The Sln1-Ypd1-Ssk1 Multistep Phosphorelay System That Regulates an Osmosensing MAP Kinase Cascade in Yeast

Histidine Kinases in Signal Transduction

Volumn , Issue , 2002, Pages 397-419

  Saito, Haruo ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; OSMOSIS; SCAFFOLDS (BIOLOGY); YEAST;

ASPARTATE RESIDUE; BINDING PROTEINS; HISTIDINE RESIDUES; MITOGEN ACTIVATED PROTEIN KINASE; OSMOTIC CONDITIONS; SCAFFOLD PROTEIN; SIGNALING PATHWAYS; STEPWISE REACTION;

ENZYMES;

EID: 9144229756     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012372484-7/50020-5     Document Type: Chapter

References (75)

1. Mager W.H., Varela J.C.S. Osmostress response of the yeast Saccharomyces. Mol. Microbiol. 1993, 10:253-258.
2. Albertyn J., Hohmann S., Thevelein J.M., Prior B.A. GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 1994, 14:4135-4144.
3. Gustin M.C., Albertyn J., Alexander M., Davenport K. MAP kinase pathways in the yeast Saccharomyces cerevisiae. Microbiol. Mol. Biol. Rev. 1998, 62:1264-1300.
4. Cobb M.H., Goldsmith E.J. How MAP kinases are regulated. J. Biol. Chem. 1995, 270:14843-14846.
5. Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
6. Boguslawski G. PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae. J. Gen. Microbiol. 1992, 138:2425-2432.
7. Brewster J.L., de Valoir T., Dwyer N.D., Winter E., Gustin M.C. An osmosensing signal transduction pathway in yeast. Science 1993, 259:1760-1763.
8. Posas F., Saito H. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: Scaffold role of Pbs2p MAPKK. Science 1997, 276:1702-1705.
9. Jacoby T., Flanagan H., Faykin A., Seto A.G., Mattison C., Ota I. Two protein-tyrosine phosphatases inactivate the osmotic stress response pathway in yeast by targeting the mitogen-activated protein kinase, Hog1. J. Biol. Chem. 1997, 272:17749-17755.
10. Wurgler-Murphy S.M., Maeda T., Witten E.A., Saito H. Regulation of the Saccharomyces cerevisiae HOG1 mitogen-activated protein kinase by the PTP2 and PTP3 protein tyrosine phosphatases. Mol. Cell. Biol. 1997, 17:1289-1297.
11. Maeda T., Tsai A.Y.M., Saito H. Mutations in a protein tyrosine phosphatase gene (PTP2) and a protein serine/threonine phosphatase gene (PTC1) cause a synthetic growth defect in Saccharomyces cerevisiae. Mol. Cell. Biol. 1993, 13:5408-5417.
12. Maeda T., Wurgler-Murphy S.M., Saito H. A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature 1994, 369:242-245.
13. Zhan X.-L., Deschenes R.J., Guan K.-L. Differential regulation of FUS3 MAP kinase by tyrosine-specific phosphatases PTP2/PTP3 and dual-specificity phosphatase MSG5 in Saccharomyces cerevisiae. Genes Dev. 1997, 11:1690-1702.
14. Ferrigno P., Posas F., Koepp D., Saito H., Silver P.A. Regulated nucleo/cytoplasmic exchange of HOG1 MPAK requires the importin b homologs NMD5 and XPO1. EMBO J. 1998, 17:5606-5614.
15. Reiser V., Ruis H., Ammerer G. Kinase activity-dependent nuclear export opposes stress-induced nuclear accumulation and retention of Hog1 mitogen-activated protein kinase in the budding yeast Saccharomyces cerevisiae. Mol. Biol. Cell 1999, 10:1147-1161.
16. Marchler G., Schüller C., Adam G., Ruis H. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 1993, 12:1997-2003.
17. Hirayama T., Maeda T., Saito H., Shinozaki K. Cloning and characterization of seven cDNAs for hyperosmolarity-responsive (HOR) genes of Saccharomyces cerevisiae. Mol. Gen. Genet. 1995, 249:127-138.
