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Volumn 15, Issue 6, 2004, Pages 599-606

Exploiting natural peptide diversity: Novel research tools and drug leads

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL EFFECTS; CHEMOATTRACTANTS; PEPTIDES; PROTEASE INHIBITORS;

EID: 9244220099     PISSN: 09581669     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.copbio.2004.10.007     Document Type: Review
Times cited : (43)

References (52)
  • 2
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • C.H. Park, E.V. Valore, A.J. Waring, and T. Ganz Hepcidin, a urinary antimicrobial peptide synthesized in the liver J Biol Chem 276 2001 7806 7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 3
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, P. Brissot, and O. Loreal A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 2001 7811 7819 Describes the discovery of the liver hormone hepcidin through a molecular-biological approach that targets genes upregulated during iron excess. It complements earlier work [1,2], which reported the isolation of the hepcidin peptide from hemofiltrate and urine.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 5
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2003 2461 2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 6
    • 4344600507 scopus 로고    scopus 로고
    • Hepcidin in iron metabolism
    • T. Ganz Hepcidin in iron metabolism Curr Opin Hematol 11 2004 251 254
    • (2004) Curr Opin Hematol , vol.11 , pp. 251-254
    • Ganz, T.1
  • 7
    • 0037847496 scopus 로고    scopus 로고
    • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
    • G. Nicolas, L. Viatte, D.Q. Lou, M. Bennoun, C. Beaumont, A. Kahn, N.C. Andrews, and S. Vaulont Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis Nat Genet 34 2003 97 101 Shortly after its discovery, the physiological significance of hepcidin in iron metabolism was demonstrated in an animal model of disease.
    • (2003) Nat Genet , vol.34 , pp. 97-101
    • Nicolas, G.1    Viatte, L.2    Lou, D.Q.3    Bennoun, M.4    Beaumont, C.5    Kahn, A.6    Andrews, N.C.7    Vaulont, S.8
  • 8
    • 12244313876 scopus 로고    scopus 로고
    • Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver
    • A. Krause, R. Sillard, B. Kleemeier, E. Klüver, E. Maronde, J.R. Conejo-Garcia, W.G. Forssmann, P. Schulz-Knappe, M.C. Nehls, and F. Wattler Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver Protein Sci 12 2003 143 152 Description of a new secretory liver peptide that fulfils the prerequisites of a typical hormone. Its physiological significance remains still to be disclosed.
    • (2003) Protein Sci , vol.12 , pp. 143-152
    • Krause, A.1    Sillard, R.2    Kleemeier, B.3    Klüver, E.4    Maronde, E.5    Conejo-Garcia, J.R.6    Forssmann, W.G.7    Schulz-Knappe, P.8    Nehls, M.C.9    Wattler, F.10
  • 9
    • 0036479317 scopus 로고    scopus 로고
    • Homodimeric theta-defensins from rhesus macaque leukocytes: Isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides
    • D. Tran, P.A. Tran, Y.Q. Tang, J. Yuan, T. Cole, and M.E. Selsted Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides J Biol Chem 277 2002 3079 3084 A paper that demonstrates the discovery of members of a structurally unique family of antimcrobial peptides with particular biochemical and antimicrobial features. An example that nature provides lead structures for molecular design and engineering.
    • (2002) J Biol Chem , vol.277 , pp. 3079-3084
    • Tran, D.1    Tran, P.A.2    Tang, Y.Q.3    Yuan, J.4    Cole, T.5    Selsted, M.E.6
  • 11
    • 2342573669 scopus 로고    scopus 로고
    • Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry
    • B. Yasin, W. Wang, M. Pang, N. Cheshenko, T. Hong, A.J. Waring, B.C. Herold, E.A. Wagar, and R.I. Lehrer Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry J Virol 78 2004 5147 5156
    • (2004) J Virol , vol.78 , pp. 5147-5156
    • Yasin, B.1    Wang, W.2    Pang, M.3    Cheshenko, N.4    Hong, T.5    Waring, A.J.6    Herold, B.C.7    Wagar, E.A.8    Lehrer, R.I.9
  • 13
    • 0038041942 scopus 로고    scopus 로고
    • Minidefensins and other antimicrobial peptides: Candidate anti-HIV microbicides
    • A.M. Cole Minidefensins and other antimicrobial peptides: candidate anti-HIV microbicides Expert Opin Ther Targets 7 2003 329 341
    • (2003) Expert Opin Ther Targets , vol.7 , pp. 329-341
    • Cole, A.M.1
  • 14
    • 1342281272 scopus 로고    scopus 로고
    • The identification of ligands at orphan G-protein coupled receptors
    • A. Wise, S.C. Jupe, and S. Rees The identification of ligands at orphan G-protein coupled receptors Annu Rev Pharmacol Toxicol 44 2004 43 66 This article comprehensively reviews the selection of target orphan receptors and technologies to discover orphan receptor ligands. The reverse pharmacology approach for investigation of the importance of orphan receptors through the discovery of new ligands is illustrated by recent examples.
