-
1
-
-
0028884033
-
PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel R (1995): PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494.
-
(1995)
J Biol Chem
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, R.5
-
2
-
-
0029099408
-
Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf
-
Alessi DR, Cohen P, Ashworth A, Cowley S, Leevers SJ, Marshall CJ (1995): Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf. Methods Enzymol 255: 279-290.
-
(1995)
Methods Enzymol
, vol.255
, pp. 279-290
-
-
Alessi, D.R.1
Cohen, P.2
Ashworth, A.3
Cowley, S.4
Leevers, S.J.5
Marshall, C.J.6
-
3
-
-
0038349992
-
Epothilone B and its analogs - A new family of anticancer agents
-
Altmann KH (2003): Epothilone B and its analogs - a new family of anticancer agents. Mini Rev Med Chem 3: 149-158.
-
(2003)
Mini Rev Med Chem
, vol.3
, pp. 149-158
-
-
Altmann, K.H.1
-
4
-
-
0025183708
-
Basic local alignment search tool
-
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990): Basic local alignment search tool. J Mol Bio 215: 403-410.
-
(1990)
J Mol Bio
, vol.215
, pp. 403-410
-
-
Altschul, S.F.1
Gish, W.2
Miller, W.3
Myers, E.W.4
Lipman, D.J.5
-
5
-
-
2942618786
-
Molecular evolution of adenylating domain of aminoadipate reductase
-
An K-D, Nishida H, Miura Y, Yokota A (2003): Molecular evolution of adenylating domain of aminoadipate reductase. BMC Evol Biol 3: 9-15 (http://www.biomedcentral.com/ 1471-2148/3/9).
-
(2003)
BMC Evol Biol
, vol.3
, pp. 9-15
-
-
An, K.-D.1
Nishida, H.2
Miura, Y.3
Yokota, A.4
-
6
-
-
0031060389
-
Cytotoxic peptides hemiasterlin, hemiasterlin A, and hemiasterlin B induce mitotic arrest and abnormal spindle formation
-
Anderson HJ, Coleman JE, Andersen RJ, Roberge M (1997): Cytotoxic peptides hemiasterlin, hemiasterlin A, and hemiasterlin B induce mitotic arrest and abnormal spindle formation. Cancer Chemother Pharmacol 39: 223-226.
-
(1997)
Cancer Chemother Pharmacol
, vol.39
, pp. 223-226
-
-
Anderson, H.J.1
Coleman, J.E.2
Andersen, R.J.3
Roberge, M.4
-
7
-
-
0031032858
-
Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity
-
Andersen RJ, Coleman JE, Piers E, Wallace DJ (1997): Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity. Tetrahedron Lett 38: 317-320.
-
(1997)
Tetrahedron Lett
, vol.38
, pp. 317-320
-
-
Andersen, R.J.1
Coleman, J.E.2
Piers, E.3
Wallace, D.J.4
-
9
-
-
0030002415
-
Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity
-
Angeles TS, Steffler C, Bartlett BA, Hudkins RL, Stephens RM, Kaplan DR, Dionne CA (1996): Enzyme-linked immunosorbent assay for trkA tyrosine kinase activity. Anal Biochem 236: 49-55.
-
(1996)
Anal Biochem
, vol.236
, pp. 49-55
-
-
Angeles, T.S.1
Steffler, C.2
Bartlett, B.A.3
Hudkins, R.L.4
Stephens, R.M.5
Kaplan, D.R.6
Dionne, C.A.7
-
10
-
-
0033607202
-
Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: Comparison with dolastatin 10 and cryptophycin 1
-
Bai R, Durso NA, Sackett DL, Hamel E (1999): Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1. Biochemistry 38: 14302-14310.
-
(1999)
Biochemistry
, vol.38
, pp. 14302-14310
-
-
Bai, R.1
Durso, N.A.2
Sackett, D.L.3
Hamel, E.4
-
12
-
-
0000719887
-
Status of the NCI preclinical drug discovery screen
-
J.B. Lippincott Publish
-
Boyd, MR (1989): Status of the NCI preclinical drug discovery screen. In: Principles and Practices of Oncology 3, pp. 1-10, J.B. Lippincott Publish.
-
(1989)
Principles and Practices of Oncology
, vol.3
, pp. 1-10
-
-
Boyd, M.R.1
-
13
-
-
0029090211
-
Cytotoxic peptides from the marine sponge Cymbastela sp
-
Coleman JE, de Silva ED, Kong F, Andersen RJ, Alien TM (1995): Cytotoxic peptides from the marine sponge Cymbastela sp. Tetrahedron 51: 10653-10662.
