A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis

Arthritis and Rheumatism

Volumn 39, Issue 4, 1996, Pages 623-628

  Barnett, Martha L ^a   Combitchi, Daniel ^a   Trentham, David E ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGEN TYPE 2; CORTICOSTEROID; NONSTEROID ANTIINFLAMMATORY AGENT; PREDNISONE;

ADOLESCENT; ARTICLE; CHICKEN; CLINICAL ARTICLE; CLINICAL TRIAL; COLLAGEN SYNTHESIS; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; JUVENILE RHEUMATOID ARTHRITIS; MALE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; SCHOOL CHILD; SCORING SYSTEM; TREATMENT OUTCOME;

ADMINISTRATION, ORAL; ADOLESCENT; ARTHRITIS, JUVENILE RHEUMATOID; CHILD; COLLAGEN; DRUG THERAPY, COMBINATION; FEMALE; HUMANS; MALE; PILOT PROJECTS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME;

EID: 0029923071     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390413     Document Type: Article

References (25)

1. Singsen BH: Epidemiology of the rheumatic diseases of childhood. Rheum Dis Clin North Am 16:581-599, 1990
2. Hanson V, Kornreich H, Bernstein B, King KK, Singsen B: Prognosis of juvenile rheumatoid arthritis. Arthritis Rheum 20 (suppl 2):279-284, 1977
3. Wallace CA, Levinson JE: Juvenile rheumatoid arthritis: outcome and treatment for the 1990's. Rheum Dis Clin North Am 17:891-905, 1991
4. Brewer EJ, Giannini EH, Kuzmina N, Alekseev L: Penicillamine and hydroxychloroquine in the treatment of severe JRA: results of the USA-USSR double-blind, placebo-controlled trial. N Engl J Med 314:1269-1276, 1986
5. Giannini EH, Brewer EJ, Kuzmina N, Shaikov A, Maximov A, Vorontsov I, Fink CW, Newman AJ, Cassidy JT, Zemel LS: Low-dose methotrexate in resistant JRA: results of the USA-USSR double-blind, placebo-controlled trial. N Engl J Med 326:1043-1049, 1992
6. Sewell KL, Trentham DE: Pathogenesis of rheumatoid arthritis. Lancet 341:283-286, 1993
7. Mowat A: The regulation of the immune responses to dietary protein antigens. Immunol Today 8:93-98, 1987
8. Friedman A, Weiner HL: Induction of anergy or active suppression following oral tolerance is determined by antigen dosage. Proc Natl Acad Sci U S A 91:6688-6692, 1994
9. Nagler-Anderson C, Bobber LA, Robinson ME, Siskind GW, Thorbecke GJ: Suppression of type II collagen-induced arthritis by intragastric administration of soluble type II collagen. Proc Natl Acad Sci U S A 83:7443-7446, 1986
10. Thompson HSG, Staines NA: Gastric administration of type II collagen delays the onset and severity of collagen-induced arthritis in rats. Clin Exp Immunol 64:581-586, 1986
11. Zhang ZY, Lee CS, Lider O, Weiner HL: Suppression of adjuvant arthritis in Lewis rats by oral administration of type II collagen. J Immunol 145:2489-2493, 1990
12. Trentham DE, Dynesius-Trentham RA, Orav EJ, Combitchi D, Lorenzo C, Sewell KL, Hafler DA, Weiner HL: Effects of oral administration of type II collagen on rheumatoid arthritis. Science 259:1321-1324, 1993
13. Brewer EJ Jr, Bass J, Baum J, Cassidy JT, Fink C, Jacobs J, Hanson V, Levinson JE, Schaller J, Stillman JS: Current proposed revision of JRA criteria. Arthritis Rheum 20 (suppl 2): 195-199, 1977
14. Weinblatt ME, Coblyn JS, Fox DA, Fraser PA, Holdsworth DE, Glass DN, Trentham DE: Efficacy of low-dose methotrexate in rheumatoid arthritis. N Engl J Med 312:818-822, 1985
15. Steinbrocker O, Traeger CH, Batterman RC: Therapeutic criteria in rheumatoid arthritis. JAMA 140:659-662, 1949
16. Weiner HL, Mackin GA, Matsui M, Orav EJ, Khoury SJ, Dawson DM: Double-blind pilot trial or oral tolerization with myelin antigens in multiple sclerosis. Science 259:1321-1324, 1993
17. Zhang ZJ, Davidson L, Eisenbarth G, Weiner HL: Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin. Proc Natl Acad Sci U S A 88:10252-10256, 1991
18. Nussenblatt RB, Caspi RR, Mahdi R, Chan CC, Roberge F, Lider O, Weiner HL: Inhibition of S-antigen induced experimental autoimmune uveoretinitis by oral induction of tolerance with S-antigen. J Immunol 144:1689-1695, 1990
19. Khoury SJ, Hancock WW, Weiner HL: Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor β, interleukin 4, and prostaglandin E expression in the brain. J Exp Med 176:1355-1364, 1992
20. Richman LK, Graeff AS, Yarchoan R, Strober W: Simultaneous induction of antigen-specific IgA helper T cells and IgG suppressor T cells in the murine Peyer's patch after protein feeding. J Immunol 126:2079-2083, 1981
21. Chen Y, Kuchroo VK, Inobe J, Hafler DA, Weiner HL: Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis. Science 265:1237-11240, 1994
22. Al-Sabbagh A, Miller A, Santos LMB, Weiner HL: Antigen-driven tissue-specific suppression following oral tolerance: orally administered myelin basic protein suppresses proteolipid protein-induced experimental autoimmune encephalomyelitis in the SJL mouse. Eur J Immunol 24:2104-2109, 1994
23. Yoshino S, Quattrocchi E, Weiner HL: Suppression of antigen-induced arthritis in Lewis rats by oral administration of type II collagen. Arthritis Rheum 38:1092-1096, 1995
24. Whitacre CC, Gienapp IE, Orosz CG, Bitar DM: Oral tolerance in experimental autoimmune encephalomyelitis. III. Evidence for clonal anergy. J Immunol 147:2155-2163, 1991
25. Garside P, Steel M, Worthey EA, Satoskar A, Alexander J, Bluethmann H, Liew FY, Mowat AMcI: T helper 2 cells are subject to high dose oral tolerance and are not essential for its induction. J Immunol 154:5649-5655, 1995