Antibacterial activity of synthetic analogues based on the disaccharide structure of moenomycin, an inhibitor of bacterial transglycosylase

Microbiology

Volumn 146, Issue 12, 2000, Pages 3129-3140

  Baizman, E R ^a   Branstrom, A A ^a   Longley, C B ^a   Allanson, N ^a   Sofia, M J ^a   Gange, D ^a   Goldman, R C ^a  

^a Advanced Medicine East   (United States)

Author keywords

Moenomycin; Peptidoglycan synthesis; Transglycosylation

Indexed keywords

ANTIINFECTIVE AGENT; BAMBERMYCIN; CHLORAMPHENICOL; DISACCHARIDE; DRUG ANALOG; GLYCOLIPID; GLYCOSYLTRANSFERASE; LIPID; N ACETYLGLUCOSAMINE; N ACETYLGLUCOSAMINE BETA 1,4 N ACETYLMURAMYLPENTAPEPTIDE PYROPHOSPHORYLUNDECAPRENOL; PENICILLIN G; PENTAPEPTIDE; PEPTIDOGLYCAN; STREPTAVIDIN; TETRACYCLINE; TS 30153; TS 30663; TS 30888; TSO 514; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL CELL WALL; BACTERIAL GROWTH; BACTERICIDAL ACTIVITY; CELL DEATH; CONTROLLED STUDY; CYTOLYSIS; DRUG ACTIVITY; DRUG DESIGN; DRUG STRUCTURE; DRUG TARGETING; ENTEROCOCCUS; ESCHERICHIA COLI; GLYCOSYLATION; GRAM POSITIVE BACTERIUM; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL;

BACTERIA (MICROORGANISMS); ENTEROCOCCUS; ESCHERICHIA COLI; NEGIBACTERIA; POSIBACTERIA;

EID: 0034529940     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-146-12-3129     Document Type: Article

References (43)

1. The bimolecular G57-V577 polypeptide chain of the class B penicillin-binding protein 3 of Escherichia coli catalyzes peptide bond formation from thiolesters and does not catalyze glycan chain intermediate
2. Biosynthesis of modified peptidoglycan precursors by vancomycin-resistant Enterococcus faecium
3. Inhibition of peptidoglycan biosynthesis in vancomycin-susceptible and -resistant bacteria by a semisynthetic glycopeptide antibiotic
4. Biosynthesis of the peptidoglycan of bacterial cell walls. I. Utilization of uridine diphosphate acetylmuramyl pentapeptide and uridine diphosphate Staphylococcus aureus and Micrococcus lysodeikticus
5. Presence of UDP-N-acetylmuramyl-hexapeptides and -heptapeptides in enterococci and staphylococci after treatment with ramoplanin, tunicamycin, or vancomycin
6. In situ assay for identifying inhibitors of bacterial transglycosylase
7. Assay for identification of inhibitors specific for bacterial Mra Y translocase and MurG transferase
8. The monofunctional glycosyltransferase of Escherichia coli is a member of a new class of peptidoglycan-synthesising enzymes
9. Moenomycin A: The role of the methyl group in the moenuronamide unit and a general discussion of structure-activity relationships
10. Characterization of (1,3)-β-glucan synthase in Candida albicans: Microsomal assay from the yeast or mycelial morphological forms and a permeabilized whole-cell assay
11. Vancomycin derivatives that inhibit peptidoglycan biosynthesis without binding d-Ala-d-Ala
12. Multimodular penicillin-binding proteins: An enigmatic family of orthologs and paralogs
13. Antifungal drug targets: Candida secreted aspartyl protease and fungal wall beta-glucan synthesis
14. A novel glycan polymerase that synthesizes uncross-linked peptidoglycan in Escherichia coli
15. Biosynthesis of the peptidoglycan of Escherichia coli K-12: Properties of the in vitro polymerization by transglycosylation
16. Polymerization by transglycosylation in the biosynthesis of the peptidoglycan of Escherichia coli K-12 and its inhibition by antibiotics
17. Effects of moenomycin on Escherichia coli
18. Membrane intermediates in the peptidoglycan metabolism of Escherichia coli: Possible roles of PBP 1b and PBP 3
19. A hypothetical holoenzyme involved in the replication of the murein sacculus of Escherichia coli
20. Molecular interplay of murein synthases and murein hydrolases in Escherichia coli
21. Growth of the stress-bearing and shape-maintaining murein sacculus of Escherichia coli
22. Moenomycin and related phosphorus-containing antibiotics
23. The murG gene of the Escherichia coli chromosome encoding UDP-N-acetyl-glucosamine: Undecaprenyl-pyrophosphoryl-N-acetylmuramoyl-pentapeptide N-acetylglucosaminyl transferase
24. Peptidoglycan synthetic enzyme activities of highly purified penicillin-binding protein 3 in Escherichia coli: A septum-forming reaction sequence
25. Expeditious route to F unit building blocks of moenomycin A
26. Inhibition of yeast (1,3)-β-glucan synthase by phospholipase A2 and its reaction products
27. The three-for-one model for gram-negative wall growth: A problem and a possible solution
28. Analysis of murein and murein precursors during antibiotic-induced lysis of Escherichia coli
29. One-step purification procedure for UDP-N-acetylmuramyl-peptide murein precursors from Bacillus cereus
30. Induction signals for vancomycin resistance encoded by the vanA gene cluster in Enterococcus faecium
31. Screening systems for detecting inhibitors of cell wall transglycosylation in Enterococcus: Cell wall transglycosylation inhibitors in Enterococcus
32. Enzymatic activities of penicillin-binding proteins of Escherichia coli and their sensitivities to β-lactam antibiotics
33. Substrate synthesis and activity assay for MurG
34. Peptidoglycan biosynthesis in a thermosensitive division mutant of Escherichia coli
35. Staphylococcus aureus and Micrococcus luteus peptidoglycan transglycosylases that are not penicillin-binding proteins
36. Affinity chromatography as a means to study multienzyme complexes involved in murein synthesis
37. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability
38. Cloning and characterization of PBP 1C, a third member of the multimodular class A penicillin-binding proteins of Escherichia coli
39. Discovery of novel disaccharide antibacterial agents using a combinatorial library approach
40. On the process of cellular division in Escherichia coli: Isolation and characterization of penicillin-binding proteins la, 1b, and 3
41. Demonstration of molecular interactions between the murein polymerase PBP1B, the lytic transglycosylase MltA, and the scaffolding protein MipA of Escherichia coli
42. DNA synthesis in nucleotide-permeable Escherichia coli cells. I. Preparation and properties of ether-treated cells
43. Moenomycin, a new antibiotic. 3. Biological properties