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Geschwind MD, Kessler JA, Geller AI, Federoff HJ. Transfer of the nerve growth factor gene into cell lines and cultured neurons using a defective herpes simplex virus vector. Mol Brain Res. 24:1994;327-335.
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Geller, A.I.3
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Battleman DS, Geller AI, Chao MV. HSV-1 vector-mediated gene transfer of the human nerve growth factor receptor p75hNGFR defines high-affinity NGF binding. J Neurosci. 13:1993;941-951.
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Battleman, D.S.1
Geller, A.I.2
Chao, M.V.3
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0027416053
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Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene
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Ho DY, Mocarski ES, Sapolsky RM. Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene. Proc Natl Acad Sci USA. 90:1993;3655-3659.
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Ho, D.Y.1
Mocarski, E.S.2
Sapolsky, R.M.3
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Herpes simplex virus vector overexpressing the glucose transporter gene protect against seizure-induced neuron loss
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Lawrence MS, Ho DY, Dash R, Sapolsky RM. Herpes simplex virus vector overexpressing the glucose transporter gene protect against seizure-induced neuron loss. Proc Natl Acad Sci USA. 92:1995;7247-7251.
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Lawrence, M.S.1
Ho, D.Y.2
Dash, R.3
Sapolsky, R.M.4
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18
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0030025668
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Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo
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of special interest. The authors use HSV1-derived amplicons to overexpress the apoptosis-inhibitory protein Bcl-2 in primary cultures of hippocampal neurons and in the hippocampus in vivo. Their results indicate that overexpression of Bcl-2 inhibits neuronal apoptosis in response to a variety of insults.
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of special interest Lawrence MS, Ho DY, Sun GH, Steinberg GK, Sapolsky RM. Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J Neurosci. 16:1996;486-496 The authors use HSV1-derived amplicons to overexpress the apoptosis-inhibitory protein Bcl-2 in primary cultures of hippocampal neurons and in the hippocampus in vivo. Their results indicate that overexpression of Bcl-2 inhibits neuronal apoptosis in response to a variety of insults.
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J Neurosci
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Lawrence, M.S.1
Ho, D.Y.2
Sun, G.H.3
Steinberg, G.K.4
Sapolsky, R.M.5
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19
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0028559601
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Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase
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During MJ, Naegele JR, O'Malley KL, Geller AI. Long-term behavioral recovery in Parkinsonian rats by an HSV vector expressing tyrosine hydroxylase. Science. 266:1994;1399-1403.
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During, M.J.1
Naegele, J.R.2
O'Malley, K.L.3
Geller, A.I.4
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20
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0026939124
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Gene transfer into mammalian central nervous system using Herpes virus vectors: Extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter
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Anderson JK, Garber DA, Meaney CA, Breakefield XO. Gene transfer into mammalian central nervous system using Herpes virus vectors: extended expression of bacterial lacZ in neurons using the neuron-specific enolase promoter. Hum Gene Ther. 3:1992;487-499.
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Anderson, J.K.1
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21
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0028226707
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Pakzaban P, Chiocca EA. Nerve growth factor protects against Herpes simplex virus type 1 neurotoxicity in the rat striatum. Neuroreport. 5:1994;993-996.
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Ho DY, Mocarski ES. Beta-galactosidase as a marker in the peripheral and nervous tissues of the herpes simplex virus-infected mouse. Virology. 174:1988;279-283.
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Ho, D.Y.1
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23
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0028826147
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Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood - Brain barrier disruption
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of outstanding interest. In this study, the authors compare the efficacy of adenovirus- and HSV1-derived vectors after delivery to brain tumors and the intact brain. These vectors are compared with respect to their ability to infiltrate tumor tissue and their cytotoxicity. This study raises the possibility that HSV1-derived vectors can be used to treat brain tumors.
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of outstanding interest Nilaver G, Muldoon LL, Kroll RS, Pagel MA, Breakefield XO, Davidson BL, Neuwelt EA. Delivery of herpesvirus and adenovirus to nude rat intracerebral tumors after osmotic blood - brain barrier disruption. Proc Natl Acad Sci USA. 92:1995;9829-9833 In this study, the authors compare the efficacy of adenovirus- and HSV1-derived vectors after delivery to brain tumors and the intact brain. These vectors are compared with respect to their ability to infiltrate tumor tissue and their cytotoxicity. This study raises the possibility that HSV1-derived vectors can be used to treat brain tumors.
