A novel strategy for introducing exogenous Bcl-2 into neuronal cells: The Cre/loxP system-mediated activation of Bcl-2 for preventing programmed cell death using recombinant adenoviruses

Molecular and Cellular Neurosciences

Volumn 12, Issue 1-2, 1998, Pages 65-78

  Sato, Noboru ^a   Wang, Siwei ^a   Li, Ling ^a   Okabe, Keiko ^b   Hashimoto, Mitsuhiro ^c   Yaginuma, Hiroyuki ^d   Mikoshiba, Katsuhiko ^c,e,f   Uchiyama, Yasuo ^g   Uetsuki, Taichi ^h   Yoshikawa, Kazuaki ^h   Milligan, Carolanne E ^a   Oppenheim, Ronald W ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

^d FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

^f Calciosignal Net Project   (Japan)

^g OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^h OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN BCL 2; RECOMBINASE; VIRUS VECTOR;

APOPTOSIS; ARTICLE; CHICKEN; DNA FLANKING REGION; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOTONEURON; MULTIGENE FAMILY; NERVE CELL; PRIORITY JOURNAL; RECOMBINANT DNA TECHNOLOGY; VIRUS RECOMBINANT;

EID: 0031726144     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1006/mcne.1998.0703     Document Type: Article

References (48)

