Structural features of the interleukin-10 family of cytokines

Current Pharmaceutical Design

Volumn 10, Issue 31, 2004, Pages 3873-3884

  Zdanov, Alexander ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Cytokines; Helix bundle; Interleukin 10; Ligand receptor interactions; Signal transduction

Indexed keywords

CYTOKINE; DIMER; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 19; INTERLEUKIN 20; INTERLEUKIN 24; INTERLEUKIN 26; INTERLEUKIN 29; LAMBDA2 INTERFERON; LAMBDA3 INTERFERON; LIGAND; MONOMER; PHENYLALANINE; TYROSINE; UNCLASSIFIED DRUG;

BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN STRUCTURE; RECEPTOR BINDING; REVIEW; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; VIRUS GENE;

CYTOKINES; HUMANS; INTERLEUKIN-10; MODELS, MOLECULAR; PROTEIN CONFORMATION;

EID: 9944229505     PISSN: 13816128     EISSN: None     Source Type: Journal    
DOI: 10.2174/1381612043382602     Document Type: Review

References (87)

1. Moore KW, de Waal MR, Coffman RL, O'Garra A. Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001; 19: 683.
2. Fiorentino DF, Bond MW, Mosmann TR. Two types of mouse T helper cell: IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones. J Exp Med 1989; 170: 2081.
3. Moore KW, Vieira P, Fiorentino DF, Trounstine ML, Khan TA, Mosmann TR. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein Barr Virus gene BCRFI. Science 1990; 248: 1230.
4. Asadullah K, Sterry W, Volk HD. Interleukin-10 therapy - review of a new approach. Pharmacol Rev 2003; 55: 241.
5. Tan JC, Indelicato SR, Narula SK, Zavodny PJ, Chou C-C. Characterization of interleukin-10 receptors on human and mouse cells. J Biol Chem 1993; 268: 21053.
6. Windsor WT, Syto R, Tsarbopoulos A, Zhang R, Durkin J, Baldwin S, et al. Disulfide bond assignments and secondary structure analysis of human and murine interleukin 10. Biochemistry 1993; 32: 8807.
7. Vieira P, Malefyt RW, Dang M-N, Johnson KE, Kastelein R, Fiorentino DF, et al. Isolation and expression of human cytokine synthesis inhibitory factor cDNA clones: Homology to Epstein-Barr virus open reading frame BCRFI. Proc Natl Acad Sci USA 1991; 88: 1172.
8. Liu Y, Wei SHY, Ho ASY, Malefyt RW, Moore KW. Expression cloning and characterization of a human IL-10 receptor. J Immunol 1994; 152: 1821.
9. Kotenko SV, Krause CD, Izotova LS, Pollack BP, Wu W, Pestka S. Identification and functional characterization of a second chain of the interleukin-10 receptor complex. EMBO J 1997; 16: 5894.
10. Bazan JF. Structural design and molecular evolutuion of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87: 6934.
11. Ho ASY, Liu Y, Khan TA, Hsu D-H, Bazan JF, Moore KW. A receptor for interleukin 10 is related to interferon receptors. Proc Natl Acad Sci USA 1993; 90: 11267.
12. Kotenko SV. The family of IL10 related cytokines and their receptors: related, but to what extent? Cytokine Growth Factor Rev 2002; 13: 223.
13. Fickenscher H, Hor S, Kupers H, Knappe A, Wittmann S, Sticht H. The interleukin-10 family of cytokines. Trends Immunol 2002; 23: 89.
14. Dumoutier L, Renauld JC. Viral and cellular interleukin-10 (IL-10)-related cytokines: from structures to functions. Eur Cytokine Netw 2002; 13: 5.
15. Renauld JC. Class II cytokine receptors and their ligands: key antiviral and inflammatory modulators. Nat Rev Immunol 2003; 3: 667.
16. Ozaki K, Leonard WJ. Cytokine and cytokine receptor pleiotropy and redundancy. J Biol Chem 2002; 277: 29355.
17. Hsu DH, de Waal Malefyt F, Fiorentino DF, Dang MN, Vieira P, de Vries J, et al. Expression of interleukin-10 activity by Epstein-Barr virus protein BCRF1. Science 1990; 250: 830.
18. Rode HJ, Janssen W, Rosen-Wolff A, Bugert JJ, Thein P, Becker Y, et al. The genome of equine herpesvirus type 2 harbors an interleukin 10 (IL10)-like gene. Virus Genes 1993; 7: 111.
19. Fleming SB, McCaughan CA, Andrews AE, Nash AD, Mercer AA. A homolog of interleukin-10 is encoded by the poxvirus orf virus. J Virol 1997; 71: 4857.
