The θ-Defensin, Retrocyclin, Inhibits HIV-1 Entry

AIDS Research and Human Retroviruses

Volumn 19, Issue 10, 2003, Pages 875-881

  Münk, Carsten ^a,f   Wei, Ge ^a   Yang, Otto O ^b,c   Waring, Alan J ^b   Wang, Wei ^b   Hong, Teresa ^b   Lehrer, Robert I ^b,c   Landau, Nathaniel R ^a   Cole, Alexander M ^b,d,e  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c AIDS Institute   (United States)

^d Will Rogers Institute Pulmonary Research Center   (United States)

^e UNIVERSITY OF CENTRAL FLORIDA   (United States)

^f PAUL EHRLICH INSTITUT   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAMASE; CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; DEFENSIN; GLYCOPROTEIN GP 120; LUCIFERASE; RETROCYCLIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

CONFOCAL MICROSCOPY; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; HUMAN GENOME; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; REVIEW; SURFACE PLASMON RESONANCE; VIRUS INFECTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTI-HIV AGENTS; CELLS, CULTURED; DEFENSINS; HIV-1; HUMANS; MEMBRANE FUSION; VIRUS REPLICATION;

EID: 17444436038     PISSN: 08892229     EISSN: None     Source Type: Journal    
DOI: 10.1089/088922203322493049     Document Type: Review

References (27)

1. Boman HG: Peptide antibiotics and their role in innate immunity. Annu Rev Immunol 1995;13:61-92.
2. Lehrer RI, Lichtenstein AK, and Ganz T: Defensins: Antimicrobial and cytotoxic peptides of mammalian cells. Annu Rev Immunol 1993;11:105-128.
3. Schonwetter BS, Stolzenberg ED, and Zasloff MA: Epithelial antibiotics induced at sites of inflammation. Science 1995;267: 1645-1648.
4. Schroder JM: Epithelial antimicrobial peptides: Innate local host response elements. Cell Mol Life Sci 1999;56:32-46.
5. Harwig SS, Swiderek KM, Kokryakov VN, et al.: Gallinacins: Cysteine-rich antimicrobial peptides of chicken leukocytes. FEBS Lett 1994;342:281-285.
6. Lehrer RI and Ganz T: Defensins of vertebrate animals. Curr Opin Immunol 2002;14:96-102.
7. Leonova L, Kokryakov VN, Aleshina GM, et al.: Circular minidefensins and posttranslational generation of molecular diversity. J Leukocyte Biol 2001;70:461-464.
8. Tang YQ, Yuan J, Osapay G, et al.: A cyclic antimicrobial peptide produced in primate leukocytes by the ligation of two truncated α-defensins. Science 1999;286:498-502.
9. Tran D, Tran PA, Tang YQ, Yuan J, Cole T, and Selsted ME: Homodimeric theta-defensins from Rhesus macaque leukocytes -Isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem 2002;277:3079-3084.
10. Cole AM, Hong T, Boo LM, et al.: Retrocyclin: A primate peptide that protects cells from infection by T-and M-tropic strains of HIV-1. Proc Natl Acad Sci USA 2002;99:1813-1818.
11. Zhang L, Yu W, He T, et al.: Contribution of human {alpha}-defensin-1, -2 and -3 to the anti-HIV-1 activity of CDS antiviral factor. Science 2002;298:995-1000.
12. Walker CM, Moody DJ, Stites DP, and Levy JA: CD8+ lymphocytes can control HIV infection in vitro by suppressing virus replication. Science 1986;234:1563-1566.
13. Trabi M, Schirra HJ, and Craik DJ: Three-dimensional structure of RTD-1, a cyclic antimicrobial defensin from Rhesus macaque leukocytes. Biochemistry 2001;40:4211-4221.
14. Wilson CC, Wong JT, Girard DD, et al.: Ex vivo expansion of CD4 lymphocytes from human immunodeficiency virus type 1-infected persons in the presence of combination antiretroviral agents. J Infect Dis 1995;172:88-96.
15. Wong JK, Hezareh M, Gunthard HE, et al.: Recovery of replication- competent HIV despite prolonged suppression of plasma viremia. Science 1997;278:1291-1295.
16. Yang OO, Tran AC, Kalams SA, Johnson RP, Roberts MR, and Walker BD: Lysis of HIV-1-infected cells and inhibition of viral replication by universal receptor T cells. Proc Natl Acad Sci USA 1997;94:11478-11483.
17. Mariani R, Rutter G, Harris ME, Hope TJ, Krausslich HG, and Landau NR: A block to human immunodeficiency virus type 1 assembly in murine cells. J Virol 2000;74:3859-3870.
18. Deng H, Liu R, Ellmeier W, et al.: Identification of a major co-receptor for primary isolates of HIV-1. Nature 1996;381:661-666.
19. Mariani R, Rasala BA, Rutter G, et al.: Mouse-human heterokaryons support efficient human immunodeficiency virus type 1 assembly. J Virol 2001;75:3141-3151.
20. Doranz BJ, Baik SS, and Doms RW: Use of a gp120 binding assay to dissect the requirements and kinetics of human immunodeficiency virus fusion events. J Virol 1999;73:10346-10358.
21. Connor RI, Chen BK, Choe S, and Landau NR: Vpr is required for efficient replication of human immunodeficiency virus type-1 in mononuclear phagocytes. Virology 1995;206:935-944.
22. Landau NR, Page KA, and Littman DR: Pseudotyping with human T-cell leukemia virus type I broadens the human immunodeficiency virus host range. J Virol 1991;65:162-169.
23. Münk C, Brandt SM, Lucero G, and Landau NR: A dominant block to HIV-1 replication at reverse transcription in simian cells. Proc Natl Acad Sci USA 2002;99:13843-13848.
24. Wang W, Cole AM, Hong T, Waring AJ, and Lehrer RI: Retrocyclin, an antiretroviral θ-defensin, is a lectin. J Immunol 2003; 170:4708-4716.
25. LaBranche CC, Galasso G, Moore JP, Bolognesi DP, Hirsch MS, and Hammer SM: HIV fusion and its inhibition. Antiviral Res 2001;50:95-115.
26. Weiss TM, Yang L, Ding L, et al.: Two states of a cyclic antimicrobial peptide theta-defensin in lipid bilayers. Biophys J 2002; 82:7A.
27. Cole AM, Dewan P, and Ganz T: Innate antimicrobial activity of nasal secretions. Infect Immun 1999;67:3267-3275.