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Volumn 9, Issue 11, 1998, Pages 1155-1166

Gene therapy of malignant glioma: Recent advances in experimental and clinical studies

Author keywords

Gene therapy; Malignant glioma

Indexed keywords

6 O METHYLGUANINE; 6 THIOXANTHINE; CYCLOPHOSPHAMIDE; CYTOSINE DEAMINASE; DIHYDROFOLATE REDUCTASE; DNA METHYLTRANSFERASE; ETHYLNITROSOUREA; FLUCYTOSINE; GANCICLOVIR;

EID: 0031743934     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008488709359     Document Type: Review
Times cited : (20)

References (101)
  • 1
    • 0026489416 scopus 로고
    • Current diagnostic concepts of astrocytic tumors
    • Vandenberg SR. Current diagnostic concepts of astrocytic tumors. J Neuropathol Exp Neurol 1992; 51: 644-57.
    • (1992) J Neuropathol Exp Neurol , vol.51 , pp. 644-657
    • Vandenberg, S.R.1
  • 2
    • 0001885597 scopus 로고    scopus 로고
    • Primary central nervous system tumors of the supratentorial compartment
    • Levin VA (ed): London: Churchill Livingstone
    • Berger MS, Leibel SA, Levin VA et al. Primary central nervous system tumors of the supratentorial compartment. In Levin VA (ed): Cancer in the Nervous System. London: Churchill Livingstone 1996; 57-126.
    • (1996) Cancer in the Nervous System , pp. 57-126
    • Berger, M.S.1    Leibel, S.A.2    Levin, V.A.3
  • 3
    • 0027954657 scopus 로고
    • Long-term survival in patients with malignant astrocytoma
    • Saleman MS, Scholtz H, Kaplan RS et al. Long-term survival in patients with malignant astrocytoma. Neurosurgery 1994; 34: 213 20.
    • (1994) Neurosurgery , vol.34 , pp. 213-220
    • Saleman, M.S.1    Scholtz, H.2    Kaplan, R.S.3
  • 4
    • 0031963921 scopus 로고    scopus 로고
    • Survival rates in patients with primary malignant brain tumors stratified by patients age and tumor histological type: An analysis based on surveillance, epidemiology, and end results (SEER) data, 1973-1991
    • Davis FG, Freels S, Gutsch J et al. Survival rates in patients with primary malignant brain tumors stratified by patients age and tumor histological type: An analysis based on surveillance, epidemiology, and end results (SEER) data, 1973-1991. J Neurosurg 1998;88: 1-10.
    • (1998) J Neurosurg , vol.88 , pp. 1-10
    • Davis, F.G.1    Freels, S.2    Gutsch, J.3
  • 5
    • 0025486836 scopus 로고
    • Treatment of severe combined immunodefieciency disease (SCID) due to adenosine deaminase (ADA) deficiency with autologous lymphocytes transduced with a human ADA gene
    • Anderson F, Blaese RH. Culver KW. Treatment of severe combined immunodefieciency disease (SCID) due to adenosine deaminase (ADA) deficiency with autologous lymphocytes transduced with a human ADA gene. Hum Gene Ther 1990; 1: 331-61.
    • (1990) Hum Gene Ther , vol.1 , pp. 331-361
    • Anderson, F.1    Blaese, R.H.2    Culver, K.W.3
  • 6
    • 0029799638 scopus 로고    scopus 로고
    • Gene therapy in the United States: A five-year status report
    • Ross G, Erickson R, Knorr D et al. Gene therapy in the United States: A five-year status report. Hum Gene Ther 1996; 7: 1781-90.
    • (1996) Hum Gene Ther , vol.7 , pp. 1781-1790
    • Ross, G.1    Erickson, R.2    Knorr, D.3
  • 7
    • 7844228755 scopus 로고    scopus 로고
    • ORDA report
    • ORDA report. Hum Gene Ther 1996; 7: 685-9.
    • (1996) Hum Gene Ther , vol.7 , pp. 685-689
  • 8
    • 0026772206 scopus 로고
    • In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors
    • Culver KW, Ram Z, Wallbridge S et al. In vivo gene transfer with retroviral vector-producer cells for treatment of experimental brain tumors. Science 1992; 256: 1550-2.
    • (1992) Science , vol.256 , pp. 1550-1552
    • Culver, K.W.1    Ram, Z.2    Wallbridge, S.3
  • 9
    • 0025095664 scopus 로고
    • Interleukin-2 production by tumor cells bypass T helper function in the generation of an antitumor response
    • Featon ER, Pardoll DM, Itaya T et al. Interleukin-2 production by tumor cells bypass T helper function in the generation of an antitumor response. Cell 1990; 60: 397-403.
    • (1990) Cell , vol.60 , pp. 397-403
    • Featon, E.R.1    Pardoll, D.M.2    Itaya, T.3
  • 10
    • 0025604195 scopus 로고
    • Retroviral vector-mediated g-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity
    • Gansbacher B, Bannerji R, Daniels B et al. Retroviral vector-mediated g-interferon gene transfer into tumor cells generates potent and long lasting antitumor immunity Cancer Res 1990; 50: 7820-5.
    • (1990) Cancer Res , vol.50 , pp. 7820-7825
    • Gansbacher, B.1    Bannerji, R.2    Daniels, B.3
  • 11
    • 0023278671 scopus 로고
    • Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld)
    • Itaya T, Yamagiwa S, Okada F et al. Xenogenization of a mouse lung carcinoma (3LL) by transfection with an allogeneic class I major histocompatibility complex gene (H-2Ld). Cancer Res 1987; 47: 3136-40.
    • (1987) Cancer Res , vol.47 , pp. 3136-3140
    • Itaya, T.1    Yamagiwa, S.2    Okada, F.3
  • 12
    • 0024502120 scopus 로고
    • Murine Interleukin-4 displays potent anti-tumor activity in vivo
    • Tepper RI, Pattengale PK, Leder P. Murine Interleukin-4 displays potent anti-tumor activity in vivo. Cell 1989; 57: 503-12.