18. Ansell R., Granath K., Hohmann S., Thevelein J., Adler L. The two isoenzymes for yeast NAD-dependent glycerol 3-phosphate dehydrogenase, encoded by GPD1 and GPD2, have distinct roles in osmoadaption and redox regulation. EMBO J. 1997, 16:2179-2187.
19. Schüller C., Brewster J.L., Alexander M.R., Gustin M.C., Ruis H. The HOG pathway controls osmotic regulation of transcription via the stress response element (STRE) of the Saccharomyces cerevisiae CTT1 gene. EMBO J. 1994, 13:4382-4389.
20. Treger J.M., Magee T.R., McEntee K. Functional analysis of the stress response element and its role in the mutistress response of Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 1998, 243:13-19.
21. Martinez-Pastor M.T., Marchler G., Schüller C., Marchler-Bauer A., Ruis H., Estruch F. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE). EMBO J. 1996, 15:2227-2235.
22. Schmitt A.P., McEntee K. Msn2p, a zinc finger DNA-binding protein, is the transcription activator of the multistress response in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 1996, 93:5777-5782.
23. Rep M., Reiser V., Gartner U., Thevelein J.M., Hohmann S., Ammerer G., Ruis H. Osmotic stress-induced gene expression in Saccharomyces cerevisiae requires Msn1p and the novel nuclear factor Hot1p. Mol. Cell. Biol. 1999, 19:5474-5485.
24. Proft M., Serrano R. Repressors and upstream repressing sequences of the stress-regulated ENA1 gene in Saccharomyces cerevisiae: bZIP protein Sko1p confers HOG-dependent osmotic regulation. Mol. Cell. Biol. 1999, 19:537-546.
25. Bilsland-Marchesan E., Ariño J., Saito H., Sunnerhagen P., Posas F. Rck2 kinase is a substrate for the osmotic stress-activated mitogen-activated protein kinase Hog1. Mol. Cell. Biol. 2000, 20:3887-3895.
26. Ota I.M., Varshavsky A. A yeast protein similar to bacterial two-component regulators. Science 1993, 262:566-569.
27. Guan K., Deschenes R.J., Dixon J.E. Isolation and characterization of a second protein tyrosine phosphatase gene, PTP2, from Saccharomyces cerevisiae. J. Biol. Chem. 1992, 267:10024-10030.
28. James P., Hall B.D., Whelen S., Craig E.A. Multiple protein tyrosine phosphatase-encoding genes in yeast Saccharomyces cerevisiae. Gene 1992, 122:101-110.
29. Ota I., Varshavsky A. A gene encoding a putative tyrosine phosphatase suppresses lethality of an N-end rule-dependent mutant. Proc. Natl. Acad. Sci. USA 1992, 89:2355-2359.
30. Robinson M.K., van Zyl W.H., Phizicky E.M., Broach J.R. TPD1 of Saccharomyces cerevisiae encodes a protein phosphatase 2C-like activity implicated in tRNA splicing and cell separation. Mol. Cell. Biol. 1994, 14:3634-3645.
31. Maeda T., Takekawa M., Saito H. Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science 1995, 269:554-558.
32. Gerwins P., Blank J.L., Johnson G.L. Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem. 1997, 272:8288-8295.
33. Takekawa M., Posas F., Saito H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J. 1997, 16:4973-4982.
34. Posas F., Wurgler-Murphy S.M., Maeda T., Witten E.A., Thai T.C., Saito H. Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 two-component osmosensor. Cell 1996, 86:865-875.
35. Ostrander D.B., Gorman J.A. The extracellular domain of the Saccharomyces cerevisiae Sln1p membrane osmolarity sensor is necessary for kinase activity. J. Bacteriol. 1999, 181:2527-2534.
36. Ishige K., Nagasawa S., Tokishita S., Mizuno T. A novel device of bacterial signal transducers. EMBO J. 1994, 13:5195-5202.
