-
1
-
-
0028287202
-
Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development
-
Peck, C. C. et al., Opportunities for integration of pharmacokinetics, pharmacodynamics, and toxicokinetics in rational drug development, J. Clin. Pharmacol., 34: 111-119, 1994.
-
(1994)
J. Clin. Pharmacol.
, vol.34
, pp. 111-119
-
-
Peck, C.C.1
-
2
-
-
0026488120
-
The role of pharmacokinetics in the development of biotechnologically derived agents
-
Wills, R. J. and Ferraiolo, B. L., The role of pharmacokinetics in the development of biotechnologically derived agents, Clin. Pharmacokinet., 23: 406-414, 1992.
-
(1992)
Clin. Pharmacokinet.
, vol.23
, pp. 406-414
-
-
Wills, R.J.1
Ferraiolo, B.L.2
-
3
-
-
0029692312
-
Methods for evaluating intestinal permeability and metabolism in vitro
-
Borchardt, R. T., Smith, P. L., and Wilson, G., Eds., Plenum Press, New York
-
Smith, P. L., Methods for evaluating intestinal permeability and metabolism in vitro, in Models for Assessing Drug Absorption and Metabolism, Borchardt, R. T., Smith, P. L., and Wilson, G., Eds., Plenum Press, New York, 1996, 13-34.
-
(1996)
Models for Assessing Drug Absorption and Metabolism
, pp. 13-34
-
-
Smith, P.L.1
-
4
-
-
0025912228
-
Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein
-
Hunter, J., Hirst, B. H., and Simmons, N. L., Epithelial secretion of vinblastine by human intestinal adenocarcinoma cell (HCT-8 and T84) layers expressing P-glycoprotein, Br. J. Cancer, 64: 437-444, 1991.
-
(1991)
Br. J. Cancer
, vol.64
, pp. 437-444
-
-
Hunter, J.1
Hirst, B.H.2
Simmons, N.L.3
-
5
-
-
0028280231
-
Use of Caco-2 cells as an in vivo intestinal absorption and metabolism model
-
Gan, L. S. et al., Use of Caco-2 cells as an in vivo intestinal absorption and metabolism model, Drug Dev. Ind. Pharm., 20: 615-631, 1994.
-
(1994)
Drug Dev. Ind. Pharm
, vol.20
, pp. 615-631
-
-
Gan, L.S.1
-
6
-
-
0031022120
-
Applications of the Caco-2 model in the design and the development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium
-
Gan, L. S. I. and Thakker, D. R., Applications of the Caco-2 model in the design and the development of orally active drugs: elucidation of biochemical and physical barriers posed by the intestinal epithelium, Adv. Drug Deliv. Res., 23: 77-98, 1997.
-
(1997)
Adv. Drug Deliv. Res
, vol.23
, pp. 77-98
-
-
Gan, L.S.I.1
Thakker, D.R.2
-
7
-
-
0033278620
-
Gastrointestinal absorption of drugs: Methods and studies
-
Barthe, L., Woodley, J., and Houin, G., Gastrointestinal absorption of drugs: methods and studies, Fundam. Clin. Pharmacol.,13: 154-168, 1999.
-
(1999)
Fundam. Clin. Pharmacol
, vol.13
, pp. 154-168
-
-
Barthe, L.1
Woodley, J.2
Houin, G.3
-
8
-
-
0000727929
-
Transport of ions across cellular membranes
-
Ussing, H. H., Transport of ions across cellular membranes, Physiol. Rev., 29: 127-155,1949.
-
(1949)
Physiol. Rev
, vol.29
, pp. 127-155
-
-
Ussing, H.H.1
-
9
-
-
85056971349
-
Bovine and porcine large intestine as model epithelia in a student lab course
-
Hegel, U. et al., Bovine and porcine large intestine as model epithelia in a student lab course, Adv. Phys. Ed., 10: S10-S19, 1993.
-
(1993)
Adv. Phys. Ed
, vol.10
, pp. S10-S19
-
-
Hegel, U.1
-
10
-
-
0015056184
-
Ion transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit current
-
Field, M., Fromm, D., and McColl, I., Ion transport in rabbit ileal mucosa. I. Na and Cl fluxes and short-circuit current, Am. J. Physiol., 220: 1388-1396, 1971.
