Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 24, 2004, Pages 6473-6494

  Garneau, Sylvie ^a   Qiao, Lei ^a   Chen, Lan ^b   Walker, Suzanne ^b   Vederas, John C ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b PRINCETON UNIVERSITY   (United States)

Author keywords

Antibiotic; Inhibitors; Lipid II; Penicillin binding protein; Peptidoglycan

Indexed keywords

2 (2 ACETAMIDO 2 DEOXY ALPHA DEXTRO GLUCOPYRANOSYL)OXYMETHYL 3 TETRADECYLBUTENEDIOIC ACID LITHIUM; 2 FARNESYL 3 METHYLBUTENEDIOIC ACID DILITHIUM; 2 GERANYL 3 METHYLBUTENEDIOIC DILITHIUM; 2 NEROLYL 3 METHYLBUTENEDIOIC ACID DILITHIUM; 3 [(2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA DEXTRO GLUCOPYRANOSYL)METHYLPHOSPHINATO] 2 (3',7' DIMETHYLOCTYLOXY)PROPANOIC ACID; 3 [(2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL (1-4) ALPHA DEXTRO GLUCOPYRANOSYL)METHYLPHOSPHINATO] 2 OCTYLOXYPROPANOIC ACID; 3 [3 O (2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL (1-4) 2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL)PROPYLPHOSPHINATO] 2 (3',7' DIMETHYLOCTYLOXY)PROPANOIC ACID; 3 [3 O (2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL (1-4) 2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL)PROPYLPHOSPHINATO] 2 OCTYLOXYPROPANOIC ACID; 3 [3 O (2 ACETAMIDO 2 DEOXY BETA DEXTRO GLUCOPYRANOSYL)PROPYLPHOSPHINATO] 2 (3',7' DIMETHYLOCTYLOXY)PROPANOIC ACID; DISACCHARIDE; ENZYME INHIBITOR; GLYCOSYLTRANSFERASE; MOENOMYCIN A; MONOSACCHARIDE; PENICILLIN BINDING PROTEIN; UNCLASSIFIED DRUG;

ARBUZOV REACTION; ARTICLE; CHEMICAL REACTION; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; MICHAEL ADDITION; PROTEIN FUNCTION; REACTION ANALYSIS;

BAMBERMYCINS; CARBOHYDRATES; DISACCHARIDES; ESCHERICHIA COLI PROTEINS; HEXOSYLTRANSFERASES; MALEATES; MONOSACCHARIDES; PENICILLIN-BINDING PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; URIDINE DIPHOSPHATE N-ACETYLMURAMIC ACID;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS PHAGE 3A;

EID: 8844223239     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.09.019     Document Type: Article

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