-
(1995)
Tetrahedron
, vol.51
, pp. 10653-10662
-
-
Coleman, J.E.1
De Silva, E.D.2
Kong, F.3
Andersen, R.J.4
Alien, T.M.5
-
15
-
-
0028241458
-
Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta
-
Crews P, Farias JJ, Emrich R, Keifer PA (1994): Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta J Org Chem 59: 2932-2934.
-
(1994)
J Org Chem
, vol.59
, pp. 2932-2934
-
-
Crews, P.1
Farias, J.J.2
Emrich, R.3
Keifer, P.A.4
-
16
-
-
0242659422
-
2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine
-
2 DNA damage checkpoint and of protein kinases Chk1 and Chk2 by the marine sponge alkaloid debromohymenialdisine. J Biol Chem 276: 17914-17919.
-
(2001)
J Biol Chem
, vol.276
, pp. 17914-17919
-
-
Curman, D.1
Cinel, B.2
Williams, D.E.3
Rundle, N.4
Block, W.D.5
Goodarzi, A.A.6
Hutchins, J.R.7
Clarke, P.R.8
Zhou, B.-B.9
Lees-Miller, S.P.10
Andersen, R.J.11
Roberge, M.12
-
17
-
-
0025105061
-
Geodiamolide C to Geodiamolide F, new cytotoxic cyclodepsipeptides from the marine sponge Pseudaxinyssa sp
-
de Suva ED, Andersen RJ, Allen TM (1990): Geodiamolide C to Geodiamolide F, new cytotoxic cyclodepsipeptides from the marine sponge Pseudaxinyssa sp. Tetrahedron Lett 31: 489-492.
-
(1990)
Tetrahedron Lett
, vol.31
, pp. 489-492
-
-
De Suva, E.D.1
Andersen, R.J.2
Allen, T.M.3
-
18
-
-
0033561601
-
Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[3-bromophenyl)amino]-6-quinaxolinyl]-2- butynamide (CL-387,785)
-
Discafani CM, Carroll ML, Floyd Jr MBF, Hollander IJ, Husain Z, Johnson BD, Kitchen D, May MK, Malo MS, Minnick Jr AA, Nilakantan R, Shen R, Wang Y-F, Wissner A, Greenberger LM (1999): Irreversible inhibition of epidermal growth factor receptor tyrosine kinase with in vivo activity by N-[4-[3-bromophenyl) amino]-6-quinaxolinyl]-2-butynamide (CL-387,785). Biochem Pharmacol 57: 917-925.
-
(1999)
Biochem Pharmacol
, vol.57
, pp. 917-925
-
-
Discafani, C.M.1
Carroll, M.L.2
Floyd Jr., M.B.F.3
Hollander, I.J.4
Husain, Z.5
Johnson, B.D.6
Kitchen, D.7
May, M.K.8
Malo, M.S.9
Minnick Jr., A.A.10
Nilakantan, R.11
Shen, R.12
Wang, Y.-F.13
Wissner, A.14
Greenberger, L.M.15
-
19
-
-
0034518173
-
Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
-
Downing, KH (2000): Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu Rev Cell Dev Biol 16: 89-111.
-
(2000)
Annu Rev Cell Dev Biol
, vol.16
, pp. 89-111
-
-
Downing, K.H.1
-
20
-
-
0034121469
-
Mechanism of action and resistance to tubulin-binding agents
-
Dumontet C (2000): Mechanism of action and resistance to tubulin-binding agents. Exp Opin Invest Drugs 9: 779-788.
-
(2000)
Exp Opin Invest Drugs
, vol.9
, pp. 779-788
-
-
Dumontet, C.1
-
21
-
-
0030899774
-
The CDKN2A (p16) gene and human cancer
-
Foulkes WD, Flanders TY, Pollock PM, Hayward NK, (1997): The CDKN2A (p16) gene and human cancer. Mol Med 3: 5-20.
-
(1997)
Mol Med
, vol.3
, pp. 5-20
-
-
Foulkes, W.D.1
Flanders, T.Y.2
Pollock, P.M.3
Hayward, N.K.4
-
22
-
-
0032769659
-
Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina sponges
-
Gamble WR, Durso NA, Fuller RW, Westergaard CK, Johnson TR, Sackett DL, Hamel E, Cardellina JH, Boyd MR (1999): Cytotoxic and tubulin-interactive hemiasterlins from Auletta sp. and Siphonochalina sponges. Bioorg Med Chem 7: 1611-1615.
-
(1999)
Bioorg Med Chem
, vol.7
, pp. 1611-1615
-
-
Gamble, W.R.1
Durso, N.A.2
Fuller, R.W.3
Westergaard, C.K.4
Johnson, T.R.5
Sackett, D.L.6
Hamel, E.7
Cardellina, J.H.8
Boyd, M.R.9
-
23
-
-
0000375616
-
The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenografts in vivo
-
Gibbons JJ, Discafani C, Peterson R, Hernandez R, Skotnicki J, Frost P (1999): The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenografts in vivo. Proc Am Assoc Cancer Res 40: 301.
