The initiation of simian virus 40 DNA replication in vitro

Critical Reviews in Biochemistry and Molecular Biology

Volumn 32, Issue 6, 1997, Pages 503-568

  Bullock, Peter A ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

DNA replication; Eukaryotes; Simian Virus 40; T antigen

Indexed keywords

VIRUS DNA; VIRUS T ANTIGEN;

DNA DENATURATION; DNA REPLICATION; DNA SYNTHESIS; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; REVIEW; SIMIAN VIRUS 40; VIRUS REPLICATION;

ANIMALIA; DNA VIRUSES; EUKARYOTA; SIMIAE; SIMIAN VIRUS; SIMIAN VIRUS 40;

EID: 0031405599     PISSN: 10409238     EISSN: None     Source Type: Journal    
DOI: 10.3109/10409239709082001     Document Type: Review

References (459)

1. Adamczewski, J. P., J. V. Gannon, and T. Hunt. 1993. Simian Virus 40 large T antigen associates with cyclin A and p33cdk2. J. Virol. 67: 6551-6557.
2. Alwine, J. C., S. I. Reed, and G. R. Stark. 1977. Characterization of the autoregulation of simian virus 40 gene A. J. Virol. 24: 22-27.
3. Amin, A., Y. Murakami, and J. Hurwitz. 1994. Initiation of DNA replication by simian virus 40 T antigen is inhibited by the p 107 protein. J. Biol. Chem. 269:7735-7743.
4. Araki, H., P. A. Ropp, A. L. Johnson, L. H. Johnson, A. Morrison, and A. Sugino. 1992. DNA polymerase II, the probable homolog of mammalian DNA polymerase ε, replicates chromosomal DNA in the yeast Saccharomyces cerevisiae. EMBO J. 11: 733-740.
5. Arthur, A. K., A. Hoss, and E. Fanning. 1988. Expression of simian virus 40 T-antigen in Escherichia coli: localization of T-antigen origin DNA-binding domain to within 129 amino acids. J. Virol. 62: 1999-2006.
6. Auborn, K. J., R. B. Markowitz, E.Wang, T. Yu, and C. Prives. 1988. Simian virus 40 (SV40) T antigen binds specifically to double-stranded DNA but not to single-stranded DNA or DNA/RNA hybrids containing the SV40 regulatory sequences. J. Virol. 62: 2204-2208.
7. Avemann, K., R. Knippers, T. Koller, and J. M. Sogo. 1988. Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol. Cell. Biol. 8: 3026-3034.
8. Avis, J. M., F. H. T. Allain, P. W. A. Howe, G. Varani, K, Nagai, and D. Neuhaus. 1996. Solution structure of the N-terminal RNP domain of U1A protein: the role of the c-terminal residues in structure stability and RNA binding. J. Mol. Biol. 257: 398-411.
9. Bakkenist, C. J. and S. Cotterill. 1994. The 50-kDa Primase Subunit of Drosophila melanogaster DNA Polymerase α. J. Biol. Chem. 269: 26759-26766.
10. Bambara, R. A. and L. Huang. 1995. Reconstitution of mammalian DNA replication. Prog. Nucl. Acid Res. Mol. Biol. 51: 93-122.
11. Bambara, R. A., R. S. Murante, and L. A. Henricksen. 1997. Enzymes and reactions at the eukaryotic DNA replication fork. J. Biol. Chem. 272: 4647-4650.
12. Baumann, E. A., C.-P. Baur, M. Baack, and S. Beck. 1985. DNA sequence of the leftward junction in the adenovirus-Simian Virus 40 hybrid Ad2+D2 and determination of the structure of the D2-T antigen. J. Virol. 54: 882-885.
13. Bax, A., M. Ikura, L. E. Kay, D. A. Torchia, and R. Tschudin. 1990. Comparison of different modes of two-dimensional reverse-correlation NMR for the study of proteins. J. Magn. Reson. 86: 304-317.
14. Bell, S. P., R. Kobayashi, and B. Stillman. 1993. Yeast origin recognition complex functions in transcription silencing and DNA replication. Science 262: 1844-1849.
15. Bell, S. P. and B. Stillman. 1992. ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357: 128-134.
16. Bennett, E. R., M. Naujokas, and J. A. Hassell. 1989. Requirements for species-specific papovavirus DNA replication. J. Virol. 63: 5371-5385.
17. Berger, L. C., D. B. Smith, I. Davidson, J.-J. Hwang, E. Fanning, and A. G. Wildeman. 1996. Interaction between T Antigen and TEA Domain of the factor TEF-1 derepresses Simian Virus 40 late promoter in vitro: identification of T-antigen domains important for transcriptional control. J. Virol. 70: 1203-1212.
18. Bhattacharyya, S., H. E. Lorimer, and C. Prives. 1995. Murine polyomavirus and Simian Virus 40 large T antigens produce different structural alterations in viral origin DNA. J. Virol. 69: 7579-7585.
19. Blackwell, L. J. and J. A. Borowiec. 1994. Human replication protein A binds single-stranded DNA in two distinct complexes. Mol Cell Biol. 14: 3993-4001.
20. Blackwell, L. J., J. A. Borowiec, and I. A. Mastrangelo. 1996. Single-stranded-DNA binding alters human replication protein A structure and facilitates interaction with DNA-dependent protein kinase. Mol. Cell. Biol. 16: 4798-4807.
21. Bochkarev, A., J. A. Barwell, R. A. Pfuetzner, E. Bochkareva, L. Frappier, and A. M. Edwards. 1996. Crystal structure of the DNA-binding domain of the Epstein-Barr virus origin-binding protein, EBNA1, bound to DNA. Cell 84: 791-800.
22. Bochkarev, A., R. A. Pfuetzner, A. M. Edwards, and L. Frappier. 1997. Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA. Nature 385: 176-181.
23. Borowiec, J. A. 1996. DNA Helicases, p. 545-574. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
24. Borowiec, J. A. 1992. Inhibition of structural changes in the simian virus 40 core origin of replication by mutation of essential origin sequences. J. Virol. 66: 5248-5255.
25. Borowiec, J. A., F. B. Dean, P. A. Bullock, and J. Hurwitz. 1990. Binding and unwinding-how T antigen engages the SV40 origin of DNA replication. Cell 60: 181-184.
26. Borowiec, J. A., F. B. Dean, and J. Hurwitz. 1991. Differential induction of structural changes in the simian virus 40 origin of replication by T-antigen. J. Virol. 65: 1228-1235.
27. Borowiec, J. A. and J. Hurwitz. 1988. ATP stimulates the binding of the simian virus 40 (SV40) large tumor antigen to the SV40 origin of replication. Proc. Natl. Acad. Sci U.S.A. 85: 64-68.
28. Borowiec, J. A., and J. Hurwitz. 1988. Localized melting and structural changes in the SV40 origin of replication induced by T-antigen. EMBO J. 7: 3149-3158.
29. Botchan, M. 1996. Coordinating DNA replication with cell division: Current status of the licensing concept. Proc. Natl. Acad. Sci U.S.A. 93: 9997-10000.
30. Bradley, M. K., J. D. Griffin, and D. M. Livingston. 1982. Relationship of oligomerization to enzymatic and DNA-binding properties of the SV40 large T antigen. Cell 28: 125-134.
31. Bradley, M. K., T. F. Smith, R. H. Lathrop, D. M. Livingston, and T. A. Webster. 1987. Consensus topography in the ATP binding site of the simian virus 40 and polyomavirus large tumor antigens. Proc. Natl. Acad. Sci U.S.A. 84: 4026-4030.
32. Braithwaite, A. W., H. W. Sturzbecher, C. Addison, C. Palmer, K. Rudge, and J. R. Jenkins. 1987. Mouse p53 inhibits SV40 origin-dependent DNA replication. Nature 329: 458-460.
33. Bravo, R., R. Frank, P. A. Blundell, and H. Macdonald-Bravo. 1987. Cyclin/ PCNA is the auxiliary protein of DNA polymerase-δ. Nature 326: 515-517.
34. Brill, S. J., and B. Stillman. 1989. Yeast replication factor-A functions in the unwinding of the SV40 origin of DNA replication. Nature 342: 92-95.
35. Brown, D. R., S. Deb, R. M. Munoz, M. A. Subler, and S. P. Deb. 1993. The Tumor Suppressor p53 and the Oncoprotein Simian Virus 40 T Antigen Bind to Overlapping Domains on the MDM2 Protein. J. Virol. 13: 6849-6857.
36. Brückner, A., F. Stadlbauer, L. A. Guarino, A. Brunahl, C. Schneider, C. Rehfuess, C. Prives, E. Fanning, and H.-P. Nasheuer. 1995. The mouse DNA polymerase α-primase subunit p48 mediates species-specific replication of polyomavirus DNA in vitro. Mol. Cell. Biol. 15: 1716-1724.
37. Brush, G. S., C. W. Anderson, and T. J. Kelly. 1994. The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication. Proc. Natl. Acad. Sci. U.S.A. 91: 12520-12524.
38. Brush, G. S., and T. J. Kelly. 1996. Mechanisms for Replicating DNA, p. 1-43. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
39. Brush, G. S., T. J. Kelly, and B. Stillman. 1995. Identification of Eukaryotic DNA Replication Proteins Using Simian Virus 40 in Vitro Replication System. In: J. L. Campbell, Ed., Methods in Enzymology, vol. 262. Academic Press, San Diego.
40. Buchman, A. R., L. Burnett, and P. Berg. 1980. The SV40 nucleotide sequence. p. 799-841. In: J. Tooze, Ed., Molecular Biology of Tumor Viruses, 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.
41. Bullock, P. A., and D. Denis. 1995. DNA synthesis generally initiates outside of the SV40 core origin in vitro. Mol. Cell. Biol. 15: 173-178.
42. Bullock, P. A., W. S. Joo, K. R. Sreekumar, and C. Mello. 1997. Initiation of SV40 DNA replication in vitro: analysis of the role played by sequences flanking the core origin on initial synthesis events. Virology 227: 460-473.
43. Bullock, P. A., Y. S. Seo, and J. Hurwitz. 1989. Initiation of simian virus 40 DNA replication in vitro: pulse-chase experiments identify the first labeled species as topologically unwound. Proc. Natl. Acad. Sd. U.S.A. 86: 3944-3948.
44. Bullock, P. A., Y. S. Seo, and J. Hurwitz. 1991. Initiation of simian virus 40 DNA Synthesis in vitro. Mol. Cell. Biol. 11: 2350-2361.
45. Bullock, P. A., S. Tevosian, C. Jones, and D. Denis. 1994. Mapping initiation sites for SV40 lagging strand DNA synthesis events in vitro. Mol Cell. Biol. 14: 5043-5055.
46. Burgers, P. M. J. 1991. Saccharomyces cerevisiae replication factor C. H. Formation and activity of complexes with the proliferating cell nuclear antigen and with DNA polymerases δ and ε J. Biol. Chem. 266: 22698-22706.
47. Burhans, W. C. and J. A. Huberman. 1994. DNA replication origins in animal cells: a question of context? Science 263: 639-640.
48. Cai, J., F. Uhlmann, E. Gibbs, H. FloresRozas, C.-G. Lee, B. Phillips, J. Finkelstein, N. Yao, M. O'Donnell, and J. Hurwitz. 1996. Reconstitution of human repliation factor C from its five subunits in baculovirus-infected insect cells. Proc. Natl. Acad. Sci. U.S.A. 93: 12896-12901.
49. Campbell, J. L., Ed. 1995. DNA Replication, vol. 262. Academic Press, San Diego.
50. Campbell, J. L. and C. S. Newlon. 1991. Chromosomal DNA replication., p. 41-146. In: J. R. B. et. al., Ed., The Molecular and Cellular Biology of the Yeast Saccharomyces: Genome Dynamics, Protein Synthesis, and Energetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
51. Campbell, K. S., K. P. Mullane, I. A. Aksoy, H. Stubdal, J. M. Pipas, P. A. Silver, T. M. Roberts, B. S. Schaffhausen, and J. A. DeCaprio. 1997. DnaJ/ hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes and Dev. 11: 1098-1110.
52. Carpenter, P. B., P. R. Mueller, and W. G. Dunphy. 1996. Role of Xenopus Orc2-related protein in controlling DNA replication. Nature 379: 357-360.
53. Carty, M. P., A. S. Levine, and K. Dixon. 1992. HeLa cell single-stranded DNA-binding protein increases the accuracy of DNA synthesis by DNA polymerase α in vitro. Mutat. Res. 274: 29-43.
54. Cegielska, A., I. Moarefi, E. Fanning, and D. M. Virshup. 1994. T-Antigen Kinase Inhibits Simian Virus 40 DNA Replication by Phosphorylation of Intact T Antigen on Serines 120 and 123. J. Virol. 68: 269-275.
