Tumor necrosis factor downregulates an endothelial nitric oxide synthase mRNA by shortening its half-life

Circulation Research

Volumn 73, Issue 1, 1993, Pages 205-209

  Yoshizumi, Masao ^a,b   Perrella, Mark A ^a,d   Burnett Jr , John C ^d   Lee, Mu En ^a,b,c  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

Author keywords

Atherosclerosis; Endothelium; Nitric oxide synthase; Transcriptional regulation; Tumor necrosis factor

Indexed keywords

COMPLEMENTARY DNA; CYCLOHEXIMIDE; CYTOKINE; ENDOTHELIUM DERIVED RELAXING FACTOR; MESSENGER RNA; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; ATHEROSCLEROSIS; DNA PROBE; DOSE RESPONSE; DOWN REGULATION; ENDOTHELIUM CELL; GENETIC TRANSCRIPTION; HALF LIFE TIME; HUMAN; HUMAN CELL; HYBRIDIZATION; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RNA DEGRADATION; TIME; VASCULAR ENDOTHELIUM; VASODILATATION;

AMINO ACID OXIDOREDUCTASES; BASE SEQUENCE; DOWN-REGULATION; ENDOTHELIUM, VASCULAR; HALF-LIFE; HUMAN; MOLECULAR SEQUENCE DATA; NITRIC-OXIDE SYNTHASE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION, GENETIC; TUMOR NECROSIS FACTOR; UMBILICAL VEINS;

EID: 0027233868     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.73.1.205     Document Type: Article

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