A novel C/EBP β-YY1 complex controls the cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region

Journal of Virology

Volumn 70, Issue 11, 1996, Pages 7695-7705

  Bauknecht, Tobias ^a,b   See, Raymond H ^b   Shi, Yang ^b  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRUS DNA;

AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; DNA FLANKING REGION; GENETIC TRANSCRIPTION; HELA CELL; INFECTION RISK; PAPILLOMA VIRUS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; VIRUS GENE; VIRUS INFECTION;

EID: 0029842880     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.11.7695-7705.1996     Document Type: Article

References (84)

1. Akira, S., H. Isshiki, T. Sugita, O. Tanabe, S. Kinoshita, Y. Nishio, T. Nakajima, T. Hirano, and T. Kishimoto. 1990. A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9:1897-1906.
2. Baker, C. C., W. C. Phelps, V. Lindgren, M. J. Braun, M. A. Gonda, and P. M. Howley. 1987. Structural and transcriptional analysis of human papillomavirus type 16 sequences in cervical carcinoma cell lines. J. Virol. 61: 962-971.
3. Bauknecht, T., P. Angel, H.D. Royer, and H. zur Hausen. 1992. Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1. EMBO J. 11:4607-4617.
4. Bauknecht, T., F. Jundt, I. Herr, T. Oehler, H. Delius, Y. Shi, P. Angel, and H. zur Hausen. 1995. A switch region determines the cell type-specific positive or negative action of YY1 on the activity of the human papillomavirus type 18 promoter. J. Virol. 69:1-12.
5. Bauknecht, T., and Y. Shi. Unpublished data.
6. Cao, Z., R. M. Umek, and S. L. McKnight. 1991. Regulated expression of three C/EBP isoforms during adipose conversion of 3T3-L1 cells. Genes Dev. 5:1538-1552.
7. Chang, C.-J., T.-T. Chen, H.-Y. Lei, D.-S. Chen, and S.-C. Lee. 1990. Molecular cloning of a transcription factor, AGP/EBP, that belongs to members of the C/EBP family. Mol. Cell. Biol. 10:6642-6653.
8. Chen, C., and H. Okayama. 1987. High-efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7:2745-2752.
9. Chen, P.-L., D. J. Riley, S. Chen-Kiang, and W.-H. Lee. 1996. Retinoblastoma protein directly interacts with and activates the transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 93:465-469.
10. 1-antitrypsin, albumin, and simian virus 40 genes. Proc. Natl. Acad. Sci. USA 85:3840-3844.
11. Descombes, P., M. Chojkier, S. Lichtsteiner, E. Falvey, and U. Schibler. 1990. LAP, a novel member of the C/EBP gene family, encodes a liverenriched transcriptional activator protein. Genes Dev. 4:1541-1551.
12. Descombes, P., and U. Schibler. 1991. A liver-enriched transcriptional activator protein, LAP, and a transcriptional inhibitory protein, LIP, are translated from the same mRNA. Cell 67:569-579.
13. De Wet, J. R., K. V. Wood, M. DeLuca, D. R. Helinski, and S. Subramani. 1987. Firefly luciferase gene: structure and expression in mammalian cells. Mol. Cell. Biol. 7:725-737.
14. Diehl, J. A., and M. Hannink. 1994. Identification of a C/EBP-Rel complex in avian lymphoid cells. Mol. Cell. Biol. 14:6635-6646.
15. Dignam, J. D., R. M. Lebovitz, and R. G. Roeder. 1983. Accurate transcription initiation by RNA polymerase Il in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475-1489.
16. Dürst, M., L. Gissmann, H. Ikenberg, and H. zur Hausen. 1983. A new papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions. Proc. Natl. Acad. Sci. USA 80:3812-3815.
17. Dyson, N., P. M. Howley, K. Münger, and E. Harlow. 1989. The human papillomavirus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science 243:934-937.
18. Flanagan, J. R., K. G. Becker, D. L. Ennist, S. L. Gleason, P. H. Driggers, B.-Z. Levi, E. Appella, and K. Ozato. 1992. Cloning of a negative transcription factor that binds to the upstream conserved region of Moloney murine leukemia virus. Mol. Cell. Biol. 12:38-44.
19. Gloss, B., and H.-U. Bernard. 1990. The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequenceaberrant Sp1 distal element. J. Virol. 64:5577-5584.