55. Challberg, M. D. and T. J. Kelly. 1989. Animal virus DNA replication. Annu. Rev. Biochem. 58: 671-717.
56. Chen, L., W. S. Joo, P. A. Bullock, and D. T. Simmons. 1997. The N-terminal Side of the Origin Binding Domain of Simian Virus 40 Large T-Antigen is Involved in A/T Untwisting. J. Virol., 71: 8743-8749.
57. Cheng, L. and T. J. Kelly. 1989. Transcriptional activator nuclear factor 1 stimulates the replication of SV40 minichromosomes in vivo and in vitro. Cell 59: 541-551.
58. Cheng, L. Z., J. L. Workman, R. E. Kingston, and T. J. Kelly. 1992. Regulation of DNA replication in vitro by the transcriptional activation domain of GAL4-VP16. Proc. Natl. Acad. Sci. U.S.A. 89: 589-593.
59. Cho, Y., S. Gorina, P. D. Jeffrey, and N. P. Pavletich. 1994. Crystal structure of a p53 tumor suppressor-DNA complex: understanding tumorigenic mutations Science 265: 346-355.
60. Chou, J. Y. and R. G. Martin. 1975. DNA infectivity and the induction of host DNA synthesis with temperature-sensitive mutants of simian virus 40. J. Virol. 15: 145-150.
61. Cicala, C., M. L. Avantaggiati, A. Graessmann, K. Rundell, A. S. Levine, and M. Carbone. 1994. Simian Virus 40 Small-t Antigen Stimulates Viral DNA Replication in Permissive Monkey Cells. J. Virol. 68: 3138-3144.
62. Clark, R., K. Peden, J. M. Pipas, D. Nathans, and R. Tjian. 1983. Biochemical activities of T-antigen proteins encoded by simain virus 40 A gene deletion mutants. Mol. Cell, Biol. 3: 220-228.
63. Cleland, W. W. and M. M. Kreevoy. 1994. Low-barrier hygrogen bonds and enzymatic catalysis Science 264: 1887-1890.
64. Clertant, P., P. Gaudray, E. May, and F. Cuzin. 1984. The nucleotide binding site detected by affinity labeling in the large T proteins of polyoma and SV40 viruses is distinct from their ATPase catalytic site. J. Biol. Chem. 259: 15196-15203.
65. Cohen, G. L., P. J. Wright, A. L. DeLucia, B. A. Lewton, M. E. Anderson, and P. Tegtmeyer. 1984. Critical spatial requirement within the origin of simian virus 40 DNA replication. J. Virol. 51: 91-96.
66. Cole, C. N., J. Tornow, R. Clark, and R. Tjian. 1986. Properties of the Simian Virus 40 (SV40) Large T Antigens Encoded by SV40 Mutants with Deletions in Gene A. J. Virol. 57: 539-546.
67. Collins, B. S. and J. M. Pipas. 1995. T Antigens Encoded by Replication-defective Simian Virus 40 Mutants d111315 and 5080. J. Biol. Chem. 270: 15377-15384.
68. Collins, K. and T. J. Kelly. 1991. Effects of T antigen and replication protein A on the initiation of DNA synthesis by DNA polymerase α-primase. Mol. Cell. Biol. 11: 2108-2115.
69. Collins, K. L., A. A. R. Russo, B. Y. Tseng, and T. J. Kelly. 1993. The role of the 70 KDa subunit of human DNA polymerase a in DNA replication. EMBO J. 12: 4555-4566.
70. Copeland, W. C. and T. S.-F. Wang. 1993. Enzymatic characterization of the individual mammalian primase subunits reveals a biphasic mechanism for initiation of DNA replication. J. Biol. Chem. 268: 26179-26189.
71. Coverley, D. and R. A. Laskey. 1994. Regulation of eukaryotic DNA replication. Annual Review of Biochemistry. 63: 745-776.
72. Cullmann, G., K. Fien, R. Kobayashi, and B. Stillman. 1995. Characterization of the Five Replication Factor C Genes of Saccharomyces cerevisiae. Mol. Cell. Biol. 15: 4661-4671.
73. D'Urso, G., R. L. Marraccino, D. R. Marshak, and J. M. Roberts. 1990. Cell cycle control of DNA replication by a homologue from human cells of the p34cdc2 protein kinase. Science 250:786-791.
74. Damania, B., and J. C. Alwine. 1996. TAF-like function of SV40 large Tantigen. Genes and Development. 10: 1369-1381.
75. Danna, K. J., and D. Nathans. 1972. Bidirectional replication of simian virus 40 DNA. Proc. Natl. Acad. Sci. U.S.A. 69: 3097-3100.
76. Dean, F. B., J. A. Borowiec, T. Eki, and J. Hurwitz. 1992. The simian virus 40 T antigen double hexamer assembles around the DNA at the replication origin. J. Biol. Chem. 267: 14129-14137.
77. Dean, F. B., J. A. Borowiec, Y. Ishimi, S. Deb, P. Tegtmeyer, and J. Hurwitz. 1987. Simian virus 40 large tumor antigen requires three core replication origin domains for DNA unwinding and replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 84: 8267-8271.
78. Dean, F. B., P. Bullock, Y. Murakami, C. R. Wobbe, L. Weissbach, and J. Hurwitz. 1987. Simian virus 40 (SV40) DNA replication: SV40 large T antigen unwinds DNA containing the SV40 origin of replication. Proc. Natl. Acad. Sci. U.S.A. 84: 16-20.
79. Dean, F. B., M. Dodson, H. Echols, and J. Hurwitz. 1987. ATP-dependent formation of a specialized nucleoprotein structue by simian virus 40 (SV40) large tumor antigen at the SV40 replication origin. Proc. Natl. Acad. Sci. U.S.A. 84: 8981-8985.
80. Dean, F. B. and J. Hurwitz. 1991. Simian virus 40 large T antigen untwists DNA at the origin of DNA replication. J. Biol. Chem. 266: 5062-5071.
81. Dean, F. B., S. H. Lee, A. D. Kwong, P. Bullock, J. A. Borowiec, M. K. Kenny, Y. S. Seo, T. Eki, T. Matsumoto, G. Hodgins, and J. Hurwitz. 1989. SV40 DNA replication in vitro. UCLA Symp. Mol. Cell. Biol. New Ser. 127: 315-326.
82. Dean, F. B. and O'Donnell. 1996. DNA-protein interactions: Two steps to binding replication origins? Current Biology. 6: 931-934.
83. Deb, S., A. L. DeLucia, C.-P. Baur, A. Koff, and P. Tegtmeyer. 1986. Domain structure of the Simian Virus 40 core origin of replication. Mol. Cell. Biol. 6:1663-1670.
84. Deb, S., A. L. DeLucia, A. Koff, S. Tsui, and P. Tegtmeyer. 1986. The adeninethymine domain of the simian virus 40 core origin directs DNA bending and coordinately regulates DNA replication. Mol. Cell. Biol. 6: 4578-4584.
85. Deb, S., S. Tsui, A. Koff, A. L. DeLucia, R. Parsons, and P. Tegtmeyer. 1987. The T-antigen-binding domain of the simian virus 40 core-origin of replication. J. Virol. 61: 2143-2149.
86. Deb, S. P. and P. Tegtmeyer. 1987. ATP enhances the binding of simian virus 40 large T antigen to the origin of replication. J. Virol. 61: 3649-3654.
87. DeCaprio, J. A., J. W. Ludlow, J. Figge, J. Y. Shew, C. M. Huang, W. H. Lee, E. Marsilio, E. Paucha, and D. M. Livingston. 1988. SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma gene product. Cell 54: 275-283.
88. Decker, R. S., M. Yamaguchi, R. Possenti, M. K. Bradley, and M. L. DePamphilis. 1987. In Vitro Initiation of DNA replication in Simian Virus 40 Chromosomes. J. Biol. Chem. 262: 10863-10872.
89. Decker, R. S., M. Yamaguchi, R. Possenti, and M. L. DePamphilis. 1986. Initian of simian virus 40 DNA replication in vitro: aphidicolin causes accumulation in early-replicating intermediates and allows determination of the initial direction od DNA synthesis. Mol. Cell. Biol. 6: 3815-3825.
90. DeLucia, A. L., S. Deb, K. Partin, and P. Tegtmeyer. 1986. Functional interactions of the Simian Virus 40 core origin of replication with flanking regulatory sequences. J. Virol. 57: 138-144.
91. DeLucia, A. L., B. A. Lewton, R. Tjian, and P. Tegtmeyer. 1983. Topography of simian virus 40 A protein-DNA complexes: arrangement of pentanucleotide interaction sites at the origin of replication. J. Virol. 46: 143-150.
92. Denis, D. and P. A. Bullock. 1993. Primer-DNA Formation during Simian Virus 40 DNA Replication In Vitro. Mol. Cell. Biol. 13: 2882-2890.
93. DePamphilis, M. L., Ed. 1996. DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.
94. DePamphilis, M. L. 1993. Eukaryotic DNA Replication: Anatomy of an origin. Annual Review of Biochemistry. 62: 29-63.
95. DePamphilis, M. L. and M. K. Bradley. 1986. Replication of SV40 and Polyoma Virus Chromosomes, vol. 1. Plenum Press, New York and London.
96. DePamphilis, M. L. and P. M. Wassarman. 1980. Replication of Eukaryotic Chromosomes: A Close-Up of The Replication Fork. Annual Review of Biochemistry. 49: 627-666.
97. Dickmanns, A., A. Zeitvogel, F. Simmersbach, R. Weber, A. K. Arthur, S. Dehde, A. G. Wildeman, and E. Fanning. 1994. The kinetics of simian virus 40-induced progression of quiescent cells into S phase depend on four independent functions of large T antigen. J. Virol. 68: 5496-5508.
98. Diffley, J. F. X. and J. H. Cocker. 1992. Protein-DNA interactions at a yeast replication origin. Nature 357: 169-172.
99. DiMaio, D. and D. Nathans. 1980. Cold-sensitive regulatory mutants of Simian Virus 40. J. Mol. Biol. 140: 129-146.
100. DiMaio, D. and D. Nathans. 1982. Regulatory mutants of simian virus 40: effect of mutations at a T antigen binding site on DNA replication and expression of viral genes. J. Mol. Biol. 156: 531-548.
101. Din, S., S. J. Brill, M. P. Fairman, and B. Stillman. 1990. Cell-cycle-regulated phosphorylation of DNA replication factor A from human and yeast cells. Genes and Dev. 4: 968-977.
102. Dixon, R. A. F. and D. Nathans. 1985. Purification of simian virus 40 large T antigen by immunoaffinity chromatography. J. Virol. 53: 1001-1004.
103. Dobbelstein, M., A. K. Arthur, S. Dehde, K. van Zee, A. Dickmanns, and E. Fanning. 1992. Intracistronic complementation reveals a new function of SV40 T antigen that cooperates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene 7: 837-847.
104. Dodson, M., F. B. Dean, P. Bullock, H. Echols, and J. Hurwitz. 1987. Unwinding of duplex DNA from the SV40 origin of replication by T antigen. Science 238: 964-967.
105. Dornreiter, L, W. C. Copeland, and T. S.-F. Wang. 1993. Initiation of simian virus 40 DNA replication requires the interaction of a specific domain of human DNA polymerase a with large T antigen. Mol. Cell. Biol. 13: 809-820.
106. Dornreiter, I, L. F. Erdile, I. U. Gilbert, D. von Winkler, T. J. Kelly, and E. Fanning. 1992. Interactions of DNA polymerase α-primase with cellular replication protein A and SV40 T antigen. EMBO J. 11: 769-776.
107. Dornreiter, L, A. Hoss, A. K. Arthur, and E. Fanning. 1990. SV40 T antigen hinds directly to the large subunit of purified DNA polymerase alpha. EMBO J. 9: 3329-3336.
108. Dutta, A. and B. Stillman. 1992. cdc2 family kinases phosphorylate a human cell DNA replication factor, RPA, and activate DNA replication. EMBO J. 11: 2189-2199.
109. Dyson, N., K. Buchkovich, P. Whyte, and E. Harlow. 1989. The cellular 107K protein that binds to adenovirus E1A also associates with the large T-antigens of SV40 and JC virus. Cell 58: 249-255.
110. Eckner, R., J. W. Ludlow, N. L. Lill, E. Oldread, Z. Arany, N. Modjtahedi, J. A. DeCaprio, D. M. Livingston, and J. A. Morgan. 1996. Association of p300 and CBP with Simian Virus 40 Large T Antigen. Mol. Cell. Biol. 16: 3454-3464.
