The hairless gene mutated in congenital hair loss disorders encodes a novel nuclear receptor corepressor

Genes and Development

Volumn 15, Issue 20, 2001, Pages 2687-2701

  Potter, G B ^a   Beaudoin III, G M J ^a   DeRenzo, C L ^a   Zarach, J M ^a   Chen, S H ^a   Thompson, C C ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Histone deacetylase; Nuclear receptor; Thyroid hormone; Transcriptional repression

Indexed keywords

CELL NUCLEUS RECEPTOR; HISTONE DEACETYLASE; THYROID HORMONE; THYROID HORMONE RECEPTOR;

ALOPECIA; ANIMAL CELL; ARTICLE; ENZYME LOCALIZATION; GENE MUTATION; GENETIC ANALYSIS; GENETIC DISORDER; GENETIC MANIPULATION; HAIR GROWTH; HAIR LOSS; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN SECONDARY STRUCTURE; RECEPTOR BINDING;

AMINO ACID SEQUENCE; BLOTTING, WESTERN; CELL NUCLEUS; CELLS, CULTURED; FLUORESCENT ANTIBODY TECHNIQUE; FUNGAL PROTEINS; GENE EXPRESSION; GENETIC VECTORS; HAIR DISEASES; HISTONE DEACETYLASES; HUMANS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; NUCLEAR PROTEINS; PROMOTER REGIONS (GENETICS); PROTEINS; RECEPTORS, THYROID HORMONE; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES;

ANIMALIA; MAMMALIA;

EID: 0035887252     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.916701     Document Type: Article

References (67)

1. Alopecia universalis associated with a mutation in the human hairless gene
2. The molecular basis of congenital atrichia in humans and mice: Mutations in the hairless gene
3. A novel missense mutation (C622G) in the zinc-finger domain of the human hairless gene associated with congenital atrichia with papular lesions
4. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression
5. Characterization of the ligand-dependent transactivation domain of thyroid hormone receptor
6. The skin in hypothyroidism
7. Alpha and beta thyroid hormone receptor (TR) gene expression during auditory neurogenesis: Evidence for TR isoform-specific transcriptional regulation in vivo
8. Hairless mice
9. Co-repressors 2000
10. Structure and expression of the hairless gene of mice
11. The hairless gene of the mouse: Relationship of phenotypic effects with expression profile and genotype
12. Interaction of proteins with transcriptionally active estrogen receptors
13. A transcriptional co-repressor that interacts with nuclear hormone receptors
14. SMRT isoforms mediate repression and anti-repression of nuclear receptor heterodimers
15. Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia
16. Atrichia with papular lesions and mental retardation in two sisters
17. Identification of a nuclear domain with deacetylase activity
18. Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily
19. Activation function 2 (AF-2) of retinoic acid receptor and 9-cis retinoic acid receptor: Presence of a conserved autonomous constitutive activating domain and influence of the nature of the response element on AF-2 activity
20. Characterization of a human RPD3 ortholog, HDAC3
21. Thyroid hormone receptor beta is essential for development of auditory function
22. Changes in the cerebellar cortex of hairless Rhino-J mice (hr-rh-j)
23. The coregulator exchange in transcriptional functions of nuclear receptors
24. The human histone deacetylase family
25. Three proteins define a class of human histone deacetylases related to yeast Hda1p
26. A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness
27. Histone deacetylase activity is required for full transcriptional repression by mSin3A
28. A signature motif in transcriptional co-activators mediates binding to nuclear receptors
29. A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression
30. Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system
31. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor corepressor
32. The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors
33. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway
34. Multiple N-CoR complexes contain distinct histone deacetylases
35. Isolation of a novel histone deacetylase reveals that class I and class II deacetylases promote SMRT-mediated repression
36. Novel hairless mutations in two kindreds with autosomal recessive papular atrichia
37. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression
38. SAP30, a component of the mSin3 corepressor complex involved in N-CoR- mediated depression by specific transcription factors
39. Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor
40. Morphogenetic actions of thyroid hormones
41. Characterization of receptor interaction and transcriptional repression by the corepressor SMRT
42. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3
43. The PSIPRED protein structure prediction server
44. Expression and hormonal regulation of coactivator and corepressor genes
45. The nuclear receptor ligand-binding domain: Structure and function
46. Nuclear receptor repression mediated by a complex containing SMRT, mSin3A, and histone deacetylase
47. Mechanism of corepressor binding and release from nuclear hormone receptors
48. Hearing loss and cochlear abnormalities in the congenital hypothyroid (hyt/hyt) mouse
49. Unique forms of human and mouse nuclear receptor corepressor SMRT
50. Molecular and functional aspects of the hairless (hr) gene in laboratory rodents and humans
51. The role of the hairless (hr) gene in the regulation of hair follicle catagen transformation
52. What's up and down with histone deacetylation and transcription?
53. Molecular determinants of nuclear receptor-corepressor interaction
54. Depletion of L-3,5,3′-triiodothyronine and L-thyroxine in euthyroid calf serum for use in cell culture studies of the action of thyroid hormone
55. Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors
56. Identification of a genetic defect in the hairless gene in atrichia with papular lesions: Evidence for phenotypic heterogeneity among inherited atrichias
57. Role of endogenous retroviruses as mutagens: The hairless mutation of mice
58. Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog
59. The product of a thyroid hormone-responsive gene interacts with thyroid hormone receptors
60. Thyroid hormone action in neural development
61. Retinoic acid and thyroid hormone induce gene expression through a common responsive element
62. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors
63. The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs)
64. The histone deacetylase-3 complex contains nuclear receptor corepressors
65. Coactivator and corepressor complexes in nuclear receptor function
66. Hormonal regulation of the growth hormone gene. Relationship of the rate of transcription to the level of nuclear thyroid hormone-receptor complexes