20. Hariharan, N., D. E. Kelley, and R. P. Perry. 1991. δ, a transcription factor that binds to downstream elements in several polymerase II promoters, is a functionally versatile zinc finger protein. Proc. Natl. Acad. Sci. USA 88: 9799-9803.
21. Hawley-Nelson, P., K. H. Vousden, N. L. Hubbert, D. R. Lowy, and J. T. Schiller. 1989. HPV16 E6 and E7 proteins cooperate to immortalize human foreskin keratinocytes. EMBO J. 8:3905-3910.
22. Heck, D. V., C. L. Yee, P. M. Howley, and K. Münger. 1992. Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses. Proc. Natl. Acad. Sci. USA 89:4442-4446.
23. Henderson, A. J., X. Zou, and K. L. Calame. 1995. C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes. J. Virol. 69:5337-5344.
24. Hoppe-Seyler, F., and K. Butz. 1992. Activation of human papillomavirus type 18 E6-E7 oncogene expression by transcription factor SP1. Nucleic Acids Res. 20:6701-6706.
25. Hoppe-Seyler, F., K. Butz, and H. zur Hausen. 1991. Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1. J. Virol. 65:5613-5618.
26. Hsu, W., and S. Chen-Kiang. 1993. Convergent regulation of NF-IL6 and Oct-1 synthesis by interleukin-6 and retinoic acid signaling in embryonal carcinoma cells. Mol. Cell. Biol. 13:2515-2523.
27. Hsu, W., T. K. Kerppola, P.-L. Chen, T. Curran, and S. Chen-Kiang. 1994. Fos and Jun repress transcription activation by NF-IL6 through association at the basic zipper region. Mol. Cell. Biol. 14:268-276.
28. Johnson, P. F., W. H. Landschulz, B. J. Graver, and S. L. McKnight. 1987. Identification of a rat liver nuclear protein that binds to the enhancer core element of three animal viruses. Genes Dev. 1:133-146.
29. Jundt, F., I. Herr, P. Angel, H. zur Hausen, and T. Bauknecht. 1995. Transcriptional control of human papillomavirus type 18 oncogene expression in different cell lines: role of transcription factor YY1. Virus Genes 11:53-58.
30. Katz, S., E. Kowenz-Leutz, C. Müller, K. Meese, S. A. Ness, and A. Leutz. 1993. The NF-M transcription factor is related to C/EBPβ and plays a role in signal transduction, differentiation and leukemogenesis of avian myelomonocytic cells. EMBO J. 12:1321-1332.
31. Kaur, P., and J. K. McDougall. 1988. Characterization of primary human keratinocytes transformed by human papillomavirus type 18. J. Virol. 62: 1917-1924.
32. Kinoshita, S., S. Akira, and T. Kishimoto. 1992. A member of the C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. USA 89:1473-1476.
33. Kowenz-Leutz, E., G. Twamley, S. Ansieau, and A. Leutz. 1994. Novel mechanism of C/EBPβ (NF-M) transcriptional control: activation through derepression. Genes Dev. 8:2781-2791.
34. Kyo, S., M. Inoue, Y. Nishio, K. Nakanishi, S. Akira, H. Inoue, M. Yutsudo, O. Tanizawa, and A. Hakura. 1993. NF-IL6 represses early gene expression of human papillomavirus type 16 through binding to the noncoding region. J. Virol. 67:1058-1066.
35. Landschulz, W. H., P. F. Johnson, E. Y. Adashi, B. J. Graves, and S. L. McKnight. 1988. Isolation of a recombinant copy of the gene encoding C/EBP. Genes Dev. 2:786-800.
36. Landschulz, W. H., P. F. Johnson, and S. L. McKnight. 1988. The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins. Science 240:1759-1764.
37. Landschulz, W. H., P. F. Johnson, and S. L. McKnight. 1989. The DNA binding domain of the rat liver nuclear protein C/EBP is bipartite. Science 243:1681-1688.
38. LeClair, K. P., M. A. Blanar, and P. A. Sharp. 1992. The p50 subunit of NF-κB associates with NF-IL6 transcription factor. Proc. Natl. Acad. Sci. USA 89:8145-8149.
39. Lee, J.-S., K. M. Galvin, R. H. See, R. Eckner, D. Livingston, E. Moran, and Y. Shi. 1995. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 9:1188-1198.
40. Lee, T.-C., Y. Shi, and R. J. Schwarz. 1992. Displacement of BrdUrd-induccd YY1 by serum response factor activates skeletal α-actin transcription in embryonic myoblasts. Proc. Natl. Acad. Sci. USA 89:9814-9818.
41. Lee, Y.-H., M. Yano, S.-Y. Liu, E. Matsunaga, P. F. Johnson, and F. J. Gonzalez. 1994. A novel cis-acting element controlling the rat CYP2D5 gene and requiring cooperativity between C/EBPβ and an Sp1 factor. Mol. Cell. Biol. 14:1383-1394.