111. Egelman, E. H., X. Yu, R. Wild, M. M. Hingorani, and S. S. Patel. 1995. Bacteriophage T7 helicase/primase proteins form rings around single-stranded DNA that suggest a general structure for hexameric helicases. Proc. Natl. Acad. Sci. U.S.A. 92: 3869-3873.
112. Ehrenhofer-Murray, A. E., M. Gossen, D. T. S. Pak, M. R. Botchan, and J. Rine. 1995. Separation of origin recognition complex functions by cross-species complementation. Science 270: 1671-1674.
113. Eki, T., T. Enomoto, C. Masutani, A. Miyajima, R. Takada, Y. Murakami, T. Ohno, F. Hanaoka, and M. Ui. 1991. Mouse DNA primase plays the principal role in determination of permissiveness for polyomavirus DNA replication. J. Virol. 65:4874-4881.
114. Eki, T., T. Matsumoto, Y. Murakami, and J. Hurwitz. 1992. The replication of DNA containing the simian virus 40 origin by the monopolymerase and the dipolymerase systems. J. Biol. Chem. 267: 7284-7294.
115. El-Deiry, W. S., T. Tokino, V. E. Velculescu, D. B. Levy, R. Parsons, J. M. Trent, D. Lin, W. E. Mercer, K. W. Kinzler, and B. Vogelstein. 1993. WAF1, a Potential Mediator of p53 Tumor Suppression. Cell 75: 817-825.
116. Eliasson, R. and P. Reichard. 1978. Replication of polyoma DNA in isolated nuclei: synthesis and distribution of initiator RNA. J. Biol. Chem. 253: 7469-7475.
117. Erdile, L. F., K. L. Collins, A. Russo, P. Simancek, D. Small, C. Umbricht, D. Virshup, L. Cheng, S. Randall, D. Weinberg, I. Moarefi, E. Fanning, and T. Kelly. 1991. Initiation of SV40 DNA Replication: Mechanism and Control. Cold Spring Harbor Symp. on Quant. Biol. LVI: 303-313.
118. Erdile, L. F., W.-D. Heyer, R. Kolodner, and T. J. Kelly. 1991. Characterization of a cDNA Encoding the 70-kDa Single-stranded DNA-binding Subunit of Human Replication Protein A and the Role of the Protein in DNA Replication. J. Biol. Chem. 266: 12090-12098.
119. Erdile, L. F., M. S. Wold, and T. J. Kelly. 1990. The Primary Structure of the 32-kDa Subunit of Human Replication Protein A. J. Biol. Chem. 265:3177-3182.
120. Ewen, M. E., B. Faha, E. Harlow, and D. Livingston. 1992. Interaction of p107 with Cyclin A Independent of Complex Formation with Viral Oncoproteins. Science 255: 85-87.
121. Ewen, M. E., J. W. Ludlow, E. Marsilio, J. A. DeCaprio, R. C. Millikan, S. H. Cheng, E. Paucha, and D. M. Livingston. 1989. An N-terminal transformation-governing sequence of SV40 large T antigen contributes to the binding of both p110Rb and a second cellular protein, p120. Cell 257-267.
122. Fairman, M. P., G. Prelich, and B. Stillman. 1987. Identification of multiple cellular factors required for SV40 replication in vitro. Phil. Trans. R. Soc. London Ser. B. 317: 495-505.
123. Fairman, M. P. and B. Stillman. 1988. Cellular factors required for multiple stages of SV40 replication in vitro. EMBO J. 7: 1211-1218.
124. Fanning, E. 1992. Simian virus 40 large T antigen: the puzzle, the pieces, and the emerging picture. J. Virol. 66: 1289-1293.
125. Fanning, E. and R. Knippers. 1992. Structure and function of simian virus 40 large tumor antigen. Annual Review of Biochemistry. 61: 55-85.
126. Fanning, E., B. Nowak, and C. Burger. 1981. Detection and characterization of multiple forms of simian virus 40 large T antigen. J. Virol. 37: 92-102.
127. Fanning, E., K. H. Westphal, D. Brauer, and D. Corlin. 1982. Subclasses of simian virus 40 large T antigen: differential binding of two subclasses of T antigen from productively infected cells to viral and cellular DNA. EMBO J. 1: 1023-1028.
128. Fareed, G. C., C. F. Garon, and N. P. Salzman. 1972. Origin and Direction of Simian Virus 40 Deoxyribonucleic Acid Replication. J. Virol. 10: 484-491.
129. Fey, G., J. B. Lewis, T. Grodzicker, and A. Bothwell. 1979. Characterization of a fused protein specified by the adenovirus type 2-simian virus 40 hybrid Ad2+ND1 dp2. J. Virol. 30: 201-217.
130. Flores-Rozas, H., Z. Kelnian, F. B. Dean, Z. Q. Pan, J. W. Harper, S. J. Elledge, M. O'Donnell, and J. Hurwitz. 1994. Cdk-interacting protein-1 (Cip1, WAFI) directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase δ holoenzyme. Proc. Natl. Acad. Sci. U.S.A.
131. Fotedar, R., R. Mossi, P. Fitzgerald, T. Rousselle, G. Maga, H. Brickner, H. Messier, S. Kasibhatla, U. Hübscher, and A. Fotedar. 1996. A conserved domain of the large subunit of replication factor C binds PCNA and acts like a dominant negative inhibitor of DNA replication in mammalian cells. EMBO J. 15: 4423-4433.
132. Friedman, P. N., S. E. Kern, B. Vogelstein, and C. Prives. 1990. Wild-type, but not mutant, human p53 proteins inhibit the replication activities of simian virus 40 large tumor antigen. Proc. Natl. Acad. Sci. U.S.A. 87: 9275-9279.
133. Frisque, R. J., G. L. Bream, and M. T. Cannella. 1984. Human polyomavirus JC virus genome. J. Virol. 51: 458-469.
134. Fry, M. and L. A. Loeb. 1986. Animal Cell DNA Polymerases. CRC Press, Inc., Boca Raton, FL.
135. Gannon, J. V. and D. P. Lane. 1990. Interactions Between SV40 T antigen and DNA Polymerase a. The New Biologist. 2: 84-92.
136. Gannon, J. V. and D. P. Lane. 1987. p53 and DNA polymerase a compete for binding to SV40 T antigen. Nature (London). 329: 456-458.
137. Gavin, K. A., M. Hidaka, and B. Stillman. 1995. Conserved initiator proteins in cukaryotes. Science 270: 1667-1671.
138. Gerard, R. and Y. Gluzman. 1986. Functional analysis of the role of the A + T-rich region and upstream flanking sequences in simian virus 40 DNA replication. Mol. Cell. Biol. 6: 4570-4577.
139. Giacherio, D. and L. P. Hager. 1979. A poly(dT)-stimulated ATPase activity associated with simian virus 40 large T antigen. J. Biol. Chem. 254: 8117-8120.
140. Gidoni, D., A. Scheller, B. Barnet, P. Hantzopoulos, M. Oren, and C. Prives. 1982. Different forms of simian virus 40 large tumor antigen varying in their affinities for DNA. J. Virol. 42: 456-466.
141. Gish, W. R. and M. R. Botchan. 1987. Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication. J. Virol. 61: 2864-2876.
142. Gjorup, O. V., P. E. Rose, P. S. Holman, B. J. Bockus, and B. S. Schaffhausen. 1994. Protein domains connect cell cycle stimulation directly to initiation of DNA replication. Proc. Natl. Acad. Sci. U.S.A. 91: 12125-12129.
143. Gluzman, Y. and B. Ahrens. 1982. SV40 early mutants that are defective for viral DNA synthesis but competent for transformation of cultured rat and simian cells. Virology. 123: 78-92.
144. Goetz, G. S., F. B. Dean, J. Hurwitz, and S. W. Matson. 1988. The unwinding of duplex regions in DNA by the simian virus 40 large tumor antigen-associated DNA helicase activity. J. Biol. Chem. 263: 383-392.
145. Gossen, M., D. T. S. Pak, S. K. Hansen, J. K. Acharya, and M. R. Botchan. 1995. A Drosophila homolog of the yeast origin recognition complex. Science 270: 1674-1677.
146. Gouaux, J. E., R. C. Stevens, and W. N. Lipscomb. 1990. Crystal Structures of Aspartate Carbamoyltransferase Ligated with Phosphonoacetamide, Malonate, and CTP or ATP at 2.8-Å Resolution and Neutral pH. Biochemistry. 29:7702-7715.
147. Goulian, M., S. H. Richards, C. J. Heard, and B. M. Bigsby. 1990. Discontinuous DNA synthesis by purified mammalian proteins. J. Biol. Chem. 265: 18461-18471.
148. Gruda, M. C., J. M. Zabolotny, J. H. Xiao, I. Davidson, and J. C. Alwine. 1993. Transcriptional activation by simian virus 40 large T-antigen: Interactions with multiple components of the transcription complex. Mol. Cell. Biol. 13: 961-969.
149. Gruss, C., J. Wu, T. Koller, and J. M. Sogo. 1993. Disruption of the nucleosomes at the replication fork. EMBO J. 12:4533-4545.
150. Gu, Y., C. W. Turck, and D. O. Morgan. 1993. Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit Nature 366: 707-710.
151. Gulbis, J. M., Z. Kelman, J. Hurwitz, M. O'Donnell, and J. Kuriyan. 1996. Structure of the C-Terminal Region of p21 WAF1/CIP1 Complexed with Human PCNA. Cell 87: 297-306.
152. Guo, Z.-S., C. Gutierrez, U. Heine, J. M. Sogo, and M. L. DePamphilis. 1989. Origin auxiliary sequences can facilitate initiation of simian virus 40 DNA replication in vitro as they do in vivo. Mol. Cell. Biol. 9: 3593-3602.
153. Guo, Z. S., U. Heine, and M. L. DePamphilis. 1991. T-antigen binding to site I facilitates initiation of SV40 DNA replication but does not affect bidirectionality. Nucleic Acids Res. 19: 7081-7088.
154. Gutierrez, C., Z.-S. Guo, J. Roberts, and M. L. DePamphilis. 1990. Simian virus 40 origin auxiliary sequences weakly facilitate T-antigen binding but strongly facilitate DNA unwinding. Mol. Cell. Biol. 10: 1719-1728.
155. Hansen, U., D. G. Tenen, D. M. Livingston, and P. A. Sharp. 1981. T antigen repression of SV40 early transcription from two promoters. Cell 27: 603-612.
156. Harper, J. W., G. R. Adami, N. Wei, K. Keyomarsi, and S. J. Elledge. 1993. The p21 Cdk-Interacting Protein Cip 1 Is a Potent Inhibitor of G1 Cyclin-Dependent Kinases. Cell 75: 805-816.
157. Harrington, J. J. and M. R. Lieber. 1994. The characterization of a mammalian DNA structure specific endonuclease. EMBO J. 13: 1235-1246.
158. Hassell, J. A. and B. T. Brinton. 1996. SV40 and Polyomavirus DNA Replication, p. 639-677. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
159. Hay, R. T. and M. L. DePamphilis. 1982. Initiation of SV40 DNA replication in vivo: location and structure 5′ ends of DNA synthesized in the on region. Cell 28:767-779.
160. He, Z., B. T. Brinton, J. Greenblatt, J. A. Hassell, and C. J. Ingles. 1993. The Transactivator Proteins VP16 and GAL4 Bind Replication Factor A. Cell 73: 1223-1232.
161. Hegde, R. S., S. R. Grossman, L. A. Laimins, and P. B. Sigler. 1992. Crystal structure at 1.7 A of the bovine papilloma-virus-1 E2 DNA-binding domain bound to its DNA target Nature 359: 505-512.
162. Herron, J. N., X. M. He, D. W. Ballard, P. R. Blier, P. E. Pace, A. L. M. Bothwell, E. W. J. Voss, and A. B. Edmundson. 1991. An autoantibody to single-stranded DNA: Comparison of the three-dimensional structures of the unliganded Fab and a deoxynucleotide-Fab complex. Proteins: structure, function and genetics. 11: 159-175.
163. Hertz, G. Z., M. R. Young, and J. E. Mertz. 1987. The A+T-rich sequence of the simian virus 40 origin is essential for replication and is involved in bending of the viral DNA. J. Virol. 61: 2322-2325.
164. Hill, R. B., J. M. Flanagan, and J. H. Prestegard. 1995. 1H and 15N magnetic resonance assignments, secondary structure, and tertiary fold of Escherichia coli DNAJ (1-78). Biochemistry 34: 5587-5596.
165. Hinzpeter, M., E. Fanning, and W. Deppert. 1986. A New Sensitive Target-Bound DNA Binding Assay for SV40 Large T Antigen. Virology 148: 159-167.
