Transforming properties of the cottontail rabbit papillomavirus oncoproteins LE6 and SE6 and of the E8 protein

Journal of Virology

Volumn 70, Issue 6, 1996, Pages 3355-3362

  Beth Harry, J O ^a,b   Wettstein, Felix O ^a,b,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING PROTEIN;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; MOUSE; NONHUMAN; OPEN READING FRAME; PAPILLOMA VIRUS; PRIORITY JOURNAL; PROTEIN ISOLATION; RABBIT; VIRUS CELL TRANSFORMATION;

EID: 9344225723     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.6.3355-3362.1996     Document Type: Article

References (60)

1. Androphy, E. J., N. L. Hubbert, J. T. Schiller, and D. R. Lowy. 1987. Identification of the HPV-16 E6 protein from transformed mouse cells and human cervical carcinoma cell lines. EMBO J. 6:989-992.
2. Androphy, E. J., J. T. Schiller, and D. R. Lowy. 1985. Identification of the protein encoded by the E6 transforming gene of the bovine papillomavirus. Science 230:442-445.
3. Baker, C. C. 1985. Sequence analysis of papillomavirus genomes, p. 321-385. In N. Salzman and P. M. Howley (ed.), The Papovaviridac. Plenum Press. New York.
4. Barbosa, M. S., D. R. Lowy, and J. T. Schiller. 1989. Papillomavirus polypeptides E6 and E7 are zinc-binding proteins. J. Virol. 63:1404-1407.
5. Barbosa, M. S., and F. O. Wettstein. 1987. Transcription of the cottontail rabbit papillomavirus early region and identification of two E6 polypeptides in COS-7 cells. J. Virol. 61:2938-2942.
6. Barbosa, M. S., and F. O. Wettstein. 1988. The two proteins encoded by the cottontail rabbit papillomavirus E6 open reading frame differ with respect to localization and phosphorylation. J. Virol. 62:1088-1092.
7. Borresen, A. L., A. Helland, J. Nesland, R. Holm, C. Trope, and J. Kaern. 1992. Papillomaviruses, p53. and cervical cancer. Lancet 339:1350-1351.
8. Busby-Earle, R. M., C. M. Steel, A. R. Williams, B. Cohen, and C. C. Bird. 1992. Papillomaviruses. p53, and cervical cancer. Lancet 339:1350.
9. Cepko, C. L., B. E. Roberts, and R. C. Mulligan. 1984. Construction and application of a highly transmissible murine retrovirus shuttle vector. Cell 37:1055-1062.
10. Chen, J. J., C. E. Reid, V. Band, and E. J. Androphy. 1995. Interaction of papillomavirus E6 oncoproteins with a putative calcium-binding protein. Science 269:529-531.
11. Crook, T., J. A. Tidy, and K. H. Vousden. 1991. Degradation of p53 can be targeted by HPV E6 sequences distinct from those required for p53 binding and trans-activation. Cell 67:547-556.
12. Crook, T., and K. H. Vousden. 1992. Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens. EMBO J. 11:3935-3940.
13. Crook, T., D. Wrede, J. A. Tidy, W. P. Mason, D. J. Evans, and K. H. Vousden. 1992. Clonal p53 mutation in primary cervical cancer: association with human-papillomavirus-negative tumours. Lancet 339:1070-1073.
14. Crook, T., D. Wrede, and K. H. Vousden. 1991. p53 point mutation in HPV negative human cervical carcinoma cell lines. Oncogene 6:873-875.
15. Danos, O., E. Georges, G. Orth, and M. Yaniv. 1985 Fine structure of the cottontail rabbit papillomavirus mRNAs expressed in the transplantable VX2 carcinoma. J. Virol. 53:735-741.
16. Defeo-Jones, D., G. A. Vuocolo, K. M. Haskell, M. G. Hanobik, D. M. Kiefer, E. M. McAvoy, M. Ivey-Hoyle, J. L. Brandsma, A. Oliff, and R. E. Jones. 1993. Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts. J. Virol. 67:716-725.
17. DiMaio, D., D. Guralski, and J. T. Schiller. 1986. Translation of open reading frame E5 of bovine papillomavirus is required for its transforming activity. Proc. Natl. Acad. Sci. USA 83:1797-1801.
