for its induction in responses to T-cell activation: purification from human T-cell leukemia line Jurkat cells and similarity to NF-kappa B. Int. Immunol. 3 (1991) 807-817.
146. Tsuruta, L., Lee, H.J., Masuda, E.S., Koyano-Nakagawa, N., Arai, N., Arai, K. and Yokota, T. cAMP inhibits expression of the IL-2 gene through the nuclear factor of activated T cells (NF-AT) site, and transfection of NF-AT cDNAs abrogates the sensitivity of EL-4 cells to cyclic AMP. J. Immunol. 154 (1995) 5255-5264.
147. Ullman, K.S., Northrop, J.P., Verweij, C.L. and Crabtree, G.R. Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: the missing link. Annu. Rev. Immunol. 8 (1990) 421-452.
148. Ullman, K.S., Northrop, J.P., Admon, A. and Crabtree, G.R. Jun family members are controlled by a calcium-regulated, cyclosporin A-sensitive signaling pathway in activated T lymphocytes. Genes Dev. 7 (1993) 188-196.
149. Wesselborg, S., Fruman, D.A., Sagoo, J.K., Bierer, B.E. and Burakoff, S.J. Identification of a physical interaction between calcineurin and nuclear factor of activated T cells (NFATp). J. Biol. Chem. 271 (1996) 1274-1277.
150. Wodner, F.A., Heusser, C.H. and Moroni, C. Production of the hemopoietic growth factors GM-CSF and interleukin-3 by mast cells in response to IgE receptor-mediated activation. Nature 339 (1989) 150-152.
151. Xu, X., Sun, Y.-L. and Hoey, T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science 273 (1996) 794-797.
152. Yamagata, T., Nishida, J., Sasaki, R., Tanaka, T., Honda, H., Hirano, N., Mano, H., Yazaki, Y. and Hirai, H. Of the GATA-binding proteins, only GATA-4 selectively regulates the human interleukin-5 gene promoter in interleukin-5 producing cells which express multiple GATA-binding proteins. Mol. Cell Biol. 15 (1995) 3830-3839.
153. Ye, J., Ghosh, P., Cippitelli, M., Subleski, J., Hardy, K.J., Ortaldo, J.R. and Young, H.A. Characterization of a silencer regulatory element in the human interferon-γ promoter. J. Biol. Chem. 269 (1994) 25728-25734.
154. Ymer, S., Tucker, W.Q., Sanderson, C.J., Hapel, A.J., Campbell, H.D. and Young, I.G. Constitutive synthesis of interleukin-3 by leukemia cell line WEHI-3B is due to retroviral insertion near the gene. Nature 317 (1985) 255-258.
155. Young, H.A., Komschlies, K.L., Ciccarone, V., Beckwith, M., Rosenberg, M., Jenkins, N.A., Copeland, N.G. and Durum, S.K. Expression of human IFN-γ genomic DNA in transgenic mice. J. Immunol. 143 (1989) 2389-2394.
156. Young, H.A., Ghosh, P., Ye, J., Lederer, J., Lichtman, A., Geraed, J.R., Penix, L., Wilson, C.B., Melvin, A.J., McGurn, M.E., Lewis, D.B. and Taub, D.D. Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-γ gene. J. Immunol. 153 (1994) 3603-3610.
157. Zurawski, G. and de Vries, J.E. Interleukin 13, an interleukin 4-like cytokine that acts on monocytes and B cells, but not on T cells. Immunology Today 15 (1994) 19-26.