166. Hiscott, J. B. and V. Defendi. 1979. Simian virus 40 gene A regulation of cellular DNA synthesis. I. In permissive cells. J. Virol. 30: 590-599.
167. Hiscott, J. B. and V. Defendi. 1981. Simian virus 40 gene A regulation of cellular DNA synthesis. II. In nonpermissive cells. J. Virol. 37: 802-812.
168. Holm, L. and C. Sander. 1993. Protein structure comparison by alignment of distance matrices. J. Mol Biol. 170: 123-138.
169. Höss, A., I. F. Moarefi, E. Fanning, and A. K. Arthur. 1990. The finger domain of simian virus 40 large T-antigen controls DNA-binding specificity. J. Virol. 64: 6291-6296.
170. Huang, L., Y. Kim, J. J. Turchi, and R. A. Bambara. 1994. Structure-specific Cleavage of the RNA Primer from Okazaki Fragments by Calf Thymus RNase HI. J. Biol. Chem. 269: 25922-25927.
171. Hurwitz, J., F. B. Dean, A. D. Kwong, and S.-H. Lee. 1990. The in vitro replication of DNA containing the SV40 origin. J. Biol. Chem. 265: 18043-18046.
172. Iftode, C. and J. A. Borowiec. 1997. Denaturation of the Simian Virus 40 Origin of Replication Mediated by Human Replication Protein A. Mol. Cell. Biol. 17: 3876-3883.
173. Ishimi, Y. 1992. Preincubation of T Antigen with DNA Overcomes Repression of SV40 DNA Replication by Nucleosome Assembly. J. Biol. Chem. 267: 10910-10913.
174. Ishimi, Y., A. Claude, P. Bullock, and J. Hurwitz. 1988. Complete enzymatic synthesis of DNA containing the SV40 origin of replication. J. Biol. Chem. 263: 19723-19733.
175. Johnson, R. T. 1983. Evidence for Polyomaviruses in Human Neurological Diseases. In: Polyomavirus and Human Neurological Diseases 183-190.
176. Johnston, S. D., X.-M. Yu, and J. E. Mertz. 1996. The Major Transcriptional Transactivation Domain of Simian Virus 40 Large T Antigen Associates Non-concurrently with Multiple Components of the Transcriptional Preinitiation Complex. J. Virol 70: 1191-1202.
177. Jones, C. 1996. Masters. Tufts University.
178. Jones, K. A. and R. Tjian. 1984. Essential contact residues within SV40 large T antigen binding sites I and II identified by alkylation-interference. Cell 36: 155-162.
179. Joo, W. S., H. Y. Kim, K. R. Sreekumar, and P. A. Bullock. 1997. Pentanucleotide requirements for T-ag hexamer and double hexamer formation on the SV40 core origin. Submitted.
180. Joo, W. S., X. Luo, D. Denis, H. Y. Kim, G. J. Rainey, C. Jones, K. R. Sreekumar, and P. A. Bullock. 1997. Purification of the SV40 T-antigen DNA
181. Kalderon, D., B. L. Roberts, W. D. Richardson, and A. E. Smith. 1984. A short amino acid sequence able to specify nuclear location. Cell 39: 499-509.
182. Kalderon, D. and A. E. Smith. 1984. In vitro mutagenesis of a putative DNA binding domain of SV40 large-T. Virology 139: 109-137.
183. Kamakaka, R. T., P. D. Kaufman, B. Stillman, P. G. Mitsis, and J. T. Kadonaga. 1994. Simian Virus 40 Origin-and T-Antigen-Dependent DNA Replication with Drosophila Factors In Vitro. Mol Cell. Biol. 14: 5114-5122.
184. Keller, J. M. and J. C. Alwine. 1984. Activation of the SV40 late promoter: Direct effects of T antigen in the absence of viral DNA replication. Cell 36: 381-389.
185. Kelley, W. L. and C. Georgopoulos. 1997. The T/t common exon of simian rus 40, JC, and BK polyomavirus T antigens can functionally replace the J-do-main of the Escherichia coli Dna J molecular chaperone. Proc. Natl. Acad. Sci. U.S.A. 94: 3679-3684.
186. Kelly, T. J. 1988. SV40 DNA replication. J. Biol. Chem. 263: 17889-17892.
187. Kelly, T. J., M. S. Wold, and J. Li. 1988. Initiation of viral DNA replication. Adv. Virus Res. 34: 1-42.
188. Kelly, W. L. and S. J. Landry. 1994. Chaperone power in a virus? TIBS. 19: 277-278.
189. Kelman, Z. 1997. PCNA: structure, functions and interactions. Oncogene 14: 629-640.
190. Kenny, M., S.-H. Lee, and J. Hurwitz. 1989. Multiple functions of human single-stranded-DNA binding protien in simian virus 40 DNA replication: Single-strand stabilization and stimulation of DNA polymerase α and δ. Proc. Natl. Acad. Sci. U.S.A. 86: 9757-9761.
191. Kenny, M. K., L. A. Balogh, and J. Hurwitz. 1988. Initiation of Adenovirus DNA Replication. I. Mechanism of action of a host protein required for replication of adenovirus DNA templates devoid of the terminal protein. J. Biol. Chem. 263: 9801-9808.
192. Kenny, M. K., U. Schlegel, H. Furneaux, and J. Hurwitz. 1990. The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J. Biol. Chem. 265: 7693-7700.
193. Khalili, K., J. Brady, J. M. Pipas, S. L. Spence, M. Sadofsky, and G. Khoury. 1988. Carboxyl-terminal mutants of the large tumor antigen of simian virus 40: A role for the early protein late in the lytic cycle. Proc. Natl. Acad. Sci. U.S.A. 85: 354-358.
194. Khoury, G. and E.May. 1977. Regulation of early and late simian virus 40 tranription: Overproduction of early viral RNA in the absence of a functional T-antigen. J. Virol. 23: 167-176.
195. Kienzle, H., M. Baack, and R. Knippers. 1989. Effects of the cellular p53 protein on Simian-virus-40-T-antigen-catalyzed DNA unwinding in vitro. Eur. J. Biochem. 184: 181-186.
196. Kierstead, T. D. and J. M. Pipas. 1996. Database of mutations that alter the large tumor antigen of simian virus 40. Nucl. Acids Res. 24: 125-126.
197. Kierstead, T. D. and M. J. Tevethia. 1993. Association of p53 Binding and Immortalization of Primary C57BL/6 Mouse Embryo Fibroblasts by Using Simian Virus 40 T-Antigen Mutants Bearing Internal Overlapping Deletion Mutations. J. Virol. 67: 1817-1829.
198. Kilwinski, J., M. Baack, S. Heiland, and R. Knippers. 1995. Transcription Factor Oct 1 Binds to the AT-Rich Segment of the Simian Virus 40 Replication Origin. J. Virol. 69: 575-578.
199. Kim, C., R. O. Snyder, and M. S. Wold. 1992. Binding properties of Replication Protein A from human and yeast cells. Mol. Cell. Biol. 12: 3050-3059.
200. Kirk, B. W., C. Harrington, F. W. Perrino, and R. D. Kuchta. 1997. Eucaryotic DNA Primase Does Not Prefer To Synthesize Primers at Pyrimidine Rich DNA Sequences When Nucleoside Triphosphates Are Present at Concentrations Found in Whole Cells. Biochemistry. 36: 6725-6731.
201. Klausing, K., M. Scheffner, K. H. Scheidtmann, H. Stahl, and R. Knippers. 1989. DNA binding properties and replication activity of the T antigen related D2 phosphoprotein. Biochemistry 28: 2238-2244.
202. Klimasauskas, S., S. Kumar, R. J. Roberts, and X. Cheng. 1994. HhaI methyltransferase flips its target base out of the DNA helix. Cell 76: 357-369.
203. Kohrman, D. C. and M. J. Imperiale. 1992. Simian Virus 40 Large T Antigen Stably Complexes with a 185-Kilodalton Host Protein. J. Virol. 66: 1752-1760.
204. Kornberg, A. and T. A. Baker. 1992. DNA Replication, 2 ed. W. H. Freeman and Co., New York.
205. Krishna, T. S. R., X.-P. Kong, S. Gary, P. M. Burgers, and J. Kuriyan. 1994. Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA. Cell 79: 1233-1243.
206. Kuchta, R. D., B. Reid, and L. M. S. Chang. 1990. DNA Primase: Processivity and the primase to polymerase a activity switch. J. Biol. Chem. 265: 16158-16165.
207. Kwon, H. J., R. Tirumalai, A. Landy, and T. Ellenberger. 1997. Flexibility in DNA Recombination: Structure of the Lambda Integrase Catalytic Core. Science 276: 126-131.
208. Lane, D. P. and L. V. Crawford. 1979. T antigen is bound to a host protein in SV40-transformed cells. Nature 278: 261-263.
209. Lanford, R. E. 1988. Expression of Simian Virus 40 T Antigen in Insect Cells Using a Baculovirus Expression Vector. Virology 167: 72-81.
210. Lee, M. Y. W. T., C.-K. Tan, K. M. Downey, and A. G. So. 1984. Further studies on calf tymus DNA polymerase δ purified to homogeneity by a new procedure. Biochemistry 23: 1906-1913.
211. Lee, S.-H., T. Eki, and J. Hurwitz. 1989. Synthesis of DNA containing the simian virus 40 origin of replication by the combined action of DNA polymerases a and δ. Proc. Natl. Acad. Sci. U.S.A. 86: 7361-7365.
212. Lee, S.-H. and J. Hurwitz. 1990. Mechanisms of elongation of primed DNA by DNA polymerase o, proliferating cell nuclear antigen, and activator I. Proc. Natl. Acad. Sci. U.S.A. 87: 5672-5676.
213. Lee, S.-H., A. D. Kwong, Z.-Q. Pan, and J. Hurwitz. 1991. Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase δ. J. Biol. Chem. 266: 594-602.
214. Lee, S.-H., Z.-Q. Pan, A. D. Kwong, P. M. J. Burgers, and J. Hurwitz. 1991. Synthesis of DNA by DNA polymerase ε in vitro. J. Biol. Chem. 266: 22707-22717.
215. Lee, S. H. and D. K. Kim. 1995. The role of the 34-kDa subunit of human replication protein A in simian virus 40 DNA replication in vitro. J. Biol. Chem. 270: 12801-12807.
216. Lehman, I. R. and L. S. Kaguni. 1989. DNA Polymerase α. J. Biol. Chem. 264: 4265-4268.
217. Levine, A. J. 1993. The tumor suppressor genes. Annu. Rev. Biochem. 623-651.
218. Lewton, B. A., A. L. DeLucia, and P. Tegtmeyer. 1984. Binding of simian virus 40 A protein to DNA with deletions at the origin of replication. J. Virol. 49: 9-13.
219. Li, C., L. G. Cao, Y. L. Wang, and E. F. Baril. 1993. Further purification and characterization of a multienzyme complex for DNA synthesis in human cells. J. Cell. Biochem. 53: 405-419.
220. Li, J. and T. Kelly. 1984. Simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 81: 6973-6977.
221. Li, J. J. and T. J. Kelly. 1985. Simian Virus 40 DNA Replication In Vitro: Specificity of Initiation and Evidence for Bidirectional Replication. Mol. Cell. Biol. 5: 1238-1246.
222. Li, J. J., K. W. C. Peden, R. A. F. Dixon, and T. Kelly. 1986. Functional organization of the simian virus 40 origin of DNA replication. Mol. Cell. Biol. 6: 1117-1128.
223. Li, L., B. L. Li, M. Hock, E. Wang, and W. R. Folk. 1995. Sequences flanking the pentanucleotide T-antigen binding sites in e polyomavirus core origin help determine selectivity of DNA replication. J. Virol. 69: 7570-7578.
224. Li, R. and M. Botchan. 1993. The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell 73: 1207-1221.
225. Li, R., S. Waga, G. J. Hannon, D. Beach, and B. Stillman. 1994. Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair. Nature 371: 534-537.
226. Li, X., J. Li, J. Harrington, M. R. Lieber, and P. M. J. Burgers. 1995. Lagging Strand DNA Synthesis at the Eukaryotic Replication Fork Involves Binding and Stimulation of FEN-1 by Proliferating Cell Nuclear Antigen. J. Biol. Chem. 270: 22109-22112.
227. Lill, N. L., M. J. Tevethia, R. Eckner, D. M. Livingston, and N. Modjtahedi. 1997. p300 Family Members Associate with the Carboxyl Terminus of Simian Virus 40 Large Tumor Antigen. J. Virol. 71: 129-137.
228. Lima, C. D., J. C. Wang, and A. Mondragon. 1994. Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature 367: 138-146.
