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1
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0030452309
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Late complications of immune deviation therapy in a nonhuman primate
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Genain CP, Abel K, Belmar N, Villinger F, Rosenberg DP, Linington C, Raine CS, Hauser SL: Late complications of immune deviation therapy in a nonhuman primate. Science 1996, 274:2054-2057. Although the onset of experimental allergic encephalomyelitis was demonstrated to be delayed by treatment with myelin oligondendrocite glycoprotein, treated animals subsequently developed a hyperacute form of the disease.
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Science
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Genain, C.P.1
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Linington, C.6
Raine, C.S.7
Hauser, S.L.8
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2
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0029807595
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Induction of autoimmune diabetes by oral administration of autoantigen
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Blanas E, Carbone FR, Allison J, Miller JFAP, Heath WR: Induction of autoimmune diabetes by oral administration of autoantigen. Science 1996, 274:1707-1709. In an animal model it was shown that the oral administration of autoantigenes could induce a cytotoxic T-lymphocyte response, which could lead to the onset of autoimmune diabetes.
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Science
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Blanas, E.1
Carbone, F.R.2
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Heath, W.R.5
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0029877801
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Intravenous immune globulin: Mechanisms of action and model disease states
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Thompson RA, Lachmann PJ, Winchester RJ, eds: Intravenous immune globulin: mechanisms of action and model disease states. Clin Exp Immunol 1996, 104(suppl 1):1-97. A supplemental volume summarizing the proceedings of a symposium on immunoglobulin therapy in a variety of autoimmune diseases.
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Clin Exp Immunol
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, pp. 1-97
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Thompson, R.A.1
Lachmann, P.J.2
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8544243725
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Immunoglobulins in autoimmunity: Fundamentals and clinical applications
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Kahaly GJ (ed): Immunoglobulins in autoimmunity: fundamentals and clinical applications. Clin Exp Rheumatol 1996, 14(suppl 15):S3-S119. A supplement volume summarizing the proceedings of a symposium on immunoglobulin therapy in a variety of autoimmune diseases.
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Clin Exp Rheumatol
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Kahaly, G.J.1
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5
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0029937656
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In vitro inhibition by intravenous immunoglobulin of human T cell-dependent B cell differentiation induced by staphylococcal superantigens
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Stohl W, Elliot JE: In vitro inhibition by intravenous immunoglobulin of human T cell-dependent B cell differentiation induced by staphylococcal superantigens. Clin Immunol Immunopathol 1996, 79:122-133.
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Clin Immunol Immunopathol
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Stohl, W.1
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Idiotype manipulation for autoimmune diseases: Where are we going?
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Zouali M, Isenberg DA, Morrow WJW: Idiotype manipulation for autoimmune diseases: where are we going? Autoimmunity 1996, 24:55-63. Links between idiotypes and certain autoimmune diseases are discussed, including the possibility that autoimmune diseases could be managed by modulation with antibodies or peptides targeted to these structures.
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Autoimmunity
, vol.24
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Zouali, M.1
Isenberg, D.A.2
Morrow, W.J.W.3
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7
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0029899152
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Pilot study of antithymocyte globulin in systemic sclerosis
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Matteson EL, Shbeeb MI, McCarthy TG, Calamia KT, Mertz LE, Goronzy JJ: Pilot study of antithymocyte globulin in systemic sclerosis. Arthritis Rheum 1996, 39:1132-1137.
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Arthritis Rheum
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Matteson, E.L.1
Shbeeb, M.I.2
McCarthy, T.G.3
Calamia, K.T.4
Mertz, L.E.5
Goronzy, J.J.6
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8
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0029984124
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Biologic agents in the treatment of inflammatory rheumatic diseases
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Kalden JR, Manger B: Biologic agents in the treatment of inflammatory rheumatic diseases. Curr Opin Rheumatol 1996, 8:195-200.
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Curr Opin Rheumatol
, vol.8
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Kalden, J.R.1
Manger, B.2
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9
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9344245755
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Vβ17 T cell receptor peptide vaccination in rheumatoid arthritis: Results of phase I dose escalation study
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Moreland LW, Heck LW Jr, Koopman WJ, Saway PA, Adamson TC, Fronek Z, O'Connor RD, Morgan EE, Diveley JP, Richieri SP, et al.: Vβ17 T cell receptor peptide vaccination in rheumatoid arthritis: results of phase I dose escalation study. J Rheumatol 1996, 23:1353-1362. First report of a phase I open-vaccination trial using Vβ17 T-cell receptor peptides. Data on lymphocyte and clinical responses are presented.