-
(1999)
Proc Am Assoc Cancer Res
, vol.40
, pp. 301
-
-
Gibbons, J.J.1
Discafani, C.2
Peterson, R.3
Hernandez, R.4
Skotnicki, J.5
Frost, P.6
-
24
-
-
0033986112
-
Anticancer drug targets: Growth factors and growth factor signaling
-
Gibbs (2000): Anticancer drug targets: growth factors and growth factor signaling. J Clin Invest 105: 9-13.
-
(2000)
J Clin Invest
, vol.105
, pp. 9-13
-
-
Gibbs1
-
25
-
-
0036176510
-
Mechanisms of cancer drug resistance
-
Gottesman MM (2002): Mechanisms of cancer drug resistance. Annu Rev Med 53: 615-627.
-
(2002)
Annu Rev Med
, vol.53
, pp. 615-627
-
-
Gottesman, M.M.1
-
26
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman MM, Fojo T, Bates SE (2002): Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
-
(2002)
Nat Rev Cancer
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
27
-
-
0029921317
-
Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
-
Hall M, Peters G (1996): Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68: 67-108.
-
(1996)
Adv Cancer Res
, vol.68
, pp. 67-108
-
-
Hall, M.1
Peters, G.2
-
28
-
-
0029965897
-
Antimitotic natural products and their interactions with tubulin
-
Hamel E (1996): Antimitotic natural products and their interactions with tubulin. Med Res Rev 16: 207-231.
-
(1996)
Med Res Rev
, vol.16
, pp. 207-231
-
-
Hamel, E.1
-
30
-
-
0029020282
-
The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
-
Hanks SK, Hunter T (1995): The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB 9: 576-596.
-
(1995)
FASEB
, vol.9
, pp. 576-596
-
-
Hanks, S.K.1
Hunter, T.2
-
31
-
-
0034812241
-
Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis
-
He H, Ding W-D, Bernan VS, Richardson AD, Ireland CM, Greenstein M, Ellestad GA, Carter GT (2001): Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis. J Am Chem Soc 123: 5362-5363.
-
(2001)
J Am Chem Soc
, vol.123
, pp. 5362-5363
-
-
He, H.1
Ding, W.-D.2
Bernan, V.S.3
Richardson, A.D.4
Ireland, C.M.5
Greenstein, M.6
Ellestad, G.A.7
Carter, G.T.8
-
32
-
-
0029134016
-
Role of the cyclin-dependent I kinase inhibitors in the development of cancer
-
Hirama T, Koeffler HP (1995): Role of the cyclin-dependent I kinase inhibitors in the development of cancer. Blood 86: 841-854.
-
(1995)
Blood
, vol.86
, pp. 841-854
-
-
Hirama, T.1
Koeffler, H.P.2
-
33
-
-
0030933277
-
Oncoprotein networks
-
Hunter T (1997): Oncoprotein networks. Cell 88: 333-346.
-
(1997)
Cell
, vol.88
, pp. 333-346
-
-
Hunter, T.1
-
34
-
-
0031054730
-
New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis
-
Imamura N, Nishijima M, Takadera T, Adachi K, Sakai M, Sano H (1997): New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis. J Antibiot 50: 8-12.
-
(1997)
J Antibiot
, vol.50
, pp. 8-12
-
-
Imamura, N.1
Nishijima, M.2
Takadera, T.3
Adachi, K.4
Sakai, M.5
Sano, H.6
-
35
-
-
0028121279
-
A cell cycle regulator potentially involved in genesis of many tumor types
-
Kamb A, Gruis NA, Weaver-Feldhaus J, Liu Q, Harshman K, Tavtigian SV, Stockert E, Day III RS, Johnson BE, Skolnick MH (1994): A cell cycle regulator potentially involved in genesis of many tumor types. Science 264: 436-440.
-
(1994)
Science
, vol.264
, pp. 436-440
-
-
Kamb, A.1
Gruis, N.A.2
Weaver-Feldhaus, J.3
Liu, Q.4
Harshman, K.5
Tavtigian, S.V.6
Stockert, E.7
Day III, R.S.8
Johnson, B.E.9
Skolnick, M.H.10
-
37
-
-
34250124977
-
Mutagenic activity of austocystins-secondary metabolities of Aspergillus ustus
-
Kfir R, Johannsen E, Vleggaar R (1986): Mutagenic activity of austocystins-secondary metabolities of Aspergillus ustus. Bull Environ Contam Toxicol 37: 643-650.