229. Lin, H. J. L., R. H. Upson, and D. T. Simmons. 1992. Nonspecific DNA binding activity of simian virus 40 large T antigen: evidence for the cooperation of two regions for full activity. J. Virol. 66: 5443-5452.
230. Lin, J.-Y. and D. T. Simmons. 1991. Stable T-p53 Complexes Are Not Required for Replication of Simian Virus 40 in Culture or for Enhanced Phosphorylation of T Antigen and p53. J. Virol. 65: 2066-2072.
231. Lin, S. and D. Kowalski. 1994. DNA Helical Instability Facilitates Initiation at e SV40 Replication Origin. J. Mol Biol. 235: 496-507.
232. Linn, S. 1991. How Many Pols Does it Take to Replicate Nuclear DNA? Cell 66: 185-187.
233. Linzer, D. I. H. and A. J. Levine. 1979. Characterization of a 54 KDa Cellular SV40 Tumor Antigen Present in SV40-Transformed Cells and Uninfected Embryonal Carcinoma Cells. Cell 17: 43-52.
234. Loeber, G., R. Parsons, and P. Tegtmeyer. 1989. The zinc finger region of simian virus 40 large T antigen. J. Virol. 63: 94-100.
235. Loeber, G., J. E. Stenger, S. Ray, R. E. Parsons, M. E. Anderson, and P. Tegtmeyer. 1991. The zinc finger region of simian virus 40 large T antigen is needed for hexamer assembly and origin melting. J. Virol. 65: 3167-3174.
236. Lohman,T. M. 1993. Helicase-catalyzed DNA Unwinding. J. Biol. Chem. 268: 2269-2272.
237. Lohman, T. M. and K. P. Bjornson. 1996. Mechanisms of Helicase-Catalyzed DNA Unwinding. Annu. Rev. Biochem. 65: 169-214.
238. Lorimer, H. E., I. Reynisdottir, S. Ness, and C. Prives. 1993. Unusual properties of a replication-defective mutant SV40 large T-antigen. Virology 192: 402-414.
239. Luo, X., D. G. Sanford, P. A. Bullock, and W. W. Bachovchin. 1996. Structure of the origin specific DNA binding domain from simian virus 40 T-antigen. Nature Structural Biology 3: 1034-1039.
240. Madden, K. R., L. Stewart, and J. J. Champoux. 1995. Preferential binding of human topoisomerase I to superhelical DNA. EMBO J. 14: 5399-5409.
241. Malkas, L. H., R. J. Hickey, C. Li, N. Pedersen, and E. F. Baril. 1990. A 21S enzyme complex from HeLa cells that functions in simian virus 40 DNA replicaon in vitro. Biochemistry 29: 6362-6374.
242. Manos, M. M. and Y. Gluzman. 1985. Genetic and biochemical analysis of transformation-competent, replication-defective simian virus 40 large T antigen mutants. J. Virol. 53: 120-127.
243. Manos, M. M. and Y. Gluzman. 1984. Simian virus 40 large T-antigen point mutants that are defective in viral DNA replication but competent in oncogenic transformation. Mol. Cell. Biol. 4: 1125-1133.
244. Margolskee, R. F. and D. Nathans. 1984. Simian virus 40 mutant T antigens with relaxed specificity for the nucleotide sequence at the viral DNA origin of replication. J. Virol. 49: 386-393.
245. Mastrangelo, I. A., M. Bezanilla, P. K. Hansma, P. V. C. Hough, and H. G. Hansma. 1994. Structures of large T-antigen at the origin of SV40 DNA replication by atomic force microscopy. Biophysical Journal 66: 293-298.
246. Mastrangelo, I. A., P. V. C. Hough, J. S. Wall, M. Dodson, F. B. Dean, and J. Hurwitz. 1989. ATP-dependent assembly of double hexamers of SV40 T antigen at the viral origin of DNA replication. Nature (London) 338: 658-662.
247. Mastrangelo, I. A., P. V. C. Hough, V. G. Wilson, J. S. Wall, J. F. Hainfield, and P. Tegtmeyer. 1985. Monomers through trimers of large tumor antigen bind in region I and monomers through tetramers bind in region II of simian virus 40 origin of replication DNA as stable structures in solution. Proc. Natl. Acad. Sci. U.S.A. 82: 3626-3630.
248. Matson, S. W. and K. A. Kaiser-Rogers. 1990. DNA helicases. Annu. Rev. Biochem. 59: 289-329.
249. Matsumoto, T., T. Eki, and J. Hurwitz. 1990. Studies on the initiation and elongation reactions in the simian virus 40 DNA plication system. Proc. Natl. Acad. Sci. U.S.A. 87: 9712-9716.
250. Maulbecker, C., I. Mohr, Y. Gluzman, J. Bartholomew, and M. Botchan. 1992. A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: new complementation function of T antigen. J. Virol. 66: 2195-2207.
251. McVey, D., L. Brizuela, I. Mohr, D. R. Marshak, Y. Gluzman, and D. Beach. 1989. Phosphorylation of large tumor antigen by cdc2 stimulates SV40 DNA replication. Nature (London) 341: 503-507.
252. McVey, D., S. Ray, Y. Gluzman, L. Berger, A. G. Wildeman, D. R. Marshak, and P. Tegtmeyer. 1993. cdc2 phosphorylation of threonine 124 activates the origin-unwinding functions of simian virus 40 T antigen. J. Virol. 67: 5206-5215.
253. McVey, D., M. Strauss, and Y. Gluzman. 1989. Properties of the DNA-binding domain of the simian virus 40 large T antigen. Mol. Cell. Biol. 9: 5525-5536.
254. McVey, D., B. Woelker, and P. Tegtmeyer. 1996. Mechanisms of Simian virus 40 T-antigen activation by phosphorylation of threonine 124. J. Virol. 70: 3887-3893.
255. Melendy, T. and B. Stillman. 1993. An interaction between replication protein A and SV40 T antigen appears essential for primosome assembly during SV40 DNA replication. J. Biol. Chem. 268: 3389-3395.
256. Melendy, T. and B. Stillman. 1991. Purification of DNA polymerase δ as an essential simian virus 40 DNA replication factor. J. Biol. Chem. 266: 1942-1949.
257. Melendy, T. and B. Stillman. 1992. SV40 DNA Replication, p. 129-158. In: F. Eckstein and D. M. J. Lilley, Ed., Nucleic Acids and Molecular Biology, vol. 6. Springer-Verlag, Berlin.
258. Mitchell, P. J., C. Wang, and R. Tjian. 1987. Positive and Negative Regulation of Transcription In Vitro: Enhancer-Binding Protein AP-2 Is Inhibited by SV40 T Antigen. Cell 50: 847-861.
259. Miyachi, K., M. J. Fritzier, and E. M. Tan. 1978. Autoantibody to a nuclear antigen in proliferating cells. J. Immunol. 12: 2228-2234.
260. Moarefi, I. F., D. Small, I. Gilbert, M. Hopfner, S. K. Randall, C. Schneider, A. A. R. Russo, U. Ramsperger, A. K. Arthur, H. Stahl, T. J. Kelly, and E. Fanning. 1993. Mutation of the cyclin-dependent kinase phosphorylation site in simian virus 40 (SV40) large T antigen specifically blocks SV40 origin DNA unwinding. Mol Cell. Biol. 67: 4992-5002.
261. Mohr, I. J., M. P. Fairman, B. Stillman, and Y. Gluzman. 1989. Large T-antigen mutants define multiple steps in the initiation of simian virus 40 DNA replication. J. Virol. 63: 4181-4188.
262. Mohr, I. J., B. Stillman, and Y. Gluzman. 1987. Regulation of SV40 DNA replication by phosphorylation of T antigen. EMBO Journal 6: 153-160.
263. Mole, S. E., J. V. Gannon, M. J. Ford, and D. P. Lane. 1987. Structure and function of SV40 large-T antigen. Phil. Trans. R. Soc. Lond. B. 317: 455-469.
264. Montenarh, M. and D. Muller. 1987. The phosphorylation at Thr 124 of simian virus 40 large T antigen is crucial for its oligomerization. FEBS Letters 221: 199-204.
265. Montenarh, M., C. Vesco, G. Kemmerling, D. Müller, and R. Henning. 1986. Regions of SV40 large T antigen necessary for oligomerization and complex formation with the cellular oncoprotein p53. J. Virol. 204: 51-55.
266. Moran, E. 1988. A region of SV40 large T antigen can substitute for a transforming domain of the adenovirus E1A products. Nature 334: 168-170.
267. Morera, S., M.-L. Lacombe, X. Yingwu, G. LeBras, and J. Janin. 1995. X-ray structure of human nucleoside diphosphate kinase B complexed with GDP at 2 A resolution. Structure 3: 1307-1314.
268. Morera, S., G. LeBras, I. Lascu, M. L. Lacombe, M. Veron, and J. Janin. 1994. Refined X-ray structure of Dictyostelium discoideum nucleoside diphosphate kinase at 1.8 A resolution. J. Mol. Biol. 243: 873-890.
269. Moréra, S., G. LeBras, I. Lascu, M. L. Lacombe, M. Véron, and J. Janin. 1994. Refined X-ray Structure of Dictyostelium discoideum Nucleoside Diphosphate Kinase at 1.8 Å resolution. J. Mol Biol. 243: 873-890.
270. Morrison, A., H. Araki, A. B. Clark, R. K. Hamatake, and A. Sugino. 1990. A third essential DNA polymerase in S. cerevisiae. Cell 62: 1143-1151.
271. Mueller, C., A. Graessmann, and M. Graessmann. 1978. Mapping of Early SV40-Specific Functions by Microinjection of Different Early Viral DNA Fragments. Cell 15: 579-585.
272. Murakami, Y., T. Eki, and J. Hurwitz 1992. Studies on the initiation of simian virus 40 replication in vitro: RNA primer synthesis and its elongation. Proc. Natl. Acad. Sci. U.S.A. 89: 952-956.
273. Murakami, Y., T. Eki, M. Yamada, C. Prives, and J. Hurwitz. 1986. Species-specific in vitro synthesis of DNA containing the polyoma virus origin of replication. Proc. Natl. Acad. Sci U.S.A. 83: 6347-6351.
274. Murakami, Y. and J. Hurwitz. 1993. DNA polymerase a stimulates the ATP-dependent binding of simian virus tumor T antigen to the SV40 origin of replication. J. Biol. Chem. 268: 11018-11027.
275. Murakami, Y. and J. Hurwitz. 1993. Functional interactions between SV40 T antigen and other replication proteins at e replication fork. J. Biol. Chem. 268: 11008-11017.
276. Murakami, Y., C. R. Wobbe, L. Weiassbach, F. B. Dean, and J. Hurwitz. 1986. Role of DNA polymerase a and DNA primase in simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 83: 2869-2873.
277. Murphy, C. I, B. Weiner, I. Bikel, H. Piwnica-Worms, M. K. Bradley, and D. M. Livingston. 1988. Purification and Functional Properties of Simian Virus 40 Large and Small T Antigens Overproduced in Insect Cells. J. Virol. 62: 2951-2959.
278. Myers, R. M., D. C. Rio, A. K. Robbins, and R. Tjian. 1981. SV40 gene expression is modulated by the cooperative binding of T antigen to DNA. Cell 25: 373-384.
279. Myers, R. M. and R. Tijan. 1980. Construction and analysis of simian virus 40 origins defective in tumor antigen binding and DNA replication. Proc. Natl. Acad. Sci U.S.A. 77: 6491-6495.
280. Myers, R. M., R. C. Williams, and R. Tjian. 1981. Oligomeric structure of a Simian Virus 40 T Antigen in free form and bound to DNA. J. Mol. Biol. 148: 347-353.
281. Naktinis, V., J. Turner, and M. O'Donnell. 1996. A molecular switch in a replication machine defined by an internal competition for protein rings. Cell 84: 137-145.
282. Nasheuer, H.-P., A. Moore, A. F. Wahl, and T. S.-F. Wang. 1991. Cell Cycle-dependent Phosphorylation of Human DNA Polymerase α. J. Biol. Chem. 266: 7893-7903.
283. Nethanel, T. and G. Kaufmann. 1990. Two DNA polymerases may be required for synthesis of the lagging DNA strand of simian virus 40. J. Virol. 64: 5912-5918.
284. Nethanel, T., S. Reisfeld, G. Dinter-Gottlieb, and G. Kaufmann. 1988. An Okazaki piece of simian virus 40 may be synthesized by ligation of shorter precursor chains. J. Virol. 62: 2867-2873.
285. Nethanel, T., T. Zlotkin, and G. Kaufmann. 1992. Assembly of Simian Virus 40 Okazaki pieces from DNA primers is reversibly arrested by ATP depletion. J. Virol. 66: 6634-6640.
