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Volumn 8, Issue 5, 1997, Pages 635-640

Plasmid DNA expression systems for the purpose of immunization

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; DNA VACCINE; MONOCLONAL ANTIBODY; PLASMID DNA;

EID: 0030700316     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0958-1669(97)80041-9     Document Type: Article
Times cited : (68)

References (61)
  • 4
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang D, DeVit M, Johnston SA: Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356:152-154.
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.1    DeVit, M.2    Johnston, S.A.3
  • 6
    • 0343117202 scopus 로고    scopus 로고
    • DNA-based immunization
    • Edited by Fairbairn LJ, Testa N. London: Plenum in press
    • Davis HL, Brazolot Millan CL: DNA-based immunization. In Blood Cell Biochemistry, vol 8: Hemopoiesis and Gene Therapy. Edited by Fairbairn LJ, Testa N. London: Plenum 1997, in press. This chapter provides a comprehensive overview of the DNA vaccine field to date, and includes a summary of all disease models that have been described.
    • (1997) Blood Cell Biochemistry, Vol 8: Hemopoiesis and Gene Therapy , vol.8
    • Davis, H.L.1    Brazolot Millan, C.L.2
  • 7
    • 0029051321 scopus 로고
    • DNA-mediated immunization to the hepatitis B surface antigen in mice: Aspects of the humoral response mimic hepatitis B viral infection in humans
    • Michel ML, Davis HL, Schleef M, Mancini M, Tiollais P, Whalen RG: DNA-mediated immunization to the hepatitis B surface antigen in mice: aspects of the humoral response mimic hepatitis B viral infection in humans. Proc Natl Acad Sci USA 1995, 92:5307-5311.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5307-5311
    • Michel, M.L.1    Davis, H.L.2    Schleef, M.3    Mancini, M.4    Tiollais, P.5    Whalen, R.G.6
  • 9
    • 0029844184 scopus 로고    scopus 로고
    • Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: Enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1
    • Bueler H, Mulligan RC: Induction of antigen-specific tumor immunity by genetic and cellular vaccines against MAGE: enhanced tumor protection by coexpression of granulocyte-macrophage colony-stimulating factor and B7-1. Mol Med 1996, 2:545-555.
    • (1996) Mol Med , vol.2 , pp. 545-555
    • Bueler, H.1    Mulligan, R.C.2
  • 10
    • 0031060327 scopus 로고    scopus 로고
    • Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2
    • Chow YH, Huang WL, Chi WK, Chu YD, Tao MH: Improvement of hepatitis B virus DNA vaccines by plasmids coexpressing hepatitis B surface antigen and interleukin-2. J Virol 1997, 71:169-178.
    • (1997) J Virol , vol.71 , pp. 169-178
    • Chow, Y.H.1    Huang, W.L.2    Chi, W.K.3    Chu, Y.D.4    Tao, M.H.5
  • 11
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • Geissler M, Gesien A, Tokushige K, Wands JR: Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J Immunol 1997, 158:1231-1237.
    • (1997) J Immunol , vol.158 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 12
    • 0030589297 scopus 로고    scopus 로고
    • A nine-amino acid peptide from IL-1 beta augments antitumor immune responses induced by protein and DNA vaccines
    • Hakim I, Levy S, Levy R: A nine-amino acid peptide from IL-1 beta augments antitumor immune responses induced by protein and DNA vaccines. J Immunol 1996, 157:5503-5511.
    • (1996) J Immunol , vol.157 , pp. 5503-5511
    • Hakim, I.1    Levy, S.2    Levy, R.3
  • 13
    • 0031569963 scopus 로고    scopus 로고
    • Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines
    • Iwasaki A, Stiernholm BJ, Chan AK, Berinstein NL, Barber BH: Enhanced CTL responses mediated by plasmid DNA immunogens encoding costimulatory molecules and cytokines. J Immunol 1997, 158:4591-4601.
    • (1997) J Immunol , vol.158 , pp. 4591-4601
    • Iwasaki, A.1    Stiernholm, B.J.2    Chan, A.K.3    Berinstein, N.L.4    Barber, B.H.5
  • 14
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim JJ, Ayyavoo V, Bagarazzi ML, Chattergoon MA, Dang K, Wang B, Boyer JD, Weiner DB: In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 1997, 158:816-826.
    • (1997) J Immunol , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3    Chattergoon, M.A.4    Dang, K.5    Wang, B.6    Boyer, J.D.7    Weiner, D.B.8
  • 15
    • 0029779577 scopus 로고    scopus 로고
    • Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: Implications for a clinically relevant tumor vaccine
    • Mahvi DM, Burkholder JK, Turner J, Culp J, Malter JS, Sondel PM, Yang NS: Particle-mediated gene transfer of granulocyte-macrophage colony-stimulating factor cDNA to tumor cells: implications for a clinically relevant tumor vaccine. Hum Gene Ther 1996, 7:1535-1543.