18. Foster, S. A., G. W. Demers, B. G. Etscheid, and D. A. Galloway. 1994. The ability of human papillomavirus E6 proteins to target p53 for degradation in vivo correlates with their ability to abrogate actinomycin D-induced growth arrest. J. Virol. 68:5698-5705.
19. Gage, J. R., C. Meyers, and F. O. Wettstein. 1990. The E7 proteins of the nononcogenic human papillomavirus type 6b (HPV- 6b) and of the oncogenic HPV-16 differ in retinoblastoma protein binding and other properties. J. Virol. 64:723-730.
20. Giri, L., O. Danos, and M. Yaniv. 1985. Genomic structure of the cottontail rabbit (Shope) papillomavirus. Proc. Natl. Acad. Sci. USA 82:1580-1584.
21. Gorman, C. M., and B. H. Howard. 1983. Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate. Nucleic Acids Res. 11:7631-7648.
22. Graham, F. L., and A. J. van der Eb. 1973. A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
23. Grossman, S., and L. A. Laimins. 1989. E6 protein of human papillomavirus type 18 binds zinc. Oncogene 4:1089-1093.
24. Haskell, K. M., G. A. Vuocolo, D. Defeo-Jones, R. E. Jones, and M. Ivey-Hoyle. 1993. Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product. J. Virol. 74:115-119.
25. Hiraiwa, A., T. Kiyono, K. Segawa, K. R. Utsumi, M. Ohashi, and M. Ishibashi. 1993. Comparative study on E6 and E7 genes of some cutaneous and genital papillomaviruses of human origin for their ability to transform 3Y1 cells. Virology 192:102-111.
26. Howley, P. M., and R. Schlegel. 1987. Papillomavirus transformation, p. 141-166. In N. Salzman and P. M. Howley (ed.), The Papovaviridae. Plenum Press. New York.
27. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1991. A cellular protein mediates association of p53 with the E6 oncoprotein of human papillomavirus types 16 or 18. EMBO J. 10:4129-4135.
28. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1993. Cloning and expression of the cDNA for E6-AP, a protein that mediates the interaction of the human papillomavirus E6 oncoprotein with p53. Mol. Cell. Biol. 13:775-784.
29. Huibregtse, J. M., M. Scheffner, and P. M. Howley. 1993. Localization of the E6-AP regions that direct human papillomavirus E6 binding, association with p53, and ubiquitination of associated proteins. Mol. Cell. Biol. 13:4918-4927.
30. Iftner, T. 1990. Papillomavirus genomes: sequence analysis related to functional aspects, p. 182-199. In Pfister (ed.), Papillomaviruses and human cancer-1990. CRC Press, Boca Raton, Fia.
31. Iftner, T., S. Bierfelder, Z. Csapo, and H. Pfister. 1988. Involvement of human papillomavirus type 8 genes E6 and E7 in transformation and replication. J. Virol. 62:3655-3661.
32. Kalderon, D., B. L. Roberts, W. D. Richardson, and A. E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39:499-509.
33. Kanda, T., S. Watanabe, S. Zanma, H. Sato, A. Furuno, and K. Yoshiike. 1991. Human papillomavirus type 16 E6 proteins with glycine substitution for cysteine in the metal-binding motif. Virology 185:536-543.
34. Keen, N., R. Elston, and L. Crawford. 1994. Interaction of the E6 protein of humar papillomavirus with cellular proteins. Oncogene 9:1493-1499.
35. Kiyono, T., A. Hiraiwa. and M. Ishibashi. 1992. Differences in transforming activity and coded amino acid sequence among E6 genes of several papillomaviruses associated with epidermodysplasia verruciformis. Virology 186: 628-639.
36. Kozak, M. 1986. Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell 44:283-292.
37. Kurvinen, K., A. Tervahauta, S. Syrjanen, F. Chang, and K. Syrjanen. 1994. The state of the p53 gene in human papillomavirus (HPV)-positive and HPV-negative genital precancer lesions and carcinomas as determined by single-strand conformation polymorphism analysis and sequencing. Anticancer Res. 14:177-181.