    • (2004) Annu Rev Pharmacol Toxicol , vol.44 , pp. 43-66
    • Wise, A.1    Jupe, S.C.2    Rees, S.3
  • 16
    • 0141993969 scopus 로고    scopus 로고
    • Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids
    • V. Wittamer, J.D. Franssen, M. Vulcano, J.F. Mirjolet, E. Le Poul, I. Migeotte, S. Brezillon, R. Tyldesley, C. Blanpain, and M. Detheux Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids J Exp Med 198 2003 977 985 An example of the isolation of an orphan GPCR employing a knowledge-based approach. Expression data of the receptor provided was used to select a source for ligand isolation.
    • (2003) J Exp Med , vol.198 , pp. 977-985
    • Wittamer, V.1    Franssen, J.D.2    Vulcano, M.3    Mirjolet, J.F.4    Le Poul, E.5    Migeotte, I.6    Brezillon, S.7    Tyldesley, R.8    Blanpain, C.9    Detheux, M.10
  • 20
    • 0344642994 scopus 로고    scopus 로고
    • Homologous proteins with different folds: The three-dimensional structures of domains 1 and 6 of the multiple Kazal-type inhibitor LEKTI
    • T. Lauber, A. Schulz, K. Schweimer, K. Adermann, and U.C. Marx Homologous proteins with different folds: the three-dimensional structures of domains 1 and 6 of the multiple Kazal-type inhibitor LEKTI J Mol Biol 328 2003 205 219 This paper convincingly demonstrates the importance of three-dimensional structural information. The obvious structural differences of the described LEKTI domains provide an explanation for the different protease selectivity, which is not possible by primary structure analysis.
    • (2003) J Mol Biol , vol.328 , pp. 205-219
    • Lauber, T.1    Schulz, A.2    Schweimer, K.3    Adermann, K.4    Marx, U.C.5
  • 21
  • 23
    • 0037133295 scopus 로고    scopus 로고
    • Discovery of five conserved β-defensin gene clusters using a computational search strategy
    • B.C. Schutte, J.P. Mitros, J.A. Bartlett, J.D. Walters, H.P. Jia, M.J. Welsh, T.L. Casavant, and P.B. McCray Jr. Discovery of five conserved β-defensin gene clusters using a computational search strategy Proc Natl Acad Sci USA 99 2002 2129 2133 Impressive use of bioinformatic tools to discover novel mammalian β-defensins based on primary structure motifs of known β-defensins.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2129-2133
    • Schutte, B.C.1    Mitros, J.P.2    Bartlett, J.A.3    Walters, J.D.4    Jia, H.P.5    Welsh, M.J.6    Casavant, T.L.7    McCray Jr., P.B.8
  • 27
    • 2342666235 scopus 로고    scopus 로고
    • An epididymis-specific β-defensin is important for the initiation of sperm maturation
    • C.X. Zhou, Y.L. Zhang, L. Xiao, M. Zheng, K.M. Leung, M.Y. Chan, P.S. Lo, L.L. Tsang, H.Y. Wong, and L.S. Ho An epididymis-specific β-defensin is important for the initiation of sperm maturation Nat Cell Biol 6 2004 458 464 This paper clearly indicates a role for a bioinformatically discovered mouse β-defensin beyond innate immunity. A function for sperm maturation was suggested earlier based on the epididymal expression of new β-defensins, which are truly multifunctional endogenous peptides.
