Molecular targets for human papillomaviruses: Prospects for antiviral therapy

Antiviral Chemistry and Chemotherapy

Volumn 9, Issue 5, 1998, Pages 359-377

  Phelps, W C ^a   Barnes, J A ^a   Lobe, D C ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Antiviral drug discovery; Cervical cancer; Warts

Indexed keywords

ANTIVIRUS AGENT; HELICASE; VIRUS ENZYME;

ANUS CANCER; CONDYLOMA; GENITAL TRACT CANCER; LARYNX PAPILLOMATOSIS; PRIORITY JOURNAL; REVIEW; VERRUCA VULGARIS; VIRION; VIRUS REPLICATION; WART VIRUS;

EID: 0031716454     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: 10.1177/095632029800900501     Document Type: Review

References (231)

1. Alexander KA & Phelps WC (1996) A fluorescence anisotropy study of DNA binding by HPV-11 E2C protein: a hierarchy of E2-binding sites. Biochemistry 35:9864-9872.
2. Androphy EJ, Lowy DR & Schiller JT (1987) Bovine papillomavirus E2 transactivating gene product binds to specific sites in papillomavirus DNA. Nature 324::70-73.
3. Anonymous. (1996) New phenylthiazole derivatives are herpes helicase primase inhibitors - useful for treating herpes infections, e.g. HSV-1, HSV-2 and HCMV. Boehringer Ingelheim, Canada: Boehringer Ingelheim Pharmaceuticals Inc.
4. Antimore MJ, Birrer MJ, Patel D, Nader L & McCance DJ (1996) The human papillomavirus type 16 E7 gene product interacts with and trans-activates the AP1 family of transcription factors. EMBO Journal 15:1950-1960.
5. Apt D, Chong T, Liu Y & Bernard H-U (1993) Nuclear factor I and epithelial cell-specific transcription of human papillomavirus type 16. Journal of Virology 67:4455-4463.
6. Arany I, Goel A & Tyring SK (1995) Interferon response depends on viral transcription in human papillomavirus-containing lesions. Anticancer Research 15:2865-2870.
7. Arbeit JM, Münger K, Howley PM & Hanahan D (1993) Neuroepithelial carcinomas in mice transgenic with human papillomavirus type 16 E6/E7 ORFs. American Journal of Pathology 142:1187-1197.
8. Ashmole I, Gallimore PH & Roberts S (1998) Identification of conserved hydrophobic C-terminal residues of the human papillomavirus type 1 E1-E4 protein necessary for E4 oligomerisation in vivo. Virology 240:221-231.
9. Auewarakul P, Gissmann L & Cid-Arregui A (1994) Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors. Molecular and Cellular Biology 14:8250-8258.
10. Badger J, Minor I, Kremer MJ, Oliveira MA, Smith TJ, Griffith JP, Guerin DMA, Krishnaswamy S, Luo M, Rossmann MG, McKinlay MA, Diana GD, Dutko FJ, Fancher M, Rueckert RR & Heinz BA (1988) Structural analysis of a series of antiviral agents complexed with human rhinovirus 14. Proceedings of the National Academy of Sciences, USA 85:3304-3308.
11. Baker CC & Howley PM (1987) Differential promoter utilization by the papillomavirus in transformed cells and productively infected wart tissues. EMBO Journal 6:1027-1035.
12. Band V, Zajchowski D, Kulesa V & Sager R (1990) Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements. Proceedings of the National Academy of Sciences, USA 87:463-467.
13. Band V, DeCaprio JA, Delmolino L, Kulesa V & Sager R (1991) Loss of p53 protein in human papillomavirus type 16 E6-immortalized human mammary epithelial cells. Journal of Virology 65:6671-6676.
14. Bauer HM, Ting Y, Greer CE, Chambers JC, Tashiro CJ, Cimera CJ, Reingold J & Manos MM (1991) Genital human papillomavirus infection in female university students as determined by a PCR-based method. Journal of the American Medical Association 265:472-477.
15. Bauknecht T, Angel P, Royer HD & Zur Hausen H (1992) Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO Journal 11:4607-4617.
16. Bauknecht T, See RH & Shi Y (1996) A novel C/EBP β-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upsteam regulatory region. Journal of Virology 70:7695-7705.
17. Becker TM, Stone KM & Alexander ER (1987) Genital human papillomavirus infection: a growing concern. Obstetrics and Gynecology Clinics of North America 14: 389-396.
18. Berezutskaya E & Bagchi S (1997) The human papillomavirus E7 oncoprotein functionally interacts with the S4 subunit of the 26S proteasome. Journal of Biological Chemistry 272:30135-30140.
19. Bernard BA, Magnaldo T, Lenoir MC, Bailly C & Darmon M (1990). Modulation of papillomavirus transcription by viral transeffectors and retinoids. In Papillomaviruses, pp. 481-490. Edited by T Broker. New York: Wiley-Liss.
20. Beutner KR & Ferenczy A (1997) Therapeutic approaches to genital warts. American Journal of Medicine 102:28-37.
21. Biblermuckelbauer JK, Kremer MJ, Rossmann MG, Diana GD, Dutko FJ, Pevear DC & McKinlay MA (1994) Human rhinovirus 14 complexed with fragments of active antiviral compounds. Virology 202:360-369.
22. Bird LE, Brannigan JA, Subramanya HS & Wigley DB (1998) Characterisation of Bacillus stearothermophilus PcrA. Nucleic Acids Research 26:2686-2693.
23. Blitz I & Laimins LA (1991) The 68 kilodalton E1 protein of bovine papillomavirus is a DNA binding phosphoprotein which associates with the E2 transcriptional activator in vitro. Journal of Virology 65:649-656.
24. Bochkarev A, Barwell JA, Pfuetzner RA, Bochkareva E, Frappier L & Edwards AM (1996) Crystal structure of the DNA binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. Cell 84:791-800.
25. Bonnez W, Darin C, Borkhuis C, Jensen KM, Reichman RC & Rose RC (1998) Isolation and propagation of human papillomavirus type 16 in human xenografts implanted in the severe combined immunodeficiency mouse. Journal of Virology 72:5256-5261.