    • (1989) Cell , vol.57 , pp. 503-512
    • Tepper, R.I.1    Pattengale, P.K.2    Leder, P.3
  • 13
    • 0029065364 scopus 로고
    • Recombinant human Interleukin-4 has antiproliferative activity on human tumor cell lines derived from epithelial and nonepithelial histologies
    • Topp MS, Papadimitriou CA, Eitelbach F et al. Recombinant human Interleukin-4 has antiproliferative activity on human tumor cell lines derived from epithelial and nonepithelial histologies. Cancer Res 1995; 55: 2173-6.
    • (1995) Cancer Res , vol.55 , pp. 2173-2176
    • Topp, M.S.1    Papadimitriou, C.A.2    Eitelbach, F.3
  • 14
    • 0025195323 scopus 로고
    • Influence of PGE2 and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2 activated lymphocytes
    • Kuppner MC, Sawamura Y, Hamou MF et al. Influence of PGE2 and cAMP-modulating agents on human glioblastoma cell killing by interleukin-2 activated lymphocytes. J Neurosurg 1990: 72: 619-25.
    • (1990) J Neurosurg , vol.72 , pp. 619-625
    • Kuppner, M.C.1    Sawamura, Y.2    Hamou, M.F.3
  • 15
    • 0025745414 scopus 로고
    • Modulation of T-cell function by gliomas
    • Roszman T, Elliott L, and Brooks W. Modulation of T-cell function by gliomas. Immunol Today 1991: 12: 370-4.
    • (1991) Immunol Today , vol.12 , pp. 370-374
    • Roszman, T.1    Elliott, L.2    Brooks, W.3
  • 16
    • 0029865486 scopus 로고    scopus 로고
    • Eradication of established intracranial rat gliomas by transforming growth factor-b antisense gene therapy
    • Fakhrai H, Dorigo O, Shawler D. L et al. Eradication of established intracranial rat gliomas by transforming growth factor-b antisense gene therapy. Proc Natl Acad Sci USA 1996; 93: 2909-14.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2909-2914
    • Fakhrai, H.1    Dorigo, O.2    Shawler, D.L.3
  • 17
    • 0028271497 scopus 로고
    • Rat glioblastoma cells expressing an antisense DNA to the insulin-like growth factor-I (IGF-I) receptor are nontumorigenic and induce regression of wild-type tumors
    • Resnicoff M, Sell C, Rubini M et al. Rat glioblastoma cells expressing an antisense DNA to the insulin-like growth factor-I (IGF-I) receptor are nontumorigenic and induce regression of wild-type tumors. Cancer Res 1994; 54: 2218-22.
    • (1994) Cancer Res , vol.54 , pp. 2218-2222
    • Resnicoff, M.1    Sell, C.2    Rubini, M.3
  • 18
    • 0026735230 scopus 로고
    • Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulun-like growth factor I
    • Trojan J, Blossey BK. Johnson TR et al. Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulun-like growth factor I. Proc Natl Acad Sci USA 1992; 89: 4874-8.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4874-4878
    • Trojan, J.1    Blossey, B.K.2    Johnson, T.R.3
  • 19
    • 0027507179 scopus 로고
    • Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor-1 RNA
    • Trojan J, Johnson TR, Rudin SD et al. Treatment and prevention of rat glioblastoma by immunogenic C6 cells expressing antisense insulin-like growth factor-1 RNA. Science 1993; 259: 94-6.
    • (1993) Science , vol.259 , pp. 94-96
    • Trojan, J.1    Johnson, T.R.2    Rudin, S.D.3
  • 21
    • 0028702018 scopus 로고
    • Drug sensitivity (suicide) gene for selective cancer chemotherapy
    • Moolten FL, Drug sensitivity (suicide) gene for selective cancer chemotherapy. Cancer Gene Ther 1994; 1: 279-87.
    • (1994) Cancer Gene Ther , vol.1 , pp. 279-287
    • Moolten, F.L.1
  • 22
    • 0028038843 scopus 로고
    • Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase
    • Culver KW, Van Gilder J, Link CJ et al. Gene therapy for the treatment of malignant brain tumors with in vivo tumor transduction with the herpes simplex thymidine kinase. Hum Gene Ther 1994; 5: 343-77.
    • (1994) Hum Gene Ther , vol.5 , pp. 343-377
    • Culver, K.W.1    Van Gilder, J.2    Link, C.J.3
  • 23
    • 0029992327 scopus 로고    scopus 로고
    • Human malignant brain tumor response to herpes simplex thymidine kinase (HSV-TK) ganciclovir gene therapy
    • Izquierdo M, Martin V, Felipe P et al. Human malignant brain tumor response to herpes simplex thymidine kinase (HSV-TK) ganciclovir gene therapy. Gene Ther 1996; 3: 491-5.
    • (1996) Gene Ther , vol.3 , pp. 491-495
    • Izquierdo, M.1    Martin, V.2    Felipe, P.3
  • 24
    • 0027317796 scopus 로고
    • Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors
    • Ram Z. Culver KW. Wallbridge S et al. Toxicity studies of retroviral-mediated gene transfer for the treatment of brain tumors. J Neurosurg 1993; 79: 400-7.
    • (1993) J Neurosurg , vol.79 , pp. 400-407
    • Ram, Z.1    Culver, K.W.2    Wallbridge, S.3
  • 25
    • 0027531548 scopus 로고
    • In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats
    • Ram Z, Culver K, Walbridge S et al. In situ retroviral-mediated gene transfer for the treatment of brain tumors in rats. Cancer Res 1993; 53: 83-8.
