L-selegiline potentiates the cellular poly(ADP-ribosyl)ation response to ionizing radiation

Journal of Pharmacology and Experimental Therapeutics

Volumn 306, Issue 3, 2003, Pages 973-979

  Brabeck, Christine ^a   Pfeiffer, Ragen ^a,b   Leake, Alan ^b   Beneke, Sascha ^a   Meyer, Ralph ^a   Bürkle, Alexander ^a,b,c  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^b NEWCASTLE UNIVERSITY   (United Kingdom)

^c UNIVERSITY OF KONSTANZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

POLY(ADENOSINE DIPHOSPHATE RIBOSE); SELEGILINE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA STRAND BREAKAGE; DOWN REGULATION; DRUG ACTIVITY; EMBRYO; ENZYME ACTIVITY; EXCISION REPAIR; GAMMA RADIATION; HAMSTER; IONIZING RADIATION; LIFESPAN; MONONUCLEAR CELL; NEUROPHARMACOLOGY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN MODIFICATION; RADIATION RESPONSE;

ANIMALS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, RADIATION; GAMMA RAYS; NEUROPROTECTIVE AGENTS; POLY ADENOSINE DIPHOSPHATE RIBOSE; POLY(ADP-RIBOSE) POLYMERASES; RADIATION, IONIZING; SELEGILINE;

EID: 0041430881     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.051342     Document Type: Article

References (37)