    • (2004) Nat Cell Biol , vol.6 , pp. 458-464
    • Zhou, C.X.1    Zhang, Y.L.2    Xiao, L.3    Zheng, M.4    Leung, K.M.5    Chan, M.Y.6    Lo, P.S.7    Tsang, L.L.8    Wong, H.Y.9    Ho, L.S.10
  • 28
    • 0347989461 scopus 로고    scopus 로고
    • Conus venoms: A rich source of novel ion channel-targeted peptides
    • H. Terlau, and B.M. Olivera Conus venoms: a rich source of novel ion channel-targeted peptides Physiol Rev 84 2004 41 68 A comprehensive overview about a large and extremely diverse peptide family, including details of structural features and activity on ion channels. Although a large number of Conus peptides are already known, most conotoxins and related peptides remain to be discovered.
    • (2004) Physiol Rev , vol.84 , pp. 41-68
    • Terlau, H.1    Olivera, B.M.2
  • 29
    • 0033865588 scopus 로고    scopus 로고
    • Conotoxins-new vistas for peptide therapeutics
    • R.M. Jones, and G. Bulaj Conotoxins-new vistas for peptide therapeutics Curr Pharm Des 6 2000 1249 1285
    • (2000) Curr Pharm des , vol.6 , pp. 1249-1285
    • Jones, R.M.1    Bulaj, G.2
  • 30
    • 3042759058 scopus 로고    scopus 로고
    • αa-Conotoxin OIVA defines a new αa-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors
    • R.W. Teichert, J. Rivier, J. Dykert, L. Cervini, J. Gulyas, G. Bulaj, M. Ellison, and B.M. Olivera αA-Conotoxin OIVA defines a new αA-conotoxin subfamily of nicotinic acetylcholine receptor inhibitors Toxicon 44 2004 207 214 An example of the discovery, structural and functional characterization of a peptide of a new conotoxin subfamily.
    • (2004) Toxicon , vol.44 , pp. 207-214
    • Teichert, R.W.1    Rivier, J.2    Dykert, J.3    Cervini, L.4    Gulyas, J.5    Bulaj, G.6    Ellison, M.7    Olivera, B.M.8
  • 31
    • 3543122391 scopus 로고    scopus 로고
    • Intrathecal ziconotide for refractory pain
    • S.A. Doggrell Intrathecal ziconotide for refractory pain Expert Opin Investig Drugs 13 2004 875 877
    • (2004) Expert Opin Investig Drugs , vol.13 , pp. 875-877
    • Doggrell, S.A.1
  • 32
    • 1542509435 scopus 로고    scopus 로고
    • Bioactive peptides from marine sources: Pharmacological properties and isolation procedures
    • A. Aneiros, and A. Garateix Bioactive peptides from marine sources: pharmacological properties and isolation procedures J Chromatogr B Analyt Technol Biomed Life Sci 803 2004 41 53 A systematic overview of peptides isolated from various marine organisms. Recent discoveries of bioactive peptides from different species are highlighted with respect to structure, function and isolation procedures.
    • (2004) J Chromatogr B Analyt Technol Biomed Life Sci , vol.803 , pp. 41-53
    • Aneiros, A.1    Garateix, A.2
  • 33
    • 2342629343 scopus 로고    scopus 로고
    • A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons
    • S. Diochot, A. Baron, L.D. Rash, E. Deval, P. Escoubas, S. Scarzello, M. Salinas, and M. Lazdunski A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neurons EMBO J 23 2004 1516 1525
    • (2004) EMBO J , vol.23 , pp. 1516-1525
    • Diochot, S.1    Baron, A.2    Rash, L.D.3    Deval, E.4    Escoubas, P.5    Scarzello, S.6    Salinas, M.7    Lazdunski, M.8
  • 34
    • 3142543798 scopus 로고    scopus 로고
    • Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity
    • X. Thomas, D. Destoumieux-Garzon, J. Peduzzi, C. Afonso, A. Blond, N. Birlirakis, C. Goulard, L. Dubost, R. Thai, J.C. Tabet, and S. Rebuffat Siderophore peptide, a new type of post-translationally modified antibacterial peptide with potent activity J Biol Chem 279 2004 28233 28242 Description of a novel post-translational modification of an antibacterial peptide. Modern NMR spectroscopic and mass spectrometric techniques were used to localize and specify the sidechain modification enhancing the antibacterial activity.