    • (1993) Cancer Res , vol.53 , pp. 83-88
    • Ram, Z.1    Culver, K.2    Walbridge, S.3
  • 26
    • 0025610750 scopus 로고
    • Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line
    • Short MP, Choi BC, Lee JK et al. Gene delivery to glioma cells in rat brain by grafting of a retrovirus packaging cell line. J Neurosci Res 1990; 27: 427-39.
    • (1990) J Neurosci Res , vol.27 , pp. 427-439
    • Short, M.P.1    Choi, B.C.2    Lee, J.K.3
  • 27
    • 0029995247 scopus 로고    scopus 로고
    • In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizer glioma cells to 5-fluorocytosine
    • Dong Y, Wen P, Manome Y et al. In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizer glioma cells to 5-fluorocytosine. Hum Gene Ther 1996; 7: 713-20.
    • (1996) Hum Gene Ther , vol.7 , pp. 713-720
    • Dong, Y.1    Wen, P.2    Manome, Y.3
  • 28
    • 0027496518 scopus 로고
    • In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase
    • Huber BE, Austine EA, Good SS et al. In vivo antitumor activity of 5-fluorocytosine on human colorectal carcinoma cells genetically modified to express cytosine deaminase. Cancer Res 1993: 53: 4619-26.
    • (1993) Cancer Res , vol.53 , pp. 4619-4626
    • Huber, B.E.1    Austine, E.A.2    Good, S.S.3
  • 29
    • 0026599586 scopus 로고
    • Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selective system
    • Mullen CA, Kilstrup M, Blaese MR et al. Transfer of the bacterial gene for cytosine deaminase to mammalian cells confers lethal sensitivity to 5-fluorocytosine: A negative selective system. Proc Natl Acad Sci USA 1992; 8: 33-7.
    • (1992) Proc Natl Acad Sci USA , vol.8 , pp. 33-37
    • Mullen, C.A.1    Kilstrup, M.2    Blaese, M.R.3
  • 30
    • 0031581178 scopus 로고    scopus 로고
    • Regression of experimental brain tumors with 6-Thioxanthine and Escherichia coli gpt gene therapy
    • Ono Y, Ikeda K, Wei MX et al. Regression of experimental brain tumors with 6-Thioxanthine and Escherichia coli gpt gene therapy. Hum Gene Ther 1997; 8: 2043-55.
    • (1997) Hum Gene Ther , vol.8 , pp. 2043-2055
    • Ono, Y.1    Ikeda, K.2    Wei, M.X.3
  • 31
    • 0039205029 scopus 로고
    • Targeting of an inducible toxic phenotype in animal cells
    • Borrelli E, Heyman R, Hsi M et al. Targeting of an inducible toxic phenotype in animal cells. Proc Natl Acad Sci USA 1988; 85: 7572-6.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 7572-7576
    • Borrelli, E.1    Heyman, R.2    Hsi, M.3
  • 32
    • 0025899005 scopus 로고
    • Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene
    • Ezzeddine ZT, Martuza RL, Platika D et al. Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene. N Biol 1991; 3: 608-14.
    • (1991) N Biol , vol.3 , pp. 608-614
    • Ezzeddine, Z.T.1    Martuza, R.L.2    Platika, D.3
  • 33
    • 0022485359 scopus 로고
    • Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: Paradigm for a prospective cancer control strategy
    • Moolten FL. Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy. Cancer Res 1986; 46: 5276-81.
    • (1986) Cancer Res , vol.46 , pp. 5276-5281
    • Moolten, F.L.1
  • 34
    • 0025241769 scopus 로고
    • Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors
    • Moolten FL, Wells JM. Curability of tumors bearing herpes thymidine kinase genes transferred by retroviral vectors. J Natl Cancer Inst 1990; 82: 297-300.
    • (1990) J Natl Cancer Inst , vol.82 , pp. 297-300
    • Moolten, F.L.1    Wells, J.M.2
  • 35
    • 0028001717 scopus 로고
    • Bystander tumoricidal effect in the treatment of experimental brain tumors
    • Wu JK, Cano WG. Meylaerts S et al. Bystander tumoricidal effect in the treatment of experimental brain tumors. Neurosurgery 1994; 35: 1094-104.
    • (1994) Neurosurgery , vol.35 , pp. 1094-1104
    • Wu, J.K.1    Cano, W.G.2    Meylaerts, S.3
  • 36
    • 0027483695 scopus 로고
    • The 'bystander effect' tumor regression when a fraction of the tumor mass is genetically modified
    • Freeman SM, Abbond CN, Whartenby K et al. The 'bystander effect' tumor regression when a fraction of the tumor mass is genetically modified. Cancer Res 1993; 53: 5274-83.
    • (1993) Cancer Res , vol.53 , pp. 5274-5283
    • Freeman, S.M.1    Abbond, C.N.2    Whartenby, K.3
  • 37
    • 0029952922 scopus 로고    scopus 로고
    • Evaluation of the bystander effect in experimental brain tumors bearing HSV-TK gene by serial MRI
    • Namba H, Iwadate Y, Tagawa M et al. Evaluation of the bystander effect in experimental brain tumors bearing HSV-TK gene by serial MRI. Hum Gene Ther 1996; 7: 1847-52.
    • (1996) Hum Gene Ther , vol.7 , pp. 1847-1852
    • Namba, H.1    Iwadate, Y.2    Tagawa, M.3
  • 38
    • 0029913138 scopus 로고    scopus 로고
    • Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro
    • Elshami,AA. Saavedra A, Zhang H et al. Gap junctions play a role in the 'bystander effect' of the herpes simplex virus thymidine kinase/ganciclovir system in vitro. Gene Ther 1996; 3: 85 92.
    • (1996) Gene Ther , vol.3 , pp. 85-92
    • Elshami, A.A.1    Saavedra, A.2    Zhang, H.3
  • 39
    • 0027787053 scopus 로고
    • In vitro evidence that metabolic corporation is responsible for the bystander effect obscured with HSV-TK retroviral gene therapy
    • Li W, Parysck LM, Warnick R et al. In vitro evidence that metabolic corporation is responsible for the bystander effect obscured with HSV-TK retroviral gene therapy. Hum Gene Ther 1993; 4: 725-31.