286. O'Reilly, D. R. and L. K. Miller. 1988. Expression and complex formation of simian virus 40 large T antigen and mouse p53 in insect cells. J. Virol. 62: 3109-3119.
287. Ollis, D. L., P. Brick, R. Hamlin, N. G. Xuong, and T. A. Steitz. 1985. Structure of a large fragment of Escherichia coli DNA polymerase I complexed with dTMP. Nature 313: 762-766.
288. Oren, M., E. Winocour, and C. Prives. 1980. Differential affinities of simian virus 40 large tumor antigen for DNA. Proc. Natl. Acad. Sci. U.S.A. 77: 220-224.
289. Orengo, C. A., D. T. Jones, and J. M. Thornton. 1994. Protein superfamilies and domain superfolds. Nature 372: 631-634.
290. Outbridge, C., N. Ito, P. R. Evans, C. H. Teo, and K. Nagai. 1994. Crystal structure at 1.92 Å resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin. Nature 372: 432-438.
291. Parsons, R., M. E. Anderson, and P. Tegtmeyer. 1990. Three domains in the simian virus 40 core origin orchestrate the binding, melting, and DNA helicase activities of T-antigen. J. Virol. 64: 509-518.
292. Parsons, R. and P. Tegtmeyer. 1992. Spacing is crucial for coordination of domain functions within the simian virus 40 core origin of replication. J. Virol. 66: 1933-1942.
293. Parsons, R. E., J. E. Stenger, S. Ray, R. Welker, M. E. Anderson, and P. Tegtmeyer. 1991. Cooperative assembly of simian virus 40 T-antigen hexamers on functional halves of the replication origin. J. Virol. 65: 2798-2806.
294. Paucha, E., D. Kalderon, R. W. Harvey, and A. E. Smith. 1986. Simian virus 40 origin DNA-binding domain on large T antigen. J. Virol. 57: 50-64.
295. Peden, K. W. C. and J. M. Pipas. 1985. Site-directed mutagenesis of the simian virus 40 large T-antigen gene: replication-defective amino acid substitution mutants that retain the ability to induce morphological transformation. J. Virol. 55: 1-9.
296. Peden, K. W. C., A. Srinivasan, J. M. Farber, and J. M. Pipas. 1989. Mutants with Changes Within or Near a Hydrophobic Region of Simian Virus 40 Large Tumor Antigen Are Defective for Binding Cellular Protein p53. Virology 168: 13-21.
297. Pellecchia, M., T. Szyperski, D. Wall, C. Georgopoulos, and K. Wüthrich. 1996. NMR Structure of the J-domain and the Gly/Phe-rich Region of the Escherichia coli DnaJ Chaperone. J. Mol. Biol. 260: 236-250.
298. Pipas, J. M. 1992. Common and Unique Features of T Antigens Encoded by the Polyomavirus Group. J. Virol. 66: 3979-3985.
299. Pipas, J. M. 1985. Mutations Near the Carboxyl Terminus of the Simian Virus 40 Large Tumor Antigen Alter Viral Host Range. J. Virol. 54: 569-575.
300. Pipas, J. M., K. W. C. Peden, and D. Nathans. 1983. Mutational analysis of simian virus 40 T antigen: isolation and characterization of mutants with deletions in the T-antigen gene. Mol. Cell. Biol. 3: 203-213.
301. Podust, L. M., V. N. Podust, J. M. Sogo, and U. Hübscher. 1995. Mammalian DNA Polymerase Auxiliary Proteins: Analysis of Replication Factor C-Catalyzed Proliferating Cell Nuclear Antigen Loading onto Circular Double-Stranded DNA. Mol. Cell. Biol. 15: 3072-3081.
302. Podust, V. N. and U. Hubscher. 1993. Lagging strand DNA synthesis by calf thymus DNA polymerase α, β, δand ε in the presence of auxiliary proteins. Nucleic Acids Research 21: 841-846.
303. Polvino-Bodnar, M. and C. N. Cole. 1982. Construction and characterization of viable deletion mutants of simian virus 40 lacking sequences near the 3′; end of the early region. J. Virol. 43: 489-502.
304. Porras, A., J. Bennett, A. Howe, K. Tokos, N. Bouck, B. Henglein, S. Sathyamangalam, B. Thimmapaya, and K. Rundell. 1996. A Novel Simian Virus 40 Early-Region Domain Mediates Transactivation of the Cyclin A Promoter by Small-t Antigen and Is Required for Transformation in Small-t Antigen-Dependent Assays. J. Virol. 70: 6902-6908.
305. Prelich, G., M. Kostura, D. R. Marshak, M. B. Mathews, and B. Stillman. 1987. The cell-cycle regulated proliferating cell nuclear antigen is required for SV40 DNA replication in vitro. Nature (London) 326: 471-475.
306. Prelich, G. and B. Stillman. 1988. Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA. Cell 53: 117-126.
307. Prelich, G., C. K. Tan, M. Kostura, M. B. Mathews, A. G. So, K. M. Downey, and B. Stillman. 1987. Functional identity of proliferating cell nuclear antigen and a DNA polymerase 6 auxiliary protein. Nature 326: 517-520.
308. Prives, C. 1990. The replication functions of SV40 T antigen are regulated by phosphorylation. Cell 61: 735-738.
309. Prives, C., L. Covey, A. Scheller, and Y. Gluzman. 1983. DNA-binding properties of simian virus 40 T-antigen mutants defective in viral DNA replication. Mol. Cell. Biol 3: 1958-1966.
310. Qian, Y. Q., D. Patel, F.-U. Hartl, and D. J. McColl. 1996. Nuclear Magnetic Resonance Solution Structure of the Human Hsp40 (HDJ-1) J-domain. J. Mol. Biol. 260: 224-235.
311. Rajan, P., S. Swaminathan, J. Zhu, C. N. Cole, G. Barber, M. J. Tevethia, and B. Thimmapaya. 1995. A Novel Translational Regulation Function for the Simian Virus 40 Large-T Antigen Gene. J. Virol. 69: 785-795.
312. Ramsperger, U. and H. Stahl. 1995. Unwinding of chromatin by the SV40 large T antigen DNA helicase. EMBO J. 14: 3215-3225.
313. Ray, S., M. E. Anderson, G. Loeber, D. McVey, and P. Tegtmeyer. 1992. Functional characterization of temperature-sensitive mutants of simian virus 40 large T antigen. J. Virol. 66: 6509-6516.
314. Reed, S. I., J. Ferguson, R. W. Davis, and G. R. Stark. 1975. T antigen binds to SV40 at the origin of DNA replication. Proc. Natl. Acad. Sci. U.S.A. 72: 1605-1609.
315. Reynisdottir, L, H. E. Lorimer, P. N. Friedman, E. H. Wang, and C. Prives. 1993. Phosphorylation and active ATP hydrolysis are not required for SV40 T antigen hexamer formation. J. Biol. Chem. 268: 24647-24654.
316. Reynisdottir, I., D. R. O'Reilly, L. K. Miller, and C. Prives. 1990. Thermally inactive simian virus 40 tsA58 mutant T antigen cannot initiate viral DNA replication in vitro. J. Virol. 64: 6234-6245.
317. Rigby, P. W. J. and D. P. Lane. 1983. Structure and function of Simian Virus 40 Large T-Antigen. Advances in Viral Oncology 3: 31-57.
318. Rio, D., A. Robbins, R. Myers, and R. Tjian. 1980. Regulation of simian virus 40 early transcription in vitro by a purified tumor antigen. Proc. Natl. Acad. Sci. U.S.A. 77: 5706-5710.
319. Roberts, J. 1989. Simian virus 40 (SV40) large tumor antigen causes stepwise changes in SV40 origin structure during initiation of DNA replication. Proc. Natl. Acad. Sci. U.S.A. 86: 3939-3943.
320. Roberts, J. D., D. C. Thomas, and T. A. Kunkel. 1991. Exonucleolytic proofreading of leading and lagging strand DNA replication errors. Proc. Natl. Acad. Sci. U.S.A. 88: 3465-3469.
321. Roberts, J. M. and G. D'Urso. 1988. An origin unwinding activity regulates initiation of DNA replication during mammalian cell cycle. Science 241: 1486-1489.
322. Roberts, J. M. and G. D'Urso. 1989. Cellular and viral control of the initiation of DNA replication. J. Cell Sci. Suppl. 12: 171-182.
323. Rowley, A., S. J. Dowell, and J. F. X. Diffley. 1994. Recent developments in the initiation of chromosomal DNA replication: a complex picture emerges. Biochimica et Biophysica Acta 1217: 239-256.
324. Runzler, R., S. Thompson, and E. Fanning. 1987. Oligomerization and Origin DNA-Binding Activity of Simian Virus 40 Large T Antigen. J. Virol. 61: 2076-2083.
325. Ryder, K., E. Vakalopoulou, R. Mertz, I. Mastrangelo, P. Hough, P. Tegtmeyer, and E. Fanning. 1985. Seventeen base pairs of region I encode a novel tripartite binding signal for SV40 T antigen. Cell 42: 539-548.
326. Salas, M., J. T. Miller, J. Leis, and M. L. DePamphilis. 1996. Mechanisms for priming DNA synthesis, p. 131-176. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
327. San Martin, M. C., C. Gruss, and J. M. Carazo. 1997. Six Molecules of SV40 Large T Antigen Assemble in a Propeller-shaped Particle Around a Channel. J. Mol. Biol. 268: 15-20.
328. Santocanale, C., M. Foiani, G. Lucchini, and P. Plevani. 1993. The Isolated 48,000-Dalton Subunit of Yeast DNA Primase Is Sufficient for RNA Primer Synthesis. J. Biol. Chem. 268: 1343-1348.
329. Sawai, E. T. and J. S. Butel. 1989. Association of a Cellular Heat Shock Protein with Simian Virus 40 Large T Antigen in Transformed Cells. J. Virol. 63: 3961-3973.
330. Scheffner, M., R. Wessel, and H. Stahl. 1989. Sequence independent duplex DNA opening reaction catalyzed by SV40 large T antigen. Nucleic Acids Res. 17: 93-106.
331. Scheidtmann, K., B. Echle, and G. Walter. 1982. Simian virus 40 large T antigen is phosphorylated at multiple sites clustered in two separate regions. J. Virol. 44: 116-133.
332. Scheidtmann, K. H., M. Buck, J. Schneider, D. Kalderon, E. Fanning, and A. E. Smith. 1991. Biochemical characterization of phosphorylation site mutants of simian virus 40 large T antigen: Evidence for interactions between amino-and carboxy-terminal domains. J. Virol. 65: 1479-1490.
333. Scheidtmann, K. H., M. Hardung, B. Echle, and G. Walter. 1984. DNA-binding activity of simian virus 40 large T antigen correlates with a distinct phosphorylation state. J. Virol. 50: 1-12.
334. Schmieg, F. I. and D. T. Simmons. 1988. Characterization of the in vitro interaction between SV40 T antigen and p53: mapping the p53 binding site. Virology 164: 132-140.
335. Schneffer, M., R. Knippers, and H. Stahl. 1989. RNA unwinding activity of SV40 large T antigen. Cell 57: 955-963.
336. Schneider, C., K. Weibhart, L. A. Guarino, I. Dornreiter, and E. Fanning. 1994. Species-specific functional interactions of DNA polymerase a-primase with simian virus 40 (SV40) T-antigen require SV40 origin DNA. J. Mol. Biol 14: 3176-3185.
337. Schneider, J. and E. Fanning. 1988. Mutations in the phosphorylation sites of simian virus 40 (SV40) T antigen alter its origin DNA-binding specificity for sites I or II and affect SV40 DNA replication activity. J. Virol. 62: 1598-1605.
338. Schwyzer, M., R. Weil, G. Frank, and H. Zuber. 1980. Amino acid sequence analysis of fragments generated by partial proteolysis from large simian virus 40 tumor antigen. J. Biol. Chem. 255: 5627-5634.
339. Seif, R. 1982. New Properties of Simian Virus 40 Large T Antigen. Mol. Cell. Biol. 2: 1463-1471.
340. SenGupta, D. J. and J. A. Borowiec. 1994. Strand and face: the topography of interactions between the SV40 origin of replication and T-antigen during the initiation of replication. EMBO Journal 13: 982-992.
341. SenGupta, D. J. and J. A. Borowiec. 1992. Strand-specific recognition of a synthetic DNA replication fork by the SV40 large tumor antigen. Science 256: 1656-1661.
342. Seto, E. and T. S. B. Yen. 1991. Mutual Functional Antagonism of the Simian Virus 40 T Antigen and the Hepatitis B Virus trans Activator. J. Virol. 65: 2351-2356.