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Proc Natl Acad Sci USA
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Nilaver, G.1
Muldoon, L.L.2
Kroll, R.S.3
Pagel, M.A.4
Breakefield, X.O.5
Davidson, B.L.6
Neuwelt, E.A.7
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24
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0028881233
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Comparison of intracerebral inoculation and osmotic blood - Brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain
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Muldoon LL, Nilaver G, Kroll RA, Pagel MA, Breakefield XO, Chiocca EA, Davidson BL, Weissleder R, Neuwelt EA. Comparison of intracerebral inoculation and osmotic blood - brain barrier disruption for delivery of adenovirus, herpesvirus, and iron oxide particles to normal rat brain. Am J Pathol. 147:1995;1840-1851.
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Muldoon, L.L.1
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Kroll, R.A.3
Pagel, M.A.4
Breakefield, X.O.5
Chiocca, E.A.6
Davidson, B.L.7
Weissleder, R.8
Neuwelt, E.A.9
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25
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Feldman, L.T.5
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Johnson PA, Miyanohara A, Levine F, Cahill T, Friedmann T. Cytotoxicity of a replication-defective mutant of Herpes simplex virus type 1. J Virol. 66:1992;2952-2965.
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Johnson, P.A.1
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Levine, F.3
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Friedmann, T.5
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27
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0028558776
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Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, retrovirus vectors
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Boviatsis EJ, Chase M, Wei MX, Tamiya T, Hurford RK, Kowall NW, Tepper RI, Breakefield XO, Chiocca EA. Gene transfer into experimental brain tumors mediated by adenovirus, herpes simplex virus, retrovirus vectors. Hum Gene Ther. 5:1994;183-191.
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Boviatsis, E.J.1
Chase, M.2
Wei, M.X.3
Tamiya, T.4
Hurford, R.K.5
Kowall, N.W.6
Tepper, R.I.7
Breakefield, X.O.8
Chiocca, E.A.9
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Jani, A.3
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Massie, B.5
Prescott, S.6
Simoneau, M.7
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La Salle GLG, Robert JJ, Berrard S, Ridoux V, Stratford-Perricaudet LD, Perricaudet M, Mallet J. An adenovirus vector for gene transfer into neurons and glia in the brain. Science. 259:1993;988-990.
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La Salle, G.L.G.1
Robert, J.J.2
Berrard, S.3
Ridoux, V.4
Stratford-Perricaudet, L.D.5
Perricaudet, M.6
Mallet, J.7
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35
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0027408530
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Akli S, Caillaud C, Vigne E, Stratford-Perricaudet LD, Poenaru L, Perricaudet M, Kahn A, Peschanski M. Transfer of a foreign gene into the brain using adenovirus vectors. Nature Genet. 3:1993;224-228.
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Akli, S.1
Caillaud, C.2
Vigne, E.3
Stratford-Perricaudet, L.D.4
Poenaru, L.5
Perricaudet, M.6
Kahn, A.7
Peschanski, M.8
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Davidson BL, Allen ED, Kozarsky KF, Wilson JM, Roessler BJ. A model system for in vivo gene transfer into the central nervous system using an adenoviral vector. Nature Genet. 3:1993;219-223.
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Davidson, B.L.1
Allen, E.D.2
Kozarsky, K.F.3
Wilson, J.M.4
Roessler, B.J.5
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Bajocchi G, Feldman SH, Crystal RG, Mastrangeli A. Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors. Nature Genet. 3:1993;229-234.
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Bajocchi, G.1
Feldman, S.H.2
Crystal, R.G.3
Mastrangeli, A.4
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Ghadge GD, Roos RP, Kang UJ, Wollmann R, Fishman PS, Kalynych AM, Barr E, Leiden JM. CNS gene delivery by retrograde transport of recombinant replication-defective adenoviruses. Gene Ther. 2:1995;132-137.
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Ghadge, G.D.1
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Kang, U.J.3
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Fishman, P.S.5
Kalynych, A.M.6
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Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain
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of special interest. A recombinant adenovirus vector expressing β-galactosidase is used to `tag' primary adult neural progenitor cells before they are transplanted into the brain. This study raises the possibility that recombinant adenovirus can be used to genetically manipulate primary neural cells for use in neural transplants.
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of special interest Gage FH, Coates PW, Palmer TD, Kuhn HG, Fisher LJ, Suhonen JO, Peterson DA, Suhr ST, Ray J. Survival and differentiation of adult neuronal progenitor cells transplanted to the adult brain. Proc Natl Acad Sci USA. 92:1995;11879-11883 A recombinant adenovirus vector expressing β-galactosidase is used to `tag' primary adult neural progenitor cells before they are transplanted into the brain. This study raises the possibility that recombinant adenovirus can be used to genetically manipulate primary neural cells for use in neural transplants.