    • (1993) Hum Gene Ther , vol.4 , pp. 725-731
    • Li, W.1    Parysck, L.M.2    Warnick, R.3
  • 40
    • 0029161615 scopus 로고
    • The 'Bystander effect': Association of U-87 cell death with ganciclovir mediated apoptosis of nearby cells and lack in athymic mice
    • Colombo BM, Benedetti S, Ottolenghi S et al. The 'Bystander effect': Association of U-87 cell death with ganciclovir mediated apoptosis of nearby cells and lack in athymic mice. Hum Gene Ther 1995: 6: 763-72.
    • (1995) Hum Gene Ther , vol.6 , pp. 763-772
    • Colombo, B.M.1    Benedetti, S.2    Ottolenghi, S.3
  • 41
    • 0028323573 scopus 로고
    • Development of anti-tumor immunity following thymidiae kinase mediated killing of experimental brain tumors
    • Barba D, Hardin J, Sadelan M et al. Development of anti-tumor immunity following thymidiae kinase mediated killing of experimental brain tumors. Proc Natl Acad Sci USA 1994; 91: 4348-52.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 4348-4352
    • Barba, D.1    Hardin, J.2    Sadelan, M.3
  • 42
    • 0028093426 scopus 로고
    • Gene therapy of rat 9L gliosarcoma tumor by transduction with selective genes does not require drug selection
    • Topscott SJ, Miller AD, Olson JM et al. Gene therapy of rat 9L gliosarcoma tumor by transduction with selective genes does not require drug selection. Proc Natl Acad Sci USA 1994; 91: 8185-9.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 8185-8189
    • Topscott, S.J.1    Miller, A.D.2    Olson, J.M.3
  • 43
    • 0028071271 scopus 로고
    • The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats
    • Ram Z. Woldbridge S, Shawker T et al. The effect of thymidine kinase transduction and ganciclovir therapy on tumor vasculature and growth of 9L gliomas in rats. J Neurosurg 1994; 81: 256-60.
    • (1994) J Neurosurg , vol.81 , pp. 256-260
    • Ram, Z.1    Woldbridge, S.2    Shawker, T.3
  • 44
    • 0027378976 scopus 로고
    • Thymidine kinase mediated killing of rat brain tumors
    • Barba D, Hardin J, Ray J et al. Thymidine kinase mediated killing of rat brain tumors. J Neurosurg 1993; 79: 729-35.
    • (1993) J Neurosurg , vol.79 , pp. 729-735
    • Barba, D.1    Hardin, J.2    Ray, J.3
  • 45
    • 0028860038 scopus 로고
    • Lung-term rat survival after malignant brain tumor regression by retroviral gene therapy
    • Izquierdo M, Cortes M. DeFelipe P et al. Lung-term rat survival after malignant brain tumor regression by retroviral gene therapy. Gene Ther 1995; 2: 66-9.
    • (1995) Gene Ther , vol.2 , pp. 66-69
    • Izquierdo, M.1    Cortes, M.2    DeFelipe, P.3
  • 46
    • 0027548077 scopus 로고
    • Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir
    • Oldlield EH, Ram Z, Culver KW et al. Gene therapy for the treatment of brain tumors using intra-tumoral transduction with the thymidine kinase gene and intravenous ganciclovir. Hum Gene Ther 1993; 4: 39-69.
    • (1993) Hum Gene Ther , vol.4 , pp. 39-69
    • Oldlield, E.H.1    Ram, Z.2    Culver, K.W.3
  • 47
    • 0030100318 scopus 로고    scopus 로고
    • Retrovirus mediated gene therapy of experimental brain neoplasms using the herpes simplex virus thymidine kinase/ganciclovir paradigm
    • Rainov NG, Kramm CM, Aboody-Guterman K et al. Retrovirus mediated gene therapy of experimental brain neoplasms using the herpes simplex virus thymidine kinase/ganciclovir paradigm. Cancer Gene Ther 1996: 3: 99-106.
    • (1996) Cancer Gene Ther , vol.3 , pp. 99-106
    • Rainov, N.G.1    Kramm, C.M.2    Aboody-Guterman, K.3
  • 48
    • 0026445469 scopus 로고
    • Gene therapy of malignant brain tumors: A rat glioma line bearing the herpes simplex virus type-1 thymidine kinase gene and wild type retrovirus kills other tumor cells
    • Takamiya Y, Short MP. Ezzeddine ZD et al. Gene therapy of malignant brain tumors: A rat glioma line bearing the herpes simplex virus type-1 thymidine kinase gene and wild type retrovirus kills other tumor cells. J Neurosci Res 1992: 33: 493 503.
    • (1992) J Neurosci Res , vol.33 , pp. 493-503
    • Takamiya, Y.1    Short, M.P.2    Ezzeddine, Z.D.3
  • 49
    • 8944248812 scopus 로고    scopus 로고
    • Flk-I as a target for tumor growth inhibition
    • Strawn LM, McMahon G, App H et al. Flk-I as a target for tumor growth inhibition. Cancer Res 1996; 56: 3540-54.
    • (1996) Cancer Res , vol.56 , pp. 3540-3554
    • Strawn, L.M.1    McMahon, G.2    App, H.3
  • 50
    • 0028075655 scopus 로고
    • Systemic gene therapy of murine melanoma using tissue specific expression of the HSV-TK gene involves an immune component
    • Vile RG, Nelson JA, Castleden S et al. Systemic gene therapy of murine melanoma using tissue specific expression of the HSV-TK gene involves an immune component. Cancer Res 1994: 54: 6225-34.