343. Shalloway, D., T. Kleinberger, and D. M. Livingston. 1980. Mapping of SV40 DNA replication origin region binding sites for the SV40 T antigen by protection against exonuclease III digestion. Cell 20: 411-422.
344. Sheaff, R. J. and R. D. Kuchta. 1993. Mechanism of Calf Thymus DNA Primase: Slow Initiation, Rapid Polymerization, and Intelligent Termination. Biochemistry 32: 3027-3037.
345. Sheng, Q., D. Denis, M. Ratnofsky, T. M. Roberts, J. A. DeCaprio, and B. Schaffhausen. 1997. The Dna J Domain of Polyoma Large T Is Required to Regulate Rb Family Tumor Suppressor Function. J. Virol. in press.
346. Shortle, D. and D. Nathans. 1979. Regulatory mutants of simian virus 40: constructed mutants with base substitutions at the origin of DNA replication. J. Mol. Biol. 131: 801-817.
347. Shortle, D. R., R. F. Margolskee, and D. Nathans. 1979. Mutational analysis of the simian virus 40 replicon: pseudorevertants of mutants with a defective replication origin. Proc. Natl. Acad. Sci. U.S.A. 76: 6128-6131.
348. Simanis, V. and D. P. Lane. 1985. An immunoaffinity purification procedure for SV40 large T antigen. Virology 144: 88-100.
349. Simmons, D. T. 1986. DNA-binding region of the simian virus 40 tumor antigen. J. Virol. 57: 776-785.
350. Simmons, D. T. 1988. Geometry of the simian virus 40 large tumor antigen-DNA complex as probed by protcase digestion. Proc. Natl. Acad. Sci. U.S.A. 85: 2086-2090.
351. Simmons, D. T., G. Loeber, and P. Tegtmeyer. 1990. Four major sequence elements of simian virus 40 large T-antigen coordinate its specific and nonspecific DNA binding. J. Virol. 64: 1973-1983.
352. Simmons, D. T., T. Melendy, D. Usher, and B. Stillman. 1996. Simian Virus 40 large T antigen binds to Topoisomerase I. Virology 222: 365-374.
353. Simmons, D. T., R. Upson, K. WunKim, and W. Young. 1993. Biochemical analysis of mutants with changes in the origin-binding domain of simian virus 40 tumor antigen. J. Virol. 67: 4227-4236.
354. Simmons, D. T., K. Wun-Kim, and W. Young. 1990. Identification of simian virus 40 T-antigen residues important for specific and nonspecific binding to DNA and for helicase activity. J. Virol. 64:4858-4865.
355. Smale, S. T. and R. Tjian. 1986. T-Antigen-DNA Polymerase a Complex Implicated in Simian Virus 40 DNA Replication. Mol. Cell. Biol. 6: 4077-4087.
356. Small, J. A., G. Khoury, G. Jay, P. M. Howley, and G. A. Scangos. 1986. Early regions of JC virus and BK virus induce distinct and tissue-specific tumors in transgenic mice. Proc. Natl. Acad. Sci. U.S.A. 83: 8288-8292.
357. Smith, S. and B. Stillman. 1989. Purification and characterization of CAF-1, a human cell factor required for chromatin assembly during DNA replication in vitro. Cell 58: 15-25.
358. So, A. G. and K. M. Downey. 1988. Mammalian DNA polymerases a and δ: current status in DNA replication. Biochemistry 27: 4591-4595.
359. Sompayrac, L. and K. J. Danna. 1994. An Amino-Terminal Fragment of SV40 T Antigen Induces Cellular DNA Synthesis in Quiescent Rat Cells. Virology 200: 849-853.
360. Soprano, K. J., N. Galanti, G. J. Jonak, S. McKercher, J. M. Pipas, K. W. C. Peden, and R. Baserga. 1983. Mutational analysis of simian virus 40 T-antigen: stimulation of cellular DNA synthesis and activation of rRNA genes by mutants with deletions in the T-antigen gene. Mol. Cell. Biol. 3: 214-219.
361. Spillman, T., D. Giacherio, and L. P. Hager. 1979. Single strand DNA binding of simian virus 40 tumor antigen. J. Biol. Chem. 254: 3100-3104.
362. Srinivasan, A., A. J. McClellan, J. Vartikar, I. Marks, P. Cantalupo, Y. Li, P. Whyte, K. Rundell, J. L. Brodsky, and J. M. Pipas. 1997. The Amino-Terminal Transforming Region of Simian Virus 40 Large T and Small t Antigens Functions as a J Domain. Mol Cell. Biol 17: 4761-4773.
363. Srinivasan, A., K. W. C. Peden, and J. M. Pipas. 1989. The large tumor antigen of simian virus 40 encodes at least two distinct transforming functions. J. Virol. 63: 5459-5463.
364. Stacy, T., M. Chamberlain, and C. N. Cole. 1989. Simian Virus 40 Host Range/ Helper Function Mutations Cause Multiple Defects in Viral Late Gene Expression. J. Virol. 63: 5208-5215.
365. Stadlbauer, F., C. Voitenleitner, A. Brückner, E. Fanning, and H.-P. Nasheuer. 1996. Species-Specific Replication of Simian Virus 40 DNA In Vitro Requires the p180 Subunit of Human DNA Polymerase α-Primase. Mol. Cell. Biol. 16: 94-104.
366. Stahl, H., P. Droge, and R. Knippers. 1986. DNA helicase activity of SV40 large tumor antigen. EMBO J. 5: 1939-1944.
367. Stahl, H., P. Droge, H. Zentgraf, and R. Knippers. 1985. A large-tumor-antigen-specific monoclonal antibody inhibits DNA replication of simian virus 40 minichromosomes in an in vitro elongation system. J. Virol. 54: 473-482.
368. Stahl, H. and R. Knippers. 1987. The simian virus 40 large tumor antigen. Biochimica et Biophysica Acta 910: 1-10.
369. Stewart, A. R., J. A. Lednicky, U. S. Benzick, M. J. Tevethia, and J. S. Butel. 1996. Identification of a Variable Region at the Carboxy Terminus of SV40 Large T-antigen. Virology 221: 355-361.
370. Stillman, B. 1996. Cell cycle control of DNA replication. Science 274:1659-1664.
371. Stillman, B. 1986. Chromatin assembly during SV40 DNA replication in vitro. Cell 45: 555-565.
372. Stillman, B. 1996. Comparison of DNA Replication in Cells from Prokarya and Eukarya, p. 435-460. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
373. Stillman, B. 1994. Initiation of chromosomal DNA replication in eukaryotes. Lessons from Lambda. J. Biol. Chem. 269: 7047-7050.
374. Stillman, B. 1994. Smart Machines at the DNA Replication Fork. Cell 78: 725-728.
375. Stillman, B., R. D. Gerard, R. A. Guggenheimer, and Y. Gluzman. 1985. T antigen and template requirement for SV40 DNA replication in vitro. EMBO J. 4: 2933-2939.
376. Stillman, B. W. 1989. Initiation of eukaryotic DNA replication in vitro. Annu. Rev. Cell Biol. 5: 197-245.
377. Stillman, B. W. and Y. Gluzman. 1985. Replication and supercoiling of simian virus 40 DNA in cell extracts from human cells. Mol. Cell. Biol. 5: 2051-2060.
378. Stillman, G. W., J. F. X. Diffley, G. Prelich, and R. A. Guggenheimer. 1986. DNA-protein interactions at the replication origins of adenovirus and SV40. Cancer Cells 4: 453-463.
379. Story, R. M., I. T. Weber, and T. A. Steitz. 1992. The structure of the E. coli recA protein monomer and polymer. Nature 355: 318-325.
380. Strauss, M., P. Argani, I. J. Mohr, and Y. Gluzman. 1987. Studies on the origin-specific DNA-binding of simian virus 40 large T antigen. J. Virol. 61: 3326-3330.
381. Stringer, J. R. 1982. Mutant of simian virus 40 large T-antigen that is defective for viral DNA synthesis, but competent for transformation of cultured rat cells. J. Virol. 42: 854-864.
382. Subramanya, H. S., L. E. Bird, J. A. Brannigan, and D. B. Wigley. 1996. Crystal structure of a DExx box DNA helicase. Nature 384: 379-383.
383. Korolev, S., J. Hsieh, G. H. Gauss, T. M. Lohman, and G. Waksman. 1997. Major Domain Swiveling Revealed by the Crystal Structures of Complexes of E coli Rep. Helicase Bound to Single-Stranded DNA and ADP (1997). Cell 90: 635-647.
384. Szyperski, T., M. Pellecchia, D. Wall, C. Georgopoulos, and K. Wüthrich. 1994. NMR structure determination of the Escherichia coli DNA J molecular chaper-one: Secondary structure and backbone fold of the N-terminal region (residues 2-108) containing the highly conserved J domain. Proc. Natl. Acad. Sci. U.S.A. 91: 11343-11347.
385. Tack, L. C., C. A. Cartwright, J. H. Wright, W. Eckhart, K. W. C. Peden, A. Srinivasan, and J. M. Pipas. 1989. Properties of a Simian Virus 40 Mutant T-Antigen Substituted in the Hydrophobic Region: Defective ATPase and Oligomerization Activities and Altered Phosphorylation Accompany an Inability To Complex with Cellular p53. J. Virol. 63: 3362-3367.
386. Tack, L. C., J. H. Wright, S. P. Deb, and P. Tegtmeyer. 1989. The p53 Complex from Monkey Cells Modulates the Biochemical Activities of Simian Virus 40 Large T Antigen. J. Virol. 63: 1310-1317.
387. Takasaki, Y., D. Fishwild, and E. M. Tan. 1984. Characterization of proliferating cell nuclear antigen recognized by autoantibodies in lupus sera. J. Exp. Med. 159: 981-992.
388. Tan, C.-K., C. Castillo, A. G. So, and K. M. Downey. 1986. An auxiliary protein for DNA polymerase-from fetal calf thymus. J. Biol. Chem. 261: 12310-12316.
389. Tegtmeyer, P. 1972. Simian virus 40 deoxyribonucleic acid synthesis: the viral replicon. J. Virol. 10: 591-598.
390. Tegtmeyer, P., B. A. Lewton, A. L. DeLucia, V. G. Wilson, and K. Ryder. 1983. Topography of simian virus 40 A protein-DNA complexes: Arrangement of protein bound to the origin of replication. J. Virol. 46: 151-161.
391. Tegtmeyer, P., M. Schwartz, J. K. Collins, and K. Rundell. 1975. Regulation of tumor antigen synthesis by simian virus 40 gene A. J. Virol. 16: 168-178.
392. Thomas, D. C., J. D. Roberts, R. D. Sabatino, T. W. Myers, C.-K. Tan, K. M. Downey, A. G. So, R. A. Bambara, and T. A. Kunkel. 1991. Fidelity of mammalian DNA replication and replicative DNA polymerases. Biochemistry 30: 11751-11759.
393. Thompson, H. C., R. J. Sheaff, and R. D. Kuchta. 1995. Interactions of calf thymus DNA polymerase a with primer/templates. Nucleic Acids Res. 23: 4109-4115.
394. Tjian, R. 1978. The binding site on SV40 DNA for α T-antigen related protein. Cell 13: 165-179.
395. Tjian, R. 1978. Protein-DNA interactions at the origin of simian virus 40 DNA replication. Cold Spring Harbor Symp. Quant. Biol. 43: 655-662.
396. Tjian, R., A. Robbins, and R. Clark. 1979. Catalytic properties of the SV40 tumor antigen. Cold Spring Harbor Symp. Quant. Biol. 44: 103-111.
397. Tooze, J. 1981. DMA Tumor Viruses. 2nd ed. Cold Spring Harbor Laboratory, Cold Spring Harbor, N. Y.
398. Tornow, J. and C. N. Cole. 1983. Intracistronic complementation in the simian virus 40 A gene. Proc. Natl. Acad. Sci. U.S.A. 80: 6312-6316.
399. Tseng, B. Y. and C. N. Ahlem. 1984. Mouse primase initiation sites in the origin region of simian virus 40. Proc. Natl. Acad. Sci. U.S.A. 81: 2342-2346.
400. Tsurimoto, T., M. P. Fairman, and B. Stillman. 1989. Simian virus 40 DNA replication in vitro: identification of multiple stages of initiation. Mol. Cell. Biol. 9: 3839-3849.
401. Tsurimoto, T., T. Melendy, and B. Stillman. 1990. Sequential initiation of lagging and leading strand synthesis by two different polymerases complexes at the SV40 DNA replication origin. Nature (London) 346: 534-539.
402. Tsurimoto, T. and B. Stillman. 1990. Functions of replication factor C and proliferating-cell nuclear antigen: Functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4. Proc. Natl. Acad. Sci. U.S.A. 87: 1023-1027.