26. Bouvard V, Matlashewski G, Gu ZM, Storey A & Banks L (1994) The human papillomavirus type 16 E5 gene cooperates with the E7 gene to stimulate proliferation of primary cells and increases viral gene expression. Virology 203:73-80.
27. Boyer SN, Wazer DE & Band V (1996) E7 protein of human papillomavirus-16 induces degradation of retinoblastoma protein through the ubiquitin-proteosome pathway. Cancer Research 56:4620-4624.
28. Breitburd F, Croissant O & Orth G (1987). Expression of human papillomavirus type-1 E4 gene products in warts. In Cancer Cells, pp. 115-122. New York: Cold Spring Harbor Laboratory Press.
29. Brown DR, Bryan J, Rodriguez M, Rose RC & Strike DG (1991) Detection of human papillomavirus types 6 and 11 E4 gene products in condylomata acuminatum. Journal of Medical Virology 34:20-28.
30. Bryan JT, Fife KH & Brown DR (1998) The intracellular expression pattern of the human papillomavirus type 11 E1∧E4 protein correlates with its ability to self associate. Virology 241:49-60.
31. Burkhardt A, DiMaio D & Schlegel R (1987) Genetic and biochemical definition of the bovine papillomavirus E5 transforming protein. EMBO Journal 6:2381-2385.
32. Canonico PG, Kastello MD, Cosgriff TM, Donovan JC, Ross PE, Spears CT & Stephen EL (1984a) Hematological and bone marrow effects of ribavirin in rhesus monkeys. Toxicology and Applied Pharmacology 74:163-172.
33. Canonico PG, Kastello MD, Spears CT, Brown JR, Jackson EA & Jenkins DE (1984b) Effects of ribavirin on red blood cells. Toxicology and Applied Pharmacology 74:155-162.
34. Carter WG, Kaur P, Gil SG, Gahr PJ & Wayner EA (1990a) Distinct functions for integrins α3β1 in focal adesions and α6β4 bullous pemphigoid antigen in a new stable anchoring contact (SAC) of keratinocytes: relation to hemidesmosomes. Journal of Cell Biology 111:3141-3154.
35. Carter WG, Kaur P, Gil SG, Gahr PJ & Wayner EA (1990b) Journal of Cell Biology 111:3141-3154.
36. Carter WG, Wayner EA, Bouchard TS & Kaur P (1990c) Journal of Cell Biology 110:1387-1404.
37. Chan W-K, Klock G & Bernard H-U (1989) Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia. Journal of Virology 63: 3261-3269.
38. Chellappan S, Kraus VB, Kroger B, Münger K, Howley PM, Phelps WC & Nevins JR (1992) Adenovirus E1A, simian virus 40 tumor antigen, and human papillomavirus E7 protein share the capacity to disrupt the interaction between the transcription factor E2F and the retinoblastoma gene product. Proceedings of the National Academy of Sciences, USA 89:4549-4553.
39. Chen JJ, Reid CE, Band V & Androphy EJ (1995) Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269:529-531.
40. Chen P-L, Riley DJ, Chen-Kiang S & Lee W-L (1996) Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proceedings of the National Academy of Sciences, USA 93:465-469.
41. Chen S-L & Mounts P (1990) Transforming activity of E5a protein of human papillomavirus type 6 in NIH 3T3 and C127 cells. Journal of Virology 64:3226-3233.
42. Chen S-L, Tsao Y-P, Lee J-W, Liu H-S & Yang C-M (1994) E5a gene of human papillomavirus type 11 is required for initiation but not for maintenance of transformation in NIH 3T3 cells. Journal of General Virology 75:1953-1960.
43. Chiang C-M, Ustav M, Stenlund A, Ho TF, Broker TR & Chow LT (1992) Viral E1 and E2 proteins support replication of homologous and heterologous papillomaviral origins. Proceedings of the National Academy of Sciences, USA 89: 5799-5803.
44. Cho HS, Ha NC, Kang LW, Chung KM, Back SH, Jang SK & Oh BH (1998) Crystal structure of RNA helicase from genotype 1B hepatitis C virus - a feasible mechanism of unwinding duplex RNA. Journal of Biological Chemistry 273:15045-15052.
45. Chong T, Apt D, Gloss B, Isa M & Bernard H-U (1991) The enhancer of human papillomavirus type 16: binding sites for the ubiquitous transcription factors oct-1, NFA, TEF-2, NF1, and AP-1 participate in epithelial cell-specific transcription. Journal of Virology 65:5933-5943.
46. Chow LT & Broker TR (1994) Papillomavirus DNA replication. Intervirology 37:150-158.
47. Ciccolini F, Pasquale GD, Carlotti F, Crawford L & Tommasino M (1994) Functional studies of E7 proteins from different HPV types. Oncogene 9:2633-2638.
48. Clertant P & Seif I (1984) A common function for polyoma virus large-T and papillomavirus E1 proteins. Nature 311:276-279.
49. Conrad M, Bubb VJ & Schlegel R (1993) The human papillomavirus type 6 and type 16 E5 proteins are membrane-associated proteins which associate with the 16-kilodalton pore-forming protein. Journal of Virology 67:6170-6178.
50. Conrad M, Goldstein D, Andresson T & Schlegel R (1994) The E5 protein of HPV-6, but not HPV-16, associates efficiently with cellular growth factor receptors. Virology 200:796-800.
51. Cripe TP, Haugen H, Turk JP, Tabatabai F, Schmid III PG, Durst M, Gissmann L, Roman A & Turek LP (1987) Transcriptional regulation of the human papillomavirus-16 E6-E7 promoter by a keratinocyte-dependent enhancer, and by viral E2 trans-activator and repressor gene products: implications for cervical carcinogenesis. EMBO Journal 6:3745-3753.
52. Crum CP, Barber S, Symbula M, Snyder K, Saleh AM & Roche JK (1990) Coexpression of the human papillomavirus type 16 E4 and L1 open reading frames in early cervical neoplasia. Virology 178:238-246.
53. Cullen A, Reid R, Campion M & Lörincz A (1991) Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasms. Journal of Virology 65:606-612.