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J Rheumatol
, vol.23
, pp. 1353-1362
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Moreland, L.W.1
Heck Jr., L.W.2
Koopman, W.J.3
Saway, P.A.4
Adamson, T.C.5
Fronek, Z.6
O'Connor, R.D.7
Morgan, E.E.8
Diveley, J.P.9
Richieri, S.P.10
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10
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0029973211
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Differential involvement of Th1 and Th2 cytokines in autoimmune diseases
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Kroemer G, Hirsch F, Gonzalez-Garcia A, Martinez AC: Differential involvement of Th1 and Th2 cytokines in autoimmune diseases. Autoimmunity 1996, 24:25-33. The differential involvement of Th1 and Th2 cytokines in autoimmune diseases is discussed as a potential base for the development of therapeutic interventions by the recovery of a normal Th1 and Th2 balance.
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Autoimmunity
, vol.24
, pp. 25-33
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Kroemer, G.1
Hirsch, F.2
Gonzalez-Garcia, A.3
Martinez, A.C.4
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0029789889
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Manipulation of the Th1/Th2 cell balance: An approach to treat human autoimmune diseases?
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Adorini L, Guery JC, Trembleau S: Manipulation of the Th1/Th2 cell balance: an approach to treat human autoimmune diseases? Autoimmunity 1996, 23:53-68. A good review paper on the implications of the Th1/Th2 concept for the pathogenesis and potential treatment of autoimmune diseases.
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(1996)
Autoimmunity
, vol.23
, pp. 53-68
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Adorini, L.1
Guery, J.C.2
Trembleau, S.3
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12
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0028882681
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Double-blind, placebo-controlled multicenter trial using chimeric monoclonal anti-CD4 antibody, cM-T412, in rheumatoid arthritis patients receiving concomitant methotrexate
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+ T-cell depletion, no clinical efficacy was reported for anti-CD4 treatment in combination with methotrexate.
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Arthritis Rheum
, vol.38
, pp. 1581-1588
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Moreland, L.W.1
Pratt, P.W.2
Mayes, M.D.3
Postlethwaite, A.4
Weisman, M.H.5
Schnitzer, T.6
Lightfoot, R.7
Calabrese, L.8
Zelinger, D.J.9
Woody, J.N.10
Koopman, W.J.11
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13
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0000056486
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T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody (mAB) treatment I: Suppression of disease activity and acute phase response
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Panayi GS, Choy EHS, Conolly DJA, Regan T, Manna VK, Rapson N, Kingsley GH, Johnston JM: T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody (mAB) treatment I: suppression of disease activity and acute phase response [abstract]. Arthritis Rheum 1996, 39(suppl 9):243.
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Arthritis Rheum
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Panayi, G.S.1
Choy, E.H.S.2
Conolly, D.J.A.3
Regan, T.4
Manna, V.K.5
Rapson, N.6
Kingsley, G.H.7
Johnston, J.M.8
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14
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0000056486
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T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody (mAB) treatment II: Clinical activity is related to pharmacodynamic effects
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Choy EHS, Conollay DJA, Regan T, Mann VK, Rapson N, Kingles GH, Panavi GS, Johnston JM: T cell hypothesis in rheumatoid arthritis tested by humanized non-depleting anti-CD4 monoclonal antibody (mAB) treatment II: clinical activity is related to pharmacodynamic effects [abstract]. Arthritis Rheum 1996, 39(suppl 9):244.
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Arthritis Rheum
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Choy, E.H.S.1
Conollay, D.J.A.2
Regan, T.3
Mann, V.K.4
Rapson, N.5
Kingles, G.H.6
Panavi, G.S.7
Johnston, J.M.8
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15
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0030587190
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Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs
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Chu CQ, Londei M: Induction of Th2 cytokines and control of collagen-induced arthritis by nondepleting anti-CD4 Abs. J Immunol 1996, 157:2685-2689. Data are reported demonstrating that CIA nondepleting anti-CD4 monoclonal antibodies could be effective in inducing a shift from a Th1- to a Th2-like immune response.
