Induction and potential biological relevance of a Ca2+‐independent nitric oxide synthase in the myocardium

British Journal of Pharmacology

Volumn 105, Issue 3, 1992, Pages 575-580

  Schulz, R ^a   Nava, E ^a   Moncada, S ^a  

^a WELLCOME RESEARCH LABORATORIES   (United Kingdom)

Author keywords

cyclic GMP; dexamethasone; Endotoxin; heart; interleukin 1 ; myocytes; nitrates; nitric oxide synthase; nitrites; tumour necrosis factor

Indexed keywords

CALCIUM; CYCLIC GMP; CYCLOHEXIMIDE; CYTOKINE; DEXAMETHASONE; ENDOTOXIN; NITRIC OXIDE; RECOMBINANT INTERLEUKIN 1BETA; RECOMBINANT TUMOR NECROSIS FACTOR ALPHA; SYNTHETASE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; HEART MUSCLE; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

AMINO ACID OXIDOREDUCTASES; ANIMAL; CALCIUM; CYCLIC GMP; CYCLOHEXIMIDE; CYTOKINES; DEXAMETHASONE; ENDOTOXINS; ENZYME INDUCTION; IN VITRO; MALE; MUSCLE PROTEINS; MYOCARDIUM; NITRIC-OXIDE SYNTHASE; RATS; RATS, INBRED STRAINS; SUPPORT, NON-U.S. GOV'T;

EID: 0026542187     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1992.tb09021.x     Document Type: Article

References (59)

1. Does the heart fail in endotoxin shock?
2. Cachectin/tumor necrosis factor: production, distribution and metabolic fate in vivo
3. Injection of guanosine 5′‐cyclic monophosphate into heart cells blocks calcium slow channels
4. Induction of nitric oxide synthase by cytokines in vascular smooth muscle cells
5. Myocardial dysfunction in sepsis
6. Reversible cardiac dysfunction associated with interferon alfa therapy in AIDS patients with Kaposi's sarcoma
7. Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L‐arginine‐dependent inhibition of mitochondrial iron‐sulfur enzymes in the macrophage effector cells
8. Regulation of myocardial contractile performance by sodium nitroprusside in the isolated perfused heart of the ferret
9. G‐nitro‐l‐arginine methyl ester in conscious, Long Evans rats
10. Influence of acetylcholine on contractile force and cyclic nucleotide levels in the isolated perfused rat heart
11. G‐monomethyl‐l‐arginine
12. Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte β‐adrenergic responsiveness
13. Left ventricular performance in endotoxin shock in dogs
14. 2+ current in cardiomyocytes
15. 2+ current in single heart cells
16. Adrenocorticotropic hormone; adrenocortical steroids and their synthetic analogs; inhibitors of adrenocortical steroid biosynthesis
17. Tumor necrosis factor depresses myocardial cell function. Results using an in vitro assay of myocyte performance
18. Interleukin‐1‐induced myocardial depression in an isolated beating heart preparation
19. Circulatory effects of hydrocortisone and protection against endotoxin shock in cats
20. Differential induction of brain, lung and liver nitric oxide synthase by endotoxin in the rat
21. Anti‐inflammatory glucocorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat
22. Stoichiometry of the reaction of oxyhemoglobin with nitrite
23. Influence of corticosteroids on mechanical performance of isolated rat papillary muscles
24. Origin of myocardial depressant factor in shock
25. Depression of isolated heart muscle by bacterial endotoxin
26. Depression of contractile responses in rat aorta by spontaneously released endothelium‐derived relaxing factor
27. Identification of N‐iminoethyl‐l‐ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells
28. 2+ current is regulated by cyclic GMP‐dependent protein kinase in mammalian cardiac myocytes
29. Biosynthesis of nitric oxide from l‐arginine. A pathway for the regulation of cell function and communication
30. Nitric oxide: physiology, pathophysiology, and pharmacology
31. Development and mechanism of a specific supersensitivity to nitrovasodilators after inhibition of vascular nitric oxide synthesis in vivo
32. Does cyclic GMP mediate the negative inotropic effect of acetylcholine in the heart?
33. Myocardial toxic effects during recombinant interleukin‐2 therapy
34. Glucocorticoids inhibit the induction of nitric oxide synthase and the related cell damage in adenocarcinoma cells
35. Nitric oxide release accounts for the biological activity of endothelium‐derived relaxing factor
36. The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids
37. Development of myocardial dysfunction in endotoxin shock
38. A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance
39. Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy
40. Electrical properties of individual cells isolated from adult rat ventricular myocardium
41. Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells
42. Agonist‐induced endothelium‐dependent relaxation in rat thoracic aorta may be mediated through cGMP
43. Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: an insight into endotoxin shock
44. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo
45. Basal and stimulated function and release of L‐arginine‐derived nitrogen oxides from cultured endothelial cells
46. Nitric oxide synthase in cultured endocardial cells of the pig
47. Effects of 8‐bromo‐cyclic GMP on contraction and on inotropic response of ferret cardiac muscle
48. Mechanism of cardiac dysfunction in hearts from endotoxin‐treated rats
49. Coronary vasodilation induced by endotoxin is nitric oxide dependent and inhibited by dexamethasone in the isolated perfused rabbit heart
50. Factors released from endocardium of the ferret and pig modulate myocardial contraction
51. Effects of interleukin 2 on cardiac function in the isolated rat heart
52. Effects of E. coli endotoxemia on ventricular performance
53. 2+ in myocytes and perfused hearts: the role of mitochondria
54. Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide
55. The cardiovascular response of normal humans to the administration of endotoxin
56. Decreases in left ventricular contractility during endotoxin shock in rabbits
57. 3 into nitrate is enhanced by endotoxin treatment
58. IL‐1 inhibits β‐adrenergic responsiveness in intact human ventricular myocardium
59. Distribution and metabolism of ingested nitrate and nitrite in germfree and conventional‐flora rats