42. Lewis, B. A., G. Tullis, E. Seto, N. Horikoshi, R. Weinmann, and T. Shenk. 1995. Adenovirus E1A proteins interact with the cellular YY1 transcription factor. J. Virol. 69:1628-1636.
43. Mack, D. H., and L. A. Laimins. 1991. A keratinocyte-specific transcription factor, KRF-1, interacts with API to activate expression of human papillomavirus type 18 in squamous epithelial cells. Proc. Natl. Acad. Sci. USA 88:9102-9106.
44. May, M., X.-P. Dong, E. Beyer-Finkler, F. Stubenrauch, P. G. Fuchs, and H. Pfister. 1994. The E6/E7 promoter of extrachromosomal HPV16 DNA in cervical cancers escapes from cellular repression by mutation of target sequences for YY1. EMBO J. 13:1460-1466.
45. McCance, D. J., R. Kopan, E. Fuchs, and L. A. Laimins. 1988. Human papillomavirus type 16 alters human epithelial cell differentiation in vitro. Proc. Natl. Acad. Sci. USA 85:7169-7173.
46. Metz, R., and E. Ziff. 1991. cAMP stimulates the C/EBP-related transcription factor rNFIL-6 to trans-locate to the nucleus and induce c-fos transcription. Genes Dev. 5:1754-1766.
47. Münger, K., W. C. Phelps, V. Bubb, P. M. Howley, and R. Schlegel. 1989. The E6 and E7 genes of human papillomavirus type 16 together are necessary and sufficient for transformation of primary human keratinocytes. J. Virol. 63:4417-4421.
48. Münger, K., B. A. Werness, N. Dyson, W. C. Phelps, E. Harlow, and P. M. Howley. 1989. Complex formation of human papillomavirus E7 proteins with the retinoblastoma tumor suppressor gene product. EMBO J. 8:4099-4105.
49. Nakajima, T., S. Kinoshita,T. Sasagawa, K. Sasaki, M.Naruto, T. Kishimoto, and S. Akira. 1993. Phosphorylation at threonine-235 by a ras-dependent mitogen-activated protein kinase cascade is essential for transcription factor NF-IL6. Proc. Natl. Acad. Sci. USA 90:2207-2211.
50. Nerlov, C., and E. B. Ziff. 1994. Three levels of functional interaction determine the activity of CCAAT/enhancer binding protein-o on the serum albumin promoter. Genes Dev. 8:350-362.
51. Nishio, Y., H. Isshiki, T. Kishimoto, and S. Akira. 1993. A nuclear factor for interleukin-6 expression (NF-IL6) and the glucocorticoid receptor synergistically activate transcription of the rat α1-acid glycoprotein gene via direct protein-protein interaction. Mol. Cell. Biol. 13:1854-1862.
52. Offord, E. A., and P. Beard. 1990. A member of the activator protein 1 family found in keratinocytes but not in fibroblasts required for transcription from a human papillomavirus type 18 promoter. J. Virol. 64:4792-4798.
53. Ossipow, V., P. Descombes, and U. Schibler. 1993. CCAAT/enhancer-binding protein mRNA is translated into multiple proteins with different transcription activation potentials. Proc. Natl. Acad. Sci. USA 90:8219-8223.
54. Park, K., and M. L. Atchison. 1991. Isolation of a candidate repressor/activator, NF-E1 (YY-1, β), that binds to the immunoglobulin κ 3́ enhancer and the immunoglobulin heavy-chain enhancer. Proc. Natl. Acad. Sci. USA 88:9804-9808.
55. Poli, V., F. P. Mancini, and R. Cortese. 1990. IL-6DBP, a nuclear protein involved in interleukin-6 signal transduction, defines a new family of leucine zipper proteins related to C/EBP. Cell 63:643-653.
56. Raynal, M.-C, Z. Liu, T. Hirano, L. Mayer, T. Kishimoto, and S. ChenKiang. 1989. Interleukin-6 induces secretion of IgG1 by coordinated transcriptional activation and differential mRNA accumulation. Proc. Natl. Acad. Sci. USA 86:8024-8028.
57. Ron, D., and J. F. Habener. 1992. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 6:439-453.
58. Scheffner, M., B. A. Werness, J. M. Huibregtse, A. J. Levine, and P. M. Howley. 1990. The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53. Cell 63:1129-1136.
59. Schneider-Gädicke, A., and E. Schwarz. 1986. Different human cervical carcinoma cell lines show similar transcription patterns of human papillomavirus type 18 early genes. EMBO J. 5:2285-2292.
60. Schwarz, E., U. K. Freese, L. Gissmann, W. Mayer, B. Roggenbuck, A. Stremlau, and H. zur Hausen. 1985. Structure and transcription of human papillomavirus sequences in cervical carcinoma cells. Nature (London) 314: 111-114.