1. Allsopp, T. E., Wyatt, S., Paterson, H. F., and Davies, A. M. (1993). The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 73: 295-307.
2. Anton, M., and Graham, F. L. (1995). Site-specific recombination mediated by an adenovirus vector expressing the Cre recombinase protein: A molecular switch for control of gene expression. J. Virol. 69: 4600-4606.
3. Batistatou, A., and Greene, L. A. (1991). Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: Correlation with suppression of endonuclease activity. J. Cell Biol. 115: 461-471.
4. Batistatou, A., Merry, D. E., Korsmeyer, S. J., and Greene, L. A. (1993). Bcl-2 affects survival but not neuronal differentiation of PC12 cells. J. Neurosci. 13: 4422-4428.
5. Baumgartner, B. J., and Shine, H. D. (1997). Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduction population. J. Neurosci. 17: 6504-6511.
6. Bilang-Bileuel, A., Revah, F., Colin, P., Locquet, I., Robert, J. J., Mallet, J., and Horellou, P. (1997). Intrastriatal injection of an adenoviral vector expressing glial-cell-line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson disease. Proc. Natl. Acad. Sci. USA 94: 8818-8823.
7. Bonfanti, L., Strettoi, E., Chierzi, S., Cenni, M. C., Liu, X-H., Martinou, J.-C., Maffei, L., and Rabacchi, S. A. (1996). Protection of retinal ganglion cells from natural and axotomy-induced cell death in neonatal transgenic mice overexpressing bcl-2. J. Neurosci. 16: 4186-4194.
8. Chen, D. F., Schneider, G. E., Martinou, J-C., and Tonegawa, S. (1997). Bcl-2 promotes regeneration of served axons in mammalian CNS. Nature 385: 434-438.
9. Chen, J., Flannery, J. G., La Vail, M. M., Steinberg, R. H., Xu, J., and Simon, M. I. (1996). bcl-2 overexpression reduces apoptotic photoreceptor cell death in three different retinal degenerations. Proc. Natl. Acad. Sci. USA 93: 7042-7047.
10. Choi-Lundberg, D. L., Lin, Q., Chang, Y. N., Chiang, Y. L., Hay, C. M., Mohajeri, H., Davidson, B. L., and Bohn, M. C. (1997). Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275: 838-841.
11. Dubois-Dauphin, M., Frankowski, H., Tsujimoto, Y., Huarte, J., and Martinou, J-C. (1994). Neonatal motoneurons overexpressing the bcl-2 protooncogene in transgenic mice are protected from axotomy-induced cell death. Proc. Natl. Acad. Sci. USA. 91: 3309-3313.
12. Ericson, J., Thor, S., Edlund, T., Jessel, T. M., and Yamada, T. (1992). Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science 256: 1555-1560.
13. Farlie, P. G., Dringen, R., Rees, S. M., Kannourakis, G., and Bernard, O. (1995). bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc. Natl. Acad. Sci. USA 92: 4397-4401.
14. Garcia, I., Martinou, I., Tsujimoto, Y., and Martinou, J-C. (1992). Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 258:302-304.
15. Gimenez, Y. R. M., Revah, F., Pradier, L., Loquet, I., Mallet, J., and Privat, A. (1997). Prevention of motoneuron death by adenovirus-mediated neurotrophic factors. J. Neurosci. Res. 48: 281-285.
16. Gravel, C., Gotz, R., Lorrain, A., and Sendtner, M. (1997). Adenoviral gene transfer of ciliary neurotrophic factor and brain-derived neurotrophic factor leads to long-term survival of axotomized motor neurons. Nat. Med. 3: 765-770.
17. Greene, L. A., and Tischler, A. S. (1982). PC12 pheochromocytoma cultures in neurobiological research. Adv. Cell Neurobiol. 3: 373-414.
18. Gu, H., Marth, J. D., Orban, P. C., Mossmann, H., and Rajewsky, K. (1994). Deletion of a DNA polymerase β gene segment in T cell using cell type-specific gene targeting. Science 265: 103-106.
19. Hashimoto, M., Aruga, J., Hosoya, Y., Kanegae, Y., Saito, I., and Mikoshiba, K. (1996). A neural cell-type-specific expression system using recombinant adenovirus vectors. Hum. Gene Ther. 7: 149-158.
20. Hashimoto, M., Saito, T., and Mikoshiba. K. (1997). Soc. Neurosci. Abstr. 346.4.
21. Jia, W. W.-G., Wang, Y., Qiang, D., Tufaro, F., Remington, R., and Cynader, M. (1996). A bcl-2 expressing viral vector protects cortical neurons from excitotoxicity even when administered several hours after the toxic insults. Mol Brain Res. 42: 350-353.
22. Kanegae, Y., Makimura, M., and Saito, I. (1994). A simple and efficient method for purification of infectious recombinant adenovirus. Jpn. J. Med. Sci. Biol. 47: 157-166.
23. Kanegae, Y., Lee, G., Sato, Y., Tanaka, M., Nakai, M., Sakai, T., Sugano, S., and Saito, I. (1995). Efficient gene activation in mammalian cells by using recombinant adenovirus expressing site-specific Cre recombinase. Nucleic Acids Res. 23: 3816-3821.
24. Kanegae, Y., Takamori, K., Sato, Y., Lee, G., Nakai, M., and Saito, I. (1996). Efficient gene activation system on mammalian cell chromosomes using recombinant adenovirus producing Cre recombinase. Gene 181: 207-212.