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Proc Natl Acad Sci USA
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Gage, F.H.1
Coates, P.W.2
Palmer, T.D.3
Kuhn, H.G.4
Fisher, L.J.5
Suhonen, J.O.6
Peterson, D.A.7
Suhr, S.T.8
Ray, J.9
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Yamagata M, Jaye DL, Sanes JR. Gene transfer to avian embryos with a recombinant adenovirus. Dev Biol. 166:1994;355-359.
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Jaye, D.L.2
Sanes, J.R.3
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41
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0030048198
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Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP
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of special interest. The authors describe modifications made to GFP that enhance its fluorescence intensity in mammalian axons and dendrites. They use recombinant adenovirus vectors expressing this enhanced GFP, in addition to a membrane-anchoring signal, to label cortical neurons and their processes in culture and in vivo, and to label hippocampal neurons in organotypic slice cultures.
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of special interest Moriyoshi K, Richards LJ, Akazawa C, O'Leary DDM, Nakanishi S. Labeling neural cells using adenoviral gene transfer of membrane-targeted GFP. Neuron. 16:1996;255-260 The authors describe modifications made to GFP that enhance its fluorescence intensity in mammalian axons and dendrites. They use recombinant adenovirus vectors expressing this enhanced GFP, in addition to a membrane-anchoring signal, to label cortical neurons and their processes in culture and in vivo, and to label hippocampal neurons in organotypic slice cultures.
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Neuron
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Moriyoshi, K.1
Richards, L.J.2
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Nakanishi, S.5
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42
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0029914570
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Proneuropeptide Y processing in large dense-core vesicles: Manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses
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of outstanding interest. One of the first studies to use recombinant adenovirus to study the biochemistry of primary neurons. Specifically, recombinant adenovirus is used to over-express processing enzymes and to examine neuropeptide Y processing.
-
of outstanding interest Paquet L, Massie B, Mains RE. Proneuropeptide Y processing in large dense-core vesicles: manipulation of prohormone convertase expression in sympathetic neurons using adenoviruses. J Neurosci. 16:1996;964-973 One of the first studies to use recombinant adenovirus to study the biochemistry of primary neurons. Specifically, recombinant adenovirus is used to over-express processing enzymes and to examine neuropeptide Y processing.
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(1996)
J Neurosci
, vol.16
, pp. 964-973
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Paquet, L.1
Massie, B.2
Mains, R.E.3
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43
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10544249872
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Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons
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of outstanding interest
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of outstanding interest Slack RS, Belliveau DJ, Rosenberg M, Atwal J, Lochmüller H, Aloyz R, Haghighi A, Lach B, Seth P, Cooper E, Miller FD. Adenovirus-mediated gene transfer of the tumor suppressor, p53, induces apoptosis in postmitotic neurons. J Cell Biol. 1996; This study documents the lack of cytotoxicity of low titres of recombinant adenovirus on primary cultured neurons as monitored by cell survival, electron microscopy, and electrophysiology. Recombinant adenovirus is used to demonstrate that overexpression of p53 in postmitotic neurons leads to apoptosis.
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(1996)
J Cell Biol
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Slack, R.S.1
Belliveau, D.J.2
Rosenberg, M.3
Atwal, J.4
Lochmüller, H.5
Aloyz, R.6
Haghighi, A.7
Lach, B.8
Seth, P.9
Cooper, E.10
Miller, F.D.11
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44
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0029868381
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An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity
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Barkats M, Remelmans A, Geoffroy M, Robert J, Loquet I, Horellou R, Revah F, Mallet J. An adenovirus encoding CuZnSOD protects cultured striatal neurones against glutamate toxicity. Neuroreport. 7:1996;497-501.
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(1996)
Neuroreport
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Barkats, M.1
Remelmans, A.2
Geoffroy, M.3
Robert, J.4
Loquet, I.5
Horellou, R.6
Revah, F.7
Mallet, J.8
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45
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0030063621
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Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons
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Wilkemeyer MS, Smith KL, Zarei MM, Benke TA, Swann JW, Angelides KJ, Eisensmith RC. Adenovirus-mediated gene transfer into dissociated and explant cultures of rat hippocampal neurons. J Neurosci Res. 43:1996;161-174.
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(1996)
J Neurosci Res
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Wilkemeyer, M.S.1
Smith, K.L.2
Zarei, M.M.3
Benke, T.A.4
Swann, J.W.5
Angelides, K.J.6
Eisensmith, R.C.7
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46
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0028246338
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Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
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Engelhardt JF, Ye X, Doranz B, Wilson JM. Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc Natl Acad Sci USA. 91:1994;6196-6200.
