Doxorubicin treatment in vivo activates caspase-12 mediated cardiac apoptosis in both male and female rats

FEBS Letters

Volumn 577, Issue 3, 2004, Pages 483-490

  Jang, Young Mok ^a   Kendaiah, Suma ^a   Drew, Barry ^a   Phillips, Tracey ^a   Selman, Colin ^a   Julian, David ^a   Leeuwenburgh, Christiaan ^a  

^a UNIVERSITY OF FLORIDA   (United States)

Author keywords

Calcium; Caspase; Gender; Hydrogen peroxide; Oxidative stress; Sex difference

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTHRACYCLINE; CALPAIN; CASPASE 12; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA FRAGMENT; DOXORUBICIN; FLICE INHIBITORY PROTEIN; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; FEMALE; HEART; HEART MITOCHONDRION; ISOLATED HEART; MALE; NONHUMAN; OBSERVATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; RAT; SARCOPLASMIC RETICULUM; SEX DIFFERENCE; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; BODY WEIGHT; CALPAIN; CASPASE 12; CASPASES; CYTOCHROMES C; CYTOSOL; DOXORUBICIN; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTRADIOL; FEMALE; GLUTATHIONE PEROXIDASE; HEART VENTRICLES; MALE; MITOCHONDRIA, HEART; MODELS, BIOLOGICAL; ORGAN SIZE; RATS; RATS, INBRED F344; SARCOPLASMIC RETICULUM; SEX FACTORS; SIGNAL TRANSDUCTION; TIME FACTORS;

EID: 9144238766     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2004.10.053     Document Type: Article

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