Deactivation of vascular endothelium by monoclonal anti-tumor necrosis factor α antibody in rheumatoid arthritis

Arthritis and Rheumatism

Volumn 39, Issue 7, 1996, Pages 1082-1091

  Paleolog, Ewa M ^a   Hunt, Mary ^a   Elliott, Michael J ^a   Feldmann, Marc ^a,b   Maini, Ravinder N ^a   Woody, James N ^b  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b CENTOCOR INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ANTIBODY; VASCULAR CELL ADHESION MOLECULE 1;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG EFFECT; HUMAN; IMMUNOREGULATION; IMMUNOTHERAPY; LEUKOCYTE MIGRATION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHEUMATOID ARTHRITIS; TREATMENT OUTCOME; VASCULAR ENDOTHELIUM;

ANTIBODIES, MONOCLONAL; ARTHRITIS, RHEUMATOID; DOUBLE-BLIND METHOD; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTE COUNT; LYMPHOCYTE ACTIVATION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0030013609     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390703     Document Type: Article

References (40)

1. Feldmann M, Brennan FM, Maini RN: Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14:397-440, 1995
2. Cronstein BN: Adhesion molecules in the pathogenesis of rheumatoid arthritis. Curr Opin Rheumatol 6:300-304, 1994
3. Carlos TM, Harlan JM: Leukocyte-endothelial adhesion molecules. Blood 84:2068-2101, 1994
4. Koch AE, Burrows JC, Haines GK, Carlos TM, Harlan JM, Leibovich SJ: Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues. Lab Invest 64:313-620, 1991
5. Johnson BA, Haines GK, Harlow LA, Koch AE: Adhesion molecule expression in human synovial tissue. Arthritis Rheum 36:137-146, 1993
6. Szekanecz Z, Haines GK, Lin TR, Harlow LA, Goerdt S, Rayan G, Koch AE: Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia: their possible pathogenetic and clinical significance in rheumatoid arthritis. Arthritis Rheum 37:221-231, 1994
7. Brennan FM, Maini RN, Feldmann M: TNFα - a pivotal role in rheumatoid arthritis? Br J Rheumatol 31:293-298, 1992
8. Arend WP, Dayer J-M: Inhibition of the production and effects of interleukin-1 and tumor necrosis factor α in rheumatoid arthritis. Arthritis Rheum 38:151-160, 1995
9. Williams RO, Feldmann M, Maini RN: Anti-tumor necrosis factor ameliorates joint disease in murine collagen-induced arthritis. Proc Natl Acad Sci U S A 89:9784-9788, 1992
10. Issekutz AC, Meager A, Otterness I, Issekutz TB: The role of tumor necrosis factor-a and IL-1 in polymorphonuclear leukocyte and T lymphocyte recruitment to joint inflammation in adjuvant arthritis. Clin Exp Immunol 97:26-32, 1994
11. Elliott MJ, Maini RN, Feldmann M, Long-Fox A, Charles P, Katsikis P, Brennan FM, Walker J, Bijl H, Ghrayeb J, Woody JN: Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum 36:1681-1690, 1993
12. Elliott MJ, Maini RN, Feldmann M, Kalden JR, Antoni C, Smolen JS, Leeb B, Breedveld FC, Macfarlane JD, Bijl H, Woody JN: Randomised double-blind comparison of chimeric monoclonal antibody to tumor necrosis factor α (cA2) versus placebo in rheumatoid arthritis. Lancet 344:1105-1110, 1994
13. Brennan FM, Chantry D, Jackson A, Maini R, Feldmann M: Inhibitory effect of TNFα antibodies on synovial cell interleukin-1 production in rheumatoid arthritis. Lancet 2:244-247, 1989
14. Haworth C, Brennan FM, Chantry D, Turner M, Foxwell B, Maini RN, Feldmann M: Expression of granulocyte-macrophage colony-stimulating factor in rheumatoid arthritis: regulation by tumour necrosis factor-α. Eur J Immunol 21:2575-2579, 1991
15. Butler DM, Maini RN, Feldmann M, Brennan FM: Modulation of proinflammatory cytokine release in rheumatoid synovial membrane cell cultures with an anti-TNFα monoclonal: comparison with blockade of IL-1 using the recombinant IL-1 receptor antagonist. Eur Cytokine Netw 6:225-230, 1995
16. Maini RN, Elliott MJ, Brennan FM, Williams RO, Chu CQ, Paleolog E, Charles PJ, Taylor PC, Feldmann M: Monoclonal anti-TNFα antibody as a probe of pathogenesis and therapy of rheumatoid disease. Immunol Rev 144:195-223, 1995
17. Gearing AJH, Newman W: Circulating adhesion molecules in disease. Immunol Today 14:506-512, 1993
18. Cush JJ, Rothlein R, Lindsley HB, Mainolfi EA, Lipsky PE: Increased levels of circulating intercellular adhesion molecule 1 in the sera of patients with rheumatoid arthritis. Arthritis Rheum 36:1098-1102, 1993
19. Mason JC, Kapahi P, Haskard DO: Detection of increased levels of circulating intercellular adhesion molecule 1 in some patients with rheumatoid arthritis but not in patients with systemic lupus erythematosus: lack of correlation with levels of circulating vascular cell adhesion molecule 1. Arthritis Rheum 36:519-527, 1993