-
(1986)
Bull Environ Contam Toxicol
, vol.37
, pp. 643-650
-
-
Kfir, R.1
Johannsen, E.2
Vleggaar, R.3
-
38
-
-
0034667593
-
Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
-
Kolch W (2000): Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351: 289-305.
-
(2000)
Biochem J
, vol.351
, pp. 289-305
-
-
Kolch, W.1
-
39
-
-
0023767544
-
Role of glutathione redox cycle in acquired and de novo multidrug resistance
-
Kramer RA, Zakher J, Kim G (1988): Role of glutathione redox cycle in acquired and de novo multidrug resistance. Science 241: 694-698.
-
(1988)
Science
, vol.241
, pp. 694-698
-
-
Kramer, R.A.1
Zakher, J.2
Kim, G.3
-
40
-
-
0027298544
-
Constitutive expression of multidrug resistance in human colorectal tumors and cell lines
-
Kramer RA, Weber TK, Morse B (1993): Constitutive expression of multidrug resistance in human colorectal tumors and cell lines. Br J Cancer 67: 959-968.
-
(1993)
Br J Cancer
, vol.67
, pp. 959-968
-
-
Kramer, R.A.1
Weber, T.K.2
Morse, B.3
-
41
-
-
17144460676
-
The discovery of potent cRaf-1 kinase inhibitors
-
Lackey K, Cory M, Davis R, Frye SV, Harris PA, Hunter RN, Jung DK, McDonald OB, McNutt RW, Peel MR, Rutkowske RD, Veal JM, Wood ER (2000): The discovery of potent cRaf-1 kinase inhibitors. Bioorg Med Chem Lett 10: 223-226.
-
(2000)
Bioorg Med Chem Lett
, vol.10
, pp. 223-226
-
-
Lackey, K.1
Cory, M.2
Davis, R.3
Frye, S.V.4
Harris, P.A.5
Hunter, R.N.6
Jung, D.K.7
McDonald, O.B.8
McNutt, R.W.9
Peel, M.R.10
Rutkowske, R.D.11
Veal, J.M.12
Wood, E.R.13
-
42
-
-
0029786329
-
Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOGMAPK pathway
-
Lavoie JN, L'Allemain G, Brunei A, Muller R, Pouyssegur J (1996): Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271: 20608-20616.
-
(1996)
J Biol Chem
, vol.271
, pp. 20608-20616
-
-
Lavoie, J.N.1
L'Allemain, G.2
Brunei, A.3
Muller, R.4
Pouyssegur, J.5
-
43
-
-
0034923131
-
Polyketide synthase genes in insect- and nematode-associated fungi
-
Lee T, Yun S-H, Hodge KT, Humber RA, Krasnoff SB, Turgeon GB, Yoder OC, Gibson DM (2001): Polyketide synthase genes in insect- and nematode-associated fungi. Appl Microbiol Biotechnol 56: 181-187.
-
(2001)
Appl Microbiol Biotechnol
, vol.56
, pp. 181-187
-
-
Lee, T.1
Yun, S.-H.2
Hodge, K.T.3
Humber, R.A.4
Krasnoff, S.B.5
Turgeon, G.B.6
Yoder, O.C.7
Gibson, D.M.8
-
44
-
-
0030952552
-
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
-
Leraer EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti M (1997): Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 15: 1283-1288.
-
(1997)
Oncogene
, vol.15
, pp. 1283-1288
-
-
Leraer, E.C.1
Zhang, T.T.2
Knowles, D.B.3
Qian, Y.4
Hamilton, A.D.5
Sebti, M.6
-
45
-
-
0028968949
-
Tyrosine kinase inhibition: An approach to drug development
-
Levitzki A, Gazit A (1995): Tyrosine kinase inhibition: an approach to drug development. Science 267: 1782-1788.
-
(1995)
Science
, vol.267
, pp. 1782-1788
-
-
Levitzki, A.1
Gazit, A.2
-
46
-
-
0031900740
-
Signal transduction through MAP kinase cascades
-
Lewis TS, Shapiro PS, Ahn NG (1998): Signal transduction through MAP kinase cascades. Adv Cancer Res 74: 49-139.
-
(1998)
Adv Cancer Res
, vol.74
, pp. 49-139
-
-
Lewis, T.S.1
Shapiro, P.S.2
Ahn, N.G.3
-
47
-
-
9444275029
-
Cells resistant to HTI-286 do not over-express P-glycoprotein but have low drug accumulation and a point mutation in α-tubulin
-
2nd ed
-
Loganzo F, Annable T, Xingzhi T, Morilla DB, Hari M, Musto S, Zask A, Kaplan J, Poruchynsky M, Fojo TMGL (2003): Cells resistant to HTI-286 do not over-express P-glycoprotein but have low drug accumulation and a point mutation in α-tubulin. Proc Amer Assoc Cancer Res 44: 1307 (2nd ed.).