38. Lee, Y. Y., S. P. Wilczynski, A. Chumakov, D. Chih, and H. P. Koeffler. 1994. Carcinoma of the vulva: HPV and p53 mutations. Oncogene 9:1655-1659.
39. Lin, Y. L., L. A. Borenstein, R. Selvakumar, R. Ahmed, and F. O. Wettstein. 1993. Progression from papilloma to carcinoma is accompanied by changes in antibody response to papillomavirus proteins. J. Virol. 67:382-389.
40. Meyers, C., J. Harry, Y. L. Lin, and F. O. Wettstein. 1992. Identification of three transforming proteins encoded by cottontail rabbit papillomavirus. J. Virol. 66:1655-1664.
41. Meyers, C., and F. O. Wettstein. 1991. The late region differentially regulates the in vitro transformation by cottontail rabbit papillomavirus DNA in different cell types. Virology 181:637-646.
42. Nasseri, M., and F. O. Wettstein. 1984. Differences exist between viral transcripts in cottontail rabbit papillomavirus-induced benign and malignant tumors as well as non-virus-producing and virus-producing tumors. J. Virol. 51:706-712.
43. Orth, G. 1987. Epidermodysplasia verruciformis, p. 199-235. In N. Salzman and P. M. Howley (ed.), The Papovaviridae, vol. 2. Plenum Press, New York.
44. Park, D. J., S. P. Wilczynski, R. L. Paquette, C. W. Miller, and H. P. Koeffler. 1994. p53 mutations in HPV-negative cervical carcinoma. Oncogene 9:205-210.
45. Pfister, H. 1992. Human papillomaviruscs and skin cancer. Semin. Cancer Biol. 3:263-271.
46. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed., p. 60-62. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, N.Y.
47. Sanger, F., S. Nicklen, and A. R. Coulson. 1977. DNA sequencing with chain-terminating inhibitors. Proc. Natl. Acad. Sci. USA 74:5463-5467.
48. Scheffner, M., K. Munger, J. C. Byrne, and P. M. Howley. 1991. The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines. Proc. Natl. Acad. Sci. USA 88:5523-5527.
49. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
50. Schmitt, A., J. B. Harry, B. Rapp, F. O. Wettstein, and T. Iftner. 1994. Comparison of the properties of the E6 and E7 genes of low- and high- risk cutaneous papillomaviruses reveals strongly transforming and high Rb-binding activity for the E7 protein of the low-risk human papillomavirus type 1. J. Virol. 68:7051-7059.
51. Steger, G., and H. Pfister. 1992. In vitro expressed HPV 8 E6 protein does not bind p53. Arch. Virol. 125:355-360.
52. Stoeppler, H., M. Conrad Stoeppler, and H. Schlegel. 1994. Transforming proteins of the papillomaviruses. Intervirology 37:168-179.
53. Syverton, J. T. 1952. The pathogenesis of the rabbit papilloma-to-carcinoma sequence. Ann. N.Y. Acad. Sci. 54:1126-1140.
54. Vousden, K. H., E. J. Androphy, J. T. Schiller, and D. R. Lowy. 1989. Mutational analysis of bovine papillomavirus E6 gene. J. Virol. 63:2340-2342.
55. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
56. Wettstein, F. O., M. S. Barbosa, and M. Nasseri. 1987. Identification of the major cottontail rabbit papillomavirus late RNA cap site and mapping and quantitation of an E2 and minor E6 coding mRNA in papillomas and carcinomas. Virology 159:321-328.
57. Wettstein, F. O., and J. G. Stevens. 1980. Distribution and state of viral nucleic acid in tumors induced by Shope papilloma virus. Cold Spring Harbor Conf. Cell Proliferation 7:301-307.
58. Wrede, D., J. A. Tidy, T. Crook, D. Lane, and K. H. Vousden. 1991. Expression of RB and p53 proteins in HPV-positive and HPV-negative cervical carcinoma cell lines. Mol. Carcinog. 4:171-175.
59. Wu, X., W. Xiao, and J. L. Brandsma. 1994. Papilloma formation by cottontail rabbit papillomavirus requires E1 and E2 regulatory genes in addition to E6 and E7 transforming genes. J. Virol. 68:6097-6102.
60. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.