20. Wellicome SM, Kapahi P, Mason JC, Lebranchu Y, Yarwood H, Haskard DO: Detection of a circulating form of vascular cell adhesion molecule-1: raised levels in rheumatoid arthritis and systemic lupus erythematosus. Clin Exp Immunol 92:412-418, 1993
21. Koch AE, Turkiewicz W, Harlow LA, Pope RM: Soluble E-selectin in arthritis. Clin Immunol Immunopathol 69:29-35, 1993
22. Blann AD, McCollum CN, Steiner M, Jayson MIV: Circulating adhesion molecules in inflammatory and atherosclerotic vascular disease. Immunol Today 16:251-252, 1995
23. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, Healey LA, Kaplan SR, Liang MH, Luthra HS, Medsger TA Jr, Wilder RL, Hunder GG: The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 31:315-324, 1988
24. Paulus HE, Egger MJ, Ward JR, Williams HJ, the Cooperative Systematic Studies of Rheumatic Diseases Group: Analysis of improvement in individual rheumatoid arthritis patients treated with disease-modifying antirheumatic drugs, based on the findings in patients treated with placebo. Arthritis Rheum 33:477-484, 1990
25. Knight DM, Trinh H, Le J, Siegel S, Shealy D, McDonough M, Seallon B, Moore MA, Vileek J, Daddona P, Ghrayeb J: Construction and initial characterization of a mouse-human chimeric anti-TNF antibody. Mol Immunol 30:1443-1453, 1993
26. Maple C, Kirk G, McLaren M, Belch JJF: A diurnal variation exists in soluble E-selectin, P-selectin and ICAM-1 levels in healthy volunteers (abstract). Br J Rheumatol 34 (suppl 1):87, 1995
27. Gearing AJ, Hemingway I, Pigott R, Hughes J, Rees AJ, Cashman SJ: Soluble forms of vascular adhesion molecules, E-selectin, ICAM-1 and VCAM-1: pathological significance. Ann N Y Acad Sci 667:324-331, 1992
28. Corkill MM, Kirkham BW, Haskard DO, Barbatis C, Gibson T, Panayi GS: Gold treatment of rheumatoid arthritis decreases synovial expression of the endothelial leukocyte adhesion receptor ELAM-1. J Rheumatol 18:1453-1460, 1991
29. Maple C, Kirk G, Veale D, Belch JJF: Reduction in cell adhesion molecule levels following sulphasalazine in patients with rheumatoid arthritis (abstract). Br J Rheumatol 34 (suppl 1):98, 1995
30. Leeuwenberg JF, Smeets EF, Neefjes JJ, Shaffer MA, Cinek T, Jeunhomme TM, Ahern TJ, Buurman WA: E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro. Immunology 77:543-549, 1992
31. Pigott R, Dillon LP, Hemingway IH, Gearing AJ: Soluble forms of E-selectin, ICAM-1 and VCAM-1 arc present in the supernatants of cytokine activated cultured endothelial cells. Biochem Biophys Res Commun 187:584-589, 1992
32. Lobb R, Chi-Rosso G, Leone D, Rosa M, Newman B, Luhowskyj S, Osborn L, Schiffer S, Benjamin C, Dougas I, Hession C, Chow P: Expression and functional characterization of a soluble form of vascular cell adhesion molecule-1. Biochem Biophys Res Commun 178:1498-1504, 1991
33. Lobb RR, Chi-Rosso G, Leone DR, Rosa MD, Bixler S, Newman BM, Luhowskyj S, Benjamin CD, Dougas IG, Goelz SE, Hession C, Chow EP: Expression and functional characterization of a soluble form of endothelial-leukocyte adhesion molecule-1. J Immunol 147:124-129, 1991
34. Koch AE, Halloran MM, Haskell CJ, Shah MR, Polverini PJ: Angiogenesis mediated by soluble forms of E-selectin and vascular cell adhesion molecule-1. Nature 376:517-519, 1995
35. Colville-Nash PR, Scott DL: Angiogenesis and rheumatoid arthritis: pathogenic and therapeutic implications. Ann Rheum Dis 51:919-925, 1992
36. Paleolog EM, Taylor PC, Hunt M, Tak PP. Elliott MJ, Feldmann M, Breedveld FC, Maini RN: Treatment of rheumatoid arthritis with antibody to TNFα decreases expression and shedding of E-sclectin (abstract). Arthritis Rheum 38 (suppl 9):S279, 1995
37. Kakimoto K, Nakamura T, Ishii K, Takashi T, Iigou H, Yagita II, Okumura K, Onoue K: The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis. Cell Immunol 142:326-337, 1992
38. Issekutz AC, Issekutz TB: A major portion of polymorphonuclear leukocyte and T lymphocyte migration to arthritic joints in the rat is via LFA-1/MAC-1-independent mechanisms. Clin Immunol Immunopathol 67:257-263, 1993
39. Wahl SM, Allen JB, Hines KL, Imamichi T, Wahl AM, Furcht LT, McCarthy JB: Synthetic fibronectin peptides suppress arthritis in rats by interrupting leukocyte adhesion and recruitment. J Clin Invest 94:655-662, 1994
40. Kavanaugh AF, Davis LS, Nichols LA, Norris SH, Rothlein R, Scharschmidt LA, Lipsky PE: Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1. Arthritis Rheum 37:992-999, 1994