메뉴 건너뛰기




Volumn 41, Issue SUPPL., 2003, Pages 15-38

Anticancer agents from unique natural products sources

(23)  Ireland, Chris M a   Aalbersberg, William i   Andersen, Raymond J e   Ayral Kaloustian, Semiramis c   Berlinck, Roberto G S h   Bernan, Valerie c   Carter, Guy c   Churchill, Alice C L j   Clardy, Jon f   Concepcion, Gisela P b   De Silva, E Dilip g   Discafani, Carolyn c   Fojo, Tito d   Frost, Philip c   Gibson, Donna k   Greenberger, Lee M c   Greenstein, Michael c   Harper, Mary Kay a   Mallon, Robert c   Loganzo, Frank c   more..


Author keywords

Antitumor agents; Austocystins; Fungi; Hemiasterlins; Marine microorganisms; Natural Products; NCDDG; Sponges

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ADENOSINE TRIPHOSPHATE; ANTIMITOTIC AGENT; ANTINEOPLASTIC AGENT; AUSTOCYSTIN D; CALICHEAMICIN; CELL DNA; CRIAMIDE A; CYCLIN B; CYTOTOXIC AGENT; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; HEMIASTERLIN; HEMIASTERLIN A; HEMIASTERLIN B; JASPAMIDE; MITOGEN ACTIVATED PROTEIN KINASE; NAMENAMICIN; NATURAL PRODUCT; PACLITAXEL; POLYKETIDE SYNTHASE; PROTEIN KINASE C; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; RAF PROTEIN; STAUROSPORINE; TALTOBULIN; TARGET OF RAPAMYCIN KINASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 9444295342     PISSN: 13880209     EISSN: None     Source Type: Journal    
DOI: 10.1080/1388020039051742     Document Type: Conference Paper
Times cited : (21)

References (83)
  • 1
    • 0028884033 scopus 로고
    • PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel R (1995): PD-098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494.
    • (1995) J Biol Chem , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, R.5
  • 3
    • 0038349992 scopus 로고    scopus 로고
    • Epothilone B and its analogs - A new family of anticancer agents
    • Altmann KH (2003): Epothilone B and its analogs - a new family of anticancer agents. Mini Rev Med Chem 3: 149-158.
    • (2003) Mini Rev Med Chem , vol.3 , pp. 149-158
    • Altmann, K.H.1
  • 5
    • 2942618786 scopus 로고    scopus 로고
    • Molecular evolution of adenylating domain of aminoadipate reductase
    • An K-D, Nishida H, Miura Y, Yokota A (2003): Molecular evolution of adenylating domain of aminoadipate reductase. BMC Evol Biol 3: 9-15 (http://www.biomedcentral.com/ 1471-2148/3/9).
    • (2003) BMC Evol Biol , vol.3 , pp. 9-15
    • An, K.-D.1    Nishida, H.2    Miura, Y.3    Yokota, A.4
  • 6
    • 0031060389 scopus 로고    scopus 로고
    • Cytotoxic peptides hemiasterlin, hemiasterlin A, and hemiasterlin B induce mitotic arrest and abnormal spindle formation
    • Anderson HJ, Coleman JE, Andersen RJ, Roberge M (1997): Cytotoxic peptides hemiasterlin, hemiasterlin A, and hemiasterlin B induce mitotic arrest and abnormal spindle formation. Cancer Chemother Pharmacol 39: 223-226.
    • (1997) Cancer Chemother Pharmacol , vol.39 , pp. 223-226
    • Anderson, H.J.1    Coleman, J.E.2    Andersen, R.J.3    Roberge, M.4
  • 7
    • 0031032858 scopus 로고    scopus 로고
    • Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity
    • Andersen RJ, Coleman JE, Piers E, Wallace DJ (1997): Total synthesis of (-)-hemiasterlin, a structurally novel tripeptide that exhibits potent cytotoxic activity. Tetrahedron Lett 38: 317-320.