-
(1971)
Am. J. Physiol.
, vol.220
, pp. 1388-1396
-
-
Field, M.1
Fromm, D.2
McColl, I.3
-
11
-
-
6544259277
-
The use of sacs of everted small intestine for the study of the transference of substance from the mucosal to the serosal surface
-
Wilson, T. H. and Wiseman, G., The use of sacs of everted small intestine for the study of the transference of substance from the mucosal to the serosal surface, J. Physiol., 123: 116-125, 1954.
-
(1954)
J. Physiol
, vol.123
, pp. 116-125
-
-
Wilson, T.H.1
Wiseman, G.2
-
12
-
-
0027231109
-
Influence of anesthetic regimens on intestinal absorption in rats
-
Yuasa, H., Matsuda, K., and Watanabe, J., Influence of anesthetic regimens on intestinal absorption in rats, Pharm. Res., 10: 884-888, 1993.
-
(1993)
Pharm. Res.
, vol.10
, pp. 884-888
-
-
Yuasa, H.1
Matsuda, K.2
Watanabe, J.3
-
13
-
-
0014589701
-
Drug absorption I: An in situ gut technique yielding realistic absorption rates
-
Doluisio, J. T. et al., Drug absorption I: an in situ gut technique yielding realistic absorption rates, J. Pharm. Sci., 58: 1196-1200, 1969.
-
(1969)
J. Pharm. Sci.
, vol.58
, pp. 1196-1200
-
-
Doluisio, J.T.1
-
14
-
-
0016714954
-
Effect of perfusion rate on absorption, surface area, unstirred water layer thickness, permeability and intraluminal pressure in the rat ileum in vivo
-
Lewis, L. D. and Fordtran, J. S., Effect of perfusion rate on absorption, surface area, unstirred water layer thickness, permeability and intraluminal pressure in the rat ileum in vivo, Gastroenterology, 68: 1509-1516, 1975.
-
(1975)
Gastroenterology
, vol.68
, pp. 1509-1516
-
-
Lewis, L.D.1
Fordtran, J.S.2
-
15
-
-
0029055473
-
Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals
-
Kararli, T. T., Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals, Biopharm. Drug Dispos., 16: 351-380, 1995.
-
(1995)
Biopharm. Drug Dispos.
, vol.16
, pp. 351-380
-
-
Kararli, T.T.1
-
16
-
-
0031915533
-
Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: Methods and applications
-
Allen, M. C., Shah, T. S., and Day, W. W., Rapid determination of oral pharmacokinetics and plasma free fraction using cocktail approaches: methods and applications, Pharm. Res., 15(1): 93-97, 1998.
-
(1998)
Pharm. Res
, vol.15
, Issue.1
, pp. 93-97
-
-
Allen, M.C.1
Shah, T.S.2
Day, W.W.3
-
17
-
-
0033008412
-
Use of “N-in One” dosing to create an in vivo pharmacokinetic database for use in developing structure-pharmacokinetic relationships
-
Shaffer, J. E. et al., Use of “N-in One” dosing to create an in vivo pharmacokinetic database for use in developing structure-pharmacokinetic relationships, J. Pharm. Sci., 88: 313-318, 1999.
-
(1999)
J. Pharm. Sci.
, vol.88
, pp. 313-318
-
-
Shaffer, J.E.1
-
18
-
-
0031873679
-
Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening
-
Hop, C. E. C. A. et al., Plasma-pooling methods to increase throughput for in vivo pharmacokinetic screening, J. Pharm. Sci., 87: 901-903, 1998.
-
(1998)
J. Pharm. Sci.
, vol.87
, pp. 901-903
-
-
Hop, C.E.C.A.1
-
19
-
-
0031456698
-
Preclinical drug metabolism in the age of high-throughput screening: An industrial perspective
-
Rodrigues, A. D., Preclinical drug metabolism in the age of high-throughput screening: an industrial perspective, Pharm. Res., 14: 1504-1510, 1997.