20. Fleming SB, Haig DM, Nettleton P, Reid HW, McCaughan CA, Wise LM, et al. Sequence and functional analysis of a homolog of interleukin-10 encoded by the parapoxvirus orf virus. Virus Genes 2000; 21: 85.
21. Kotenko SV, Saccani S, Izotova LS, Mirochnitchenko OV, Pestka S. Human cytomegalovirus harbors its own unique IL-10 homolog (cmvIL-10). Proc Natl Acad Sci USA 2000; 97: 1695.
22. Lockridge KM, Zhou SS, Kravitz RH, Johnson JL, Sawai ET, Blewett EL, et al. Primate cytomegaloviruses encode and express an IL-10-like protein. Virol 2000; 268: 272.
23. Lee HJ, Essani K, Smith GL. The genome sequence of Yaba-like disease virus, a yatapoxvirus. Virol 2001; 281: 170.
24. Zdanov A, Schalk-Hihi C, Menon S, Moore KW, Wlodawer A. Crystal structure of Epstein-Barr virus protein BCRF1, a homolog of cellular interleukin-10. J Mol Biol 1997; 268: 460.
25. Jones BC, Logsdon NJ, Josephson K, Cook J, Barry PA, Walter MR. Crystal structure of human cytomegalovirus IL-10 bound to soluble human IL-10R1. Proc Natl Acad Sci USA 2002; 99: 9404.
26. Gallagher G, Dickensheets H, Eskdale J, Izotova LS, Mirochnitchenko OV, Peat JD, et al. Cloning, expression and initial characterization of interleukin-19 (IL- 19), a novel homologue of human interleukin-10 (IL-10). Genes Immun 2000; 1: 442.
27. Blumberg H, Conklin D, Xu WF, Grossmann A, Brender T, Carollo S, et al. Interleukin 20: discovery, receptor identification, and role in epidermal function. Cell 2001; 104: 9.
28. Dumoutier L, Van Roost E, Colau D, Renauld JC. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc Natl Acad Sci USA 2000; 97: 10144.
29. Xie MH, Aggarwal S, Ho WH, Foster J, Zhang Z, Stinson J, et al. Interleukin (IL)-22, a novel human cytokine that signals through the interferon receptor-related proteins CRF2-4 and IL-22R. J Biol Chem 2000; 275: 31335.
30. Jiang H, Su ZZ, Lin JJ, Goldstein NI, Young CS, Fisher PB. The melanoma differentiation associated gene mda-7 suppresses cancer cell growth. Proc Natl Acad Sci USA 1996; 93: 9160.
31. Knappe A, Hor S, Wittmann S, Fickenscher H. Induction of a novel cellular homolog of interleukin-10, AK155, by transformation of T lymphocytes with herpesvirus saimiri. J Virol 2000; 74: 3881.
32. Kotenko SV, Gallagher G, Baurin VV, Lewis-Antes A, Shen M, Shah NK, et al. IFN-lambdas mediate antiviral protection through a distinct class II cytokine receptor complex. Nature Immunol 2003; 4: 69.
33. Sheppard P, Kindsvogel W, Xu W, Henderson K, Schlutsmeyer S, Whitmore TE, et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nature Immunol 2003; 4: 63.
34. Chang C, Magracheva E, Kozlov S, Fong S, Tobin G, Kotenko S, et al. Crystal structure of interleukin-19 defines a new subfamily of helical cytokines. J Biol Chem 2003; 278: 3308.
35. Nagem RAP, Colau D, Dumoutier L, Renauld J-C, Ogata C, Polikarpov I. Crystal structure of recombinant human interleukin-22. Structure 2002; 10: 1051.
36. Schein CH. The shape of the messenger: using protein structure information to design novel cytokine-based therapeutics. Curr Pharm Des 2002; 8: 2113.
37. Sprang SR, Bazan JF. Cytokine structural taxonomy and mechanisms of receptor engagement. Curr Opin Struct Biol 1993; 3: 815.
38. Rozwarski DA, Gronenborn AM, Clore GM, Bazan JF, Bohm A, Wlodawer A, et al. Structural comparisons among the short-chain helical cytokines. Structure 1994; 2: 159.
39. Zdanov A, Schalk-Hihi C, Gustchina A, Tsang M, Weatherbee J, Wlodawer A. Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon γ. Structure 1995; 3: 591.
40. Zdanov A, Schalk-Hihi C, Wlodawer A. Crystal structure of human interleukin-10 at 1.6 Å resolution and a model of a complex with its soluble receptor. Protein Sci 1996; 5: 1955.
41. Walter MR, Nagabhushan TL. Crystal structure of interleukin 10 reveals an interferon gamma- like fold. Biochemistry 1995; 34: 12118.