    • (2004) J Biol Chem , vol.279 , pp. 28233-28242
    • Thomas, X.1    Destoumieux-Garzon, D.2    Peduzzi, J.3    Afonso, C.4    Blond, A.5    Birlirakis, N.6    Goulard, C.7    Dubost, L.8    Thai, R.9    Tabet, J.C.10    Rebuffat, S.11
  • 35
    • 0041305874 scopus 로고    scopus 로고
    • Polypeptide hormones: Signaling molecules in plants
    • P. Chilley Polypeptide hormones: signaling molecules in plants Vitam Horm 66 2003 317 344 Overview of the current knowledge of peptides as signal transducers in plants, a field of peptide research that appears to be underrepresented.
    • (2003) Vitam Horm , vol.66 , pp. 317-344
    • Chilley, P.1
  • 37
    • 0344630197 scopus 로고    scopus 로고
    • Systemins: A functionally defined family of peptide signals that regulate defensive genes in Solanaceae species
    • C.A. Ryan, and G. Pearce Systemins: a functionally defined family of peptide signals that regulate defensive genes in Solanaceae species Proc Natl Acad Sci USA 100 Suppl 2 2003 14577 14580
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.2 , pp. 14577-14580
    • Ryan, C.A.1    Pearce, G.2
  • 38
    • 0036489968 scopus 로고    scopus 로고
    • The cyclotides: Novel macrocyclic peptides as scaffolds in drug design
    • D.J. Craik, S. Simonsen, and N.L. Daly The cyclotides: novel macrocyclic peptides as scaffolds in drug design Curr Opin Drug Discov Devel 5 2002 251 260 Peptides of the cyclotide family contain a rigid framework maintained by multiple disulfide bonds. As a consequence, cyclotides display considerable thermal stability and resistance against proteolytic cleavage and are considered to be lead structures for targeted peptide design.
    • (2002) Curr Opin Drug Discov Devel , vol.5 , pp. 251-260
    • Craik, D.J.1    Simonsen, S.2    Daly, N.L.3
  • 39
    • 0035845584 scopus 로고    scopus 로고
    • Biosynthesis and insecticidal properties of plant cyclotides: The cyclic knotted proteins from Oldenlandia affinis
    • C. Jennings, J. West, C. Waine, D. Craik, and M. Anderson Biosynthesis and insecticidal properties of plant cyclotides: the cyclic knotted proteins from Oldenlandia affinis Proc Natl Acad Sci USA 98 2001 10614 10619
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 10614-10619
    • Jennings, C.1    West, J.2    Waine, C.3    Craik, D.4    Anderson, M.5
  • 43
    • 0037084079 scopus 로고    scopus 로고
    • An automated on-line multidimensional HPLC system for protein and peptide mapping with integrated sample preparation
    • K. Wagner, T. Miliotis, G. Marko-Varga, R. Bischoff, and K.K. Unger An automated on-line multidimensional HPLC system for protein and peptide mapping with integrated sample preparation Anal Chem 74 2002 809 820
    • (2002) Anal Chem , vol.74 , pp. 809-820
    • Wagner, K.1    Miliotis, T.2    Marko-Varga, G.3    Bischoff, R.4    Unger, K.K.5
  • 45
    • 2942607405 scopus 로고    scopus 로고
    • Combinatorial peptidomics: A generic approach for protein expression profiling
    • M. Soloviev, R. Barry, E. Scrivener, and J. Terrett Combinatorial peptidomics: a generic approach for protein expression profiling J Nanobiotechnology 1 2003 4 18 This article presents a new approach to identify peptides from complex mixtures making a chromatographic separation unnecessary. Serial covalent immobilization using selective crosslinking of peptide sidechain functional groups to polymeric beads is used to remove certain peptides from the mixture. This approach is suitable for quantification.
    • (2003) J Nanobiotechnology , vol.1 , pp. 4-18
    • Soloviev, M.1    Barry, R.2    Scrivener, E.3    Terrett, J.4
  • 46
    • 0037174927 scopus 로고    scopus 로고
    • Peptidomics of the larval Drosophila melanogaster central nervous system
    • G. Baggermann, A. Cerstiaens, A. De Loof, and L. Schoofs Peptidomics of the larval Drosophila melanogaster central nervous system J Biol Chem 277 2002 40368 40374 This paper convincingly demonstrates how efficient modern MS can be applied in terms of sensitivity and sequence elucidation. A total of 28 neuropeptides were identified from only 50 larval Drosophila, whereas classical approaches required several 100 000 larvae.