    • (1997) Tetrahedron Lett , vol.38 , pp. 317-320
    • Andersen, R.J.1    Coleman, J.E.2    Piers, E.3    Wallace, D.J.4
  • 10
    • 0033607202 scopus 로고    scopus 로고
    • Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: Comparison with dolastatin 10 and cryptophycin 1
    • Bai R, Durso NA, Sackett DL, Hamel E (1999): Interactions of the sponge-derived antimitotic tripeptide hemiasterlin with tubulin: comparison with dolastatin 10 and cryptophycin 1. Biochemistry 38: 14302-14310.
    • (1999) Biochemistry , vol.38 , pp. 14302-14310
    • Bai, R.1    Durso, N.A.2    Sackett, D.L.3    Hamel, E.4
  • 12
    • 0000719887 scopus 로고
    • Status of the NCI preclinical drug discovery screen
    • J.B. Lippincott Publish
    • Boyd, MR (1989): Status of the NCI preclinical drug discovery screen. In: Principles and Practices of Oncology 3, pp. 1-10, J.B. Lippincott Publish.
    • (1989) Principles and Practices of Oncology , vol.3 , pp. 1-10
    • Boyd, M.R.1
  • 15
    • 0028241458 scopus 로고
    • Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta
    • Crews P, Farias JJ, Emrich R, Keifer PA (1994): Milnamide A, an unusual cytotoxic tripeptide from the marine sponge Auletta cf. constricta J Org Chem 59: 2932-2934.
    • (1994) J Org Chem , vol.59 , pp. 2932-2934
    • Crews, P.1    Farias, J.J.2    Emrich, R.3    Keifer, P.A.4
  • 17
    • 0025105061 scopus 로고
    • Geodiamolide C to Geodiamolide F, new cytotoxic cyclodepsipeptides from the marine sponge Pseudaxinyssa sp
    • de Suva ED, Andersen RJ, Allen TM (1990): Geodiamolide C to Geodiamolide F, new cytotoxic cyclodepsipeptides from the marine sponge Pseudaxinyssa sp. Tetrahedron Lett 31: 489-492.
    • (1990) Tetrahedron Lett , vol.31 , pp. 489-492
    • De Suva, E.D.1    Andersen, R.J.2    Allen, T.M.3
  • 19
    • 0034518173 scopus 로고    scopus 로고
    • Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics
    • Downing, KH (2000): Structural basis for the interaction of tubulin with proteins and drugs that affect microtubule dynamics. Annu Rev Cell Dev Biol 16: 89-111.
    • (2000) Annu Rev Cell Dev Biol , vol.16 , pp. 89-111
    • Downing, K.H.1
  • 20
    • 0034121469 scopus 로고    scopus 로고
    • Mechanism of action and resistance to tubulin-binding agents
    • Dumontet C (2000): Mechanism of action and resistance to tubulin-binding agents. Exp Opin Invest Drugs 9: 779-788.
    • (2000) Exp Opin Invest Drugs , vol.9 , pp. 779-788
    • Dumontet, C.1
  • 23
    • 0000375616 scopus 로고    scopus 로고
    • The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenografts in vivo
    • Gibbons JJ, Discafani C, Peterson R, Hernandez R, Skotnicki J, Frost P (1999): The effect of CCI-779, a novel macrolide anti-tumor agent, on the growth of human tumor cells in vitro and in nude mouse xenografts in vivo. Proc Am Assoc Cancer Res 40: 301.
    • (1999) Proc Am Assoc Cancer Res , vol.40 , pp. 301
    • Gibbons, J.J.1    Discafani, C.2    Peterson, R.3    Hernandez, R.4    Skotnicki, J.5    Frost, P.6
  • 24
    • 0033986112 scopus 로고    scopus 로고
    • Anticancer drug targets: Growth factors and growth factor signaling
    • Gibbs (2000): Anticancer drug targets: growth factors and growth factor signaling. J Clin Invest 105: 9-13.
    • (2000) J Clin Invest , vol.105 , pp. 9-13
    • Gibbs1
  • 25
    • 0036176510 scopus 로고    scopus 로고
    • Mechanisms of cancer drug resistance
    • Gottesman MM (2002): Mechanisms of cancer drug resistance. Annu Rev Med 53: 615-627.
    • (2002) Annu Rev Med , vol.53 , pp. 615-627
    • Gottesman, M.M.1
  • 26
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: Role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE (2002): Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer 2: 48-58.