403. Tsurimoto, T. and B. Stillman. 1989. Multiple replication factors augment DNA synthesis by the two eukaryotic DNA polymerases. EMBO J. 8: 3883-3889.
404. Tsurimoto, T. and B. Stillman. 1989. Purification of a cellular replication factor, RF-C, that is required for coordinated synthesis of leading and lagging strands during simian virus 40 DNA replication in vitro. Mol. Cell. Biol. 9: 609-619.
405. Tsurimoto, T. and B. Stillman. 1991. Replication Factors Required for SV40 DNA Replication in vitro. J. Biol. Chem. 266: 1950-1960.
406. Tsurimoto, T. and B. Stillman. 1991. Replication factors required for SV40 DNA replication in vitro. J. Biol. Chem. 266: 1961-1968.
407. Turchi, J. J., L. Huang, R. S. Murante, Y. Kim, and R. A. Bambara. 1994. Enzymatic completion of mammalian lagging-strand DNA replication. Proc. Natl. Acad. Sci. U.S.A. 91: 9803-9807.
408. Uhlmann, F., E. Gibbs, J. Cai, M. O'Donnell, and J. Hurwitz. 1997. Identification of Regions within the Four Small Subunits of Human Repiation Factor C Required for Complex Formation and DNA Replication. J. Biol. Chem. 272: 10065-10071.
409. Umbricht, C. B., L. F. Erdile, E. W. Jabs, and T. J. Kelly. 1993. Cloning, Over-expression, and Genomic Mapping of the 14-kDa Subunit of Human Replication Protein A. J. Biol. Chem. 268:6131-6138.
410. Van Roy, F., L. Fransen, and W. Fiers. 1983. Improved localization of phosphorylation sites in simian virus 40 large T-antigen. J. Virol. 45: 442-446.
411. Virshup, D. M., M. G. Kaufman, and T. J. Kelly. 1989. Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A. EMBO J. 8: 3891-3898.
412. Virshup, D. M. and T. J. Kelly. 1989. Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 86: 3584-3588.
413. Virshup, D. M., A. A. R. Russo, and T. J. Kelly. 1992. Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A. Mol. Cell. Biol. 12: 4883-4895.
414. Voitenleitner, C., E. Fanning, and H. P. Nasheuer. 1997. Phosphorylation of DNA polymerase α-primase by cyclin A-dependent kinases regulates initiation of DNA replication in vitro. Oncogene. 14: 1611-1615.
415. von Der Weth, A. and W. Deppert. 1993. Wild-Type p53 Is Not a Negative Regulator of Simian Virus 40 DNA Replication in Infected Monkey Cells. J. Virol. 67: 886-893.
416. Wachter, M., G. Riedle, and R. Henning. 1985. Functional Implications of Oligomerization of Simian Virus 40 Large T-Antigen during Lytic Virus Infection. J. Virol. 56: 520-526.
417. Waga, S., G. Bauer, and B. Stillman. 1994. Reconstitution of complete SV40 DNA replication with purified replication factors. J. Biol. Chem. 269: 10923-10934.
418. Waga, S., G. J. Hannon, D. Beach, and B. Stillman. 1994. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA. Nature (London) 369: 574-578.
419. Waga, S. and B. Stillman. 1994. Anatomy of a DNA replication fork revealed by reconstitution of SV40 DNA replication in vitro. Nature (London) 369: 207-212.
420. Wang, E. H., P. N. Friedman, and C. Prives. 1989. The murine p53 protein blocks replication of SV40 DNA in vitro by inhibiting the initiation functions of SV40 large T antigen. Cell 57: 379-392.
421. Wang, E. H. and C. Prives. 1991. DNA Helicase and Duplex DNA Fragment Unwinding Activities of Polyoma and Simian Virus 40 Large T Antigen Display Similarities and Differences. J. Biol. Chem. 266: 12668-12675.
422. Wang, J. C. 1996. DNA Topoisomerases. Annu. Rev. Biochem. 65: 635-692.
423. Wang, T. S.-F. 1996. Cellular DNA Polymerases, p. 461-493. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
424. Wang, T. S.-F. 1991. Eukaryotic DNA polymerases. Annual Review of Biochemistry 60: 513-552.
425. Weinberg, D. H., K. L. Collins, P. Simancek, A. Russo, M. S. Wold, D. M. Virshup, and T. J. Kelly. 1990. Reconstitution of simian virus 40 DNA replication with purified proteins. Proc. Natl. Acad. Sci. U.S.A. 87: 8692-8696.
426. Weinberg, D. H. and T. J. Kelly. 1989. Requirement for two DNA polymerases in the replication of simian virus 40 DNA in vitro. Proc. Natl. Acad. Sci. U.S.A. 86: 9742-9746.
427. Weinberg, R. A. 1995. The Retinoblastoma Protein and Cell Cycle Control. Cell 81: 323-330.
428. Weisshart, K., M. K. Bradley, B. M. Weiner, C. Schneider, I. Moarefi, E. Fanning, and A. K. Arthur. 1996. An N-terminal deletion mutant of simian virus 40 (SV40) large T antigen oligomerizes incorrectly on SV40 DNA but retains the ability to bind to DNA polymerase a and replicate SV40 DNA in vitro. J. Virol. 70: 3509-3516.
429. Weisshart, K. and E. Fanning. 1996. Roles of Phosphorylation in DNA Replication, p. 295-330. In: M. L. DePamphilis, Ed., DNA Replication in Eukaryotic Cells. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
430. Wessel, R., J. Schweizer, and H. Stahl. 1992. Simian virus 40 T-antigen DNA helicase is a hexamer which forms a binary complex during bidirectional unwinding from the viral origin of DNA replication. J. Virol. 66: 804-815.
431. West, S. C. 1996. DNA Helicases: New Breeds of Translocating Motors and Molecular Pumps. Cell 86: 177-180.
432. Wiekowski, M., P. Droge, and R. Knippers. 1987. Monoclonal antibodies as probes for a function of large T antigen during the elongation process of simian virus 40 DNA replication. J. Virol. 61: 411-418.
433. Wiekowski, M., M. W. Schwarz, and H. Stahl. 1988. Simian virus 40 large T-antigen DNA helicase. J. Biol. Chem. 263: 436-442.
434. Wilson, V. G., M. J. Tevethia, B. A. Lewton, and P. Tegtmeyer. 1982. DNA binding properties of simian virus 40 temperature-sensitive A proteins. J. Virol. 44: 458-466.
435. Wobbe, C. R., F. Dean, L. Weissbach, and J. Hurwitz. 1985. In vitro replication of duplex circular DNA containing the simian virus 40 DNA origin site. Proc. Natl. Acad. Sci. U.S.A. 82: 5710-5714.
436. Wobbe, C. R., F. B. Dean, Y. Murakami, L. Weissbach, and J. Hurwitz. 1986. Simian virus 40 DNA replication in vitro : study of events preceding elongation of chains. Proc. Natl. Acad. Sci. U.S.A. 83: 4612-4616.
437. Wobbe, C. R., L. Weissbach, J. A. Borowiec, F. B. Dean, Y. Murakami, P. Bullock, and J. Hurwitz. 1987. Replication of simian virus 40 origin-containing DNA in vitro with purified proteins. Proc. Natl. Acad. Sci. U.S.A. 84: 1834-1838.
438. Wold, M. S. 1997. Replication protein A: A Heterotrimeric, single-stranded DNA-binding protein required for eukaryotic DNA metabolism. Annual Review of Biochemistry 66: 61-92.
439. Wold, M. S. and T. J. Kelly. 1988. Purification and characterization of replication protein A, a cellular protein required for in vitro replication of simian virus 40 DNA. Proc. Natl. Acad. Sci. U.S.A. 85: 2523-2527.
440. Wold, M. S., J. J. Li, and T. J. Kelly. 1987. Initiation of simian virus 40 DNA replication in vitro : Large-tumor-antigen-and origin-dependent unwinding of the template. Proc. Natl. Acad. Sci. U.S.A. 84: 3643-3647.
441. Wold, M. S., D. H. Weinberg, D. M. Virshup, J. J. Li, and T. J. Kelly. 1989. Identification of cellular proteins required for simian virus 40 DNA replication. J. Biol. Chem. 264: 2801-2809.
442. Wong, I. and T. M. Lohman. 1992. Allosteric effects of nucleotide cofactors on Escherichia coli Rep Helicase-DNA binding. Science 256: 350-355.
443. Wright, P. J., A. L. DeLucia, and P. Tegtmeyer. 1984. Sequence-specific binding of simian virus 40 A protein to nonorigin and cellular DNA. Mol. Cell. Biol. 4: 2631-2638.
444. Wun-Kim, K. and D. T. Simmons. 1990. Mapping of helicase and helicase substrate-binding domains on simian virus 40 large T antigen. J. Virol. 64: 2014-2020.
445. Wun-Kim, K., R. Upson, W. Young, T. Melendy, B. Stillman, and D. T. Simmons. 1993. The DNA-binding domain of simian virus 40 tumor antigen has multiple functions. J. Virol. 67: 7608-7611.
446. Xiong, Y., G. J. Hannon, H. Zhang, D. Casso, R. Kobayashi, and D. Beach. 1993. p21 is a universal inhibitor of cyclin kinases. Nature 366: 701-704.
447. Xue, Z., X. Shan, B. Lapeyre, and T. Melese. 1993. The amino terminus of mammalian nucleolin specifically recognizes SV40 T-antigen type nuclear localization sequences. European J, Cell Biology 62: 13-21.
448. Yamaguchi, M. and M. L. DePamphilis. 1986. DNA binding site for a factor(s) required to initiate simain virus 40 DNA replication. Proc. Natl. Acad. Sci. U.S.A. 83: 1646-1650.
449. Yamaguchi, M., E. A. Hendrickson, and M. L. DePamphilis. 1985. DNA Primase-DNA Polymerase a from Simian Cells: Modulation of RNA Primer synthesis by ribonucloeside triphosphates. J. Biol. Chem. 260: 6254-6263.
450. Yamaguchi, M., E. A. Hendrickson, and M. L. DePamphilis. 1985. DNA Primase-DNA Polymerase a from Simian Cells: Sequence Specificity of Initiation Sites on Simian Virus 40 DNA. Mol. Cell. Biol. 5: 1170-1183.
451. Yang, L., M. S. Wold, J. J. Li, T. J. Kelly, and L. F. Liu. 1987. Roles of DNA topisomerases in simian virus 40 DNA replication in vitro. Proc. Natl. Acad. Sci. U.S.A. 84: 950-954.
452. Yao, N., T. Hesson, M. Cable, Z. Hong, A. D. Kwong, H. V. Le, and P. C. Weber. 1997. Structure of the hepatitis C virus RNA helicase domain. Nature Structural Biology 4: 463-467.
453. Yao, N., J. Turner, Z. Kelman, P. A. Stukenberg, F. Dean, D. Shechter, Z.-Q. Pan, J. Hurwitz, and M. O'Donnell. 1996. Clamp loading, unloading and intrinsic stability of the PCNA, β and gp45 sliding clamps of human, E. coli and T4 replicases. Genes to Cells 1: 101-113.
454. Zalvide, J. and J. A. DeCaprio. 1995. Role of pRb-Related Proteins in Simian Virus 40 Large-T-Antigen-Mediated Transformation. Mol. Cell. Biol. 15: 5800-5810.
455. Zerrahn, J., U. Knippschild, T. Winkler, and W. Deppert. 1993. Independent expression of the transforming amino-terminal domain of SV40 large T antigen from an alternatively spliced third SV40 early mRNA. EMBO J. 12: 4739-4746.
456. Zhang, S.-J., X.-R. Zeng, P. Zhang, N. L. Toomey, R. Y. Chuang, L.-S. Chang, and M. Y. W. T. Lee. 1995. A Conserved Region in the Amino Terminus of DNA Polymerase δ Is Involved in Proliferating Cell Nuclear Antigen Binding. J. Biol. Chem. 270: 7988-7992.
457. Zhou, J. Q., H. He, C.-K. Tan, K. M. Downey, and A. G. So. 1997. The small subunit is required for functional interaction of DNA polymerase δ with the prolifcrating cell nuclear antigen. Nucleic Acids Res. 25: 1094-1099.
458. Zhu, J., P. W. Rice, M. Chamberlain, and C. N. Cole. 1991. Mapping the transcriptional transactivation function of simian virus 40 large T antigen. J. Virol. 65: 2778-2790.
459. Zlotkin, T., G. Kaufmann, Y. Jiang, M. Y. W. T. Lee, L. Uitto, J. Syvaoja, I. Dornreiter, E. Fanning, and T. Nethanel. 1996. DNA polymerase epsilon may be dispensable for SV40-but not cellular-DNA replication. EMBO J. 15: 2298-2305.