Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2- (dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA: X-ray structure complexed to d(CG(5-Bru)ACG)2 at 1.3-Å resolution [2]

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 536-540

  Todd, Alan K ^a   Adams, Adrienne ^b,e   Thorpe, James H ^a   Denny, William A ^c   Wakelin, Laurence P G ^d,f   Cardin, Christine J ^a  

^a UNIVERSITY OF READING   (United Kingdom)

^b TRINITY COLLEGE DUBLIN   (Ireland)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

^d UNIVERSITY COLLEGE DUBLIN   (Ireland)

^e UNIVERSITY OF SYDNEY   (Australia)

^f UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

1 [2 (DIMETHYLAMINO)ETHYL]ACRIDINE 4 CARBOXAMIDE; DNA TOPOISOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CRYSTAL STRUCTURE; DRUG DNA BINDING; DRUG STRUCTURE; INTERCALATION COMPLEX; LETTER; OPTICAL RESOLUTION; PROTON TRANSPORT; STEREOCHEMISTRY; STRUCTURE ANALYSIS;

ACRIDINES; ANTINEOPLASTIC AGENTS; CRYSTALLOGRAPHY, X-RAY; DNA TOPOISOMERASES, TYPE I; DNA TOPOISOMERASES, TYPE II; HYDROGEN BONDING; INTERCALATING AGENTS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION;

EID: 0033602134     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980479u     Document Type: Letter

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