54. Dalence CR (1993) Diagnostic and therapeutic technology assessment: human papillomavirus DNA testing in the management of cervical neoplasia. Journal of the American Medical Association 270:2975-2981.
55. DeLuca M, Tamura RN, Kajiji S, Bondanza S, Rossino P, Cancedda R, Marchisio PC & Quaranta V (1990) Polarized integrin mediates human keratinocyte adhesion to basal lamina. Proceedings of the National Academy of Sciences, USA 87:6888-6892.
56. Del Vecchio AM, Romanczuk H, Howley PM & Baker CC (1992) Transient replication of human papillomavirus DNAs. Journal of Virology 66:5949-5958.
57. Demers GW, Foster SA, Halbert CL & Galloway DA (1994) Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proceedings of the National Academy of Sciences, USA 91:4382-4386.
58. Diana GD & Pevear DC (1997) Antipicornavirus drugs - current status. Antiviral Chemistry and Chemotherapy 8:401-408.
59. DiMaio D, Guralski D & Schiller JT (1986) Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity. Proceedings of the National Academy of Sciences, USA 83:1797-1801.
60. Doorbar J (1991) An emerging function for E4. Papillomavirus Report 2:145-148.
61. Doorbar J, Campbell D, Grand RJA & Gallimore PH (1986) Identification of the human papillomavirus-1a E4 gene products. EMBO Journal 5:355-362.
62. Doorbar J, Evans HS, Coneron I, Crawford LV & Gallimore PH (1988) Analysis of HPV1 E4 gene expression using epitope-defined antibodies. EMBO Journal 7:825-833.
63. Doorbar J, Coneron I & Gallimore PH (1989) Sequence divergence yet conserved physical characteristics among the E4 proteins of cutaneous human papillomaviruses. Virology 172:51-62.
64. Doorbar J, Ely S, Sterling J, McLean C & Crawford L (1991) Specific interaction between HPV16 E1∧E4 and cytokeratins results in collapse of the epithelial cell intermediate filament network. Nature 352:824-827.
65. Doorbar J, Medcalf E & Napthine S (1996) Analysis of HPV1 E4 complexes and their association with keratins in vivo. Virology 218:114-126.
66. Durst M, Bosch FX, Glitz D, Schneider A & zur Hausen H (1991) Inverse relationship between human papillomavirus (HPV) type 16 early gene expression and cell differentiation in nude mouse epithelial cysts and rumors induced by HPV-positive human cell lines. Journal of Virology 65:796-804.
67. Dyson N, Howley PM, Münger K & Harlow E (1989) The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
68. 6 integrin as a candidate receptor for papillomaviruses. Journal of Virology 71:2449-2456.
69. Farnham PJ, Slansky JE & Kollmar R (1993) The role of E2F in the mammalian cell cycle. Biochimica et Biopbysica Acta 1155:125-131.
70. Flores ER & Lambert PF (1997) Evidence for a switch in the mode of human papillomavirus type 16 DNA replication during the viral life cycle. Journal of Virology 71:7167-7179.
71. Frattini MG, Lim HB, Doorbar J & Laimins LA (1997) Induction of human papillomavirus type 18 late gene expression and genomic amplification in organotypic cultures from transfected DNA templates. Journal of Virology 71:7068-7072.
72. Frazier IH (1996) The role of vaccines in the control of STDs: HPV vaccines. Genitourinary Medicine 72:398-403.
73. Funk JO, Waga S, Harry JB, Espling E, Stillman B &. Galloway DA (1997) Inhibition of CDK activity and PCNA-dependent DNA replication by p21 is blocked by interaction with the HPV16 E7 oncoprotein. Genes and Development 11:2090-2100.
74. Giri I & Yaniv M (1988) Structural and mutational analysis of E2 trans-activating proteins of papillomaviruses reveals three distinct functional domains. EMBO Journal 7:2823-2829.
75. Gissmann L, Diehl V, Schultz-Coulon HJ & zur Hausen H (1982) Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma. Journal of Virology 44:393-400.
76. Gissmann L, Wolnik L, Ikenberg H, Koldovsky U, Schnurch HG & zur Hausen H (1983) Human papillomavirus type 6 and 11 DNA sequences in genital and laryngeal papillomas and in some cervical cancers. Proceedings of the National Academy of Sciences, USA 80:560-563.
77. Gloss B, Bernard HU, Seedorf K & Klock G (1987) The upstream regulatory region of the human papillomavirus-16 contains an E2 protein-independent enhancer which is specific for cervical carcinoma cells and regulated by glucocorticoid hormones. EMBO Journal 6: 3735-3743.
78. Goldstein DJ, Finbow ME, Andresson T, McClean P, Smith K, Bubb V & Schlegel R (1991) Bovine papillomavirus E5 oncoprotein binds to the 16K component of the vacuolar H+ATPase. Nature 352:347-349.
79. Gopalakrishnan V & Khan SA (1994) E1 protein of human papillomavirus type 1a is sufficient for intiation of viral DNA replication. Proceedings of the National Academy of Sciences, USA 91:9597-9601.
80. Grassman K, Rapp B, Maschek H, Petry K & Iftner T (1996) Identification of a differentiation-inducible promoter in the E7 open reading frame of HPV16 in raft cultures of a new line containing high copy episomal HPV16 DNA. Journal of Virology 70:2339-2349.
81. Griep AE, Herber R, Jeon S, Lohse JK, Dubielzig RR & Lambert PF (1993) Tumorigenicity by human papillomavirus type 16 E6 and E7 in transgenic mice correlates with alterations in epithelial cell growth and differentiation. Journal of Virology 67:1373-1384.
82. Hajduk PJ, Dinges J, Miknis GF, Merlock M, Middleton T, Kempf DJ, Egan DA, Walter KA, Robins TS, Shuker SB, Holzman TF & Fesik SW (1997) NMR-based discovery of lead inhibitors that block DNA binding of te human papillomavirus E2 protein. Journal of Medicinal Chemistry 40:3144-3150.