25. Kilby, N. J., Snaith, M. R., and Murray, J. A. H. (1993). Site-specific recombinases: Tools for genome engineering. Trends Genet. 9: 413-421.
26. Kobayashi, M., Nagata, S., Kita, Y, Nakatsu, N., Ihara, S., Kaibuchi, K., Kuroda, S., Ui, M., Iba, H., Konishi, H., Kikkawa, U., Saitoh, I., and Fukui, Y. (1997). Expression of a constitutively active phosphatidylinositol 3-kinase induces process formation in rat PC12 cells. J. Biol. Chem. 272: 16089-16092.
27. Kumar, S., Kinoshita, M., Noda, M., Copeland, N. G., and Jenkins, N. A. (1994). Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1β-converting enzyme. Genes Dev. 8: 1613-1626.
28. Lakso, M., Sauer, B., Mosinger, B., Jr., Lee, E. J., Manning, R. W., Yu, S.-H., Mulder, K. L., and Westphal, H. (1992). Targeted oncogene activation by site-specific recombination in transgenic mice. Proc. Natl Acad. Sci. USA 89: 6232-6236.
29. Lawrence, M. S., Ho, D. Y., Sun, G. H., Steinberg, G. K., and Sapolsky, R. M. (1996). Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci. 16: 486-496.
30. Le Gal La Salle, G., Robert, J. J., Berrard, S., Ridoux, V., Stratford-Perricaudet, L. D., Perricaudet, M., and Mallet, J. (1993). An adenovirus vector for gene transfer into neurons and glia in the brain. Science 259: 988-990.
31. Mah, S. P., Zhong, L. T., Liu, Y., Roghani, A., Edwards, R. H., and Bredesen, D. E. (1993). The protooncogene bcl-2 inhibits apoptosis in PC12 cells. J. Neurochem. 60: 1183-1186.
32. Martinou, J-C., Dubois-Dauphin, M., Staple, J. K., Rodriguez, I., Frankowski, H., Missotten, M., Albertini, P., Talabot, D., Catsicas, S., Pietra, C., and Huarte, J. (1994). Overexpression of bcl-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia. Neuron 13: 1017-1030.
33. Merry, D. E., Veis, D. J., Hickey, W. F., and Korsmeyer, S. J. (1994). bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 120: 301-311.
34. Merry, D. E., and Korsmeyer, S. J. (1997). Bcl-2 gene family in the nervous system. Annu. Rev. Neurosci. 20: 245-267.
35. Milligan, C. E., Oppenheim, R. W., and Schwartz, L. M. (1994). Motoneurons deprived of trophic support in vitro require new gene expression to undergo cell death. J. Neurobiol. 25: 1005-1016.
36. Miyake, S., Makimura, M., Kanegae, Y., Harada, S., Sato, Y., Takamori, K., Tokuda, C., and Saito, I. (1996). Efficient generation of recombinant adenoviruses using adenovirus DNA-terminal protein complex and a cosmid bearing the full length virus genome. Proc. Natl. Acad. Sci. USA 93: 1320-1324.
37. Niwa, H., Yamamura, K., and Miyazaki, J. (1991). Efficient selection for high-expression transfectants with a novel eukaryotic vector. Gene 108: 193-200.
38. Oppenheim, R. W., Haverkamp, L. J., Prevette, D., McManaman, J. L., and Appel, S. H. (1988). Reduction of naturally occurring motoneuron death in vivo by a target derived neurotrophic factor. Science 240: 919-922.
39. Oppenheim, R. W., Houenou, L. J., Johnson, J. E., Lin, L.-F. H., Li, L., Lo, A. C., Newsome, A. L., Prevette, D. M., and Wang, S. W. (1995). Developing motoneurons rescued from programmed and axotomy-induced cell death by GDNF. Nature 373: 344-346.
40. Oppenheim, R. W. (1992). Motor neuron disease. High hopes of a trophic factor. Nature 358: 451-452.
41. Oppenheim, R. W. (1996). Neurotrophic survival molecules for moto-neurons: An embarrassment of riches. Neuron 17: 195-197.
42. Sagot, Y., Dubois-Dauphin, M., Tan, S. A., de Bilbao, F., Aebischer, P., Martinou, J-C., and Kato, A. C. (1995). Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease. J. Neurosci. 15: 7727-7733.
43. Sato, N., Hotta, K., Waguri, S., Nitatori, T., Tohyama, K., Tsujimoto, Y., and Uchiyama, Y. (1994). Neuronal differentiation of PC12 cells as a result of prevention of cell death by bcl-2. J. Neurobiol. 25: 1227-1234.
44. Sato, N., Milligan, C. E., Uchiyama, Y., and Oppenheim, R. W. (1997). Cloning and expression of the cDNA encoding rat caspase-2. Gene 202: 127-132.
45. Slack, R. S., and Miller, F. D. (1996). Viral vectors for modulating gene expression in neurons. Curr. Opin. Neurobiol. 6: 576-583.
46. Slack, R. S., Belliveau, D. J., Rosenberg, M., Atwal, J., Lochmüller, H., Aloyz, R., Haghighi, A., Lach, B., Seth, P., Coorper, E., and Miller, F. D. (1996). Adenovirus-mediated gene transfer of the tumor suppressor, p53, induce apoptosis in postmitotic neurons. J. Cell Biol. 135: 1085-1096.
47. Smith, R. G., Alexianu, M. E., Crawford, G., Nyormoi, O., Stefani, E., and Appel. S. H. (1994). Cytotoxicity of immunoglobulins from amytrophic lateral sclerosis patients on a hybrid motoneuron cell line. Proc. Natl. Acad. Sci. USA 91: 3393-3397.
48. Subramanian, T., Tarodi, B., and Chinnadurai, G. (1995). p53-independent apoptotic and necrotic cell deaths induced by adenovirus infection: Suppression by E1B 19K and Bcl-2 proteins. Cell Growth Differ. 6: 131-137.