-
(1997)
Pharm. Res
, vol.14
, pp. 1504-1510
-
-
Rodrigues, A.D.1
-
20
-
-
0344237436
-
The in vivo assessment of human hepatic drug metabolism
-
O’Grady, J. and Joubert, P. H., Eds., CRC Press, Boca Raton, FL
-
Tucker, G. T., The in vivo assessment of human hepatic drug metabolism, in Handbook of Phase I/II Clinical Drug Trials, O’Grady, J. and Joubert, P. H., Eds., CRC Press, Boca Raton, FL, 1997, 51-63.
-
(1997)
Handbook of Phase I/II Clinical Drug Trials
, pp. 51-63
-
-
Tucker, G.T.1
-
21
-
-
0010720477
-
Role of pharmacokinetics in drug discovery and development
-
Welling, P. G. and Balant, L. P., Eds., Springer-Verlag, Heidelberg
-
Welling, P. G., Role of pharmacokinetics in drug discovery and development, in Pharmacokinetics of Drugs, Welling, P. G. and Balant, L. P., Eds., Springer-Verlag, Heidelberg, 1994, 3-19.
-
(1994)
Pharmacokinetics of Drugs
, pp. 3-19
-
-
Welling, P.G.1
-
22
-
-
0002487498
-
Biological effects of blood loss: Implications for sampling volumes and techniques
-
McGuill, M. W. and Rowan, A. N., Biological effects of blood loss: implications for sampling volumes and techniques, ILAR News, 31: 5-20, 1989.
-
(1989)
ILAR News
, vol.31
, pp. 5-20
-
-
McGuill, M.W.1
Rowan, A.N.2
-
23
-
-
0033812182
-
Use of nonlinear mixed effect modeling for the meta-analysis of preclinical pharmacokinetic data: Application to S 20342 in the rat
-
Bouzom, F. et al., Use of nonlinear mixed effect modeling for the meta-analysis of preclinical pharmacokinetic data: application to S 20342 in the rat, J. Pharm. Sci., 89: 603-613, 2000.
-
(2000)
J. Pharm. Sci.
, vol.89
, pp. 603-613
-
-
Bouzom, F.1
-
24
-
-
0030956910
-
A sparse sampling, mixed effects approach to toxicokinetic analyses
-
Gething, P. A. and Daley-Yates, P. T., A sparse sampling, mixed effects approach to toxicokinetic analyses, Drug Inf. J., 31: 521-527, 1997.
-
(1997)
Drug Inf. J.
, vol.31
, pp. 521-527
-
-
Gething, P.A.1
Daley-Yates, P.T.2
-
25
-
-
0030017331
-
Sparse sampling for assessment of drug exposure in toxicological studies
-
Burtin, P. et al., Sparse sampling for assessment of drug exposure in toxicological studies, Eur. J. Drug Metab. Pharmacokinet., 21: 105-111, 1996.
-
(1996)
Eur. J. Drug Metab. Pharmacokinet
, vol.21
, pp. 105-111
-
-
Burtin, P.1
-
26
-
-
0029856273
-
Characterization of AUCs from sparsely sampled populations in toxicology studies
-
Pai, S. M. et al., Characterization of AUCs from sparsely sampled populations in toxicology studies, Pharm. Res., 13: 1283-1290, 1996.
-
(1996)
Pharm. Res
, vol.13
, pp. 1283-1290
-
-
Pai, S.M.1
-
27
-
-
0002209037
-
The use of interspecies scaling in toxicokinetics
-
Yacobi, A., Skelly, J. P., and Batra, V. K., Eds., Pergamon Press, Elmsford, NY
-
Mordenti, J. and Chappell, W., The use of interspecies scaling in toxicokinetics, in Toxicokinetics and New Drug Development, Yacobi, A., Skelly, J. P., and Batra, V. K., Eds., Pergamon Press, Elmsford, NY, 1989, 42-96.
-
(1989)
Toxicokinetics and New Drug Development
, pp. 42-96
-
-
Mordenti, J.1
Chappell, W.2
-
28
-
-
0025767307
-
Extrapolation of toxicological and pharmacological data from animals to humans
-
Chappell, W. R. and Mordenti, J., Extrapolation of toxicological and pharmacological data from animals to humans, Adv. Drug Res., 20: 1-116, 1991.