    • (1996) Hum Gene Ther , vol.7 , pp. 1535-1543
    • Mahvi, D.M.1    Burkholder, J.K.2    Turner, J.3    Culp, J.4    Malter, J.S.5    Sondel, P.M.6    Yang, N.S.7
  • 16
    • 0031038566 scopus 로고    scopus 로고
    • Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen
    • Tsuji T, Hamajima K, Ishii N, Aoki I, Fukushima J, Xin KQ, Kawamoto S, Sasaki S, Matsunaga K, Ishigatsubo Y et al.: Immunomodulatory effects of a plasmid expressing B7-2 on human immunodeficiency virus-1-specific cell-mediated immunity induced by a plasmid encoding the viral antigen. Eur J Immunol 1997, 27:782-787.
    • (1997) Eur J Immunol , vol.27 , pp. 782-787
    • Tsuji, T.1    Hamajima, K.2    Ishii, N.3    Aoki, I.4    Fukushima, J.5    Xin, K.Q.6    Kawamoto, S.7    Sasaki, S.8    Matsunaga, K.9    Ishigatsubo, Y.10
  • 17
    • 0029991928 scopus 로고    scopus 로고
    • Neonatal tolerance revisited: Turning on newborn T cells with dendritic cells
    • Ridge JP, Fuchs EJ, Matzinger P: Neonatal tolerance revisited: turning on newborn T cells with dendritic cells. Science 1996, 271:1723-1726.
    • (1996) Science , vol.271 , pp. 1723-1726
    • Ridge, J.P.1    Fuchs, E.J.2    Matzinger, P.3
  • 19
    • 0029982850 scopus 로고    scopus 로고
    • DNA vaccine for hepatitis B: Evidence for immunogenicity in chimpanzees and comparison with other vaccines
    • Davis HL, McCluskie MJ, Gerin JL, Purcell RH: DNA vaccine for hepatitis B: evidence for immunogenicity in chimpanzees and comparison with other vaccines. Proc Natl Acad Sci USA 1996, 93:7213-7218. This is the first demonstration of a DNA vaccine in chimpanzees, which are generally recognized to be most predictive of vaccine responses in humans owing to their very similar genetic make-up and, thus, immune systems.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7213-7218
    • Davis, H.L.1    McCluskie, M.J.2    Gerin, J.L.3    Purcell, R.H.4
  • 20
    • 16944363710 scopus 로고    scopus 로고
    • Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination
    • Boyer JD, Ugen KE, Wang B, Agadjanyan M, Gilbert L, Bagarazzi ML, Chattergoon M, Frost P, Javadian A, Williams WV et al.: Protection of chimpanzees from high-dose heterologous HIV-1 challenge by DNA vaccination. Nat Med 1997, 3:526-532. The results from this study using multivalent DNA vaccines in chimpanzees are very exciting in that they demonstrate protective efficacy against a heterologous strain of HIV.
    • (1997) Nat Med , vol.3 , pp. 526-532
    • Boyer, J.D.1    Ugen, K.E.2    Wang, B.3    Agadjanyan, M.4    Gilbert, L.5    Bagarazzi, M.L.6    Chattergoon, M.7    Frost, P.8    Javadian, A.9    Williams, W.V.10
  • 26
    • 0031029854 scopus 로고    scopus 로고
    • Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA
    • Schubbert R, Renz D, Schmitz B, Doerfler W: Foreign (M13) DNA ingested by mice reaches peripheral leukocytes, spleen, and liver via the intestinal wall mucosa and can be covalently linked to mouse DNA. Proc Natl Acad Sci USA 1997, 94:961-966. The results of this paper provide hope that it may be possible to develop DNA vaccines that can be delivered by noninvasive means, and in particular by oral or respiratory routes. Such delivery could have high impact on vaccine delivery in the developing world and may allow induction of specific mucosal immunity.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 961-966
    • Schubbert, R.1    Renz, D.2    Schmitz, B.3    Doerfler, W.4
  • 27
    • 0027214439 scopus 로고
    • Bovine herpes virus 1: Immune responses in mice and cattle injected with plasmid DNA
    • Cox GJ, Zamb TJ, Babiuk LA: Bovine herpes virus 1: immune responses in mice and cattle injected with plasmid DNA. J Virol 1993, 67:1164-1168.