83. Ham J, Steger G & Yaniv M (1994) Cooperativity in vivo between the E2 transactivator and the TATA box binding protein depends on core promoter structure. EMBO Journal 13:147-157.
84. Harry JB & Wettstein FO (1996) Transforming properties of the cottontail rabbit papillomavirus oncoproteins LE6 and SE6 and of the E8 protein. Journal of Virology 70:3355-3362.
85. Hawley-Nelson P, Vousden KH, Hubbert NL, Lowy DR & Schiller JT (1989) HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO Journal 8:3905-3910.
86. Hegde RS, Grossman SR, Laimins LA & Sigler PB (1992) Crystal structure at 1.7 Å of the bovine papillomavirus-1 E2 DNA-binding domain bound to its DNA target. Nature 359:505-512.
87. Hiraiwa A, Kiyono T, Segawa K, Utsumi KR, Ohashi M & Ishibashi M (1993) Comparative study on E6 and E7 genes of some cutaneous and genital papillomaviruses of human origin for their ability to transform 3Y1 cells. Virology 192:102-111.
88. Hiraiwa A, Kiyono T, Suzuki S, Ohashi M & Ishibashi M (1996) E7 proteins of four groups of human papillomaviruses, irrespective of their tissue tropism or cancer association, possess the ability to transactivate transcriptional promoters E2F site dependently. Virus Genes 12:27-35.
89. Hu TH, Ferril SC, Snider AM & Barbosa MS (1995) In vivo analysis of HPV E7 protein association with pRB, p107, and p130. International Journal of Oncology 6:167-174.
90. Hu G, Liu W, Mendelsohn J, Ellis LM, Radinsky R, Andreeff M & Deisseroth AB (1997) Expression of epidermal growth factor receptor and human papillomavirus E6/E7 proteins in cervical carcinoma cells. Journal of the National Cancer Institute 89:1271-1276.
91. Hubbert NL, Sedman SA & Schiller JT (1992) Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes. Journal of Virology 66:6237-6241.
92. Huber HE, Koblan KS & Heimbrook DC (1994) Protein-protein interactions as therapeutic targets for cancer. Current Medicinal Chemistry 1:13-34.
93. Huibregtse JM & Beaudenon SL (1996) Mechanism of HPV E6 proteins in cellular transformation. Seminars in Cancer Biology 7:317-326.
94. Huibregtse JM, Scheffner M & Howley PM (1991) A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO Journal 10:4129-4135.
95. Huibregtse JM, Scheffner M, Beaudenon S & Howley PM (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proceedings of the National Academy of Sciences, USA 92:2563-2567.
96. Huibregtse JM, Scheffner M & Howley PM (1993a) Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Molecular and Cellular Biology 13:775-784.
97. Huibregtse JM, Scheffner M & Howley PM (1993b) Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Molecular and Cellular Biology 13:4918-4927.
98. Hummel M, Hudson JB & Laimins LA (1992) Differentiation-induced and constitutive transcription of human papillomavirus type 31b in cell lines containing viral episomes. Journal of Virology 66:6070-6080.
99. Hummel M, Lim HB & Laimins LA (1995) HPV31 late gene expression is regulated through protein kinase C-mediated changes in RNA processing. Journal of Virology 69:3381-3388.
100. Hwang ES, Nottoli T & DiMaio D (1995) The HPV16 E5 protein: expression, detection, and stable complex formation with transmembrane protein in COS cells. Virology 211:227-233.
101. Iftner T, Bierfelder S, Csapo Z & Pfister H (1988) Involvement of human papillomavirus type 8 genes E6 and E7 in transformation and replication. Journal of Virology 62:3655-3661.
102. Imai Y, Matsushima Y, Sugimura T & Terada M (1991) Purification and characterization of human papillomavirus type 16 E7 protein with preferential binding capacity to the underphosphorylated form of retinoblastoma gene product. Journal of Virology 65: 4966-4972.
103. Jareborg N & Burnett S (1991) Immunofluorescent detection of bovine papillomavirus E4 antigen in the cytoplasm of cells permissive in vitro for viral DNA amplification. Journal of General Virology 72:2269-2274.
104. Jenkins O, Earnshaw D, Sarginson G, Del Vecchio A, Tsai J, Kallender H, Amegadzie B & Browne M (1996) Characterization of the helicase and ATPase activity of human papillomavirus type 6b E1 protein. Journal of General Virology 77:1805-1809.
105. Jeon S & Lambert PF (1995) Integration of human papillomavirus type 16 DNA into the human genome leads to increased stability of E6 and E7 mRNAs: Implication for cervical cancer. Proceedings of the National Academy of Sciences, USA 92:1654-1658.
106. Jones DL & Munger K (1997) Analysis of the p53-mediated growth arrest pathway in cells expressing the human papillomavirus type 16 E7 oncoprotein. Journal of Virology 71:2905-2912.
107. Jones DL, Alani RM & Munger K (1997a) The human papillomavirus E7 oncoprotein can uncouple cellular differentiation and proliferation in human keratinocytes by abrogating p21Cip1-mediated inhibition of cdk2. Genes and Development 11:2101-2111.
108. Jones DL, Thompson DA & Munger K (1997b) Destabilization of the RB tumor suppressor protein and stabilization of p53 contribute to HPV type 16 E7-induced apoptosis. Virology 239:97-107.
109. Kajiji S, Tamura RN & Quaranta V (1989) A novel integrin (alpha E beta 4) from human epithelial cells suggests a fourth family of integrin adhesion receptors. EMBO Journal 8:673-680.
110. Kirnbauer R, Taub J, Greenstone H, Roden R, Durst M, Gissmann L, Lowy DR & Schiller JT (1993) Efficient self-assembly of human papillomavirus type-16 L1 and L1-L2 into virus-like particles. Journal of Virology 67:6929-6936.
111. Kiyono T, Hiraiwa A & Ishibashi M (1992) Differences in transforming activity and coded amino acid sequence among E6 genes of several papillomaviruses associated with epidermodysplasia verruciformis. Virology 186:628-639.