-
(1991)
Adv. Drug Res
, vol.20
, pp. 1-116
-
-
Chappell, W.R.1
Mordenti, J.2
-
29
-
-
0028828607
-
Interspecies scaling of interferon disposition and comparison of allometric scaling with concentration-time transformations
-
Lave, T. et al., Interspecies scaling of interferon disposition and comparison of allometric scaling with concentration-time transformations, J. Pharm. Sci., 84: 1285-1290, 1995.
-
(1995)
J. Pharm. Sci.
, vol.84
, pp. 1285-1290
-
-
Lave, T.1
-
30
-
-
0030036409
-
Animal pharmacokinetics and interspecies scaling from animals to man of lamifiban, a new platelet aggregation inhibitor
-
Lave, T. et al., Animal pharmacokinetics and interspecies scaling from animals to man of lamifiban, a new platelet aggregation inhibitor, J. Pharm. Pharmacol., 48: 573-577, 1996.
-
(1996)
J. Pharm. Pharmacol
, vol.48
, pp. 573-577
-
-
Lave, T.1
-
31
-
-
0033016936
-
Interspecies pharmacokinetic comparisons and allometric scaling of napsagartran, a low molecular weight thrombin inhibitor
-
Lave, T. et al., Interspecies pharmacokinetic comparisons and allometric scaling of napsagartran, a low molecular weight thrombin inhibitor, J. Pharm. Pharmacol., 51: 85-91, 1999.
-
(1999)
J. Pharm. Pharmacol
, vol.51
, pp. 85-91
-
-
Lave, T.1
-
32
-
-
0034120946
-
Allometric pharmacokinetic scaling: Towards the prediction of human oral pharmacokinetics
-
Feng, M. R. et al., Allometric pharmacokinetic scaling: towards the prediction of human oral pharmacokinetics, Pharm. Res., 17: 410-418, 2000.
-
(2000)
Pharm. Res
, vol.17
, pp. 410-418
-
-
Feng, M.R.1
-
33
-
-
0026063359
-
Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins
-
Mordenti, J. et al., Interspecies scaling of clearance and volume of distribution data for five therapeutic proteins, Pharm. Res., 8: 1351-1358, 1991.
-
(1991)
Pharm. Res
, vol.8
, pp. 1351-1358
-
-
Mordenti, J.1
-
34
-
-
0037525986
-
Pharmacokinetics, pharmacodynamics, allometry, and dose selection of rPSGL-Ig for Phase I trial
-
Khor, S. P. et al., Pharmacokinetics, pharmacodynamics, allometry, and dose selection of rPSGL-Ig for Phase I trial, J. Pharmacol. Exp. Ther., 293: 618-624, 2000.
-
(2000)
J. Pharmacol. Exp. Ther
, vol.293
, pp. 618-624
-
-
Khor, S.P.1
-
35
-
-
0032962265
-
Preclinical pharmacokinetics, interspecies scaling and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor
-
Lin, Y. S. et al., Preclinical pharmacokinetics, interspecies scaling and tissue distribution of a humanized monoclonal antibody against vascular endothelial growth factor, J. Pharmacol. Exp. Ther., 288: 371-378, 1999.
-
(1999)
J. Pharmacol. Exp. Ther
, vol.288
, pp. 371-378
-
-
Lin, Y.S.1
-
36
-
-
0028997410
-
Pharmacokinetics and pharmacodynamics of TP-9201, a gpIIbIIIa antagonist, in rats and dogs
-
Modi, N. B. et al., Pharmacokinetics and pharmacodynamics of TP-9201, a gpIIbIIIa antagonist, in rats and dogs, J. Cardiovasc. Pharmacol., 25: 888-897, 1995.
-
(1995)
J. Cardiovasc. Pharmacol
, vol.25
, pp. 888-897
-
-
Modi, N.B.1
-
37
-
-
0031931135
-
Pharmacokinetics and pharmacodynamics of recombinant tissuetype plasminogen activator following intravenous administration in rabbits: Comparison of three dosing regimens
-
Eppler, S. et al., Pharmacokinetics and pharmacodynamics of recombinant tissuetype plasminogen activator following intravenous administration in rabbits: comparison of three dosing regimens, Biopharm. Drug Dispos., 19: 31-38, 1998.