    • (1994) Cancer Res , vol.54 , pp. 6225-6234
    • Vile, R.G.1    Nelson, J.A.2    Castleden, S.3
  • 51
    • 0028218528 scopus 로고
    • In vivo transfer of the human interleukin-2 gene: Negative tumoricidal results in experimental brain tumors
    • Ram Z, Woldbridge S, Heiss JD et al. In vivo transfer of the human interleukin-2 gene: Negative tumoricidal results in experimental brain tumors. J Neurosurg 1994; 80: 535-40.
    • (1994) J Neurosurg , vol.80 , pp. 535-540
    • Ram, Z.1    Woldbridge, S.2    Heiss, J.D.3
  • 52
    • 16944361879 scopus 로고    scopus 로고
    • Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspective for the combined transduction of the Interleukin-4 gene
    • Benedetti S, Dimeco F, Pollo B et al. Limited efficacy of the HSV-TK/GCV system for gene therapy of malignant gliomas and perspective for the combined transduction of the Interleukin-4 gene. Hum Gene Ther 1997; 8: 1345 53.
    • (1997) Hum Gene Ther , vol.8 , pp. 1345-1353
    • Benedetti, S.1    Dimeco, F.2    Pollo, B.3
  • 53
    • 0028805459 scopus 로고
    • Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents
    • Kim JH, Kim SH, Kolozsvary A et al. Selective enhancement of radiation response of herpes simplex virus thymidine kinase transduced 9L gliosarcoma cells in vitro and in vivo by antiviral agents, Int J Radiat Oncol Biol Phys 1995; 33: 861-8.
    • (1995) Int J Radiat Oncol Biol Phys , vol.33 , pp. 861-868
    • Kim, J.H.1    Kim, S.H.2    Kolozsvary, A.3
  • 54
    • 0028202066 scopus 로고
    • Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo
    • Chen SH, Shine HD, Goodman JC et al. Gene therapy for brain tumors: Regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci USA 1994; 91: 3054-7.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3054-3057
    • Chen, S.H.1    Shine, H.D.2    Goodman, J.C.3
  • 55
    • 0029991063 scopus 로고    scopus 로고
    • Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene; long term follow-up by MRI
    • Maron A, Gustin T. Roux AL et al. Gene therapy of rat C6 glioma using adenovirus-mediated transfer of the herpes simplex virus thymidine kinase gene; long term follow-up by MRI. Gene Ther 1996; 3: 315-22.
    • (1996) Gene Ther , vol.3 , pp. 315-322
    • Maron, A.1    Gustin, T.2    Roux, A.L.3
  • 56
    • 0027973509 scopus 로고
    • Adenovirus-mediated gene therapy of experimental gliomas
    • Perez-Cruet MJ, Trask TW, Chen SH et al. Adenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res 1994; 39: 506-11.
    • (1994) J Neurosci Res , vol.39 , pp. 506-511
    • Perez-Cruet, M.J.1    Trask, T.W.2    Chen, S.H.3
  • 57
    • 0030803888 scopus 로고    scopus 로고
    • Preelinical testing of recombinant adenoviral Herpes simplex virus thymidine kinase gene therapy for CNS malignancies
    • Vincent AJ, Esandi MC, Avezaat CJ et al. Preelinical testing of recombinant adenoviral Herpes simplex virus thymidine kinase gene therapy for CNS malignancies. Neurosurg 1997: 41: 442-52.
    • (1997) Neurosurg , vol.41 , pp. 442-452
    • Vincent, A.J.1    Esandi, M.C.2    Avezaat, C.J.3
  • 58
    • 0028458928 scopus 로고
    • Enhanced cytoloxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rats glioma cells
    • Shewach DS, Zerbe LK. Hughes TL et al. Enhanced cytoloxicity of antiviral drugs mediated by adenovirus directed transfer of the herpes simplex virus thymidine kinase gene in rats glioma cells. Cancer Gene Ther 1994; 1: 107-12.
    • (1994) Cancer Gene Ther , vol.1 , pp. 107-112
    • Shewach, D.S.1    Zerbe, L.K.2    Hughes, T.L.3
  • 59
    • 19144362837 scopus 로고    scopus 로고
    • Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors
    • Vincent AJ, Vogels R, Someren GV et al. Herpes simplex virus thymidine kinase gene therapy for rat malignant brain tumors. Hum Gene Ther 1996; 7: 197-205.
    • (1996) Hum Gene Ther , vol.7 , pp. 197-205
    • Vincent, A.J.1    Vogels, R.2    Someren, G.V.3
  • 60
    • 0029973565 scopus 로고    scopus 로고
    • Prevention of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-TK) modified tumor cells
    • Vrionis FD, Wu JK, Qi P et al. Prevention of the bystander cytocidal effect of irradiated herpes simplex virus thymidine kinase (HSV-TK) modified tumor cells. J Neuro-Oncol 1996; 30: 225-36.
    • (1996) J Neuro-Oncol , vol.30 , pp. 225-236
    • Vrionis, F.D.1    Wu, J.K.2    Qi, P.3
  • 61
    • 19144364318 scopus 로고    scopus 로고
    • Curative potential of Herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma
    • Cool V, Pirotte B, Gerard C et al. Curative potential of Herpes simplex virus thymidine kinase gene transfer in rats with 9L gliosarcoma. Hum Gene Ther 1996; 7: 627-35.
    • (1996) Hum Gene Ther , vol.7 , pp. 627-635
    • Cool, V.1    Pirotte, B.2    Gerard, C.3
  • 62
    • 0001171494 scopus 로고
    • Summary of results and conclusion of the gene therapy of malignant brain tumor: Clinical study
    • Ram Z, Culver KW, Oshiro E et al. Summary of results and conclusion of the gene therapy of malignant brain tumor: Clinical study. J Neurosurg 1995;82: 343A.
