Mechanism of Action of the Mannopeptimycins, a Novel Class of Glycopeptide Antibiotics Active against Vancomycin-Resistant Gram-Positive Bacteria

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 3, 2004, Pages 728-738

  Ruzin, Alexey ^a   Singh, Guy ^a   Severin, Anatoly ^a   Yang, Youjun ^a,b   Dushin, Russell G ^a   Sutherland, Alan G ^a   Minnick, Albert ^a   Greenstein, Michael ^a   May, Michael K ^a   Shlaes, David M ^a,c   Bradford, Patricia A ^a  

^a WYETH RESEARCH   (United States)

^b Avon Products Inc   (United States)

^c Idenix Pharmaceuticals Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AC98 0708; AC98 1; AC98 4800; AC98 5; AC98 5370; AC98 6446; ANTIBIOTIC AGENT; GLYCOPEPTIDE; LIGAND; LIPOTEICHOIC ACID; MANNOPEPTIMYCIN DELTA; MANNOPEPTIMYCIN DERIVATIVE; MERSACIDIN; MURAMIC ACID; UNCLASSIFIED DRUG; VANCOMYCIN;

ANTIBIOTIC RESISTANCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL CELL; BACTERIAL CELL WALL; BINDING AFFINITY; BIOACCUMULATION; BIOSYNTHESIS; DRUG MECHANISM; GRAM POSITIVE BACTERIUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN LIPID INTERACTION; STRUCTURE ACTIVITY RELATION;

AFFINITY LABELS; ANTI-BACTERIAL AGENTS; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL PROTEINS; BINDING, COMPETITIVE; CARRIER PROTEINS; CELL MEMBRANE; CHROMATOGRAPHY, THIN LAYER; CULTURE MEDIA; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; GLYCOPEPTIDES; GRAM-POSITIVE BACTERIA; HEXOSYLTRANSFERASES; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN; PEPTIDYL TRANSFERASES; PROTEIN BINDING; RECEPTORS, VIRUS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS EPIDERMIDIS; VANCOMYCIN RESISTANCE;

EID: 10744231848     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.3.728-738.2004     Document Type: Article

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