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Volumn , Issue , 2005, Pages 387-416

Optimization of High Cell Density Perfusion Bioreactors

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EID: 85134923168     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1201/9780849351068-14     Document Type: Chapter
Times cited : (24)

References (107)
  • 1
    • 7644236915 scopus 로고
    • A method of furnishing a continuous supply of new medium to a tissue culture in vitro
    • Burrows MT. A method of furnishing a continuous supply of new medium to a tissue culture in vitro. Anatomical Rev 1912; 6:141-144.
    • (1912) Anatomical Rev , vol.6 , pp. 141-144
    • Burrows, M.T.1
  • 2
    • 34250388620 scopus 로고
    • Perfusion and mass culture systems
    • Patterson MKJ. Perfusion and mass culture systems. TCA Man 1975; 1:243-249.
    • (1975) TCA Man , vol.1 , pp. 243-249
    • Patterson, M.K.J.1
  • 3
    • 0025616789 scopus 로고
    • Perfusion systems for cell cultivation
    • Lubiniecki AS, ed, New York: Marcel Dekker, Inc
    • Griffiths B. Perfusion systems for cell cultivation. In: Lubiniecki AS, ed. Large Scale Mammalian Cell Culture Technology. New York: Marcel Dekker, Inc., 1990:217-250.
    • (1990) Large Scale Mammalian Cell Culture Technology , pp. 217-250
    • Griffiths, B.1
  • 4
    • 0025579290 scopus 로고
    • Suspension culture of mammalian cells
    • Lubiniecki AS, ed, New York: Marcel Dekker, Inc
    • Birch JR, Arathoon R. Suspension culture of mammalian cells. In: Lubiniecki AS, ed. Large Scale Mammalian Cell Culture Technology. New York: Marcel Dekker, Inc., 1990:251-270.
    • (1990) Large Scale Mammalian Cell Culture Technology , pp. 251-270
    • Birch, J.R.1    Arathoon, R.2
  • 5
    • 0022631608 scopus 로고
    • Factors affecting cell growth and monoclonal antibody production in stirred reactors
    • Reuveny S, Velez D, Miller L, Macmillan JD. Factors affecting cell growth and monoclonal antibody production in stirred reactors. J Immunol Methods 1986; 86:53-59.
    • (1986) J Immunol Methods , vol.86 , pp. 53-59
    • Reuveny, S.1    Velez, D.2    Miller, L.3    Macmillan, J.D.4
  • 6
    • 0022657328 scopus 로고
    • Comparison of cell propagation methods for their effect on monoclonal antibody yield in fermentors
    • Reuveny S, Velez D, Miller L, MacMillan JD. Comparison of cell propagation methods for their effect on monoclonal antibody yield in fermentors. J Immunol Methods 1986; 86:61-69.
    • (1986) J Immunol Methods , vol.86 , pp. 61-69
    • Reuveny, S.1    Velez, D.2    Miller, L.3    MacMillan, J.D.4
  • 7
    • 0011210335 scopus 로고
    • Strategies to extend longevity of hybridomas in culture and promote yield of monoclonal-antibodies
    • Luan YT, Mutharasan R, Magee WE. Strategies to extend longevity of hybridomas in culture and promote yield of monoclonal-antibodies. Biotechnol Lett 1987; 9:691-696.
    • (1987) Biotechnol Lett , vol.9 , pp. 691-696
    • Luan, Y.T.1    Mutharasan, R.2    Magee, W.E.3
  • 8
    • 84988106827 scopus 로고
    • A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH
    • Miller WM, Blanch HW, Wilke DR. A kinetic analysis of hybridoma growth and metabolism in batch and continuous suspension culture: Effect of nutrient concentration, dilution rate, and pH. Biotechnol Bioeng 1988; 32:947-965.
    • (1988) Biotechnol Bioeng , vol.32 , pp. 947-965
    • Miller, W.M.1    Blanch, H.W.2    Wilke, D.R.3
  • 9
    • 0027628305 scopus 로고
    • Glycosidase activities in Chinese-Hamster ovary cell lysate and cell-culture supernatant
    • Gramer MJ, Goochee CJ. Glycosidase activities in Chinese-Hamster ovary cell lysate and cell-culture supernatant. Biotechnology Progress 1993; 9:366-373.
    • (1993) Biotechnology Progress , vol.9 , pp. 366-373
    • Gramer, M.J.1    Goochee, C.J.2
  • 10
    • 0025700415 scopus 로고
    • The loss of anitbody productivity in continuous cultures of hybridoma cells
    • Frame KK, Hu WS. The loss of anitbody productivity in continuous cultures of hybridoma cells. Biotechnol Bioeng 1990; 35:469-476.
    • (1990) Biotechnol Bioeng , vol.35 , pp. 469-476
    • Frame, K.K.1    Hu, W.S.2
  • 11
    • 0025305013 scopus 로고
    • Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum free media
    • Ozturk SS, Palsson BO. Loss of antibody productivity during long-term cultivation of a hybridoma cell line in low serum and serum free media. Hybridoma 1990; 9:167-175.