1. Alvarez-Gonzalez R, Spring H, Müller M, and Bürkle A (1999) Selective loss of poly(ADP-ribose) and the 85-kDa fragment of poly(ADP-ribose) polymerase in nucleoli during alkylation-induced apoptosis of HeLa cells. J Biol Chem 274: 32122-32126.
2. Ame JC, Rolli V, Schreiber V, Niedergang C, Apiou F, Decker P, Muller S, Hoger T, Menissier-de Murcia J, and de Murcia G (1999) PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem 274:17860-17868.
3. Beneke S, Alvarez-Gonzalez R, and Bürkle A (2000) Comparative characterisation of poly(ADP-ribose) polymerase-1 from two mammalian species with different life span. Exp Gerontol 35:989-1002.
4. Berger NA and Petzold SJ (1985) Identification of minimal size requirements of DNA for activation of poly(ADP-ribose) polymerase. Biochemistry 24:4352-4355.
5. Berghammer H, Ebner M, Marksteiner R, and Auer B (1999) pADPRT-2: a novel mammalian polymerizing(ADP-ribosyl)transferase gene related to truncated pADPRT homologues in plants and Caenorhabditis elegans. FEBS Lett 449:259-263.
6. Birnboim HC and Jevcak JJ (1981) Fluorometric method for rapid detection of DNA strand breaks in human white blood cells produced by low doses of radiation. Cancer Res 41:1889-1892.
7. Brunk CF, Jones KC, and James TW (1979) Assay for nanogram quantities of DNA in cellular homogenates. Anal Biochem 92:497-500.
8. Bürkle A (2001a) Mechanisms of ageing. Eye 15:371-375.
9. Bürkle A (2001b) Physiology and pathophysiology of poly(ADP-ribosyl)ation. Bioessays 23:795-806.
10. Bürkle A (2001c) Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability. Cancer Lett 163:1-5.
11. Dantzer F, Schreiber V, Niedergang C, Trucco C, Flatter E, De La Rubia G, Oliver J, Rolli V, Menissier-de Murcia J, and de Murcia G (1999) Involvement of poly(ADP-ribose) polymerase in base excision repair. Biochimie 81:69-75.
12. Davidovic L, Vodenicharov M, Affar EB, and Poirier GG (2001) Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res 268:7-13.
13. + depletion and cell death induced by oxidative stress. J Biol Chem 278:18426-18433.
14. Ebadi M, Sharma S, Shavali S, and El Refaey H (2002) Neuroprotective actions of selegiline. J Neurosci Res 67:285-289.
15. Freisleben HJ, Lehr F, and Fuchs J (1994) Lifespan of immunosuppressed NMRI-mice is increased by deprenyl. J Neural Transm Suppl 41:231-236.
16. Gerlach M, Youdim MB, and Riederer P (1996) Pharmacology of selegiline. Neurology 47:S137-S145.
17. Grube K and Bürkle A (1992) Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span. Proc Natl Acad Sci USA 89:11759-11763.
18. Ha HC and Snyder SH (2000) Poly(ADP-ribose) polymerase-1 in the nervous system. Neurobiol Dis 7:225-239.
19. Jacobson MK and Jacobson EL (1999) Discovering new ADP-ribose polymer cycles: protecting the genome and more. Trends Biochem Sci 24:415-417.
20. Jacobson MK, Payne DM, Alvarez-Gonzalez R, Juarez-Salinas H, Sims JL, and Jacobson EL (1984) Determination of in vivo levels of polymeric and monomeric ADP-ribose by fluorescence methods. Methods Enzymol 106:483-494.
21. Johansson M (1999) A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. Genomics 57:442-445.
22. Kitani K, Kanai S, Ivy GO, and Carrillo MC (1999) Pharmacological modifications of endogenous antioxidant enzymes with special reference to the effects of deprenyl: a possible antioxidant strategy. Mech Ageing Dev 111:211-221.
23. Kitani K, Minami C, Yamamoto T, Maruyama W, Kanai S, Ivy GO, and Carrillo MC (2001) Do antioxidant strategies work against aging and age-associated disorders? Propargylamines: a possible antioxidant strategy. Ann NY Acad Sci 928:248-260.
24. Klegeris A and McGeer PL (2000) R-(-)-Deprenyl inhibits monocytic THP-1 cell neurotoxicity independently of monoamine oxidase inhibition. Exp Neurol 166:458-464.
25. Knoll J, Dallo J, and Yen TT (1989) Striatal dopamine, sexual activity and lifespan. Longevity of rats treated with (-)-deprenyl. Life Sci 45:525-531.
26. Liu J, Ying W, Massa S, Duriez PJ, Swanson RA, Poirier GG, and Sharp FR (2000) Effects of transient global ischemia and kainate on poly(ADP-ribose) polymerase (PARP) gene expression and proteolytic cleavage in gerbil and rat brains. Brain Res Mol Brain Res 80:7-16.
27. Maruyama W and Naoi M (1999) Neuroprotection by (-)-deprenyl and related compounds. Mech Ageing Dev 111:189-200.
28. Meyer R, Müller M, Beneke S, Küpper JH, and Bürkle A (2000) Negative regulation of alkylation-induced sister-chromatid exchange by poly(ADP-ribose) polymerase-1 activity. Int J Cancer 88:851-855.
29. Muiras ML, Müller M, Schachter F, and Bürkle A (1998) Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians. J Mol Med 76:346-354.
30. Nagayama T, Simon RP, Chen D, Henshall DC, Pei W, Stetler RA, and Chen J (2000) Activation of poly(ADP-ribose) polymerase in the rat hippocampus may contribute to cellular recovery following sublethal transient global ischemia. J Neurochem 74:1636-1645.
31. Naoi M, Maruyama W, Yagi K, and Youdim M (2000) Anti-apoptotic function of L-(-)deprenyl (selegiline) and related compounds. Neurobiology 8:69-80.
32. Ruehl WW, Entriken TL, Muggenburg BA, Bruyette DS, Griffith WC, and Hahn FF (1997) Treatment with L-deprenyl prolongs life in elderly dogs. Life Sci 61:1037-1044.
33. Semkova I, Wolz P, Schilling M, and Krieglstein J (1996) Selegiline enhances NGF synthesis and protects central nervous system neurons from excitotoxic and ischemic damage. Eur J Pharmacol 315:19-30.
34. Shall S and de Murcia G (2000) Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model? Mutat Res 460:1-15.
35. Shieh WM, Ame JC, Wilson MV, Wang ZQ, Koh DW, Jacobson MK, and Jacobson EL (1998) Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers. J Biol Chem 273:30069-30072.
36. Stoll S, Hafner U, Kränzlin B, and Müller WE (1997) Chronic treatment of Syrian hamsters with low-dose selegiline increases life span in females but not males. Neurobiol Aging 18:205-211.
37. Trucco C, Oliver FJ, de Murcia G, and Menissier-de Murcia J (1998) DNA repair defect in poly(ADP-ribose) polymerase-deficient cell lines. Nucleic Acids Res 26: 2644-2649.