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J Immunol
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, pp. 2685-2689
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Chu, C.Q.1
Londei, M.2
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17
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0028862268
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CAMPATH-1H humanized monoclonal antibody, in refractory rheumatoid arthritis: An intravenous dose-escalation study
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Weinblatt ME, Maddison PJ, Bulpitt KJ, Hazleman BL, Urowitz MB, Sturrock RD, Coblyn JS, Maier AL, Spreen WR, et al: CAMPATH-1H humanized monoclonal antibody, in refractory rheumatoid arthritis: an intravenous dose-escalation study. Arthritis Rheum 1995, 38:1589-1594. Treatment with the anti-CD52 antibody CAMPATH-1 H produces a profound immediate and sustained reduction of the peripheral lymphocyte count. Sixty-five percent of patients developed a clinical response without correlation to the biologic effect.
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Arthritis Rheum
, vol.38
, pp. 1589-1594
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Weinblatt, M.E.1
Maddison, P.J.2
Bulpitt, K.J.3
Hazleman, B.L.4
Urowitz, M.B.5
Sturrock, R.D.6
Coblyn, J.S.7
Maier, A.L.8
Spreen, W.R.9
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18
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0029992796
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Adhesion molecules as targets for the treatment of autoimmune diseases
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Oppenheimer-Marks N, Lipsky PE: Adhesion molecules as targets for the treatment of autoimmune diseases. Clin Immunol Immunopathol 1996, 79:203-210. Comprehensive review of adhesion molecules and their potential role as targets for the treatment of autoimmune diseases.
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Clin Immunol Immunopathol
, vol.79
, pp. 203-210
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Oppenheimer-Marks, N.1
Lipsky, P.E.2
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19
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0029925483
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Cellular adhesion molecules in rat adjuvant arthritis
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Halloran MM, Szekanecz Z, Barquin N, Haines GK, Koch AE: Cellular adhesion molecules in rat adjuvant arthritis. Arthritis Rheum 1996, 39:810-819.
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Arthritis Rheum
, vol.39
, pp. 810-819
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Halloran, M.M.1
Szekanecz, Z.2
Barquin, N.3
Haines, G.K.4
Koch, A.E.5
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20
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0030267310
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Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1
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Bullard DC, Hurley LA, Lorenzo I, Sly LM, Beaudet AL, Starte ND: Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1. J Immunol 1996, 157:3153-3158.
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J Immunol
, vol.157
, pp. 3153-3158
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Bullard, D.C.1
Hurley, L.A.2
Lorenzo, I.3
Sly, L.M.4
Beaudet, A.L.5
Starte, N.D.6
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21
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0029739255
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A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis
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Kavanaugh AF, Davis LS, Jain RI, Nichols LA, Morris SH, Lipsky PE: A phase I/II open label study of the safety and efficacy of an anti-ICAM-1 (intercellular adhesion molecule-1; CD54) monoclonal antibody in early rheumatoid arthritis. J Rheumatol 1996, 23:1338-1344. In a phase I and II open-label study with anti-ICAM-1 monoclonal antibody in early RA, seven of 10 patients had a marked or moderate response to a single course of therapy after 1 month of follow-up.
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(1996)
J Rheumatol
, vol.23
, pp. 1338-1344
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Kavanaugh, A.F.1
Davis, L.S.2
Jain, R.I.3
Nichols, L.A.4
Morris, S.H.5
Lipsky, P.E.6
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22
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0029875804
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Anticytokine treatment of established type II collagen-induced arthritis in DA/1 mice
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Joosten LAB, Helsen MMA, van de Loo FAJ, von den Berg WB: Anticytokine treatment of established type II collagen-induced arthritis in DA/1 mice. Arthritis Rheum 1996, 39:797-809. This paper demonstrates that in type Il CIA in DA/1 mice, TNF-α treatment primarily prevents synovitis, whereas IL-1 inhibition appears to be more effective in the prevention of cartilage destruction.