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Proc Natl Acad Sci USA
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Engelhardt, J.F.1
Ye, X.2
Doranz, B.3
Wilson, J.M.4
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47
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0029655456
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Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
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of outstanding interest. As in [46], new-generation adenovirus vectors with deletions in the E1 and E4 regions of the viral genome are described. These new vectors may well diminish, or potentially abolish, the cytotoxicity observed with high titres of current adenoviral vectors.
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of outstanding interest Yeh P, Dedieu J, Orsini C, Vigne E, Denefle P, Perricaudet M. Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J Virol. 70:1996;559-565 As in [46], new-generation adenovirus vectors with deletions in the E1 and E4 regions of the viral genome are described. These new vectors may well diminish, or potentially abolish, the cytotoxicity observed with high titres of current adenoviral vectors.
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(1996)
J Virol
, vol.70
, pp. 559-565
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Yeh, P.1
Dedieu, J.2
Orsini, C.3
Vigne, E.4
Denefle, P.5
Perricaudet, M.6
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48
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0027243657
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Expression of heterologous proteins in cultured rat hippocampal neurons using the semliki forest virus vector
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Olkkonen VM, Liljestrom P, Garoff H, Simons K, Dotti CG. Expression of heterologous proteins in cultured rat hippocampal neurons using the semliki forest virus vector. J Neurosci Res. 35:1993;445-451.
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J Neurosci Res
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Olkkonen, V.M.1
Liljestrom, P.2
Garoff, H.3
Simons, K.4
Dotti, C.G.5
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49
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0029155983
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Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture
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De Hoop M, Von Poser C, Lange C, Ikonen E, Hunziker W, Dotti CG. Intracellular routing of wild-type and mutated polymeric immunoglobulin receptor in hippocampal neurons in culture. J Cell Biol. 130:1995;1447-1459.
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J Cell Biol
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De Hoop, M.1
Von Poser, C.2
Lange, C.3
Ikonen, E.4
Hunziker, W.5
Dotti, C.G.6
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50
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0029935765
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Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons
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of special interest. This study exploits the SFV vector to study cellular processing and routing of the human amyloid precursor protein in a number of different populations of primary neurons.
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of special interest Simons M, De Strooper B, Multhaup G, Tiernari PJ, Dotti CG, Beyreuther K. Amyloidogenic processing of the human amyloid precursor protein in primary cultures of rat hippocampal neurons. J Neurosci. 16:1996;899-908 This study exploits the SFV vector to study cellular processing and routing of the human amyloid precursor protein in a number of different populations of primary neurons.
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(1996)
J Neurosci
, vol.16
, pp. 899-908
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Simons, M.1
De Strooper, B.2
Multhaup, G.3
Tiernari, P.J.4
Dotti, C.G.5
Beyreuther, K.6
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51
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0028169741
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Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain
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Kaplitt MG, Leone P, Samulski RJ, Xiao X, Pfaff DW, O'Malley KL, During MJ. Long-term gene expression and phenotypic correction using adeno-associated virus vectors in the mammalian brain. Nature Genet. 8:1994;148-154.
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(1994)
Nature Genet
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Kaplitt, M.G.1
Leone, P.2
Samulski, R.J.3
Xiao, X.4
Pfaff, D.W.5
O'Malley, K.L.6
During, M.J.7
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52
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0028956371
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Sendai virosomal infusion of an adeno-associated virus-derived construct containing neuropeptide Y into primary rat brain cultures
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Wu P, De Fiebre CM, Millard WJ, Elmstrom K, Gao Y, Meyer EM. Sendai virosomal infusion of an adeno-associated virus-derived construct containing neuropeptide Y into primary rat brain cultures. Neurosci Lett. 190:1995;73-76.
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Neurosci Lett
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Wu, P.1
De Fiebre, C.M.2
Millard, W.J.3
Elmstrom, K.4
Gao, Y.5
Meyer, E.M.6
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53
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0029996147
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In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector
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of outstanding interest. The authors describe a novel HIV-derived retroviral vector that is capable of transducing terminally differentiated, postmitotic cells, including neurons in the adult brain.
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of outstanding interest Naldini L, Blömer U, Gallay P, Ory D, Mulligan R, Gage FH, Verma IM, Trono D. In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science. 272:1996;263-267 The authors describe a novel HIV-derived retroviral vector that is capable of transducing terminally differentiated, postmitotic cells, including neurons in the adult brain.
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(1996)
Science
, vol.272
, pp. 263-267
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-
Naldini, L.1
Blömer, U.2
Gallay, P.3
Ory, D.4
Mulligan, R.5
Gage, F.H.6
Verma, I.M.7
Trono, D.8
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