    • (1993) J Virol , vol.67 , pp. 1164-1168
    • Cox, G.J.1    Zamb, T.J.2    Babiuk, L.A.3
  • 28
    • 0030965404 scopus 로고    scopus 로고
    • Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA
    • Davis HL, Brazolot Millan CL, Watkins SC: Immune-mediated destruction of transfected muscle fibers after direct gene transfer with antigen-expressing plasmid DNA. Gene Ther 1997,4:181-188.
    • (1997) Gene Ther , vol.4 , pp. 181-188
    • Davis, H.L.1    Brazolot Millan, C.L.2    Watkins, S.C.3
  • 29
    • 0026033729 scopus 로고
    • Novel pathways of antigen presentation for the maintenance of memory
    • Gray D, Kosco M, Stockinger B: Novel pathways of antigen presentation for the maintenance of memory, Int Immunol 1991, 3:141-148.
    • (1991) Int Immunol , vol.3 , pp. 141-148
    • Gray, D.1    Kosco, M.2    Stockinger, B.3
  • 30
    • 0029789751 scopus 로고    scopus 로고
    • Generation of MHC class-I restricted T lymphocytes by expression of a viral protein in muscle cells: Antigen presentation by non-muscle cells
    • Ulmer JB, Deck RR, DeWitt CM, Donnelly JJ, Liu MA: Generation of MHC class-I restricted T lymphocytes by expression of a viral protein in muscle cells: antigen presentation by non-muscle cells. Immunology 1996, 89:59-67. Although it did not completely answer the question, this is the first paper to shed light on the possible mechanism of antigen presentation with DNA vaccines.
    • (1996) Immunology , vol.89 , pp. 59-67
    • Ulmer, J.B.1    Deck, R.R.2    DeWitt, C.M.3    Donnelly, J.J.4    Liu, M.A.5
  • 31
    • 0029956512 scopus 로고    scopus 로고
    • Gene vaccination with naked plasmid DNA: Mechanism of CTL priming
    • Corr M, Lee DJ, Carson DA, Tighe H: Gene vaccination with naked plasmid DNA: mechanism of CTL priming. J Exp Med 1996, 184:1555-1560.
    • (1996) J Exp Med , vol.184 , pp. 1555-1560
    • Corr, M.1    Lee, D.J.2    Carson, D.A.3    Tighe, H.4
  • 32
    • 0029737350 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells
    • Doe B, Selby M, Barnett S, Baenziger J, Walker CM: Induction of cytotoxic T lymphocytes by intramuscular immunization with plasmid DNA is facilitated by bone marrow-derived cells. Proc Natl Acad Sci USA 1996, 93:8578-8583.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 8578-8583
    • Doe, B.1    Selby, M.2    Barnett, S.3    Baenziger, J.4    Walker, C.M.5
  • 33
    • 0031059565 scopus 로고    scopus 로고
    • Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells
    • Manickan E, Karem KL, Rouse BT: Enhancement of immune response to naked DNA vaccine by immunization with transfected dendritic cells. J Leukoc Biol 1997, 61:125-132.
    • (1997) J Leukoc Biol , vol.61 , pp. 125-132
    • Manickan, E.1    Karem, K.L.2    Rouse, B.T.3
  • 34
    • 0030174678 scopus 로고    scopus 로고
    • DMA-mediated immunization to hepatitis B surface antigen: Longevity of primary response and effect of boost
    • Davis HL, Mancini M, Michel ML, Whalen RG: DMA-mediated immunization to hepatitis B surface antigen: longevity of primary response and effect of boost Vaccine 1996, 14:910-915.
    • (1996) Vaccine , vol.14 , pp. 910-915
    • Davis, H.L.1    Mancini, M.2    Michel, M.L.3    Whalen, R.G.4
  • 35
    • 0029664297 scopus 로고    scopus 로고
    • Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization
    • Raz E, Tighe H, Sato Y, Corr M, Dudler JA, Roman M, Swain SL, Spiegelberg HL, Carson DA: Preferential induction of a Th1 immune response and inhibition of specific IgE antibody formation by plasmid DNA immunization. Proc Natl Acad Sci USA 1996, 93:5141-5145. This paper is important in that it evokes the possibility of using DNA vaccines for the immunotherapeutic treatment of asthma, through redirection of a Th2 to a Th1 response.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 5141-5145
    • Raz, E.1    Tighe, H.2    Sato, Y.3    Corr, M.4    Dudler, J.A.5    Roman, M.6    Swain, S.L.7    Spiegelberg, H.L.8    Carson, D.A.9
  • 36
    • 0030791541 scopus 로고    scopus 로고
    • Biological features of genetic immunization
    • in press
    • Barry MA, Johnston SA: Biological features of genetic immunization. Vaccine 1997, 15:in press.