-
(2003)
Proc Amer Assoc Cancer Res
, vol.44
, pp. 1307
-
-
Loganzo, F.1
Annable, T.2
Xingzhi, T.3
Morilla, D.B.4
Hari, M.5
Musto, S.6
Zask, A.7
Kaplan, J.8
Poruchynsky, M.9
Fojo, T.M.G.L.10
-
48
-
-
0037447174
-
HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo
-
Loganzo F, Discafani C, Annable T, Beyer C, Musto S, Tan X, Hardy C, Hernandez R, Baxter M, Singanallore T, Khafizova G, Poruchynsky MS, Fojo T, Nieman JA, Ayral-Kaloustian S, Zask A, Andersen RJ, Greenberger LM (2003): HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo. Cancer Res 63: 1838-1845.
-
(2003)
Cancer Res
, vol.63
, pp. 1838-1845
-
-
Loganzo, F.1
Discafani, C.2
Annable, T.3
Beyer, C.4
Musto, S.5
Tan, X.6
Hardy, C.7
Hernandez, R.8
Baxter, M.9
Singanallore, T.10
Khafizova, G.11
Poruchynsky, M.S.12
Fojo, T.13
Nieman, J.A.14
Ayral-Kaloustian, S.15
Zask, A.16
Andersen, R.J.17
Greenberger, L.M.18
-
49
-
-
0035398696
-
An enzyme-linked immunosorbent assay for the Raf/MEK-1/MAPK signaling cascade
-
Mallon R, Feldberg LR, Kim SC, Collins K, Wojciechowicz D, Hollander I, Kovacs ED, Kohler C (2001): An enzyme-linked immunosorbent assay for the Raf/MEK-1/MAPK signaling cascade. Anal Biochem 294: 48-54.
-
(2001)
Anal Biochem
, vol.294
, pp. 48-54
-
-
Mallon, R.1
Feldberg, L.R.2
Kim, S.C.3
Collins, K.4
Wojciechowicz, D.5
Hollander, I.6
Kovacs, E.D.7
Kohler, C.8
-
50
-
-
0031873963
-
New aspects of genes and enzymes for β-lactam antibiotic biosynthesis Appl
-
Martin JF (1998): New aspects of genes and enzymes for β-lactam antibiotic biosynthesis Appl. Microbiol Biotechnol 50: 1-15.
-
(1998)
Microbiol Biotechnol
, vol.50
, pp. 1-15
-
-
Martin, J.F.1
-
51
-
-
0006039327
-
Namenamicin, a new enediyne antitumor antibiotic from the marine ascidian Polysyncraton lithostrotum
-
McDonald LA, Capson TL, Krishnamurthy G, Ding W, Ellestad GA, Bernan VS, Maiese WM, Lassota P, Discafani C, Kramer RA, Ireland CM (1996): Namenamicin, a new enediyne antitumor antibiotic from the marine ascidian Polysyncraton lithostrotum. J Amer Chem Soc 118: 10898-10899.
-
(1996)
J Amer Chem Soc
, vol.118
, pp. 10898-10899
-
-
McDonald, L.A.1
Capson, T.L.2
Krishnamurthy, G.3
Ding, W.4
Ellestad, G.A.5
Bernan, V.S.6
Maiese, W.M.7
Lassota, P.8
Discafani, C.9
Kramer, R.A.10
Ireland, C.M.11
-
52
-
-
0344177511
-
A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: High-throughput screening and identification of selective enzyme inhibitors
-
McDonald OB, Chen WJ, Ellis B, Huffman C, Overton L, Rink M, Smith A, Marshall CJ, Wood ER (1999): A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors. Anal Biochem 268: 318-329.
-
(1999)
Anal Biochem
, vol.268
, pp. 318-329
-
-
McDonald, O.B.1
Chen, W.J.2
Ellis, B.3
Huffman, C.4
Overton, L.5
Rink, M.6
Smith, A.7
Marshall, C.J.8
Wood, E.R.9
-
53
-
-
0030753686
-
Chemical inhibitors of cyclin-dependent kinases
-
Meijer L, Kim S-H (1997): Chemical inhibitors of cyclin-dependent kinases. Methods Enzymol 283: 113-128.
-
(1997)
Methods Enzymol
, vol.283
, pp. 113-128
-
-
Meijer, L.1
Kim, S.-H.2
-
54
-
-
0034010742
-
Inhibition of cyclin-dependent kinases, GSK-3 and CK1, by hymenialdisine, a marine sponge constituent
-
Meijer L, Thunnissen A-MWH, White AW, Garnier M, Nikolic M, Tsai L-H, Walter J, Cleverley KE, Salinas PC, Wu Y-Z, Biernat J, Mandelkow E-M, Kim S-H, Pettit GR (2000): Inhibition of cyclin-dependent kinases, GSK-3 and CK1, by hymenialdisine, a marine sponge constituent. Chem Biol 7: 51-63.
