T Cell-Derived IL-10 Antagonizes Macrophage Function in Mycobacterial Infection

Journal of Immunology

Volumn 158, Issue 1, 1997, Pages 315-321

  Murray, Peter J ^a,b   Wang, Lynn ^c   Onufryk, Christina ^a,b   Tepper, Robert I ^c,d   Young, Richard A ^a,b,e  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

^d MILLENNIUM PHARMACEUTICALS INC   (United States)

^e White head Institute for Biomedical Research   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2;

ANIMAL; ANTIGEN PRESENTING CELL; ARTICLE; BIOSYNTHESIS; DOWN REGULATION; DRUG EFFECT; GENETICS; IMMUNOLOGY; MACROPHAGE; METABOLISM; MOUSE; MYCOBACTERIUM BOVIS; PATHOGENICITY; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE; TUBERCULOSIS;

ANIMALS; ANTIGEN-PRESENTING CELLS; DOWN-REGULATION; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-2; MACROPHAGES; MICE; MICE, TRANSGENIC; MYCOBACTERIUM BOVIS; T-LYMPHOCYTES; TRANSGENES; TUBERCULOSIS;

EID: 0030639088     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Moore, K. W., A. O'Garra, R. de Waal Malefyt, P. Vieira, and T. R. Mosmann. 1993. Interleukin-10. Annu. Rev. Immunol. 11:165.
2. Fiorentino, D. F., A. Zlotnik, P. Vieira, T. R. Mosmann, M. Howard, K. W. Moore, and A. O'Garra. 1991. IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells. J. Immunol. 146:3444.
3. Moore, K. W., P. Vieira, D. F. Fiorentino, M. L. Trounstine, T. A. Khan, and T. R. Mosmann. 1990. Homology of cytokine synthesis inhibitory factor (IL-10) to the Epstein-Barr virus gene BCRF1. Science 248:1230.
4. Hsieh, C. S., A. B. Heimberger, J. S. Gold, A. O'Garra, and K. M. Murphy. 1992. Differential regulation of T helper phenotype development by interleukins-4 and -10 in an αβ T-cell-receptor transgenic system. Proc. Natl. Acad. Sci. USA 89: 6065.
5. Powrie, F., S. Menon, and R. L. Coffman. 1993. Interleukin-4 and interleukin-10 synergize to inhibit cell-mediated immunity in vivo. Eur. J. Immunol. 23:3043.
6. + T cell subsets in vivo. Immunol. Rev. 123:189.
7. Kuhn, R., J. Lohler, D. Rennick, K. Rajewsky, and W. Muller. 1993. Interleukin-10-deficient mice develop chronic enterocolitis. Cell 75:263.
8. Bogdan, C., Y. Vodovotz, and C. Nathan. 1991. Macrophage deactivation by interleukin 10. J. Exp. Med. 174:1549.
9. Ding, L., P. S. Linsley, L. Y. Huang, R. N. Germain, and E. M. Shevach. 1993. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J. Immunol. 151:1224.
10. Flesch, I. E., J. H. Hess, I. P. Oswald, and S. H. E. Kaufmann. 1994. Growth inhibition of Mycobacterium bovis by IFN-γ stimulated macrophages: regulation by endogenous tumor necrosis factor-α and by IL-10. Int. Immunol. 6:693.
11. Gazzinelli, R. T., I. P. Oswald, S. L. James, and A. Sher. 1992. IL-10 inhibits parasite killing and nitrogen oxide production by IFN-γ-activated macrophages. J. Immunol. 148:1792.
12. Oswald, I. P., T. A. Wynn, A. Sher, and S. L. James. 1992. Interleukin 10 inhibits macrophage microbicidal activity by blocking the endogenous production of tumor necrosis factor alpha required as a costimulatory factor for interleron γ-induced activation. Proc. Natl. Acad. Sci. USA 89:8676.
13. Silva, J. S., P. J. Morrissey, K. H. Grabstein, K. M. Mohler, D. Anderson, and S. G. Reed. 1992. Interleukin 10 and interferon γ regulation of experimental Trypanosoma cruzi infection. J. Exp. Med. 175:169.
14. Wang, L., E. Goillot, and R. I. Tepper. 1994. IL-10 inhibits alloreactive cytotoxic T lymphocyte generation in vivo. Cell. Immunol. 159:152.
15. Dalton, D. K., S. Pitts-Meek, S. Keshav, I. S. Figari, A. Bradley, and T. A. Stewart. 1993. Multiple defects of immune cell function in mice with disrupted interferon-γ genes. Science 259:1739.
16. Danner, D., and P. Leder. 1985. Role of an RNA cleavage/poly(A) addition site in the production of membrane-bound and secreted IgM mRNA. Proc. Natl. Acad. Sci. USA 82:8658.
