Spiroquinazolinones as novel, potent, and selective PDE7 inhibitors. Part 1

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 18, 2004, Pages 4623-4626

  Lorthiois, Edwige ^a,b   Bernardelli, Patrick ^a   Vergne, Fabrice ^a   Oliveira, Chrystelle ^a   Mafroud, Abdel Kader ^a   Proust, Emmanuelle ^a   Heuze, Lamia ^a   Moreau, François ^a   Idrissi, Moulay ^a   Tertre, Anita ^a   Bertin, Bernadette ^a   Coupe, Magali ^a   Wrigglesworth, Roger ^a   Descours, Arnaud ^a   Soulard, Patricia ^a   Berna, Patrick ^a  

^a PFIZER INC   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

PDE7; Phosphodiesterase

Indexed keywords

ISOENZYME; PHOSPHODIESTERASE INHIBITOR; PHOSPHODIESTERASE VII INHIBITOR; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG SELECTIVITY; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; CELL LINE; DRUG EVALUATION, PRECLINICAL; HUMANS; ISOENZYMES; PHOSPHODIESTERASE INHIBITORS; QUINAZOLINES; SOLUBILITY; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 8544276586     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.07.011     Document Type: Article

References (25)

1. J.A. Beavo Physiol. Rev. 75 1995 725 748
2. S.H. Francis, I.V. Turko, and J.D. Corbin K. Moldave Progress in Nucleic Acid Research and Molecular Biology Vol. 65 2000 Academic Press New York 1 52
3. M. Conti Principles of Molecular Regulation P.M. Conn A.R. Means 2000 Humana Press New York 261 275
4. S.H. Soderling, and J.A. Beavo Curr. Opin. Cell Biol. 12 2000 174 179
5. S.H. Soderling, S.J. Bayuga, and J.A. Beavo J. Biol. Chem. 273 1998 15553 15558
6. M. Conti, and S.L.C. Jin K. Moldave Progress in Nucleic Acid Research and Molecular Biology Vol. 63 1999 Academic Press New York 1 38
7. D.M. Essayan J. Allergy Clin. Immunol. 108 2001 671 680
8. L. Li, C. Yee, and J.A. Beavo Science 283 1999 848 851
9. A. Nakata, T. Ogawa, T. Sasaki, N. Koyama, K. Wada, J. Kotera, H. Kikkawa, K. Omori, and O. Kaminuma Clin. Exp. Immunol. 128 2002 460 466
10. S.J. Smith, S. Brookes-Fazakerley, L.E. Donnelly, P.J. Barnes, M.S. Barnette, and M.A. Giembycz Am. J. Physiol. Lung Cell Mol. Physiol. 284 2003 L279 L289
11. R. Lee, S. Wolda, E. Moon, J. Esselstyn, C. Hertel, and A. Lerner Cell. Signalling 14 2002 277 284
12. S. Perez-Torres, R. Cortes, M. Tolnay, A. Probst, J.M. Palacios, and G. Mengod Exp. Neurol. 182 2003 322 334
13. X. Miro, S. Perez-Torres, J.M. Palacios, P. Puigdomenech, and G. Mengod Synapse 40 2001 201 214
14. T. Sasaki, J. Kotera, and K. Omori Biochem. J. 361 2002 211 220
15. Kotera, J. PDE7-news and views, William Harvey Research Conferences, Porto, Portugal, December 5-7, 2001
16. Kluxen, F. W. PCT int. Appl. WO 0183772 A1, 2001
17. M.J. Barnes, N. Cooper, R.J. Davenport, H.J. Dyke, F.P. Galleway, F.C.A. Galvin, L. Gowers, A.F. Haughan, C. Lowe, J.W.G. Meissner, J.G. Montana, T. Morgan, C.L. Picken, and R.J. Watson Bioorg. Med. Chem. Lett. 11 2001 1081 1083
18. A. Castro, M.I. Abasolo, C. Gil, V. Segarra, and A. Martinez Eur. J. Med. Chem. 36 2001 333 338
19. A. Martinez, A. Castro, C. Gil, M. Miralpeix, V. Segarra, T. Domenech, J. Beleta, J.M. Palacios, H. Ryder, X. Miro, C. Bonet, J.M. Casacuberta, F. Azorin, B. Pina, and P. Puigdomenec J. Med. Chem. 43 2000 683 689
20. W.J. Pittz, W. Vaccaro, T. Huynh, K. Leftheris, J.Y. Roberge, J. Barbosa, J. Guo, B. Brown, A. Watson, K. Donaldson, G.C. Starling, P.A. Kiener, M.A. Poss, J.H. Dodd, and J.C. Barrish Bioorg. Med. Chem. Lett. 14 2004 2955 2958
21. Bernardelli, P.; Ducrot, P.; Lorthiois, E.; Vergne, F. PCT int. Appl. WO 0276954 A1, 2002
22. F.L. Lambert, W.D. Ellis, and R.J. Parry J. Org. Chem. 30 1965 304 306
23. L.H. Zhang, J. Duan, Y. Xu, and W.R. Dolbier Tetrahedron. Lett. 39 1998 9621 9622
24. P.N. Craig J. Med. Chem. 14 1971 680 684
25. 4 buffer for 24 h