37. Uhl M.A., Miller J.F. Integration of multiple domains in a two-component sensor protein: The Bordetella pertussis BvgAS phosphorelay. EMBO J. 1996, 15:1028-1036.
38. Kato M., Mizuno T., Shimizu T., Hakoshima T. Insights into multistep phosphorelay from the crystal structure of the C-terminal HPt domain of ArcB. Cell 1997, 88:717-723.
39. Song H.K., Lee J.Y., Lee M.G., Moon J., Min K., Yang J.K., Suh S.W. Insights into eukaryotic multistep phosphorelay signal transduction revealed by the crystal structure of Ypd1 from Saccharomyces cerevisiae. J. Mol. Biol. 1999, 293:753-761.
40. Xu Q., West A.H. Conservation of structure and function among histidine-containing phoshotransfer (HPt) domains as revealed by the crystal structure of YPD1. J. Mol. Biol. 1999, 292:1039-1050.
41. Janiak-Spens F., Sparling J.M., Gurfinkel M., West A.H. Differential stabilities of phosphorylated response regulator domains reflect functional roles of the yeast osmoregulatory SLN1 and SSk1 proteins. J. Bacteriol. 1999, 181:411-417.
42. Burbulys D., Trach K.A., Hoch J.A. Initiation of sporulation in B. subtilis is controlled by a multicomponent phosphorelay. Cell 1991, 64:545-552.
43. Tsuzuki M., Ishige K., Mizuno T. Phosphotransfer circuitry of the putative multi-signal transducer, ArcB, of Escherichia coli: In vitro studies with mutants. Mol. Microbiol. 1995, 18:953-962.
44. Hoch J.A. Two-component and phosphorelay signal transduction. Curr. Opin. Microbiol. 2000, 3:165-170.
45. Ohlsen K.L., Grimsley J.K., Hoch J.A. Deactivation of the sporulation transcription factor Spo0A by the Spo0E protein phosphatase. Proc. Natl. Acad. Sci. USA 1994, 91:1756-1760.
46. Perego M., Hanstein C., Welsh K.M., Djavakhishvili T., Glaser P., Hoch J.A. Multiple protein-aspartate phosphatases provide a mechanism for the integration of diverse signals in the control of development in B. subtilis. Cell 1994, 79:1047-1055.
47. Perego M., Glaser P., Hoch J.A. Aspartyl-phosphate phosphatases deactivate the response regulator components of the sporulation signal transduction system in Bacillus subtilis. Mol. Microbiol. 1996, 19:1151-1157.
48. Posas F., Saito H. Activation of the yeast SSK2 MAP kinase kinase kinase by the SSK1 two-component response regulator. EMBO J. 1998, 17:1385-1394.
49. Minden A., Lin A., McMahon M., Lange-Carter C., Dérijard B., Davis R.J., Johnson G.L., Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 1994, 266:1719-1723.
50. Kato T., Okazaki K., Murakami H., Stettler S., Fantes P.A., Okayama H. Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast. FEBS Lett. 1996, 378:207-212.
51. Samejima I., Mackie S., Fantes P.A. Multiple modes of activation of the stress-responsive MAP kinase pathway in fission yeast. EMBO J. 1997, 16:6162-6170.
52. Millar J.B.A. Stress-activated MAP kinase (mitogen-activated protein kinase) pathways of budding and fission yeasts. Biochem. Soc. Symp. 1999, 64:49-62.
53. Nguyen A.N., Lee A., Place W., Shiozaki K. Multistep phosphorelay proteins transmit oxidative stress signals to the fission yeast stress-activated protein kinase. Mol. Biol. Cell 2000, 11:1169-1181.
54. Buck V., Quinn J., Pino T.S., Martin H., Saldanha J., Makino K., Morgan B., Millar J.B.A. Peroxide sensors for the fission yeast stress activated MAP kinase pathway. Mol. Biol. Cell. 2000.
55. Aoyama K., Mitsubayashi Y., Aiba H., Mizuno T. Spy1, a histidine-containing phosphotransfer signaling protein, regulates the fission yeast cell cycle through the Mcs4 response regulator. J. Bact. 2000, 182:4868-4874.