61. Shi, Y., E. Seto, L.-S. Chang, and T. Shenk. 1991. Transcriptional repression by YY1, a human GL1-Krüppel related protein, and relief of repression by adenovirus EIA protein. Cell 67:377-388.
62. Shrivastava, A., and K. Calame. 1994. An analysis of genes regulated by the multi-functional transcriptional regulator Yin Yang-1. Nucleic Acids Res. 22:5151-5155.
63. Smotkin, D., and F. O. Wettstein. 1986. Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein. Proc. Natl. Acad. Sci. USA 83:4680-4684.
64. Spergel, J. M., and S. Chen-Kiang. 1991. Interleukin 6 enhances a cellular activity that functionally substitutes for E1A protein in transcription. Proc. Natl. Acad. Sci. USA 88:6472-6476.
65. Spergel, J. M., W. Hsu, S. Akira, B. Thimmappaya, T. Kishimoto, and S. Chen-Kiang. 1992. NF-IL6. a member of the C/EBP family, regulates E1A-responsive promoters in the absence of E1A. J. Virol. 66:1021-1030.
66. Stein, B., and A. S. Baldwin, Jr. 1993. Distinct mechanisms for regulation of the interleukin-8 gene involve synergism and cooperativity between C/EBP and NF-κB. Mol. Cell. Biol. 13:7191-7198.
67. Stein, B., P. C. Cogswell, and A. S. Baldwin, Jr. 1993. Functional and physical associations between NF-κB and C/EBP family members: a Rel domainbZIP interaction. Mol. Cell. Biol. 13:3964-3974.
68. Stein, B., and M. X. Yang. 1995. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ. Mol. Cell. Biol. 15:4971-4979.
69. Thierry, F., A. Garcia-Carranca, and M. Yaniv. 1987. Elements that control the transcription of genital papillomavirus type 18. Cancer Cells 5:23-32.
70. Thierry, F., G. Spyrou, M. Yaniv, and P. M. Howley. 1992. Two API sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes. J. Virol. 66:3740-3748.
71. Trautwein, C., C. Caelles, P. van der Geer, T. Hunter, M. Karin, and M. Chojkier. 1993. Transactivation by NF-1L6/LAP is enhanced by phosphorylation of its activation domain. Nature (London) 364:544-547.
72. . Tsukada, J., K. Saito, W. R. Waterman, A. C. Webb, and P. E. Auron. 1994. Transcription factors NF-IL6 and CREB recognize a common essential site in the human prointerleukin 1β gene. Mol. Cell. Biol. 14:7285-7297.
73. Umek, R. M., A. D. Friedman, and S. L. McKnight. 1991. CCAAT-enhancer binding protein: a component of a differentiation switch. Science 251:288-292.
74. Vallejo, M., D. Ron, C. P. Miller, and J. F. Habener. 1993 C/ATF, a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements. Proc. Natl. Acad. Sci. USA 90:4679-4683.
75. Vinson, C. R., P. B. Sigler, and S. L. McKnight. 1989. Scissors-grip model for DNA recognition by a family of leucine zipper proteins. Science 246:911-916.
76. Wegner, M., Z. Cao, and M. G. Rosenfeld. 1992. Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256:370-373.
77. Werness, B. A., A. J. Levine, and P. M. Howley. 1990. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76-79.
78. Williams, S. C., M. Baer, A. J. Dillner, and P. F. Johnson. 1995. CRP2 (C/EBPβ) contains a bipartite regulatory domain that controls transcriptional activation, DNA binding and cell specificity. EMBO J. 14:3170-3183.
79. Williams, S. C., C. A. Cantwell, and P. F. Johnson. 1991. A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro. Genes Dev. 5:1553-1567.
80. Woodworth, C. D., S. Waggoner, W. Barnes, M. H. Stoler, and J. A. DiPaolo. 1990. Human cervical and foreskin epithelial cells immortalized by human papillomavirus DNAs exhibit dysplastic differentiation in vivo. Cancer Res. 50:3709-3715.
81. Yeh, W.-C., Z. Cao, M. Classon, and S. L. McKnight. 1995. Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168-181.
82. zur Hausen, H. 1989. Papillomaviruses in anogenital cancer its a model to understand the role of viruses in human cancers. Cancer Res. 49:4677-4681.
83. zur Hausen, H. 1991. Viruses in human cancers. Science 254:1167-1173.
84. zur Hausen, H. 1991. Human papillomaviruses in the pathogenesis of anogenital cancer. Virology 184:9-13.