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The glucagon-like peptide-1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
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Nauck MA, Niedereichholz U, Ettler R, Holst JJ, Ørskov C, Ritzelt R, Schmiegel WH: The glucagon-like peptide-1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol 1997, 273:2295-2302. This study clearly illustrates the potent effects of GLP-1 on gastric emptying.
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Wettergren A, Petersen H, Ørskov C, Christiansen J, Sheikh SP, Holst JJ: Glucagon-like peptide-1 (GLP-1) 7-36 amide and peptide YY from the L-cell in the ileal mucosa are potent inhibitors of vagally induced gastric acid in man. Scand J Gastroenterol 1994, 29:501-505.
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GLP-1 receptors in the subfornical organ and the area postrema are accessible to circulating glucagon-like peptide-1
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Gutniak M, Ørskov C, Holst JJ, Ahren B, Efendic S: Antidiabetogenic effect of glucagon-like peptide-1 (7-36) amide in normal subjects and patients with diabetes mellitus. N Engl J Med 1992, 326:1316-1322.
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Nauck MA, Kleine N, Ørskov C, Holst JJ, Willms B, Creutzfeldt W: Normalization of fasting hyperglycemia by exogenous GLP-1 (7-36 amide) in type 2-diabetic patients. Diabetologia 1993, 36:741-744.
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The antidiabetogenic effect of GLP-1 is maintained during a 7-day treatment period and improves diabetic dyslipoproteinemia in NIDDM patients
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Deacon CF, Nauck MA, Toft-Nielsen M, Pridal L, Willms B, Holst JJ: Both subcutaneous and intravenously administered glucagon-like peptide-1 are rapidly degraded from the amino terminus in type II diabetic patients and in healthy subjects. Diabetes 1995, 44:1126-1131.
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