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 27
    • 0029921317 scopus 로고    scopus 로고
    • Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer
    • Hall M, Peters G (1996): Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res 68: 67-108.
    • (1996) Adv Cancer Res , vol.68 , pp. 67-108
    • Hall, M.1    Peters, G.2
  • 28
    • 0029965897 scopus 로고    scopus 로고
    • Antimitotic natural products and their interactions with tubulin
    • Hamel E (1996): Antimitotic natural products and their interactions with tubulin. Med Res Rev 16: 207-231.
    • (1996) Med Res Rev , vol.16 , pp. 207-231
    • Hamel, E.1
  • 30
    • 0029020282 scopus 로고
    • The eukaryotic protein kinase superfamily: Kinase (catalytic) domain structure and classification
    • Hanks SK, Hunter T (1995): The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification. FASEB 9: 576-596.
    • (1995) FASEB , vol.9 , pp. 576-596
    • Hanks, S.K.1    Hunter, T.2
  • 32
    • 0029134016 scopus 로고
    • Role of the cyclin-dependent I kinase inhibitors in the development of cancer
    • Hirama T, Koeffler HP (1995): Role of the cyclin-dependent I kinase inhibitors in the development of cancer. Blood 86: 841-854.
    • (1995) Blood , vol.86 , pp. 841-854
    • Hirama, T.1    Koeffler, H.P.2
  • 33
    • 0030933277 scopus 로고    scopus 로고
    • Oncoprotein networks
    • Hunter T (1997): Oncoprotein networks. Cell 88: 333-346.
    • (1997) Cell , vol.88 , pp. 333-346
    • Hunter, T.1
  • 34
    • 0031054730 scopus 로고    scopus 로고
    • New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis
    • Imamura N, Nishijima M, Takadera T, Adachi K, Sakai M, Sano H (1997): New anticancer antibiotics pelagiomicins, produced by a new marine bacterium Pelagiobacter variabilis. J Antibiot 50: 8-12.
    • (1997) J Antibiot , vol.50 , pp. 8-12
    • Imamura, N.1    Nishijima, M.2    Takadera, T.3    Adachi, K.4    Sakai, M.5    Sano, H.6
  • 37
    • 34250124977 scopus 로고
    • Mutagenic activity of austocystins-secondary metabolities of Aspergillus ustus
    • Kfir R, Johannsen E, Vleggaar R (1986): Mutagenic activity of austocystins-secondary metabolities of Aspergillus ustus. Bull Environ Contam Toxicol 37: 643-650.
    • (1986) Bull Environ Contam Toxicol , vol.37 , pp. 643-650
    • Kfir, R.1    Johannsen, E.2    Vleggaar, R.3
  • 38
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W (2000): Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions. Biochem J 351: 289-305.
    • (2000) Biochem J , vol.351 , pp. 289-305
    • Kolch, W.1
  • 39
    • 0023767544 scopus 로고
    • Role of glutathione redox cycle in acquired and de novo multidrug resistance
    • Kramer RA, Zakher J, Kim G (1988): Role of glutathione redox cycle in acquired and de novo multidrug resistance. Science 241: 694-698.
    • (1988) Science , vol.241 , pp. 694-698
    • Kramer, R.A.1    Zakher, J.2    Kim, G.3
  • 40
    • 0027298544 scopus 로고
    • Constitutive expression of multidrug resistance in human colorectal tumors and cell lines
    • Kramer RA, Weber TK, Morse B (1993): Constitutive expression of multidrug resistance in human colorectal tumors and cell lines. Br J Cancer 67: 959-968.
    • (1993) Br J Cancer , vol.67 , pp. 959-968
    • Kramer, R.A.1    Weber, T.K.2    Morse, B.3
  • 42
    • 0029786329 scopus 로고    scopus 로고
    • Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOGMAPK pathway
    • Lavoie JN, L'Allemain G, Brunei A, Muller R, Pouyssegur J (1996): Cyclin D1 expression is regulated positively by the p42/p44 MAPK and negatively by the p38/HOGMAPK pathway. J Biol Chem 271: 20608-20616.