    • (1997) Vaccine , vol.15
    • Barry, M.A.1    Johnston, S.A.2
  • 38
    • 0031093543 scopus 로고    scopus 로고
    • Different T helper cell types and antibody isotopes generated by saline and gene gun DNA immunization
    • Feltquate DM, Heaney S, Webster RG, Robinson HL: Different T helper cell types and antibody isotopes generated by saline and gene gun DNA immunization. J Immunol 1997, 158:2278-2284.
    • (1997) J Immunol , vol.158 , pp. 2278-2284
    • Feltquate, D.M.1    Heaney, S.2    Webster, R.G.3    Robinson, H.L.4
  • 39
    • 0029813303 scopus 로고    scopus 로고
    • Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
    • Pertmer TM, Roberts TR, Haynes JR: Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J Virol 1996, 70:6119-6125.
    • (1996) J Virol , vol.70 , pp. 6119-6125
    • Pertmer, T.M.1    Roberts, T.R.2    Haynes, J.R.3
  • 40
    • 0031570044 scopus 로고    scopus 로고
    • Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations
    • Torres CA, Iwasaki A, Barber BH, Robinson HL: Differential dependence on target site tissue for gene gun and intramuscular DNA immunizations. J Immunol 1997, 158:4529-4532.
    • (1997) J Immunol , vol.158 , pp. 4529-4532
    • Torres, C.A.1    Iwasaki, A.2    Barber, B.H.3    Robinson, H.L.4
  • 41
    • 0029984358 scopus 로고    scopus 로고
    • CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma
    • Klinman DM, Yi AK, Beaucage SL, Conover J, Kreig AM: CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA 1996, 93:2879-2883.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 2879-2883
    • Klinman, D.M.1    Yi, A.K.2    Beaucage, S.L.3    Conover, J.4    Kreig, A.M.5
  • 42
    • 8944253295 scopus 로고    scopus 로고
    • Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
    • Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, Lotz M, Carson DA, Raz E: Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science 1996, 273:352-354. This paper is the first to show that CpG-containing immunostimulatory motifs are essential for the efficacy of DNA vaccines.
    • (1996) Science , vol.273 , pp. 352-354
    • Sato, Y.1    Roman, M.2    Tighe, H.3    Lee, D.4    Corr, M.5    Nguyen, M.D.6    Silverman, G.J.7    Lotz, M.8    Carson, D.A.9    Raz, E.10
  • 43
    • 0031569601 scopus 로고    scopus 로고
    • Contribution of CpG motifs to the immunogenicity of DNA vaccines
    • Klinman DM, Yamshchikov G, Ishigatsubo Y: Contribution of CpG motifs to the immunogenicity of DNA vaccines. J Immunol 1997, 158:3635-3639.
    • (1997) J Immunol , vol.158 , pp. 3635-3639
    • Klinman, D.M.1    Yamshchikov, G.2    Ishigatsubo, Y.3
  • 46
    • 0030239828 scopus 로고    scopus 로고
    • Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
    • Ballas ZK, Rasmussen WL, Krieg AM: Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. J Immunol 1996, 157:1840-1845.
    • (1996) J Immunol , vol.157 , pp. 1840-1845
    • Ballas, Z.K.1    Rasmussen, W.L.2    Krieg, A.M.3
  • 47
    • 0029934754 scopus 로고    scopus 로고
    • Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides
    • Cowdery JS, Chace JH, Yi AK, Krieg AM: Bacterial DNA induces NK cells to produce IFN-gamma in vivo and increases the toxicity of lipopolysaccharides. J Immunol 1996, 156:4570-4575.
    • (1996) J Immunol , vol.156 , pp. 4570-4575
    • Cowdery, J.S.1    Chace, J.H.2    Yi, A.K.3    Krieg, A.M.4
  • 49
    • 0001408940 scopus 로고    scopus 로고
    • Immune response of neonates elicited by somatic transgene vaccination with naked DNA
    • Bot A, Antohi S, Bona CA: Immune response of neonates elicited by somatic transgene vaccination with naked DNA. Front Biosci 1997, 2:173-188.
    • (1997) Front Biosci , vol.2 , pp. 173-188
    • Bot, A.1    Antohi, S.2    Bona, C.A.3
  • 50
    • 0031575531 scopus 로고    scopus 로고
    • Immune response to a neonatal genetic immunization
    • Wang Y, Ziang Z, Pasquini S, Ertl HCJ: Immune response to a neonatal genetic immunization. Virology 1997, 228:278-284. This is the first paper to describe successful immunization of neonates with DNA vaccines.