    • (1995) J Neurosurg , vol.82
    • Ram, Z.1    Culver, K.W.2    Oshiro, E.3
  • 63
    • 0028129836 scopus 로고
    • Release of an inhibitor of angiogenesis upon induction of wild-type p53 expression in glioblastoma cells
    • Van Meir EG, Polverini PJ. Chazin VR et al. Release of an inhibitor of angiogenesis upon induction of wild-type p53 expression in glioblastoma cells. Nat Genet 1994; 8: 171-6.
    • (1994) Nat Genet , vol.8 , pp. 171-176
    • Van Meir, E.G.1    Polverini, P.J.2    Chazin, V.R.3
  • 64
    • 0030980946 scopus 로고    scopus 로고
    • Transreceptor inhibition of human glioblastoma cells by erbB family ectodomains
    • O'Rourke DM, Qian X, Zhang H-T et al. Transreceptor inhibition of human glioblastoma cells by erbB family ectodomains. Proc Natl Acad Sci USA 1997; 94: 3250-5.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3250-3255
    • O'Rourke, D.M.1    Qian, X.2    Zhang, H.-T.3
  • 65
    • 0026502773 scopus 로고
    • Anti-oncogenic activity of signaling-defective epidermal growth factor receptor mutants
    • Redemann N, Holzmann B, Von Ruden T et al. Anti-oncogenic activity of signaling-defective epidermal growth factor receptor mutants. Mol Cell Biol 1992; 12: 491 8.
    • (1992) Mol Cell Biol , vol.12 , pp. 491-498
    • Redemann, N.1    Holzmann, B.2    Von Ruden, T.3
  • 66
    • 0028997079 scopus 로고
    • Resistence to toxic chemotherapy produced in mouse marrow cells by safety modified retroviruses containing a human MRD-1 transcription unit
    • Hanania EG, Fu S, Roninson I et al. Resistence to toxic chemotherapy produced in mouse marrow cells by safety modified retroviruses containing a human MRD-1 transcription unit. Gene Ther 1995; 2: 279 84.
    • (1995) Gene Ther , vol.2 , pp. 279-284
    • Hanania, E.G.1    Fu, S.2    Roninson, I.3
  • 67
    • 0026637623 scopus 로고
    • Selection of drugresistant bone marrow cells in vivo after retroviral transfer of human MDR-1
    • Sovrentino BP, Branott SJ, Bodine D et al. Selection of drugresistant bone marrow cells in vivo after retroviral transfer of human MDR-1. Science 1992; 257: 99 103.
    • (1992) Science , vol.257 , pp. 99103
    • Sovrentino, B.P.1    Branott, S.J.2    Bodine, D.3
  • 68
    • 0030833675 scopus 로고    scopus 로고
    • Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant glioma
    • Nagane M, Asai A, Shibui S et al. Application of antisense ribonucleic acid complementary to O6-methylguanine-deoxyribonucleic acid methyltransferase messenger ribonucleic acid for therapy of malignant glioma. Neurosurg 1997: 41: 434-41.
    • (1997) Neurosurg , vol.41 , pp. 434-441
    • Nagane, M.1    Asai, A.2    Shibui, S.3
  • 69
    • 0029073752 scopus 로고
    • Fas/APO-1 gene transfer for human malignant glioma
    • Weller M, Malipiero U. Rensing-Ehl A et al. Fas/APO-1 gene transfer for human malignant glioma. Cancer Res 1995; 55: 2936-44.
    • (1995) Cancer Res , vol.55 , pp. 2936-2944
    • Weller, M.1    Malipiero, U.2    Rensing-Ehl, A.3
  • 70
    • 0027955365 scopus 로고
    • Specific inhibition of c-sis protein synthesis and cell proliferation with antisense oligodeoxy-nucleotides in human glioma cells
    • Nitta T & Sato K. Specific inhibition of c-sis protein synthesis and cell proliferation with antisense oligodeoxy-nucleotides in human glioma cells. Neurosurg 1994; 34: 309-15.
    • (1994) Neurosurg , vol.34 , pp. 309-315
    • Nitta, T.1    Sato, K.2
  • 71
    • 0028861548 scopus 로고
    • Transduction with bFGF sense and antisense cDNA resulting in modification of malignant glioma growth
    • Redekop GJ, Naus CG. Transduction with bFGF sense and antisense cDNA resulting in modification of malignant glioma growth. J Neurosurg 1995; 82: 83-90.
    • (1995) J Neurosurg , vol.82 , pp. 83-90
    • Redekop, G.J.1    Naus, C.G.2
  • 72
    • 0026446102 scopus 로고
    • Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo
    • Plate KH, Breier G, Weich HA, Risau W. Vascular endothelial growth factor is a potential tumor angiogenesis factor in human gliomas in vivo. Nature (London) 1992; 359: 845 8.
    • (1992) Nature (London) , vol.359 , pp. 845-848
    • Plate, K.H.1    Breier, G.2    Weich, H.A.3    Risau, W.4
  • 73
    • 0026485002 scopus 로고
    • Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
    • Shwciki D, Itin A, Soffer D, Keshet E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature (London) 1992; 359: 843- 5.
    • (1992) Nature (London) , vol.359 , pp. 843-845
    • Shwciki, D.1    Itin, A.2    Soffer, D.3    Keshet, E.4
  • 74
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo
    • Kim KJ, Li B, Winer J et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature 1993; 362: 841-84.
    • (1993) Nature , vol.362 , pp. 841-884
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 75
    • 0028174337 scopus 로고
    • Glioblastoma growth inhibited in vivo by a dominant negative Flk-1 mutant
    • Millauer B, Shawver LK. Plate KH et al. Glioblastoma growth inhibited in vivo by a dominant negative Flk-1 mutant. Nature 1994; 367: 576-9.