112. Kiyono T, Hiraiwa A, Fujita M, Hayashi Y, Akiyama T & Ishibashi M (1997) Binding of high-risk human papillomavirus E6 oncoproteins to the human homologue of the Drosophila discs large tumor suppressor protein. Proceedings of the National Academy of Sciences, USA 94:11612-11616.
113. Ko LJ & Prives C (1996) p53: puzzle and paradigm. Genes and Development 10:1054-1072.
114. Koonin EV (1993) A common set of conserved motifs in a vast variety of putative nucleic acid-dependent ATPases including MCM proteins involved in the initiation of eukaryotic DNA replication. Nucleic Acids Research 21:2541-2547
115. Korolev S, Yao NH, Lohman TM, Weber PC & Waksman G (1998) Comparisons between the structures of HCV and rep helicases reveal structural similarities between SF1 and SF2 super-families of helicases. Protein Science 7:605-610.
116. Koutsky LA, Galloway DA & Holmes KK (1988) Epidemiology of genital human papillomavirus infection. Epidemiological Reviews 10:122-162.
117. Krebs HB (1989). Management Strategies. In Clinical Obstetrics and Gynecology, pp. 200-213. Edited by RM Pitkin & JR Scott. Philadelphia: JB Lippincott.
118. Kreider JW, Howett MK, Wolfe SA, Bartlett GL, Zaino RJ, Sedlacek TV & Mortelk R (1985) Morphological transformation in vivo of human uterine cervix with papillomavirus from condylomata acuminata. Nature 317:639-641.
119. Kuo S-R, Liu J-S, Broker TR & Chow LT (1994) Cell-free replication of the human papillomavirus DNA with homologous viral E1 and E2 proteins and human cell extracts. Journal of Biological Chemistry 269:24058-24065.
120. Lambert PF, Spalholz BA & Howley PM (1987) A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator. Cell 50:69-78.
121. Lee J-O, Russo AA & Pavletich NP (1998) Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391:859-865.
122. Lee SS, Weiss RS & Javier RT (1997) Binding of human virus oncoproteins to hDlg/SAP97, a mammalian homolog of the Drosophila discs large tumor suppressor protein. Proceedings of the National Academy of Sciences, USA 94:6670-6675.
123. Leechanachai P, Banks L, Moreau F & Matlashewski G (1992) The E5 gene from human papillomavirus type 16 is an oncogene which enhances growth factor-mediated signal transduction in the nucleus. Oncogene 7:17-25.
124. Levitzki A & Gazit A (1995) Tyrosine kinase inhibition: an approach to drug development. Science 267:1782-1788.
125. Li R & Botchan MR (1994) Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1. Proceedings of the National Academy of Sciences, USA 91:7051-7055.
126. Li A Simmons PJ & Kaur P (1998) Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype. Proceedings of the National Academy of Sciences, USA 95:3902-3907.
127. Li R, Knight JD, Jackson SP, Tjian R & Botchan MR (1991) Direct interaction between Sp1 and the BPV enhacer E2 protein mediates synergistic activation of transcription. Cell 65:493-505.
128. Liang H, Petros AM, Meadows RP, Yoon HS, Egan DA, Walter K, Hozman TF, Robins, T & Fesik SW (1996) Solution structure of the DNA-binding domain of a human papillomavirus E2 protein: evidence for flexible DNA -binding regions. Biochemistry 35:2095-2103.
129. Lu JZJ, Sun YN, Rose RC, Bonnez W & McCance DJ (1993) Two E2 binding sites (E2BS) alone or one E2BS plus an A/T-rich region are minimal requirements for the replication of the human papillomavirus type-11 origin. Journal of Virology 67:7131-7139.
130. Lusky M, Hunvitz J & Seo Y-S (1993) Cooperative assembly of the bovine papillomavirus E1 and E2 proteins on the replication origin requires an intact E2 binding site. Journal of Biological Chemistry 268:15795-15803.
131. McBride AA, Byrne JC & Howley PM (1989) E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxy-terminal domain: Transactivation is mediated by the conserved amino terminal domain. Proceedings of the National Academy of Sciences, USA 86:510-514.
132. McBride AA, Romanczuk H & Howley PM (1991) The papillomavirus E2 regulatory proteins. Journal of Biological Chemistry 266:18411-18414.
133. McCarthy MP, White WI, Palmerhill F, Koenig S & Suzich JA (1998) Quantitative disassembly and reassembly of human papillomavirus type 11 viruslike particles in vitro. Journal of Virology 72:32-41.
134. McGlennen RC, Adams GL, Lewis CM, Faras AJ & Ostrow RS (1993) Pilot trial of ribavirin for the treatment of laryngeal papillomatosis. Head and Neck 15:504-513.
135. McShan GD & Wilson VG (1997) Reconstitution of a functional bovine papillomavirus type 1 origin of replication reveals a modular tripartite replicon with an essential AT-rich element Virology 237:198-208.
136. Maki CG, Huibregtse JM & Howley PM (1996) In vivo ubiquitination and proteasome-mediated degradation of p53. Cancer Research 56:2649-2654.
137. Mansky KC, Batiza A & Lambert PF (1997) Bovine papillomavirus type 1 E1 and simian virus 40 large T antigen share regions of sequence similarity required for multiple functions. Journal of Virology 71:7600-7608.
138. Massimi P, Pim D, Storey A & Banks L (1996) HPV-16 E7 and adenovirus E1a complex formation with TATA box binding protein is enhanced by casein kinase II phosphorylation. Oncogene 12:2325-2330.
139. Matlashewski G, Schneider J, Banks L, Jones N, Murray A & Crawford L (1987) Human papillomavirus type 16 cooperates with activated ras in transforming primary cells. EMBO Journal 6:1741-1746.
140. Matson SW & Kaiser-Rogers KA (1990) DNA helicases. Annual Review of Biochemistry 59:289-329.
141. Mazzarelli JM, Atkins GB, Geisberg JV & Ricciardi RP (1995) The viral oncoproteins Ad5 E1A, HPV16 E7 and SV40Tag bind a common region of the TBP-associated factor-110. Oncogene 11:1859-1864.
142. Meyers C, Frattini MG, Hudson JB & Laimins LL (1992) Biosynthesis of human papillomavirus from a continuous cell line upon epithelial differentiation. Science 257:971-973.