    • (1990) Hybridoma , vol.9 , pp. 167-175
    • Ozturk, S.S.1    Palsson, B.O.2
  • 12
    • 0024993786 scopus 로고
    • Stability in continuous cultures of recombinant bacteria
    • Bentley WE, Kompala DS. Stability in continuous cultures of recombinant bacteria. Biotechnol Lett 1990; 12:329-334.
    • (1990) Biotechnol Lett , vol.12 , pp. 329-334
    • Bentley, W.E.1    Kompala, D.S.2
  • 13
    • 0030440688 scopus 로고    scopus 로고
    • Engineering challenges in high density cell culture systems
    • Ozturk SS. Engineering challenges in high density cell culture systems. Cytotechnology 1996; 22:3-16.
    • (1996) Cytotechnology , vol.22 , pp. 3-16
    • Ozturk, S.S.1
  • 14
    • 0032422376 scopus 로고    scopus 로고
    • Mammalian cell retention devices for stirred perfusion bioreactors
    • Woodside SM, Bowen BD, Piret JM. Mammalian cell retention devices for stirred perfusion bioreactors. Cytotechnology 1998; 28:163-175.
    • (1998) Cytotechnology , vol.28 , pp. 163-175
    • Woodside, S.M.1    Bowen, B.D.2    Piret, J.M.3
  • 15
    • 0037572331 scopus 로고    scopus 로고
    • Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells
    • Voisard D, Meuwly F, Ruffieux P-A, Beaer G, Kadourin A. Potential of cell retention techniques for large-scale high-density perfusion culture of suspended mammalian cells. Biotechnol Bioeng 2003; 82:751-765.
    • (2003) Biotechnol Bioeng , vol.82 , pp. 751-765
    • Voisard, D.1    Meuwly, F.2    Ruffieux, P.-A.3    Beaer, G.4    Kadourin, A.5
  • 16
    • 0017120530 scopus 로고
    • The production of foot-and-mouth disease virus from BHK 21 C13 cells grown on the surface of glass spheres
    • Spier RE, Whiteside JP. The production of foot-and-mouth disease virus from BHK 21 C13 cells grown on the surface of glass spheres. Biotechnol Bioeng 1976; 18:649-657.
    • (1976) Biotechnol Bioeng , vol.18 , pp. 649-657
    • Spier, R.E.1    Whiteside, J.P.2
  • 17
    • 0019765854 scopus 로고
    • The development and use of microcarriers and glass sphere culture techniques for the production of Herpes simplex virus
    • Griffiths JB, Thornton B, McEntee I. The development and use of microcarriers and glass sphere culture techniques for the production of Herpes simplex virus. Dev Bio Stand 1982; 50:103-110.
    • (1982) Dev Bio Stand , vol.50 , pp. 103-110
    • Griffiths, J.B.1    Thornton, B.2    McEntee, I.3
  • 18
    • 0033735662 scopus 로고    scopus 로고
    • Justification of continuous packed bed reactor for retroviral vector production from amphotropic OCRIP muring producer cell
    • Kang SH, Kim BG, Lee GM. Justification of continuous packed bed reactor for retroviral vector production from amphotropic OCRIP muring producer cell. Cytotechnology 2000; 34:151-158.
    • (2000) Cytotechnology , vol.34 , pp. 151-158
    • Kang, S.H.1    Kim, B.G.2    Lee, G.M.3
  • 19
    • 0018814147 scopus 로고
    • The mass culture of human diploid fibroblast in packed beds of glass beads
    • Burbidge C. The mass culture of human diploid fibroblast in packed beds of glass beads. Dev Bio Stand 1980; 46:169-172.
    • (1980) Dev Bio Stand , vol.46 , pp. 169-172
    • Burbidge, C.1
  • 20
    • 13644265742 scopus 로고
    • Protein production from mammalian cells grown on glass beads
    • Spier RE, Griffiths JB, eds., London: Academic Press
    • Brown PC, Figueroa C, Costello MAC, Oakley R, Maciukas SM. Protein production from mammalian cells grown on glass beads. In: Spier RE, Griffiths JB, eds. Animal Cell Biotechnology. Vol. 3. London: Academic Press, 1988:251-262.
    • (1988) Animal Cell Biotechnology , vol.3 , pp. 251-262
    • Brown, P.C.1    Figueroa, C.2    Costello, M.A.C.3    Oakley, R.4    Maciukas, S.M.5
  • 21
    • 0343752155 scopus 로고
    • Continuous production of monoclonal antibodies in Celligen packed bed reactor using Fibra-Cel carrier
    • Spier RE, Griffiths JB, MacDonald C, eds, Butterworth-Heinemann
    • Wang G, Zhang W, Freedman D, Eppstein L, Kadouri A. Continuous production of monoclonal antibodies in Celligen packed bed reactor using Fibra-Cel carrier. In: Spier RE, Griffiths JB, MacDonald C, eds. Animal Cell Technology: Developments, Process and Products. Butterworth-Heinemann, 1992:460-464.
