Protein farnesyltransferase inhibitors interfere with farnesyl diphosphate binding by rubber transferase

European Journal of Biochemistry

Volumn 270, Issue 19, 2003, Pages 3939-3945

  Mau, Christopher J D ^a   Garneau, Sylvie ^b   Scholte, Andrew A ^b   Van Fleet, Jennifer E ^a   Vederas, John C ^b   Cornish, Katrina ^a  

^a WESTERN REGIONAL RESEARCH CENTER   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Chaetomellic acid A; Hevea brasiliensis; Hydroxyfarnesylphosphonic acid; Parthenium argentatum

Indexed keywords

ALPHA HYDROXYFARNESYLPHOSPHONIC ACID; DIMETHYLALLYLTRANSFERASE; FARNESYL DIPHOSPHATE; ISOPENTENYL DIPHOSPHATE; PROTEIN FARNESYLTRANSFERASE INHIBITOR;

ARTICLE; BAY REGION BINDING SITE; CATALYSIS; CHEMICAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; HEVEA; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION; PROTEINASE INHIBITION; SPECIES DIFFERENCE;

ALKYL AND ARYL TRANSFERASES; ASTERACEAE; BINDING SITES; DIMETHYLALLYLTRANSTRANSFERASE; ENZYME INHIBITORS; FARNESOL; FARNESYLTRANSTRANSFERASE; GLUTARATES; HEVEA; KINETICS; LITHIUM COMPOUNDS; MALEATES; PHOSPHONIC ACIDS; POLYISOPRENYL PHOSPHATES; SALTS; SOLVENTS; SPECIES SPECIFICITY;

HEVEA; HEVEA BRASILIENSIS; PARTHENIUM; PARTHENIUM ARGENTATUM;

EID: 0141704105     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2003.03775.x     Document Type: Article

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