    • (1994) Nature , vol.367 , pp. 576-579
    • Millauer, B.1    Shawver, L.K.2    Plate, K.H.3
  • 76
    • 0027421333 scopus 로고
    • Inhibition of vascular endothelial cell growth factor activity by an endogeneously encoded soluble receptor
    • Kendal RL, Thomas KA Inhibition of vascular endothelial cell growth factor activity by an endogeneously encoded soluble receptor. Proc Natl Acad Sci USA 1993; 90: 10705-9.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 10705-10709
    • Kendal, R.L.1    Thomas, K.A.2
  • 77
    • 0029782859 scopus 로고    scopus 로고
    • Suppression of glioblastoma angiogenecity and tumorigenicity by inhibition of endogeneous expression of vascular endothelial growth factor
    • Cheng SY, Huang HJ, Nagone M et al. Suppression of glioblastoma angiogenecity and tumorigenicity by inhibition of endogeneous expression of vascular endothelial growth factor. Proc Natl Acad Sci USA 1996; 93: 8502-7.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8502-8507
    • Cheng, S.Y.1    Huang, H.J.2    Nagone, M.3
  • 78
    • 0030029271 scopus 로고    scopus 로고
    • Inhibition of growth of C6 glioma cells in vivo by expression of antisense VEGF sequences
    • Salah M, Stacker SA, Wilks AF. Inhibition of growth of C6 glioma cells in vivo by expression of antisense VEGF sequences. Cancer Res 1996; 56: 393-401.
    • (1996) Cancer Res , vol.56 , pp. 393-401
    • Salah, M.1    Stacker, S.A.2    Wilks, A.F.3
  • 79
    • 8944222562 scopus 로고    scopus 로고
    • Gene therapy of malignant glioma via inhibition of tumor angiogenesis
    • Plate KH. Gene therapy of malignant glioma via inhibition of tumor angiogenesis. Cancer Metas Rev 1996; 15: 237-40.
    • (1996) Cancer Metas Rev , vol.15 , pp. 237-240
    • Plate, K.H.1
  • 80
    • 0028931228 scopus 로고
    • Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma
    • Chambers R, Gillespie GT, Soroceanu L et al. Comparison of genetically engineered herpes simplex viruses for the treatment of brain tumors in a scid mouse model of human malignant glioma. Proc Natl Acad Sci USA 1995; 92: 1411-5.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1411-1415
    • Chambers, R.1    Gillespie, G.T.2    Soroceanu, L.3
  • 81
    • 0027419624 scopus 로고
    • Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants retains susceptibility to acyclovir
    • Markert JM, Malick A, Coen DM et al. Reduction and elimination of encephalitis in an experimental glioma therapy model with attenuated herpes simplex mutants retains susceptibility to acyclovir. Neurosurgery 1993; 32: 597-603.
    • (1993) Neurosurgery , vol.32 , pp. 597-603
    • Markert, J.M.1    Malick, A.2    Coen, D.M.3
  • 82
    • 0025864440 scopus 로고
    • Experimental therapy of human glioma by means of genetically engineered virus mutant
    • Martuza RL, Malick A, Markert JM et al. Experimental therapy of human glioma by means of genetically engineered virus mutant. Science 1991: 252: 854-6.
    • (1991) Science , vol.252 , pp. 854-856
    • Martuza, R.L.1    Malick, A.2    Markert, J.M.3
  • 83
    • 0028108669 scopus 로고
    • Treament of malignant gliomas using ganciclovir hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant
    • Mineta T, Rabkin SD, Martuza RL et al. Treament of malignant gliomas using ganciclovir hypersensitive, ribonucleotide reductase-deficient herpes simplex viral mutant. Cancer Res 1994; 54: 3963-6.
    • (1994) Cancer Res , vol.54 , pp. 3963-3966
    • Mineta, T.1    Rabkin, S.D.2    Martuza, R.L.3
  • 84
    • 0027217637 scopus 로고
    • An experimental model of retrovirus gene therapy for malignant brain tumors
    • Takamiya Y, Short MP, Moolten FL et al. An experimental model of retrovirus gene therapy for malignant brain tumors. J Neurosurg 1993; 79: 104-10.
    • (1993) J Neurosurg , vol.79 , pp. 104-110
    • Takamiya, Y.1    Short, M.P.2    Moolten, F.L.3
  • 85
    • 0027421951 scopus 로고
    • Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells
    • Kunwar S, Pai LH, Pastan I. Cytotoxicity and antitumor effects of growth factor-toxin fusion proteins on human glioblastoma multiforme cells. J Neurosurg 1993; 79: 569-76.
    • (1993) J Neurosurg , vol.79 , pp. 569-576
    • Kunwar, S.1    Pai, L.H.2    Pastan, I.3
  • 86
    • 0031463632 scopus 로고    scopus 로고
    • Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells
    • Ram Z, Culver KW, Oshiro EM et al. Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells. Nature Med 1997; 3(12): 1354-61.
    • (1997) Nature Med , vol.3 , Issue.12 , pp. 1354-1361
    • Ram, Z.1    Culver, K.W.2    Oshiro, E.M.3
  • 87
    • 85012461000 scopus 로고
    • Regulatory issues
    • Recombinant DNA Advisory Committee. Regulatory issues. Hum Gene Ther 1995; 6: 1065-124.
    • (1995) Hum Gene Ther , vol.6 , pp. 1065-1124
  • 88
    • 0029013431 scopus 로고
    • Clinical protocol: Intrathecal gene therapy for the treatment of lepromeningeal carcinomatosis (phase 1-11 study)
    • Oldfield EH, Ram Z. Clinical protocol: Intrathecal gene therapy for the treatment of lepromeningeal carcinomatosis (phase 1-11 study) Hum Gene Ther 1995; 6: 55-85.
    • (1995) Hum Gene Ther , vol.6 , pp. 55-85
    • Oldfield, E.H.1    Ram, Z.2
  • 89
    • 0029818276 scopus 로고    scopus 로고
    • Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment
    • Kramm CM, Rainov NG, Sene-Esteves M et al. Long-term survival in a rodent model of disseminated brain tumors by combined intrathecal delivery of herpes vectors and ganciclovir treatment. Hum Gene Ther 1996; 7: 1989-94.