    • (1997) Virology , vol.228 , pp. 278-284
    • Wang, Y.1    Ziang, Z.2    Pasquini, S.3    Ertl, H.C.J.4
  • 51
    • 0029985146 scopus 로고    scopus 로고
    • DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state
    • Mancini M, Hadchouel M, Davis HL, Whalen RG, Tiollais P, Michel ML: DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state. Proc Natl Acad Sci USA 1996, 93:12496-12501. This paper shows the potential of DNA vaccines for immunotherapeutic treatment of chronic viral infections. In this case, a DNA vaccine was able to break tolerance in a transgenic mouse model of the hepatitis B chronic carrier and to down regulate viral gene expression in the liver through a noncytolytic mechanism.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 12496-12501
    • Mancini, M.1    Hadchouel, M.2    Davis, H.L.3    Whalen, R.G.4    Tiollais, P.5    Michel, M.L.6
  • 52
    • 0029887746 scopus 로고    scopus 로고
    • Polynucleotide-mediated immunization therapy of cancer
    • Conry RM, LoBuglio AF, Curiel DT: Polynucleotide-mediated immunization therapy of cancer. Semin Oncol 1996, 23:135-147.
    • (1996) Semin Oncol , vol.23 , pp. 135-147
    • Conry, R.M.1    LoBuglio, A.F.2    Curiel, D.T.3
  • 55
    • 0030587855 scopus 로고    scopus 로고
    • DNA vaccination primes MHC class I-restricted, simian virus 40 large tumor antigen-specific CTL in H-2d mice that reject syngeneic tumors
    • Schirmbeck R, Bohm W, Reimann J: DNA vaccination primes MHC class I-restricted, simian virus 40 large tumor antigen-specific CTL in H-2d mice that reject syngeneic tumors. J Immunol 1996, 157:3550-3558.
    • (1996) J Immunol , vol.157 , pp. 3550-3558
    • Schirmbeck, R.1    Bohm, W.2    Reimann, J.3
  • 56
    • 0030022796 scopus 로고    scopus 로고
    • Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases
    • Irvine KR, Rao JB, Rosenberg SA, Restifo NP: Cytokine enhancement of DNA immunization leads to effective treatment of established pulmonary metastases. J Immunol 1996, 156:238-245.
    • (1996) J Immunol , vol.156 , pp. 238-245
    • Irvine, K.R.1    Rao, J.B.2    Rosenberg, S.A.3    Restifo, N.P.4
  • 57
    • 0029947820 scopus 로고    scopus 로고
    • Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors
    • Rakhmilevich AL, Turner J, Ford MJ, McCabe D, Sun WH, Sondel PM, Grota K, Yang NS: Gene gun-mediated skin transfection with interleukin 12 gene results in regression of established primary and metastatic murine tumors. Proc Natl Acad Sci USA 1996, 93:6291-6296.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 6291-6296
    • Rakhmilevich, A.L.1    Turner, J.2    Ford, M.J.3    McCabe, D.4    Sun, W.H.5    Sondel, P.M.6    Grota, K.7    Yang, N.S.8
  • 58
    • 0029878034 scopus 로고    scopus 로고
    • Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes
    • Ciernik IF, Berzofsky JA, Carbone DP: Induction of cytotoxic T lymphocytes and antitumor immunity with DNA vaccines expressing single T cell epitopes. J Immunol 1996, 156:2369-2375. This is a novel approach to immunization which is really only possible with the DNA vaccine approach - namely immunization with short peptides representing single T-cell epitopes. With antigen-based approaches, such short peptides are too unstable and thus they have to be covalently linked to some other molecule.
    • (1996) J Immunol , vol.156 , pp. 2369-2375
    • Ciernik, I.F.1    Berzofsky, J.A.2    Carbone, D.P.3
  • 59
    • 0028863527 scopus 로고
    • Protection against mycoplasma infection using expression-library immunization
    • Barry MA, Lai WC, Johnston SA: Protection against mycoplasma infection using expression-library immunization. Nature 1995, 377:632-635.
    • (1995) Nature , vol.377 , pp. 632-635
    • Barry, M.A.1    Lai, W.C.2    Johnston, S.A.3
  • 61
    • 0029939724 scopus 로고    scopus 로고
    • ELI's coming: Expression library immunization and vaccine antigen discovery
    • Ulmer JB, Lui MA: ELI's coming: expression library immunization and vaccine antigen discovery. Trends Microbiol 1996, 4:169-170.
    • (1996) Trends Microbiol , vol.4 , pp. 169-170
    • Ulmer, J.B.1    Lui, M.A.2


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