143. Mohr IJ, Clark R, Sun S, Androphy EJ, MacPherson P & Botchan MR (1990) Targeting the E1 replication protein to the papilllomavirus origin of replication by complex formation with the E2 transactivator. Science 250:1694-1699.
144. Monini P, Grossman SR, Pepinsky B, Androphy EJ & Laimins LA (1991) Cooperative DNA binding of the E2 protein of bovine papillomavirus to adjacent E2-responsive sequences. Journal of Virology 65:2124-2130.
145. Moskaluk C & Bastia D (1987) The E2 "gene" of bovine papillomavirus encodes an enhancer-binding protein. Proceedings of the National Academy of Sciences, USA 84:1215-1218.
146. Muller F, Seo Y-S & Hurwitz J (1994) Replication of bovine papillomavirus type 1 origin-containing DNA in crude extracts and with purified proteins. Journal of Biological Chemistry 269:17086-17094.
147. Muller F, Giroglou T & Sapp M (1997) Characterization of the DNA-binding activity of the E1 and E2 proteins and the E1/E2 DNA complex of human papillomavirus type 33. Journal of General Virology 78:911-915.
148. Münger K, Phelps WC, Bubb V, Howley PM & Schlegel R (1989a) The E6 and E7 genes of the human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. Journal of Virology 63:4417-4421.
149. Münger K, Werness BA, Dyson N, Phelps WC, Harlow E & Howley PM (1989b) Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO Journal 8:4099-4105.
150. Nasseri M, Hirochika R, Broker TR & Chow L (1987) A human papillomavirus type 11 transcript encoding an E1∧E4 protein Virology 159:433-439.
151. Nevins JR (1992) E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science 258:424-429.
152. Nilson LA & DiMaio D (1993) Flatlet-derived growth factor receptor can mediate tumorigenic transformation by the bovine papillomavirus E5 protein. Molecular and Cellular Biology 13:4137-4145.
153. Nuovo GJ, Blanco JS, Leipzig S & Smith D (1990) Human papillomavirus detection in cervical lesions nondiagnostic for cervical intraepithelial neoplasia: correlation with Papanicolaou smear, colposcopy, and occurrence of cervical intraepithelial neoplasia. Obstetrics and Gynecology 75:1006-1011.
154. Oelze I, Kartenbeck J, Crusius K & Alonso A (1995) Human papillomavirus type 16 E5 protein affects cell-cell communication in an epithelial cell line. Journal of Virology 69:4489-4494.
155. Oriel J (1971) Natural history of genital warts. British Journal of Venereal Disease 47:1-13.
156. Orth G (1987). Epidermodysplasia verruciformis. In The Papovaviridae, pp. 199-243. NP Salzman & PM Howley. New York: Plenum Press.
157. Pahel G, Aulabaugh A, Short SA, Barnes JA, Painter GR, Ray P & Phelps WC (1993) Structural and functional characterization of the HPV16 E7 protein expressed in bacteria. Journal of Biological Chemistry 268:26018-26025.
158. Palermo-Dilts DA, Broker TR & Chow LT (1990) Human papillomavirus type 1 produces redundant as well as polycistronic mRNAs in plantar warts. Journal of Virology 64:3144-3149.
159. Peltonen J, Larjava H, Jaakkola S, Grainick H, Akiyama SK, Yamada SS, Yamada KM, & Uitto J (1989) Journal of Clinical Investigation 84:1916-1923.
160. Perea SE, Lopez-Ocejo O, Von Gabain A & Arana MDJ (1997) Human papillomavirus type-16 (HPV-16) major transforming proteins functionally interact with interferon signaling mechanisms. International Journal of Oncology 11:169-173.
161. Petti L & DiMaio D (1994) Specific interaction between the bovine papillomavirus E5 transforming protein and the β receptor for platlet-derived growth factor in stably transformed and acutely transfected cells. Journal of Virology 68:3582-3592.
162. Petti L, Nilson LA & DiMaio D (1991) Activation of the platelet-derived growth factor receptor by the bovine papillomavirus E5 transforming protein. EMBO Journal 10:845-855.
163. Phelps WC, Bagchi S, Barnes JA, Raychaudhuri P, Kraus V, Münger K, Howley PM & Nevins JR (1991) Analysis of trans activation by human papillomavirus type 16 E7 and adenovirus 12S E1A suggests a common mechanism. Journal of Virology 65:6922-6930.
164. Phelps WC & Howley PM (1987) Transcriptional trans-activation by the human papillomavirus type 16 E2 gene product. Journal of Virology 61:1630-1638.
165. Phelps WC, Yee CL, Münger K & Howley PM (1988) The human papillomavirus type 16 E7 gene encodes transactivation and transformation functions similar to adenovirus E1a. Cell 53:539-547.
166. Phillips AC & Vousden KH (1997) Analysis of the interaction between human papillomavirus type 16 E7 and the TATA-binding protein, TBP. Journal of General Virology 78:905-909.
167. Pietenpol JA, Stein RW, Moran E, Yaciuk P, Schlegel R, Lyons RM, Pittelkow MR, Münger K, Howley PM & Moses HL (1990) TGFβ1 inhibition of c-myc transcription and growth in keratinocytes is abrogated by viral transforming proteins with pRB binding domains. Cell 61:777-785.
168. Pim D, Collins M & Banks L (1992) Human papillomavirus type 16 E5 gene stimulates the transforming activity of the epidermal growth factor receptor. Oncogene 7:27-32.
169. Prakash SS, Grossman SR, Pepinsky RB, Laimins LA & Androphy EJ (1992) Amino acids necessary for DNA contact and dimerization imply novel motifs in the papillomavirus E2 transactivator. Genes and Development 6:105-116.
170. Raney KD, Sowers LC, Millar DP & Benkovic SJ (1994) A fluorescence-based assay for monitoring helicase activity. Proceedings of the National Academy of Sciences, USA 91:6644-6648.
171. Remm M, Brain R & Jenkins JR (1992) The E2 binding sites determine the efficiency of replication for the origin of human papillomavirus type 18. Nucleic Acids Research 20:6015-6021.