-
(2000)
Chem Biol
, vol.7
, pp. 51-63
-
-
Meijer, L.1
Thunnissen, A.-M.W.H.2
White, A.W.3
Garnier, M.4
Nikolic, M.5
Tsai, L.-H.6
Walter, J.7
Cleverley, K.E.8
Salinas, P.C.9
Wu, Y.-Z.10
Biernat, J.11
Mandelkow, E.-M.12
Kim, S.-H.13
Pettit, G.R.14
-
56
-
-
0028931265
-
Principles of CDK regulation
-
Morgan DO (1995): Principles of CDK regulation. Nature 374: 131-134.
-
(1995)
Nature
, vol.374
, pp. 131-134
-
-
Morgan, D.O.1
-
57
-
-
0025775062
-
Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
-
Monks A, Scudiero D, Skehan P (1991): Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83: 757-766.
-
(1991)
J Natl Cancer Inst
, vol.83
, pp. 757-766
-
-
Monks, A.1
Scudiero, D.2
Skehan, P.3
-
58
-
-
0037331338
-
Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogs
-
Nieman J, Coleman J, Wallace D, Piers E, Lim LY, Roberge M, Andersen RJ (2003): synthesis and antimitotic/cytotoxic activity of hemiasterlin analogs. J Nat Prod 66: 183-199.
-
(2003)
J Nat Prod
, vol.66
, pp. 183-199
-
-
Nieman, J.1
Coleman, J.2
Wallace, D.3
Piers, E.4
Lim, L.Y.5
Roberge, M.6
Andersen, R.J.7
-
59
-
-
0028275733
-
Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
-
Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994): Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368: 753-756.
-
(1994)
Nature
, vol.368
, pp. 753-756
-
-
Nobori, T.1
Miura, K.2
Wu, D.J.3
Lois, A.4
Takabayashi, K.5
Carson, D.A.6
-
61
-
-
0344239446
-
Two photoaffinity analogs of HTI-286, a synthetic analog of hemiasterlin, interact with alpha-tubulin
-
Nunes M, Kaplan J, Loganzo F, Zask A, Ayral-Kaloustian S, Greenberger L (2002): Two photoaffinity analogs of HTI-286, a synthetic analog of hemiasterlin, interact with alpha-tubulin. Eur J Cancer 38: S119.
-
(2002)
Eur J Cancer
, vol.38
-
-
Nunes, M.1
Kaplan, J.2
Loganzo, F.3
Zask, A.4
Ayral-Kaloustian, S.5
Greenberger, L.6
-
62
-
-
0033378009
-
c-Raf-1 depletion and tumor responses in patients treated with the c-Raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A)
-
O'Dwyer PJ, Stevenson JP, Gallagher M, Cassella A, Vasilevskaya I, Monia BP, Holmlund J, Dorr FA, Yao KS (1999): c-Raf-1 depletion and tumor responses in patients treated with the c-Raf-1 antisense oligodeoxynucleotide ISIS 5132 (CGP 69846A). Clin Cancer Res 5: 3977-3982.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 3977-3982
-
-
O'Dwyer, P.J.1
Stevenson, J.P.2
Gallagher, M.3
Cassella, A.4
Vasilevskaya, I.5
Monia, B.P.6
Holmlund, J.7
Dorr, F.A.8
Yao, K.S.9
-
63
-
-
0029034774
-
Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
-
Pang L, Sawada T, Decker SJ, Saltiel AR (1995): Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 23: 13585-13588.
-
(1995)
J Biol Chem
, vol.23
, pp. 13585-13588
-
-
Pang, L.1
Sawada, T.2
Decker, S.J.3
Saltiel, A.R.4
-
64
-
-
0033032591
-
Signaling networks-do all roads lead to the same genes?
-
Pawson T, Saxton TM (1999): Signaling networks-do all roads lead to the same genes? Cell 97: 675-678.
-
(1999)
Cell
, vol.97
, pp. 675-678
-
-
Pawson, T.1
Saxton, T.M.2
-
65
-
-
9444229485
-
Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analog, HTI-286, have mutations in α- or β-tubulin and increased microtubule stability
-
2nd ed
-
Poruchynsky MS, Kim JH, Nogales E, Loganzo F, Greenberger LM (2003): Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analog, HTI-286, have mutations in α- or β-tubulin and increased microtubule stability. Proc Am Assoc Cancer Res 44: 535 (2nd ed.).