42. Presnell SR, Cohen FE. Topological distribution of four-α-helix bundles. Proc Natl Acad Sci USA 1989; 86: 6592.
43. Liu Y, Eisenberg D. 3D domain swapping: as domains continue to swap. Protein Sci 2002; 11: 1285.
44. Josephson K, DiGiacomo R, Indelicato SR, Iyo AH, Nagabhushan TL, Parker MH, et al. Design and analysis of an engineered human interleukin-10 monomer. J Biol Chem 2000; 275: 13552.
45. Josephson K, Jones BC, Walter LJ, DiGiacomo R, Indelicato SR, Walter MR. Noncompetitive antibody neutralization of IL-10 revealed by protein engineering and x-ray crystallography. Structure (Camb) 2002; 10: 981.
46. Syto R, Murgolo NJ, Braswell EH, Mui P, Huang E, Windsor WT. Structural and biological stability of the human interleukin 10 homodimer. Biochemistry 1998; 37: 16943.
47. Liu Y, de Waal Malefyt R, Briere F, Parham C, Bridon JM, Banchereau J, et al. The EBV IL-10 homolog is a selective agonist with impaired binding to the IL-10 receptor. J Immunol 1997; 158: 605.
48. Spencer SD, Di Marco F, Hooley J, Pitts-Meek S, Bauer M, Ryan AM, et al. The orphan receptor CRF2-4 is an essential subunit of the interleukin 10 receptor. J Exp Med 1998; 187: 571.
49. Josephson K, McPherson DT, Walter MR. Purification, crystallization and preliminary X-ray diffraction of a complex between IL-10 and soluble IL-10R1. Acta Crystallogr D Biol Crystallogr 2001; 57: 1908.
50. Tan JC, Braun S, Rong H, DiGiacomo R, Dolphin E, Baldwin S, et al. Characterization of recombinant extracellular domain of human interleukin-10 receptor. J Biol Chem 1995; 270: 12906.
51. Hoover DM, Schalk-Hihi C, Chou CC, Menon S, Wlodawer A, Zdanov A. Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. Eur J Biochem 1999; 262: 134.
52. Josephson K, Logsdon NJ, Walter MR. Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity 2001; 15: 35.
53. Bork P, Holm L, Sander C. The Immunoglobulin Fold. Structural classification, sequence patterns and common core. J Mol Biol 1994; 242: 309.
54. Somers W, Ultsch M, de Vos AM, Kossiakoff AA. The X-ray structure of a growth hormone-prolactin receptor complex. Nature 1994; 372: 478.
55. Livnah O, Stura EA, Johnson DL, Middleton SA, Mulcahy LS, Wrighton NC, et al. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science 1996; 273: 464.
56. de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex. Science 1992; 255: 306.
57. Hage T, Sebald W, Reinemer P. Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface. Cell 1999; 97: 271.
58. Hilton DJ, Watowich SS, Katz L, Lodish HF. Saturation mutagenesis of the WSXWS motif of the erythropoietin receptor. J Biol Chem 1996; 271: 4699.
59. Hilton DJ, Watowich SS, Murray PJ, Lodish HF. Increased cell surface expression and enhanced folding in the endoplasmic reticulum of a mutant erythropoietin receptor. Proc Natl Acad Sci USA 1995; 92: 190.
60. Walter MR. Strucure of interleukin-10/interleukin-10R1 complex: a paradigm for class 2 cytokine activation. Immunol Res 2002; 26: 303.
61. Pletnev S, Magracheva E, Kozlov S, Tobin G, Kotenko SV, Wlodawer A, et al. Characterization of the recombinant extracellular domains of human interleukin-20 receptors and their complexes with interleukin-19 and interleukin-20. Biochemistry 2003; In press:
62. Sauane M, Gopalkrishnan RV, Sarkar D, Su ZZ, Lebedeva IV, Dent P, et al. MDA-7/IL-24: novel cancer growth suppressing and apoptosis inducing cytokine. Cytokine Growth Factor Rev 2003; 14: 35.
63. Sauane M, Gopalkrishnan RV, Lebedeva I, Mei MX, Sarkar D, Su ZZ, et al. Mda-7/IL-24 induces apoptosis of diverse cancer cell lines through JAK/STAT-independent pathways. J Cell Physiol 2003; 196: 334.
64. Su ZZ, Lebedeva IV, Sarkar D, Gopalkrishnan RV, Sauane M, Sigmon C, et al. Melanoma differentiation associated gene-7, mda-7/IL-24, selectively induces growth suppression, apoptosis and radiosensitization in malignant gliomas in a p53-independent manner. Oncogene 2003; 22: 1164.