172. Riou G, Favre M, Jeannel D, Bourhis J, Le Doussal V & Orth G (1990) Association between poor prognosis in early-stage invasive cervical carcinomas and non-detection of HPV DNA. Lancet 335:1171-1174.
173. Roberts S, Ashmole I, Gibson L, Rookes SM, Barton GJ & Gallimore PH (1994a) Mutational analysis of human papillomavirus E4 proteins: identification of structural features important in the formation of cytoplasmic E4/cytokeratin networks in epithelial cells. Journal of Virology 68:6432-6455.
174. Roberts S, Ashmole I, Sheehan TMT, Davies AH & Gallimore PH (1994b) Human papillomavirus type 1 E4 is a zinc binding protein. Virology 202:865-874.
175. Roden RBS, Kirnbauer R, Jenson AB, Lowy DR & Schiller JT (1994) Interaction of papillomaviruses with the cell surface. Journal of Virology 68:7260-7266.
176. Rogel-Gaillard C, Breitburd F & Orth G (1992) Human papillomavirus type 1 E4 proteins differing by their N-terminal ends have distinct cellular locations when transiently expressed in vitro. Journal of Virology 66:816-823.
177. Rossmann MG (1988) Antiviral agents targeted to interact with viral capsid proteins and a possible application to human immunodeficiency virus. Proceedings of the National Academy of Sciences, USA 85:4625-4627.
178. Rossmann MG (1989) The structure of antiviral agents that inhibit uncoating when complexed with viral capsids. Antiviral Research 11:3-14.
179. Rossmann MG (1993) The viral canyon. Current Biology 3:566.
180. Russell J & Botchan MR (1995) cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin. Journal of Virology 69:651-660.
181. Sanders CM & Maitland NJ (1994) Kinetic and equilibrium binding studies of the huamn papillomavirus type-16 transcription regulatory protein E2 interacting with core enhancer elements. Nucleic Acids Research 22:4890-4897.
182. Scheffner M, Werness BA, Huibregtse JM, Levine AJ & Howley PM (1990) The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
183. Scheffner M, Münger K, Byrne JC & Howley PM (1991) The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proceedings of the National Academy of Sciences, USA 88:5523-5527.
184. Scheffner M, Nuber U & Huibregtse JM (1995) Protein ubiquitination involving an E1-E2-E3 enzyme thioester cascade. Nature 373:81-83.
185. Schilling B, De Medina T, Syken J, Vidai M & Munger K (1998) A novel human DNA J protein, hTid-1, a homolog of the Drosophila tumor suppressor protein Tid56, can interact with the human papillomavirus type 16 E7 oncoprotein. Virology 241:74-85.
186. Schmitt A, Harry JB, Rapp B, Wettstein FO & Iftner T (1994) Comparison of the properties of the E6 and E7 genes of low and high risk cutaneous papillomaviruses reveals strongly transforming and high RB-binding activity for the E7 protein of the low-risk human papillomavirus type 1. Journal of Virology 68:7051-7059.
187. Sedman J & Stenlund A (1996) The initiator protein E1 binds to the bovine papillomvirus origin of replication as a trimeric ring-like structure. EMBO Journal 15:5085-5092.
188. Sedman T, Sedman J & Stenlund A (1997) Binding of the E1 and E2 proteins to the origin of replication of bovine papillomavirus. Journal of Virology 71:2887-2896.
189. Shah KV & Howley PM (1996). Papillomaviruses. In Fields Virology, pp. 2077-2109. Edited by BN Fields, DM Knipe & PM Howley. New Yorlc Lippincott-Raven.
190. Skiadopoulos MH & McBride AA (1998) Bovine papillomavirus type 1 genomes and the E2 transactivator protein are closely associated with mitotic chromatin. Journal of Virology 72:2079-2088.
191. Slebos RJC, Lee MH, Plunkett BS, Kessis TD, Williams BO, Jacks T, Hedrick L, Kastan MB & Cho KR (1994) p53 dependent G1 arrest involves pRB-related proteins and is discrupted by the human papillomavirus 16 E7 oncoprotein. Proceedings of the National Academy of Science, USA 91:5320-5324.
192. Sonnenberg A, Calafat J, Janssen H, Daaams H, Raaij HVD, Falcioni R, Kennel SJ, Aplin JD, Baker J, Loizidou M et al. (1991) Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion. Journal of Cell Biology 113:907-917.
193. Spalholz BA, Yang Y-C & Howley PM (1985) Transactivation of a bovine papillomavirus transcriptional regulatory element by the E2 gene product. Cell 42:183-191.
194. Stanley MA, Masterson PJ & Nicholls PK (1997) In vitro and animal models for antiviral therapy in papillomavirus infections. Antiviral Chemistry and Chemotherapy 8:381-400.
195. Steger G & Pfister H (1992) In vitro expressed HPV 8 E6 protein does not bind p53. Archives of Virology 125:355-360.
196. Sterling J, Stanley M, Gatward G & Minson J (1990) Production of human papillomavirus type 16 virions in a keratinocyte cell line. Journal of Virology 64:6305-6307.
197. Sterling JC, Skepper JN & Stanley MA (1993) Immunoelectron microscopical localization of the human papillomavirus type 16 L1 and E4 proteins in cervical keratinocytes cultured in vitro. Journal of Investigative Dermatology 100:154-158.
198. Stoler MH, Wolinsky SM, Whitbeck A, Broker TR & Chow L (1989) Differentiation-linked human papillomavirus type 6 and 11 transcription in genital condylomata revealed by in situ hybridization with message-specific RNA probes. Virology 172:331-340.
199. Stoppler MC, Straight SW, Tsao G, Schlegel R & McCance DJ (1996) The E5 gene of HPV-16 enhances keratinocyte immortalization by full-length DNA. Virology 223:251-254.
200. Straight SW, Hinkle PM, Jewers RJ & McCance DJ (1993) The E5 oncoprotein of human papillomavirus type-16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes. Journal of Virology 67:4521-4532.