    • (1996) J Biol Chem , vol.271 , pp. 20608-20616
    • Lavoie, J.N.1    L'Allemain, G.2    Brunei, A.3    Muller, R.4    Pouyssegur, J.5
  • 44
    • 0030952552 scopus 로고    scopus 로고
    • Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
    • Leraer EC, Zhang TT, Knowles DB, Qian Y, Hamilton AD, Sebti M (1997): Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene 15: 1283-1288.
    • (1997) Oncogene , vol.15 , pp. 1283-1288
    • Leraer, E.C.1    Zhang, T.T.2    Knowles, D.B.3    Qian, Y.4    Hamilton, A.D.5    Sebti, M.6
  • 45
    • 0028968949 scopus 로고
    • Tyrosine kinase inhibition: An approach to drug development
    • Levitzki A, Gazit A (1995): Tyrosine kinase inhibition: an approach to drug development. Science 267: 1782-1788.
    • (1995) Science , vol.267 , pp. 1782-1788
    • Levitzki, A.1    Gazit, A.2
  • 46
    • 0031900740 scopus 로고    scopus 로고
    • Signal transduction through MAP kinase cascades
    • Lewis TS, Shapiro PS, Ahn NG (1998): Signal transduction through MAP kinase cascades. Adv Cancer Res 74: 49-139.
    • (1998) Adv Cancer Res , vol.74 , pp. 49-139
    • Lewis, T.S.1    Shapiro, P.S.2    Ahn, N.G.3
  • 50
    • 0031873963 scopus 로고    scopus 로고
    • New aspects of genes and enzymes for β-lactam antibiotic biosynthesis Appl
    • Martin JF (1998): New aspects of genes and enzymes for β-lactam antibiotic biosynthesis Appl. Microbiol Biotechnol 50: 1-15.
    • (1998) Microbiol Biotechnol , vol.50 , pp. 1-15
    • Martin, J.F.1
  • 52
    • 0344177511 scopus 로고    scopus 로고
    • A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: High-throughput screening and identification of selective enzyme inhibitors
    • McDonald OB, Chen WJ, Ellis B, Huffman C, Overton L, Rink M, Smith A, Marshall CJ, Wood ER (1999): A scintillation proximity assay for the Raf/MEK/ERK kinase cascade: high-throughput screening and identification of selective enzyme inhibitors. Anal Biochem 268: 318-329.
    • (1999) Anal Biochem , vol.268 , pp. 318-329
    • McDonald, O.B.1    Chen, W.J.2    Ellis, B.3    Huffman, C.4    Overton, L.5    Rink, M.6    Smith, A.7    Marshall, C.J.8    Wood, E.R.9
  • 53
    • 0030753686 scopus 로고    scopus 로고
    • Chemical inhibitors of cyclin-dependent kinases
    • Meijer L, Kim S-H (1997): Chemical inhibitors of cyclin-dependent kinases. Methods Enzymol 283: 113-128.
    • (1997) Methods Enzymol , vol.283 , pp. 113-128
    • Meijer, L.1    Kim, S.-H.2
  • 56
    • 0028931265 scopus 로고
    • Principles of CDK regulation
    • Morgan DO (1995): Principles of CDK regulation. Nature 374: 131-134.
    • (1995) Nature , vol.374 , pp. 131-134
    • Morgan, D.O.1
  • 57
    • 0025775062 scopus 로고
    • Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines
    • Monks A, Scudiero D, Skehan P (1991): Feasibility of a high-flux anticancer drug screen using a diverse panel of cultured human tumor cell lines. J Natl Cancer Inst 83: 757-766.
    • (1991) J Natl Cancer Inst , vol.83 , pp. 757-766
    • Monks, A.1    Scudiero, D.2    Skehan, P.3
  • 59
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA (1994): Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 368: 753-756.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 61
    • 0344239446 scopus 로고    scopus 로고
    • Two photoaffinity analogs of HTI-286, a synthetic analog of hemiasterlin, interact with alpha-tubulin
    • Nunes M, Kaplan J, Loganzo F, Zask A, Ayral-Kaloustian S, Greenberger L (2002): Two photoaffinity analogs of HTI-286, a synthetic analog of hemiasterlin, interact with alpha-tubulin. Eur J Cancer 38: S119.