65. Ramesh R, Mhashilkar AM, Tanaka F, Saito Y, Branch CD, Sieger K, et al. Melanoma Differentiation-associated Gene 7/Interleukin (IL)-24 Is a Novel Ligand That Regulates Angiogenesis via the IL-22 Receptor. Cancer Res 2003; 63: 5105.
66. Mhashilkar AM, Stewart AL, Sieger K, Yang HY, Khimani AH, Ito I, et al. MDA-7 negatively regulates the beta-catenin and PI3K signaling pathways in breast and lung tumor cells. Mol Ther 2003; 8: 207.
67. Yacoub A, Mitchell C, Brannon J, Rosenberg E, Qiao L, McKinstry R, et al. MDA-7 (interleukin-24) inhibits the proliferation of renal carcinoma cells and interacts with free radicals to promote cell death and loss of reproductive capacity. Mol Cancer Ther 2003; 2: 623.
68. Lebedeva IV, Su ZZ, Sarkar D, Fisher PB. Restoring apoptosis as a strategy for cancer gene therapy: focus on p53 and mda-7. Semin Cancer Biol 2003; 13: 169.
69. Chen J, Chada S, Mhashilkar A, Miano JM. Tumor suppressor MDA-7/IL-24 selectively inhibits vascular smooth muscle cell growth and migration. Mol Ther 2003; 8: 220.
70. Nagem RA, Lucchesi KW, Colau D, Dumoutier L, Renauld JC, Polikarpov I. Crystallization and synchrotron X-ray diffraction studies of human interleukin-22. Acta Crystallogr D Biol Crystallogr 2002; 58: 529.
71. Genetics Computer Group. Program Manual for the GCG Package, Ver. 8. Madison, WI 1994.
72. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 2001; 167: 3545.
73. Wang M, Tan Z, Zhang R, Kotenko SV, Liang P. Interleukin 24 (MDA-7/MOB-5) signals through two heterodimeric receptors, IL-22R1/IL-20R2 and IL-20R1/IL-20R2. J Biol Chem 2002; 277: 7341.
74. Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, et al. Identification of the functional interleukin-22 (IL-22) receptor complex: the IL-10R2 chain (IL-10Rbeta ) is a common chain of both the IL-10 and IL-22 (IL-10-related T cell-derived inducible factor, IL-TIF) receptor complexes. J Biol Chem 2001; 276: 2725.
75. Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, et al. Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J Immunol 2001; 166: 7096.
76. Dumoutier L, Lejeune D, Colau D, Renauld JC. Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol 2001; 166: 7090.
77. Xu W, Presnell SR, Parrish-Novak J, Kindsvogel W, Jaspers S, Chen Z, et al. A soluble class II cytokine receptor, IL-22RA2, is a naturally occurring IL-22 antagonist. Proc Natl Acad Sci USA 2001; 98: 9511.
78. Parrish-Novak J, Xu W, Brender T, Yao L, Jones C, West J, et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem 2002; 277: 47517.
79. Logsdon NJ, Jones BC, Josephson K, Cook J, Walter MR. Comparison of interleukin-22 and interleukin-10 soluble receptor complexes. J Interferon Cytokine Res 2002; 22: 1099.
80. Radhakrishnan R, Walter LJ, Hruza A, Reichert P, Trotta PP, Nagabhushan TL, et al. Zinc mediated dimer of human interferon-alpha 2b revealed by X-ray crystallography. Structure 1996; 4: 1453.
81. Sims JE, Nicklin MJ, Bazan JF, Barton JL, Busfield SJ, Ford JE, et al. A new nomenclature for IL-1-family genes. Trends Immunol 2001; 22: 536.
82. Gibbs VC, Pennica D. CRF2-4: isolation of cDNA clones encoding the human and mouse proteins. Gene 1997; 186: 97.
83. Lutfalla G, Gardiner K, Uze G. A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR. Genomics 1993; 16: 366.
84. Carson M. RIBBONS 4.0. J Appl Crystallogr 1991; 24: 958.
85. Amati L, Caradonna L, Magrone T, Mastronardi ML, Cuppone R, Cozzolongo R, et al. Modifications of the immune responsiveness in patients with hepatitis C virus infection following treatment with IFN-alpha/ribavirin. Curr Pharm Design 2002; 8(11): 981-93.
86. Takano H, Ohtsuka M, Akazawa H, Toko H, Harada M, Hasegawa H, et al. Pleiotropic effects of cytokines on acute myocardial infarction: G-CSF as a novel therapy for acute myocardial infarction. Curr Pharm Design 2003; 9(14): 1121-7.
87. Yang X. Role of cytokines in Chlamydia trachomatis protective immunity and immunopathology. Curr Pharm Design 2003; 9(1): 67-73.