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(1996)
Arthritis Rheum
, vol.39
, pp. 797-809
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Joosten, L.A.B.1
Helsen, M.M.A.2
Van De Loo, F.A.J.3
Von Den Berg, W.B.4
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23
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0029671297
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In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis: Short term cellular and molecular effects
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Lorenz HM, Antoni C, Valerius T, Repp R, Grünke M, Schwerdtner N, NüBlein H, Woody J, Kalden JR, Manger B: In vivo blockade of TNF-alpha by intravenous infusion of a chimeric monoclonal TNF-alpha antibody in patients with rheumatoid arthritis: short term cellular and molecular effects. J Immunol 1996, 156:1646-1653. Parallel to a clinical trial, cellular and molecular effects of a TNF-α therapy were analyzed in RA patients. The main effects were a reduction in monocyte counts and in monokines as well as a reduction in soluble ICAM-1 in the circulation.
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(1996)
J Immunol
, vol.156
, pp. 1646-1653
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Lorenz, H.M.1
Antoni, C.2
Valerius, T.3
Repp, R.4
Grünke, M.5
Schwerdtner, N.6
Nüblein, H.7
Woody, J.8
Kalden, J.R.9
Manger, B.10
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24
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0030013609
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Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis
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Paleolog EM, Hunt M, Elliott MJ, Feldmann M, Maini RN, Woody JN: Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor alpha antibody in rheumatoid arthritis. Arthritis Rheum 1996, 39:1082-1091. In addition to reduced serum ICAM-1 levels under TNF-α therapy, as reported by Lorenz et al. (J Immunol 1996, 156:1646-1653), a decrease in serum E-selectin levels was found. No changes in levels of vascular cell adhesion molecule-1 were detected.
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(1996)
Arthritis Rheum
, vol.39
, pp. 1082-1091
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Paleolog, E.M.1
Hunt, M.2
Elliott, M.J.3
Feldmann, M.4
Maini, R.N.5
Woody, J.N.6
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25
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0029896957
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Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis
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Tak PP, Taylor PC, Breedveld FC, Smeets TJM, Daha MR, Kluin PM, Meinders AE, Maini RN: Decrease in cellularity and expression of adhesion molecules by anti-tumor necrosis factor alpha monoclonal antibody treatment in patients with rheumatoid arthritis. Arthritis Rheum 1996, 39:1077-1081. In RA patients treated with anti-TNF-α antibody, significant reductions in T-cell infiltration and in expression of adhesion molecules were demonstrated in inflammatory synovial tissue.
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(1996)
Arthritis Rheum
, vol.39
, pp. 1077-1081
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Tak, P.P.1
Taylor, P.C.2
Breedveld, F.C.3
Smeets, T.J.M.4
Daha, M.R.5
Kluin, P.M.6
Meinders, A.E.7
Maini, R.N.8
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26
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0030586573
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Inhibition of superantigen-induced proinflammatory cytokine production and inflammation arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha
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Edwards III CK, Zhou T, Zhang J, Baker TJ, De M, Long RE, Borcherding DR, Bowlin TL, Bluethmann H, Mountz JD: Inhibition of superantigen-induced proinflammatory cytokine production and inflammation arthritis in MRL-lpr/lpr mice by a transcriptional inhibitor of TNF-alpha. J Immunol 1996, 157:1758-1772.
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J Immunol
, vol.157
, pp. 1758-1772
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Edwards III, C.K.1
Zhou, T.2
Zhang, J.3
Baker, T.J.4
De, M.5
Long, R.E.6
Borcherding, D.R.7
Bowlin, T.L.8
Bluethmann, H.9
Mountz, J.D.10
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27
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0000002244
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Anti-TNF-alpha monoclonal antibody (mAB) treatment of rheumatoid arthritis (RA) patients with active disease on methotrexate (MTX): Results of double-blind, placebo controlled multicenter trial
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Kavanaugh AF, Cush JJ, St Clair EW, McCune WJ, Braakman TAJ, Nichols LA, Lipsky PE: Anti-TNF-alpha monoclonal antibody (mAB) treatment of rheumatoid arthritis (RA) patients with active disease on methotrexate (MTX): results of double-blind, placebo controlled multicenter trial [abstract]. Arthritis Rheum 1996, 39(suppl 9):123.
