Identification of a cysteine residue essential for activity of protein farnesyltransferase: Cys 299 is exposed only upon removal of zinc from the enzyme

Journal of Biological Chemistry

Volumn 271, Issue 45, 1996, Pages 28541-28548

  Fu, Hua Wen ^a   Moomaw, John F ^a   Moomaw, Carolyn R ^b   Casey, Patrick J ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; FARNESYL TRANS TRANSFERASE; ZINC;

AMINO ACID SEQUENCE; ARTICLE; BINDING SITE; ENZYME ACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

ALKYL AND ARYL TRANSFERASES; CHROMATOGRAPHY, ION EXCHANGE; CYSTEINE; DIMETHYLALLYLTRANSTRANSFERASE; DITHIOTHREITOL; ETHYLMALEIMIDE; KINETICS; MUTAGENESIS, SITE-DIRECTED; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL REAGENTS; TRANSFERASES; TRYPSIN; ZINC;

ESCHERICHIA COLI;

EID: 0029905595     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.45.28541     Document Type: Article

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