Efficient syntheses, human and yeast farnesyl-protein transferase inhibitory activities of chaetomellic acids and analogues

Bioorganic and Medicinal Chemistry

Volumn 8, Issue 3, 2000, Pages 571-580

  Singh, Sheo B ^a   Jayasuriya, Hiranthi ^a   Silverman, Keith C ^a   Bonfiglio, Cynthia A ^a   Williamson, Joanne M ^a   Lingham, Russell B ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHAETOMELLIC ACID; CHAETOMELLIC ACID A; CHAETOMELLIC ACID B; CHAETOMELLIC ACID C; CHAETOMELLIC ACID DERIVATIVE; DICARBOXYLIC ACID; DIMETHYLALLYLTRANSFERASE; GERANYLGERANYL PROTEIN TRANSFERASE 1; PROTEIN FARNESYLTRANSFERASE; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CATTLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; MASS SPECTROMETRY; MOLECULAR MODEL; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION; YEAST;

ALKYL AND ARYL TRANSFERASES; ANIMALS; CATTLE; DIMETHYLALLYLTRANSTRANSFERASE; ENZYME INHIBITORS; FATTY ACIDS, UNSATURATED; HUMANS; INHIBITORY CONCENTRATION 50; MALEATES; STRUCTURE-ACTIVITY RELATIONSHIP; YEASTS;

BOVINAE; CHAETOMELLA ACUTISETA;

EID: 0033998993     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(99)00312-0     Document Type: Article

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