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(1996)
Arthritis Rheum
, vol.39
, Issue.9 SUPPL.
, pp. 123
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Kavanaugh, A.F.1
Cush, J.J.2
St Clair, E.W.3
McCune, W.J.4
Braakman, T.A.J.5
Nichols, L.A.6
Lipsky, P.E.7
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28
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0002595102
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Double-blind, placebo-controlled trial of tumor necrosis factor receptor (p80) fusion protein (TNFR:Fc) in active rheumatoid arthritis
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Baumgartner S, Moreland LW, Schiff MH, et al.: Double-blind, placebo-controlled trial of tumor necrosis factor receptor (p80) fusion protein (TNFR:Fc) in active rheumatoid arthritis [abstract]. Arthritis Rheum 1996, 39(suppl 9):74. A dose-dependent clinical response was reported in RA patients, which was in striking contrast to the placebo-treated group. No antibodies to the TNF-α receptor construct were detected.
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(1996)
Arthritis Rheum
, vol.39
, Issue.9 SUPPL.
, pp. 74
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Baumgartner, S.1
Moreland, L.W.2
Schiff, M.H.3
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29
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0030267786
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Attenuation of collagen-induced arthritis in 55-kDA TNF receptor type 1 (TNFR1)-IgG-treated and TNFR1-deficient mice
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Mori L, Iselin S, De Libero G, Lesslauer W: Attenuation of collagen-induced arthritis in 55-kDA TNF receptor type 1 (TNFR1)-IgG-treated and TNFR1-deficient mice. J Immunol 1996, 157:3178-3182. In mice deficient in TNF receptor type 1 and with a CIA-susceptible genetic background, it was demonstrated that the progression of arthritis and tissue destruction including ankylosis is dependent on TNF receptor type 1.
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(1996)
J Immunol
, vol.157
, pp. 3178-3182
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Mori, L.1
Iselin, S.2
De Libero, G.3
Lesslauer, W.4
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30
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0029943271
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Dose-range and dose-frequency of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis
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Campion GV, Lebsack ME, Lookabaugh J, Gordon G, Catalano M, the IL-1Ra Arthritis Study Group: Dose-range and dose-frequency of recombinant human interleukin-1 receptor antagonist in patients with rheumatoid arthritis. Arthritis Rheum 1996, 39:1092-1101. As early as 2 weeks after the initiation of treatment with IL-1 receptor antagonist, clinical improvement was demonstrated by a decrease in tender joints, morning stiffness, and pain in patients with active RA.
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(1996)
Arthritis Rheum
, vol.39
, pp. 1092-1101
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Campion, G.V.1
Lebsack, M.E.2
Lookabaugh, J.3
Gordon, G.4
Catalano, M.5
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31
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0000168402
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Treatment with recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in rheumatoid arthritis (RA): Results of a randomized double-blind, placebo-controlled multicenter trial
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Bresnihan B, Lookabaugh J, Witt K, Musikic P: Treatment with recombinant human interleukin-1 receptor antagonist (rhIL-1ra) in rheumatoid arthritis (RA): results of a randomized double-blind, placebo-controlled multicenter trial [abstract]. Arthritis Rheum 1996, 39(suppl 9):73.
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(1996)
Arthritis Rheum
, vol.39
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, pp. 73
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Bresnihan, B.1
Lookabaugh, J.2
Witt, K.3
Musikic, P.4
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32
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0029875804
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Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: A comparative study using anti-TNF-alpha, anti-IL-1 alpha/beta, and IL-1RA
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Joosten LAB, Helsen MMA, van de Loo FAJ, van den Berg WB: Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNF-alpha, anti-IL-1 alpha/beta, and IL-1RA. Arthritis Rheum 1996, 39:797-809. In CIA, anti-TNF-α treatment was efficacious when given shortly after onset of disease but had little effect on fully established disease, in contrast to IL-1-blocking therapies. This finding shows that blocking of TNF-α does not necessarily eliminate effects caused by IL-1.