-
(1998)
Biopharm. Drug Dispos.
, vol.19
, pp. 31-38
-
-
Eppler, S.1
-
38
-
-
0030033884
-
Pharmacokinetics and pharmacodynamics of TP-9201, a gpIIbIIIa antagonist, administered in combination with Activase® t-PA, heparin, and aspirin in beagles
-
Modi, N. B. et al., Pharmacokinetics and pharmacodynamics of TP-9201, a gpIIbIIIa antagonist, administered in combination with Activase® t-PA, heparin, and aspirin in beagles, J. Cardiovasc. Pharmacol., 27: 105-112, 1996.
-
(1996)
J. Cardiovasc. Pharmacol
, vol.27
, pp. 105-112
-
-
Modi, N.B.1
-
39
-
-
0031716322
-
Pharmacokinetics and pharmacodynamics of sibrafiban (Ro 48-3657), an orally active IIbIIIa antagonist, administered alone or in combination with heparin, aspirin and recombinant tissue-type plasminogen activator in beagles
-
Modi, N. B. et al., Pharmacokinetics and pharmacodynamics of sibrafiban (Ro 48-3657), an orally active IIbIIIa antagonist, administered alone or in combination with heparin, aspirin and recombinant tissue-type plasminogen activator in beagles, J. Cardiovasc. Pharmacol., 32: 397-405, 1998.
-
(1998)
J. Cardiovasc. Pharmacol
, vol.32
, pp. 397-405
-
-
Modi, N.B.1
-
40
-
-
0031974072
-
Pharmacokinetics, pharmacodynamics, and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administration of a prodrug form
-
Refino, C. J. et al., Pharmacokinetics, pharmacodynamics, and tolerability of a potent, non-peptidic, GP IIb/IIIa receptor antagonist following multiple oral administration of a prodrug form, Thromb. Haemost, 79: 169-176, 1998.
-
(1998)
Thromb. Haemost
, vol.79
, pp. 169-176
-
-
Refino, C.J.1
-
41
-
-
0027487990
-
A system approach to pharmacodynamics. Plasma iron mobilization by endogenous erythropoietin in the sheep fetus; evidence of threshold response in spontaneous hypoxemia
-
Veng-Pedersen, P. et al., A system approach to pharmacodynamics. Plasma iron mobilization by endogenous erythropoietin in the sheep fetus; evidence of threshold response in spontaneous hypoxemia, J. Pharm. Sci., 82: 804-807, 1993.
-
(1993)
J. Pharm. Sci.
, vol.82
, pp. 804-807
-
-
Veng-Pedersen, P.1
-
42
-
-
0033018871
-
Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans
-
Mordenti, J. et al., Efficacy and concentration-response of murine anti-VEGF monoclonal antibody in tumor-bearing mice and extrapolation to humans, Toxicol. Pathol., 27: 14-21, 1999.
-
(1999)
Toxicol. Pathol
, vol.27
, pp. 14-21
-
-
Mordenti, J.1
-
43
-
-
0000106986
-
Biotransformation of xenobiotics
-
5th ed., Klaassen, C. D., Ed., McGraw-Hill, New York
-
Parkinson, A., Biotransformation of xenobiotics, in Casarett & Doull’s Toxicology, The Basic Science of Poisons, 5th ed., Klaassen, C. D., Ed., McGraw-Hill, New York, 1996, 113-186.
-
(1996)
Casarett & Doull’s Toxicology, The Basic Science of Poisons
, pp. 113-186
-
-
Parkinson, A.1
-
44
-
-
0031975185
-
Update: Clinically significant cytochrome P-450 drug interactions
-
Michalets, E. L., Update: clinically significant cytochrome P-450 drug interactions, Pharmacotherapy, 18: 84-112, 1998.
-
(1998)
Pharmacotherapy
, vol.18
, pp. 84-112
-
-
Michalets, E.L.1
|