56. Cottarel G. Mcs4, a two-component system response regulator homologue, regulates the Schizosaccharomyces ombe cell cycle control. Genetics 1997, 147:1043-1051.
57. Shieh J.-C., Wilkinson M.G., Buck V., Morgan B.A., Makino K., Millar J.B.A. The Mcs4 response regulator coordinately controls the stress-activated Wak1-Wis1-Sty1 MAP kinase pathway and fission yeast cell cycle. Genes Dev. 1997, 11:1008-1022.
58. +) that encodes a response regulator implicated in oxidative stress response. J. Biochem. 1999, 125:1061-1066.
59. Shiozaki K., Shiozaki M., Russell P. Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Mol. Biol. Cell 1997, 8:409-419.
60. Crews S.T., Fan C.M. Remembrance of the things PAS: regulation of development by bHLH-PAS proteins. Curr. Opin. Genet. 1999, 9:580-587.
61. Gong W., Hao B., Mansy S.S., Gonzalez G., Gilles-Gonzalez M.A., Chan M.K. Structure of a biological oxygen sensor: A new mechanism for heme-driven signal transduction. Proc. Natl. Acad. Sci. USA 1998, 95:15177-15182.
62. O'Rourke S.M., Herskowitz I. The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiae. Genes Dev. 1998, 12:2874-2886.
63. Posas F., Witten E.A., Saito H. Requirement of STE50 for osmostress-induced activation of the STE11 mitogen-activated protein kinase kinase kinase in the high-osmolarity glycerol response pathway. Mol. Cell. Biol. 1998, 18:5788-5796.
64. Raitt D.C., Posas F., Saito H. Yeast Cdc42 GTPase and Ste20 PAK-like kinase regulate Sho1-dependent activation of the Hog1 MAPK pathway. EMBO J. 2000, 19:4623-4631.
65. Herskowitz I. MAP kinase pathways in yeast: For mating and more. Cell 1995, 80:187-197.
66. Cohen G.B., Ren R., Baltimore D. Modular binding domains in signal transduction proteins. Cell 1995, 80:237-248.
67. Pawson T. Protein modules and signalling networks. Nature 1995, 373:573-580.
68. Reiser V., Salah S.M., Ammerer G. Polarized localization of yeast Pbs2 depends on osmostress, the membrane protein Sho1 and Cdc42. Nature Cell Biol. 2000, 2:620-627.
69. Ziman M., Preuss D., Mulholland J., O'Brien J.M., Botstein D., Johnson D.L. Subcellular localization of Cdc42p, a Saccharomyces cerevisiae GTP-binding protein involved in the control of cell polarity. Mol. Biol. Cell 1993, 4:1307-1316.
70. Leberer E., Wu C., Leeuw T., Fourest-Lieuvin A., Segall J.E., Thomas D.Y. Functional characterization of the Cdc42p binding domain of yeast Ste20p protein kinase. EMBO J. 1997, 16:83-97.
71. Choi K.Y., Satterberg B., Lyons D.M., Elion E.A. Ste5 tethers multiple protein kinases in the MAP kinase cascade required for mating in S. cerevisiae. Cell 1994, 78:499-512.
72. Marcus S., Polverino A., Barr M., Wigler M. Complexes between STE5 and components of the pheromone-responsive mitogen-activated protein kinase module. Proc. Natl. Acad. Sci. USA 1994, 91:7762-7766.
73. Printen J.A., Sprague G.F. Protein-protein interactions in the yeast pheromone response pathway: Ste5p interacts with all members of the MAP kinase cascade. Genetics 1994, 138:609-619.
74. Nagahashi S., Mio T., Ono N., Yamada-Okabe T., Arisawa M., Bussey H., Yamada-Okabe H. Isolation of CaSLN1 and CaNIK1, the genes for osmosensing histidine kinase homologues, from the pathogenic fungus Candida albicans. Microbiology 1998, 144:425-532.
75. Urao T., Yakubov B., Satoh R., Yamaguchi-Shinozaki K., Seki M., Hirayama T., Shinozaki K. A transmembrane hybrid-type histidine kinase in Arabidopsis functions as an osmosensor. Plant Cell 1999, 11:1743-1754.