-
(2003)
Proc Am Assoc Cancer Res
, vol.44
, pp. 535
-
-
Poruchynsky, M.S.1
Kim, J.H.2
Nogales, E.3
Loganzo, F.4
Greenberger, L.M.5
-
66
-
-
3142657011
-
Phase I and pharmacological study of HTI-286, a novel antimicrotubule agent: Correlation of neutropenia with time above threshold plasma concentration
-
abstract 516
-
Ratain MJ, Undevia S, Janisch L, Roman S, Mayer P, Buckwalter M, Foss D, Hamilton BL, Fischer J, Bukowski RM (2003): Phase I and pharmacological study of HTI-286, a novel antimicrotubule agent: correlation of neutropenia with time above threshold plasma concentration. Proc Am Soc Clin Oncol: abstract 516.
-
(2003)
Proc Am Soc Clin Oncol
-
-
Ratain, M.J.1
Undevia, S.2
Janisch, L.3
Roman, S.4
Mayer, P.5
Buckwalter, M.6
Foss, D.7
Hamilton, B.L.8
Fischer, J.9
Bukowski, R.M.10
-
67
-
-
0034665125
-
Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts
-
Roberge M, Cinel B, Anderson HJ, Lim L, Jiang X, Xu L, Kelly MT, Andersen RJ (2000): Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts. Cancer Res 60: 5052-5058.
-
(2000)
Cancer Res
, vol.60
, pp. 5052-5058
-
-
Roberge, M.1
Cinel, B.2
Anderson, H.J.3
Lim, L.4
Jiang, X.5
Xu, L.6
Kelly, M.T.7
Andersen, R.J.8
-
68
-
-
0030898417
-
Mitogen-activated protein kinase pathways
-
Robinson MJ, Cobb MH (1997): Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9: 180-186.
-
(1997)
Curr Opin Cell Biol
, vol.9
, pp. 180-186
-
-
Robinson, M.J.1
Cobb, M.H.2
-
69
-
-
0000589775
-
Antimicrotubule agents
-
Devita Jr VT, Hellman S, Rosenberg SA, eds., Philadelphia, Lippincott Williams and Wilkins
-
Rowinsky EK, Tolcher AW (2001): Antimicrotubule Agents. In: Devita Jr VT, Hellman S, Rosenberg SA, eds., Cancer Principles and Practice. 6th ed., Philadelphia, Lippincott Williams and Wilkins, pp. 431-452.
-
(2001)
Cancer Principles and Practice. 6th Ed.
, pp. 431-452
-
-
Rowinsky, E.K.1
Tolcher, A.W.2
-
70
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciadiello F, Normanno N (1995): Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Haematol 19: 183-232.
-
(1995)
Crit Rev Oncol Haematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciadiello, F.3
Normanno, N.4
-
71
-
-
0032984348
-
Blockade of the MAP kinase pathway supresses growth of colon tumors in vivo
-
Sebolt-Leopold JS, Dudley DT, Herrera R, Van Becelaere K, Wiland A, Gowan RC, Tecle H, Barrett SD, Bridges A, Przybranowski S, Leopold WR, Saltiel AR (1999): Blockade of the MAP kinase pathway supresses growth of colon tumors in vivo. Nat Med 5: 810-816.
-
(1999)
Nat Med
, vol.5
, pp. 810-816
-
-
Sebolt-Leopold, J.S.1
Dudley, D.T.2
Herrera, R.3
Van Becelaere, K.4
Wiland, A.5
Gowan, R.C.6
Tecle, H.7
Barrett, S.D.8
Bridges, A.9
Przybranowski, S.10
Leopold, W.R.11
Saltiel, A.R.12
-
72
-
-
0017250977
-
DNA related to the transforming gene of avian sarcoma virus is present in normal avian DNA
-
Stehelin D, Varmus HE, Bishop JM, Vogt PK (1976): DNA related to the transforming gene of avian sarcoma virus is present in normal avian DNA. Nature 260: 170-173.
-
(1976)
Nature
, vol.260
, pp. 170-173
-
-
Stehelin, D.1
Varmus, H.E.2
Bishop, J.M.3
Vogt, P.K.4
-
73
-
-
0016247422
-
Austocystins. Six novel dihydrofurol[3′,2′:4,5]furo[3,2-b] xanthenones from Aspergillus ustus
-
Steyn PS, Vleggaar R (1974): Austocystins. Six novel dihydrofurol[3′,2′:4,5]furo[3,2-b]xanthenones from Aspergillus ustus. J Chem Soc Perkin I 19: 2250-2256.