    • (1996) Hum Gene Ther , vol.7 , pp. 1989-1994
    • Kramm, C.M.1    Rainov, N.G.2    Sene-Esteves, M.3
  • 90
    • 0028351719 scopus 로고
    • Intrathecal gene therapy for malignant leptomeningeal neoplasia
    • Ram Z, Wallbridge S, Oshiro EM et al. Intrathecal gene therapy for malignant leptomeningeal neoplasia. Cancer Res 1994; 54: 2141-5.
    • (1994) Cancer Res , vol.54 , pp. 2141-2145
    • Ram, Z.1    Wallbridge, S.2    Oshiro, E.M.3
  • 91
    • 10144229106 scopus 로고    scopus 로고
    • Treatment of leptomeningeal metastases in rat model using a recombinant adenovirus containing the HSV-TK gene
    • Vincent AJ, Esandi MD, Someren G et al. Treatment of leptomeningeal metastases in rat model using a recombinant adenovirus containing the HSV-TK gene. J Neurosurg 1996; 85: 648-54.
    • (1996) J Neurosurg , vol.85 , pp. 648-654
    • Vincent, A.J.1    Esandi, M.D.2    Someren, G.3
  • 92
    • 19244362665 scopus 로고    scopus 로고
    • Treatment of advanced CNS malignancies with the recombinant adenovirus H5010RSVTK: A phase 1 trial
    • Eck SL, Alavi JB, Alavi A et al. Treatment of advanced CNS malignancies with the recombinant adenovirus H5010RSVTK: A phase 1 trial. Hum Gene Ther 1996; 7: 1465-82.
    • (1996) Hum Gene Ther , vol.7 , pp. 1465-1482
    • Eck, S.L.1    Alavi, J.B.2    Alavi, A.3
  • 93
    • 0029990867 scopus 로고    scopus 로고
    • Gene therapy against an experimental glioma using adeno-associated virus vectors
    • Okada H, Miyamura K, Itoh T et al. Gene therapy against an experimental glioma using adeno-associated virus vectors. Gene Ther 1996; 4: 957-64.
    • (1996) Gene Ther , vol.4 , pp. 957-964
    • Okada, H.1    Miyamura, K.2    Itoh, T.3
  • 94
    • 0029888339 scopus 로고    scopus 로고
    • A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy
    • Zhu J, Zhang L, Hanisch UK et al. A continuous intracerebral gene delivery system for in vivo liposome-mediated gene therapy. Gene Ther 1996; 3: 472-6.
    • (1996) Gene Ther , vol.3 , pp. 472-476
    • Zhu, J.1    Zhang, L.2    Hanisch, U.K.3
  • 95
    • 7844252568 scopus 로고
    • Cytokine gene therapy of malignant glioma by means of DNA/Liposomes
    • Nagai M (ed): Tokyo: Springer
    • Yoshida J, Wakabayashi T, Mizuno M et al. Cytokine gene therapy of malignant glioma by means of DNA/Liposomes. In Nagai M (ed): Brain Tumor: Research and Therapy. Tokyo: Springer 1995; 423-34.
    • (1995) Brain Tumor: Research and Therapy , pp. 423-434
    • Yoshida, J.1    Wakabayashi, T.2    Mizuno, M.3
  • 96
    • 0028567517 scopus 로고
    • Tissue-specific targeting of retroviral vectors through ligand-receptor interactions
    • Kasahara N, Dozy AM, Kan YW. Tissue-specific targeting of retroviral vectors through ligand-receptor interactions. Science 1994; 266: 1373-6.
    • (1994) Science , vol.266 , pp. 1373-1376
    • Kasahara, N.1    Dozy, A.M.2    Kan, Y.W.3
  • 97
    • 0031581182 scopus 로고    scopus 로고
    • Commentary: Promotor attenuation in gene therapy. Causes and remedies
    • Pillard F. Commentary: Promotor attenuation in gene therapy. Causes and remedies. Hum Gene Ther 1997; 8: 2009-10.
    • (1997) Hum Gene Ther , vol.8 , pp. 2009-2010
    • Pillard, F.1
  • 98
    • 0030937038 scopus 로고    scopus 로고
    • Cellular and molecular neurosurgery: Pathway from concept to reality-Part II
    • Zlokovic BV, and Apuzzo MLJ. Cellular and molecular neurosurgery: Pathway from concept to reality-Part II. Neurosurgery 1997; 40: 805-13.
    • (1997) Neurosurgery , vol.40 , pp. 805-813
    • Zlokovic, B.V.1    Apuzzo, M.L.J.2
  • 99
    • 0028908299 scopus 로고
    • Isolation, characterization and use of stem cells from the CNS
    • Gage FH, Ray J and Fisher LJ. Isolation, characterization and use of stem cells from the CNS. Annu Rev Neurosci 1995; 18: 159 92.
    • (1995) Annu Rev Neurosci , vol.18 , pp. 159-192
    • Gage, F.H.1    Ray, J.2    Fisher, L.J.3
  • 100
    • 0027462920 scopus 로고
    • Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells
    • Groves, Barnett SC, Franklin RJM et al. Repair of demyelinated lesions by transplantation of purified O-2A progenitor cells. Nature 1993; 362: 453-5.
    • (1993) Nature , vol.362 , pp. 453-455
    • Groves1    Barnett, S.C.2    Franklin, R.J.M.3
  • 101
    • 0018414728 scopus 로고
    • Macrophages in experimental human brain tumors
    • Morantz RA, Wood GW, Foster M et al. Macrophages in experimental human brain tumors. J Neurosurg 1979; 50: 298-304.
    • (1979) J Neurosurg , vol.50 , pp. 298-304
    • Morantz, R.A.1    Wood, G.W.2    Foster, M.3


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