    • (2002) J Biol Chem , vol.277 , pp. 40368-40374
    • Baggermann, G.1    Cerstiaens, A.2    De Loof, A.3    Schoofs, L.4
  • 47
    • 2542460134 scopus 로고    scopus 로고
    • Miniaturized proteomics and peptidomics using capillary liquid separation and high resolution mass spectrometry
    • M. Ramström, and J. Bergquist Miniaturized proteomics and peptidomics using capillary liquid separation and high resolution mass spectrometry FEBS Lett 567 2004 92 95
    • (2004) FEBS Lett , vol.567 , pp. 92-95
    • Ramström, M.1    Bergquist, J.2
  • 48
    • 0002652573 scopus 로고    scopus 로고
    • Peptidomics technologies for human body fluids
    • M. Schrader, and P. Schulz-Knappe Peptidomics technologies for human body fluids Trends Biotechnol 19 Suppl 10 2001 S55 S60
    • (2001) Trends Biotechnol , vol.19 , Issue.10
    • Schrader, M.1    Schulz-Knappe, P.2
  • 49
    • 3142557616 scopus 로고    scopus 로고
    • Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation
    • T. Kaiser, H. Kamal, A. Rank, H.J. Kolb, E. Holler, A. Ganser, B. Hertenstein, H. Mischak, and E.M. Weissinger Proteomics applied to the clinical follow-up of patients after allogeneic hematopoietic stem cell transplantation Blood 104 2004 340 349 An example of a sophisticated analytical procedure and its application in diagnostics. CE-MS instrumentation combined with bioinformatics has added a new tool to a specific clinical field. A closely related application of this technique is described in [50].
    • (2004) Blood , vol.104 , pp. 340-349
    • Kaiser, T.1    Kamal, H.2    Rank, A.3    Kolb, H.J.4    Holler, E.5    Ganser, A.6    Hertenstein, B.7    Mischak, H.8    Weissinger, E.M.9
  • 51
    • 1542722311 scopus 로고    scopus 로고
    • Amyloid β peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ionization time-of-flight mass spectrometry: Evidence of novel biomarkers in Alzheimer's disease
    • P. Lewczuk, H. Esselmann, T.W. Groemer, M. Bibl, J.M. Maler, P. Steinacker, M. Otto, J. Kornhuber, and J. Wiltfang Amyloid β peptides in cerebrospinal fluid as profiled with surface enhanced laser desorption/ ionization time-of-flight mass spectrometry: evidence of novel biomarkers in Alzheimer's disease Biol Psychiatry 55 2004 524 530
    • (2004) Biol Psychiatry , vol.55 , pp. 524-530
    • Lewczuk, P.1    Esselmann, H.2    Groemer, T.W.3    Bibl, M.4    Maler, J.M.5    Steinacker, P.6    Otto, M.7    Kornhuber, J.8    Wiltfang, J.9
  • 52
    • 0036733748 scopus 로고    scopus 로고
    • Peptidomics-based approach reveals the secretion of the 29-residue COOH-terminal fragment of the putative tumor suppressor protein DMBT1 from pancreatic adenocarcinoma cell lines
    • K. Sasaki, K. Sato, Y. Akiyama, K. Yanagihara, M. Oka, and K. Yamaguchi Peptidomics-based approach reveals the secretion of the 29-residue COOH-terminal fragment of the putative tumor suppressor protein DMBT1 from pancreatic adenocarcinoma cell lines Cancer Res 62 2002 4894 4898 Example of the use of SELDI technology to detect potential cancer-related biomarkers. Combination of a less complex test mixture of cultured cell supernatants with selective on-target sample preparation represents a promising application for SELDI-MS broadening its diagnostic value.
    • (2002) Cancer Res , vol.62 , pp. 4894-4898
    • Sasaki, K.1    Sato, K.2    Akiyama, Y.3    Yanagihara, K.4    Oka, M.5    Yamaguchi, K.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.