17. Laird, P. W., A. Zijderveld, K. Linders, M. A. Rudnicki, R. Jaenisch, and A. Berns. 1991. Simplified mammalian DNA isolation procedure. Nucleic Acids Res. 19:4293.
18. Murray, P. J., A. Aldovini, and R. A. Young. 1996. Manipulation and potentiation of the anti-mycobacterial immunity using recombinant bacille Calmette-Guerin strains that secrete cytokines. Proc. Natl. Acad. Sci. USA 93:934.
19. Falk, L. A. 1994. Isolation of murine bone marrow-derived macrophages. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Margulies, E. M. Shevach, and W. Strober, ed. John Wiley and Sons, New York, pp. 14.1.3-14.1.6.
20. Ding, L., and E. M. Shevach. 1992. IL-10 inhibits mitogen-induced T cell proliferation by selectively inhibiting macrophage costimulatory function. J. Immunol. 148:3133.
21. Wogensen, L., X. Huang, and N. Sarvetnick. 1993. Leukocyte extravasation into the pancreatic tissue in transgenic mice expressing interleukin 10 in the islets of Langerhans. J. Exp. Med. 178:175.
22. Wogensen, L., M. S. Lee, and N. Sarvetnick. 1994. Production of interleukin 10 by islet cells accelerates immune-mediated destruction of beta cells in nonobese diabetic mice. J. Exp. Med 179:1379.
23. Moritani, M., K. Yoshimoto, F. Tashiro, C. Hashimoto, J. Miyazaki, S. Ii, E. Kudo, H. Iwahana, Y. Hayashi, T. Sano, and M. Itakura. 1994. Transgenic expression of IL-10 in pancreatic islet A cells accelerates autoimmune insulitis and diabetes in non-obese diabetic mice. Int. Immunol. 6:1927.
24. Giovarelli, M., P. Musiani, A. Modesti, P. Dellabona, G. Casorati, A. Allione, M. Consalvo, F. Cavallo, F. di Pierro, C. De Giovanni, T. Musso, and G. Forni. 1995. Local release of IL-10 by transfected mouse mammary adenocarcinoma cells does not suppress but enhances antitumor reaction and elicits a strong cytotoxic lymphocyte and antibody-dependent immune memory. J. Immunol. 155: 3112.
25. Bermudez, L. E., and J. Champsi. 1993. Infection with Mycobacterium avium induces production of interleukin-10 (IL-10). and administration of anti-IL-10 antibody is associated with enhanced resistance to infection in mice. Infect. Immun. 61:3093.
26. Denis, M., and E. Ghadirian. 1993. IL-10 neutralization augments mouse resistance to systemic Mycobacterium avium infections. J. Immunol. 151:5425.
27. Ho, A. S., Y. Liu, T. A. Khan, D. H. Hsu, J. F. Bazan, and K. W. Moore. 1993. A receptor for interleukin 10 is related to interferon receplors. Proc. Natl. Acad. Sci. USA 90:11267.
28. Ho, A. S., S. H. Wei, A. L. Mui, A. Miyajima, and K. W. Moore. 1995. Functional regions of the mouse interleukin-10 receptor cytoplasmic domain. Mol. Cell. Biol. 15:5043.
29. Lehmann, J., D. Seegert, I. Strehlow, C. Schindler, M. L. Lohmann-Matthes, and T. Decker. 1994. IL-10-induced factors belonging to the p91 family of proteins bind to IFN-γ-responsive promoter elements. J. Immunol. 153:165.
30. Uze, G., G. Lutfalla, and K. E. Mogensen. 1995. Alpha and beta interferons and their receptor and their friends and relations. J. Interferon Cytokine Res. 15:3.
31. Flynn, J. L., M. M. Goldstein, J. Chan, K. L. Triebold, K. Pfeffer, C. J. Lowenstein, R. Schreiber, T. W. Mak, and B. R. Bloom. 1995. Tumor necrosis factor-α is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity 2:561.
32. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ-production by suppressing natural killer cell stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
33. Flesch, I. E. A., J. H. Hess, S. Huang, M. Aguet, J. Rome, H. Bluethmann, and S. H. E. Kaufmann. 1995. Early interleukin 12 production by macrophages in response to mycobacterial infection depends on interferon γ and tumor necrosis factor α. J. Exp. Med. 181:1615.