201. Straight SW, Herman B & McCance DJ (1995) The E5 oncoprotein of human papillomavirus type 16 inhibits the acidification of endosomes in human keratinocytes. Journal of Virology 69:3185-3192.
202. Sverdrup F & Khan SA (1994) Replication of human papillomavirus (HPV) DNAs supported by the HPV type 18 E1 and E2 proteins. Journal of Virology 68:505-509.
203. 4 laminin adhesion and integrin regulation are associated with the initial steps in keratinocyte maturation. Cell Growth and Differentiation 7:615-628.
204. Testerman TL, Gerster JF, Imbertson LM, Reiter MJ, Miller RL, Gibson SJ, Wagner T L & Tomai MA (1995) Cytokine induction by the immunomodulators imiquimod and S-27609. Journal of Leukocyte Biology 58:365-372.
205. Thierry F & Yaniv M (1987) The BPV-1 E2 trans-acting protein can be either an activator or repressor of the HPV-18 regulatory region. EMBO Journal 6:3391-3397.
206. Tong X & Howley PM (1997) The bovine papillomavirus E6 oncoprotein interacts with paxillin and disrupts the actin cytoskeleton. Proceedings of the National Academy of Sciences, USA 94:4412-4417.
207. Tong X, Salgia R, Li J-L, Griffin JD & Howley PM (1997) The bovine papillomavirus E6 protein binds to the LD motif repeats of paxillin and blocks its interaction with vinculin and the focal adhesion kinase. Journal of Biological Chemistry 272:33373-33376.
208. Trautwein C, Caelles C, van der Geer P, Hunter T, Karin M & Chojkier M (1993) Transactivation by NF-IL6/LAP is enhanced by phosphorylation of its activation domain. Nature 364:544-547.
209. Trofatter KF (1991) Interferon treatment of anogenital human papillomavirus-related diseases. Dermatologic Clinics 9:343-352.
210. Tyring SK (1988) Treatment of condyloma acuminatum with interferon. Seminars in Oncology 15:35-40.
211. Ustav E, Ustav M, Szymanski P & Stenlund A (1993) The bovine papillomavirus origin of replication requires a binding site for the E2 transcriptional activator. Proceedings of the National Academy of Sciences, USA 90:898-902.
212. Ustav M & Stenlund A (1991) Transient replication of BPV-1 requires two viral polypeptides encoded by the E1 and E2 open reading frames. EMBO Journal 10:449-457.
213. Ustav M, Ustav E, Szymanski P & Stenlund A (1991) Identification of the origin of replication of bovine papillomavirus and characterization of the viral origin recognition factor E1. EMBO Journal 10:4321-4329.
214. Valle GF & Banks L (1995) The human papillomavirus (HPV)-6 and HPV-16 E5 proteins co-operate with HPV-16 E7 in the transformation of primary rodent cells. Journal of General Virology 76:1239-1245.
215. Vousden KH, Vojtesek B, Fisher C & Lane D (1993) HPV-16 E7 or adenovirus E1A can overcome the growth arrest of cells immortalized with a temperature-sensitive p53. Oncogene 8:1697-1702.
216. Waddell S & Jenkins JR (1998) Defining the minimal requirements for papilloma viral E6-mediated inhibition of human p53 activity in fission yeast. Oncogene 16:1759-1765.
217. Watanabe S, Kanda T & Yoshiike K (1989) Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7. Journal of Virology 63:965-969.
218. Watanabe S, Sato H, Komiyama N, Kanda T & Yoshiike, K (1992) The E7 functions of human papillomaviruses in rat 3Y1 cells. Virology 187:107-114.
219. Watts SL, Phelps WC, Ostrow RS, Zachow KR & Faras AJ (1984) Cellular transformation by human papillomavirus DNA in vitro. Science 225:634-636.
220. Weis K, Griffiths G & Lamond AI (1994) The endoplasmic reticulum calcium binding protein of 55 kDa is a novel EF-hand protein retained in the endoplasmic reticulum by a carboxyl-terminal His-Asp-Glu-Leu motif. Journal of Biological Chemistry 269:19142-19150.
221. Werness BA, Levine AJ & Howley PM (1990) Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
222. Werness BA, Munger K & Howley PM (1991). The role of the human papillomavirus oncoproteins in transformation and carcinogenic progression. In Important Advances in Oncology, pp. 2-18. Edited by VT DeVita, S Hellman & SA Rosenberg. Philadelphia: JB Lippincott.
223. Wu EW, Clemens KE, Heck DV & Münger K (1993) The human papillomavirus E7 oncoprotein and the cellular transcription factor E2F bind to separate sites on the retinoblastoma tumor suppressor protein. Journal of Virology 67:2402-2407.
224. Wu X, Xiao W & Brandsma JL (1994) Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes. Journal of Virology 68:6097-6102.
225. Yang L, Li R, Mohr IJ, Clark R & Botchan MR (1991) Activation of BPV-1 replication in vitro by the transcription factor E2. Science 353:628-632.
226. Zerfass-Thome K, Zwerschke W, Mannhardt B, Tindle R, Botz JW & Jansen-Durr P (1996) Inactivation of the cdk inhibitor p27KIP1 by the human papillomavirus type 16 E7 oncoprotein. Oncogene 13:2323-2330.
227. Zhou J, Stenzel DJ, Sun XY & Frazer IH (1993) Synthesis and assembly of infectious bovine papillomavirus particles in vitro. Journal of General Virology 74:763-768.
228. Zou N, Liu J-S, Kuo S-R, Broker T & Chow LT (1998) The carboxy-terminal region of the human papillomavirus type 16 E1 protein determines E2 protein specificity during DNA replication. Journal of Virology 72:3436-3441.
229. zur Hausen H (1991) Viruses in human cancer. Science 254:1167-1172.
230. zur Hausen H (1994) Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types. In Human Pathogenic Papillomaviruses, pp. 131-156. Edited by H zur Hausen. Heidelberg: Springer Verlag.
231. zur Hausen H & Schneider A (1987). The role of papillomaviruses in human anogenital cancers. In The Papovaviridae, pp. 245-263. Edited by N Salzman and PM Howley. New York: Plenum Press.