-
(1974)
J Chem Soc Perkin I
, vol.19
, pp. 2250-2256
-
-
Steyn, P.S.1
Vleggaar, R.2
-
74
-
-
9444244583
-
Dihydroruro[3′,2′:4,5]furo[3,2-b]xanthenones: The structures of austocystins G, H, and I
-
Steyn PS, Vleggaar R (1975): Dihydroruro[3′,2′:4,5]furo[3,2- b]xanthenones: the structures of austocystins G, H, and I. J South African Chemical Institute 28: 375-377.
-
(1975)
J South African Chemical Institute
, vol.28
, pp. 375-377
-
-
Steyn, P.S.1
Vleggaar, R.2
-
75
-
-
85017325712
-
Tyrosine kinases in disease: Overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials
-
Strawn, LM, Shawver LK (1998): Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials. Exp Opin Invest Drugs 7: 553-573.
-
(1998)
Exp Opin Invest Drugs
, vol.7
, pp. 553-573
-
-
Strawn, L.M.1
Shawver, L.K.2
-
76
-
-
0028305511
-
Hemiasterlin and geodiamolide-TA - 2 new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick)
-
Talpir R, Benayahu Y, Kashman Y, Pannell L, Schleyer M (1994): Hemiasterlin and geodiamolide-TA - 2 new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick). Tetrahedron Lett 35: 4453-4456.
-
(1994)
Tetrahedron Lett
, vol.35
, pp. 4453-4456
-
-
Talpir, R.1
Benayahu, Y.2
Kashman, Y.3
Pannell, L.4
Schleyer, M.5
-
77
-
-
0037122752
-
Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1)
-
Tasdemir D, Mallon R, Greenstein M, Feldberg LR, Kim SC, Collins K, Wojciechowicz W, Mangalindan GC, Concepción GP, Harper MK, Ireland CM (2002): Aldisine alkaloids from the Philippine sponge Stylissa massa are potent inhibitors of mitogen-activated protein kinase kinase-1 (MEK-1) J Med Chem 45: 529-532.
-
(2002)
J Med Chem
, vol.45
, pp. 529-532
-
-
Tasdemir, D.1
Mallon, R.2
Greenstein, M.3
Feldberg, L.R.4
Kim, S.C.5
Collins, K.6
Wojciechowicz, W.7
Mangalindan, G.C.8
Concepción, G.P.9
Harper, M.K.10
Ireland, C.M.11
-
79
-
-
0028284699
-
The peptide synthetase catalyzing eyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
-
Weber G, Schorgendorfer K, Schneider-Scherzer E, Leitner E (1994): The peptide synthetase catalyzing eyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26: 120-125.
-
(1994)
Curr Genet
, vol.26
, pp. 120-125
-
-
Weber, G.1
Schorgendorfer, K.2
Schneider-Scherzer, E.3
Leitner, E.4
-
80
-
-
9444268241
-
Molecular biology of carcinogenesis
-
Broder S, ed. Williams & Wilkins
-
Weinber RA (1991): Molecular Biology of Carcinogenesis. In: Broder S, ed., Molecular Foundations of Oncology. Williams & Wilkins, pp. 27-39.
-
(1991)
Molecular Foundations of Oncology
, pp. 27-39
-
-
Weinber, R.A.1
-
81
-
-
0033063774
-
The epidermal growth factor receptor and its inhibition in cancer therapy
-
Woodburn JR (1999): The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 82: 241-250.
-
(1999)
Pharmacol Ther
, vol.82
, pp. 241-250
-
-
Woodburn, J.R.1
-
82
-
-
0033152122
-
Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
-
Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA (1999): Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res 59: 2566-2569.
-
(1999)
Cancer Res
, vol.59
, pp. 2566-2569
-
-
Zaharevitz, D.W.1
Gussio, R.2
Leost, M.3
Senderowicz, A.M.4
Lahusen, T.5
Kunick, C.6
Meijer, L.7
Sausville, E.A.8
-
83
-
-
9444233506
-
Synthesis and biological activity of analogs of the antimicrotubule agent HTI-286
-
Zask A, Birnberg G, Cheung K, Cole D, Kaplan J, Niu C, Norton E, Sandanayaka V, Suayan R, Tang Z, Yamashita A, Loganzo F, Beyer C, Discafani C, Greenberger LM, Ayral-Kaloustian S (2002): Synthesis and biological activity of analogs of the antimicrotubule agent HTI-286. Proc Amer Assoc Cancer Res 43: 737.
-
(2002)
Proc Amer Assoc Cancer Res
, vol.43
, pp. 737
-
-
Zask, A.1
Birnberg, G.2
Cheung, K.3
Cole, D.4
Kaplan, J.5
Niu, C.6
Norton, E.7
Sandanayaka, V.8
Suayan, R.9
Tang, Z.10
Yamashita, A.11
Loganzo, F.12
Beyer, C.13
Discafani, C.14
Greenberger, L.M.15
Ayral-Kaloustian, S.16
|