    • (2002) Eur J Cancer , vol.38
    • Nunes, M.1    Kaplan, J.2    Loganzo, F.3    Zask, A.4    Ayral-Kaloustian, S.5    Greenberger, L.6
  • 63
    • 0029034774 scopus 로고
    • Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
    • Pang L, Sawada T, Decker SJ, Saltiel AR (1995): Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor. J Biol Chem 23: 13585-13588.
    • (1995) J Biol Chem , vol.23 , pp. 13585-13588
    • Pang, L.1    Sawada, T.2    Decker, S.J.3    Saltiel, A.R.4
  • 64
    • 0033032591 scopus 로고    scopus 로고
    • Signaling networks-do all roads lead to the same genes?
    • Pawson T, Saxton TM (1999): Signaling networks-do all roads lead to the same genes? Cell 97: 675-678.
    • (1999) Cell , vol.97 , pp. 675-678
    • Pawson, T.1    Saxton, T.M.2
  • 65
    • 9444229485 scopus 로고    scopus 로고
    • Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analog, HTI-286, have mutations in α- or β-tubulin and increased microtubule stability
    • 2nd ed
    • Poruchynsky MS, Kim JH, Nogales E, Loganzo F, Greenberger LM (2003): Tumor cells resistant to a microtubule-depolymerizing hemiasterlin analog, HTI-286, have mutations in α- or β-tubulin and increased microtubule stability. Proc Am Assoc Cancer Res 44: 535 (2nd ed.).
    • (2003) Proc Am Assoc Cancer Res , vol.44 , pp. 535
    • Poruchynsky, M.S.1    Kim, J.H.2    Nogales, E.3    Loganzo, F.4    Greenberger, L.M.5
  • 67
    • 0034665125 scopus 로고    scopus 로고
    • Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts
    • Roberge M, Cinel B, Anderson HJ, Lim L, Jiang X, Xu L, Kelly MT, Andersen RJ (2000): Cell-based screen for antimitotic agents and identification of analogues of rhizoxin, eleutherobin, and paclitaxel in natural extracts. Cancer Res 60: 5052-5058.
    • (2000) Cancer Res , vol.60 , pp. 5052-5058
    • Roberge, M.1    Cinel, B.2    Anderson, H.J.3    Lim, L.4    Jiang, X.5    Xu, L.6    Kelly, M.T.7    Andersen, R.J.8
  • 68
    • 0030898417 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase pathways
    • Robinson MJ, Cobb MH (1997): Mitogen-activated protein kinase pathways. Curr Opin Cell Biol 9: 180-186.
    • (1997) Curr Opin Cell Biol , vol.9 , pp. 180-186
    • Robinson, M.J.1    Cobb, M.H.2
  • 69
    • 0000589775 scopus 로고    scopus 로고
    • Antimicrotubule agents
    • Devita Jr VT, Hellman S, Rosenberg SA, eds., Philadelphia, Lippincott Williams and Wilkins
    • Rowinsky EK, Tolcher AW (2001): Antimicrotubule Agents. In: Devita Jr VT, Hellman S, Rosenberg SA, eds., Cancer Principles and Practice. 6th ed., Philadelphia, Lippincott Williams and Wilkins, pp. 431-452.
    • (2001) Cancer Principles and Practice. 6th Ed. , pp. 431-452
    • Rowinsky, E.K.1    Tolcher, A.W.2
  • 70
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon DS, Brandt R, Ciadiello F, Normanno N (1995): Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Haematol 19: 183-232.
    • (1995) Crit Rev Oncol Haematol , vol.19 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciadiello, F.3    Normanno, N.4
  • 72
    • 0017250977 scopus 로고
    • DNA related to the transforming gene of avian sarcoma virus is present in normal avian DNA
    • Stehelin D, Varmus HE, Bishop JM, Vogt PK (1976): DNA related to the transforming gene of avian sarcoma virus is present in normal avian DNA. Nature 260: 170-173.
