Structure of interleukin-10/interleukin-10R1 complex: A paradigm for class 2 cytokine activation

Immunologic Research

Volumn 26, Issue 1-3, 2002, Pages 303-308

  Walter, Mark R ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Crystal structure; Cytokine; Interferon ; Interleukin 10; Molecular recognition; Protein structure; Receptor

Indexed keywords

CELL SURFACE RECEPTOR; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 10 RECEPTOR; CYTOKINE; INTERLEUKIN RECEPTOR;

ANTIVIRAL ACTIVITY; ARTICLE; CELL AGGREGATION; CELL GROWTH; CELL SURFACE; COMPLEX FORMATION; CRYSTAL STRUCTURE; CYTOKINE PRODUCTION; INFLAMMATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; X RAY CRYSTALLOGRAPHY; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; HUMAN; MACROMOLECULE; METABOLISM; REVIEW;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYTOKINES; HUMANS; INTERLEUKIN-10; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-10;

EID: 0036025156     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1385/IR:26:1-3:303     Document Type: Article

References (10)

1. Moore KW, de Waal Malefyt R, Coffman RL, O'Garra A: Interleukin-10 and the interleukin-10 receptor. Annu Rev Immunol 2001;19:683-765.
2. Walter MR, Nagabhushan TL: Crystal structure of interleukin 10 reveals an interferon gamma-like fold. Biochemistry 1995;34:12,118-12,125.
3. Josephson K, Logsdon NJ, Walter MR: Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity 2001;14:35-46.
4. Walter MR, Windsor WT, Nagabhushan TL, Lundell DJ, Lunn CA, Zauodny PJ, Narula SK: Crystal structure of a complex between interferon-gamma and its soluble high-affinity receptor. Nature 1995;376:230-235.
5. Clackson T, Wells JA: A hot spot of binding energy in a hormone-receptor interface. Science 1995;267:383-386.
6. Bach EA, Aguet M, Schreiber RD: The IFN gamma receptor: a paradigm for cytokine receptor signaling. Annu Rev Immunol 1997;15:563-591.
7. Dumoutier L, Leemans C, Lejeune D, Kotenko SV, Renauld JC: 8 Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol 2001;167:3545-3549.
8. Dumoutier L, Lejeune D, Colau D, Renauld JC: Cloning and characterization of IL-22 binding protein, a natural antagonist of IL-10-related T cell-derived inducible factor/IL-22. J Immunol 2001;166:7090-7095.
9. Kotenko SV, Izotova LS, Mirochnitchenko OV, Esterova E, Dickensheets H, Donnelly RP, Pestka S: Identification, cloning, and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J Immunol 2001;166:7096-7103.
10. Pestka S: The human interferon alpha species and receptors. Biopolymers 2000;55:254-287.