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(1996)
Arthritis Rheum
, vol.39
, pp. 797-809
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Joosten, L.A.B.1
Helsen, M.M.A.2
Van De Loo, F.A.J.3
Van Den Berg, W.B.4
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33
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0029925484
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Prevention and reversal of cartilage degradation in rheumatoid arthritis by Interleukin-10 and Interleukin-4
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Van Roon JAG, van Roy JLA, Gmelig-Meyling FHJ, Lafeber FPJG, Bijlsma JWJ: Prevention and reversal of cartilage degradation in rheumatoid arthritis by Interleukin-10 and Interleukin-4. Arthritis Rheum 1996, 39:829-835. As demonstrated in this study, IL-10 reverses the cartilage degradation induced by antigen-stimulated mononuclear cells. IL-4 has an additive effect on this process. These results provide evidence in favor of a combination of these two cytokines in the treatment of RA.
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(1996)
Arthritis Rheum
, vol.39
, pp. 829-835
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Van Roon, J.A.G.1
Van Roy, J.L.A.2
Gmelig-Meyling, F.H.J.3
Lafeber, F.P.J.G.4
Bijlsma, J.W.J.5
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34
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0029951421
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Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I
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Sugiyama E, Taki H, Kuroda A, Mino T, Yamashita N, Kobayashi M: Interleukin-4 inhibits prostaglandin E2 production by freshly prepared adherent rheumatoid synovial cells via inhibition of biosynthesis and gene expression of cyclo-oxygenase II but not of cyclo-oxygenase I. Ann Rheum Dis 1996, 55:375-382.
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(1996)
Ann Rheum Dis
, vol.55
, pp. 375-382
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Sugiyama, E.1
Taki, H.2
Kuroda, A.3
Mino, T.4
Yamashita, N.5
Kobayashi, M.6
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35
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0029740959
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The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis
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Isomäki P, Luukkainen R, Toivanen P, Punnonen J: The presence of interleukin-13 in rheumatoid synovium and its antiinflammatory effects on synovial fluid macrophages from patients with rheumatoid arthritis. Arthritis Rheum 1996, 39:1693-1702. It is demonstrated that IL-13 is consistently present in rheumatoid synovium and that exogenously added IL-13 decreases the production of proinflammatory cytokines by synovial cells.
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(1996)
Arthritis Rheum
, vol.39
, pp. 1693-1702
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Isomäki, P.1
Luukkainen, R.2
Toivanen, P.3
Punnonen, J.4
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36
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0029797868
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Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13
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Bessis N, Boissier MC, Ferrara P, Blankenstein T, Fradeliji D, Fournier C: Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13. Eur J Immunol 1996, 26:2399-2403. These experiments demonstrated that the administration of IL-13 and IL-4 using vector cells engineered to secrete the proteins is a powerful method of attenuating significantly the progression of CIA. Other experiments have suggested that IL-13 exerts its beneficial effects by a down-regulation of expression of the TNF-α gene.
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(1996)
Eur J Immunol
, vol.26
, pp. 2399-2403
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Bessis, N.1
Boissier, M.C.2
Ferrara, P.3
Blankenstein, T.4
Fradeliji, D.5
Fournier, C.6
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37
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0030042970
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Oral type II collagen treatment in early rheumatoid arthritis: A double-blind, placebo-controlled, randomized trial
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Listing, J.8
Ulbrich, N.9
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A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis
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Barnett ML, Combitchi D, Trentham DE: A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis. Arthritis Rheum 1996, 39:623-628.
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Barnett, M.L.1
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Trentham, D.E.3
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Direct gene delivery to synovium: An evaluation of potential vectors in vitro and in vivo
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Nita I, Ghivizzani C, Galea-Lauri J, Bandara G, Georgescu HI, Robbins PD, Evans CH: Direct gene delivery to synovium: an evaluation of potential vectors in vitro and in vivo. Arthritis Rheum 1996, 39:820-828.
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Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice: Response correlates with the absence of an anti-antibody response
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Early GS, Zhao W, Burns CM: Anti-CD40 ligand antibody treatment prevents the development of lupus-like nephritis in a subset of New Zealand black x New Zealand white mice: response correlates with the absence of an anti-antibody response. J Immunol 1996, 157:3159-3164. In a subset of NZB x NZW mice it was shown that an anti-CD40 ligand antibody prevented the development of lupus nephritis associated with a reduction of anti-DNA antibody titer and a significantly prolonged survival.
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Early, G.S.1
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