    • (1976) Nature , vol.260 , pp. 170-173
    • Stehelin, D.1    Varmus, H.E.2    Bishop, J.M.3    Vogt, P.K.4
  • 73
    • 0016247422 scopus 로고
    • Austocystins. Six novel dihydrofurol[3′,2′:4,5]furo[3,2-b] xanthenones from Aspergillus ustus
    • Steyn PS, Vleggaar R (1974): Austocystins. Six novel dihydrofurol[3′,2′:4,5]furo[3,2-b]xanthenones from Aspergillus ustus. J Chem Soc Perkin I 19: 2250-2256.
    • (1974) J Chem Soc Perkin I , vol.19 , pp. 2250-2256
    • Steyn, P.S.1    Vleggaar, R.2
  • 74
    • 9444244583 scopus 로고
    • Dihydroruro[3′,2′:4,5]furo[3,2-b]xanthenones: The structures of austocystins G, H, and I
    • Steyn PS, Vleggaar R (1975): Dihydroruro[3′,2′:4,5]furo[3,2- b]xanthenones: the structures of austocystins G, H, and I. J South African Chemical Institute 28: 375-377.
    • (1975) J South African Chemical Institute , vol.28 , pp. 375-377
    • Steyn, P.S.1    Vleggaar, R.2
  • 75
    • 85017325712 scopus 로고    scopus 로고
    • Tyrosine kinases in disease: Overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials
    • Strawn, LM, Shawver LK (1998): Tyrosine kinases in disease: overview of kinase inhibitors as therapeutic agents and current drugs in clinical trials. Exp Opin Invest Drugs 7: 553-573.
    • (1998) Exp Opin Invest Drugs , vol.7 , pp. 553-573
    • Strawn, L.M.1    Shawver, L.K.2
  • 76
    • 0028305511 scopus 로고
    • Hemiasterlin and geodiamolide-TA - 2 new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick)
    • Talpir R, Benayahu Y, Kashman Y, Pannell L, Schleyer M (1994): Hemiasterlin and geodiamolide-TA - 2 new cytotoxic peptides from the marine sponge Hemiasterella minor (Kirkpatrick). Tetrahedron Lett 35: 4453-4456.
    • (1994) Tetrahedron Lett , vol.35 , pp. 4453-4456
    • Talpir, R.1    Benayahu, Y.2    Kashman, Y.3    Pannell, L.4    Schleyer, M.5
  • 79
    • 0028284699 scopus 로고
    • The peptide synthetase catalyzing eyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame
    • Weber G, Schorgendorfer K, Schneider-Scherzer E, Leitner E (1994): The peptide synthetase catalyzing eyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr Genet 26: 120-125.
    • (1994) Curr Genet , vol.26 , pp. 120-125
    • Weber, G.1    Schorgendorfer, K.2    Schneider-Scherzer, E.3    Leitner, E.4
  • 80
    • 9444268241 scopus 로고
    • Molecular biology of carcinogenesis
    • Broder S, ed. Williams & Wilkins
    • Weinber RA (1991): Molecular Biology of Carcinogenesis. In: Broder S, ed., Molecular Foundations of Oncology. Williams & Wilkins, pp. 27-39.
    • (1991) Molecular Foundations of Oncology , pp. 27-39
    • Weinber, R.A.1
  • 81
    • 0033063774 scopus 로고    scopus 로고
    • The epidermal growth factor receptor and its inhibition in cancer therapy
    • Woodburn JR (1999): The epidermal growth factor receptor and its inhibition in cancer therapy. Pharmacol Ther 82: 241-250.
    • (1999) Pharmacol Ther , vol.82 , pp. 241-250
    • Woodburn, J.R.1
  • 82
    • 0033152122 scopus 로고    scopus 로고
    • Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases
    • Zaharevitz DW, Gussio R, Leost M, Senderowicz AM, Lahusen T, Kunick C, Meijer L, Sausville EA (1999): Discovery and initial characterization of the paullones, a novel class of small-molecule inhibitors of cyclin-dependent kinases. Cancer Res 59: 2566-2569.
    • (1999) Cancer Res , vol.59 , pp. 2566-2569
    • Zaharevitz, D.W.1    Gussio, R.2    Leost, M.3    Senderowicz, A.M.4    Lahusen, T.5    Kunick, C.6    Meijer, L.7    Sausville, E.A.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.