    • (1992) Animal Cell Technology: Developments, Process and Products , pp. 460-464
    • Wang, G.1    Zhang, W.2    Freedman, D.3    Eppstein, L.4    Kadouri, A.5
  • 22
    • 0033791103 scopus 로고    scopus 로고
    • Continuous production and recovery of recombinant Ca2þ binding receptor from HEK 293 cells using perfusion through a packed bed bioreactor
    • Kaufman JB, Wang G, Zhang W, Valle MA, Shiloach J. Continuous production and recovery of recombinant Ca2þ binding receptor from HEK 293 cells using perfusion through a packed bed bioreactor. Cytotechnology 2000; 33:3-11.
    • (2000) Cytotechnology , vol.33 , pp. 3-11
    • Kaufman, J.B.1    Wang, G.2    Zhang, W.3    Valle, M.A.4    Shiloach, J.5
  • 23
    • 0027022940 scopus 로고
    • Maximisation of perfusion systems and process comparison with batch-type cultures. Maximisation of perfusion cultures
    • Griffiths JB, Looby D, Racher AJ. Maximisation of perfusion systems and process comparison with batch-type cultures. Maximisation of perfusion cultures. Cytotechnology 1992; 9:3-9.
    • (1992) Cytotechnology , vol.9 , pp. 3-9
    • Griffiths, J.B.1    Looby, D.2    Racher, A.J.3
  • 24
    • 84941944978 scopus 로고
    • The scale-up from 0.1 to 100 litre of a unit process system based on 3mm diameter glass spheres for the production of four strains of FMDV from BHK monolayer cells
    • Whiteside JP, Spier RE. The scale-up from 0.1 to 100 litre of a unit process system based on 3mm diameter glass spheres for the production of four strains of FMDV from BHK monolayer cells. Biotechnol Bioeng 1981; 23:551-565.
    • (1981) Biotechnol Bioeng , vol.23 , pp. 551-565
    • Whiteside, J.P.1    Spier, R.E.2
  • 25
    • 85064672929 scopus 로고
    • Two ceramic matrices for the long-term growth of adherent or suspension cells
    • Moody GW, Baker PB, eds, London: Elsevier
    • Pugh GG, Berg GJ. Two ceramic matrices for the long-term growth of adherent or suspension cells. In: Moody GW, Baker PB, eds. Bioreactors and Biotransformations. London: Elsevier, 1983:121-131.
    • (1983) Bioreactors and Biotransformations , pp. 121-131
    • Pugh, G.G.1    Berg, G.J.2
  • 27
    • 0011324920 scopus 로고
    • Employing a ceramic matrix for the immobilization of mammlian cells in culture
    • Spier RE, Griffiths JB, eds., Academic Press
    • Berg GJ, Bödeker BGD. Employing a ceramic matrix for the immobilization of mammlian cells in culture. In: Spier RE, Griffiths JB, eds. Animal Cell Biotechnology. Vol. 3. Academic Press, 1988:321-335.
    • (1988) Animal Cell Biotechnology , vol.3 , pp. 321-335
    • Berg, G.J.1    Bödeker, B.G.D.2
  • 30
    • 0025550647 scopus 로고
    • Immobilized mammalian cell cultivation in hollow fiber bioreactors
    • Piret JM, Cooney CL. Immobilized mammalian cell cultivation in hollow fiber bioreactors. Biotechnol Adv 1990; 8:763-783.
    • (1990) Biotechnol Adv , vol.8 , pp. 763-783
    • Piret, J.M.1    Cooney, C.L.2
  • 31
    • 0001477001 scopus 로고
    • Hollow fiber cell culture systems for economical cell-product manufacturing
    • Hopkinson J. Hollow fiber cell culture systems for economical cell-product manufacturing. Biotechnology 1985; 3:225-230.
    • (1985) Biotechnology , vol.3 , pp. 225-230
    • Hopkinson, J.1
  • 32
    • 0026138673 scopus 로고
    • Nutrient and metabolite gradients in mammalian hollow-fiber bioreactors
    • Piret JM, Devens DA, Cooney CL. Nutrient and metabolite gradients in mammalian hollow-fiber bioreactors. Can J Chem Eng 1991; 69:421-428.
    • (1991) Can J Chem Eng , vol.69 , pp. 421-428
    • Piret, J.M.1    Devens, D.A.2    Cooney, C.L.3
  • 33
    • 84966146903 scopus 로고
    • Immobilized animal cells: The gentle way to productivity
    • van Brunt J. Immobilized animal cells: the gentle way to productivity. Biotechnology 1986; 4:505-510.
    • (1986) Biotechnology , vol.4 , pp. 505-510
    • van Brunt, J.1
  • 34
    • 0022679115 scopus 로고
    • A radial flow hollow fiber reactor for the large-scale culture of mammalian cells
    • Tharakan JP, Chau PC. A radial flow hollow fiber reactor for the large-scale culture of mammalian cells. Biotechnol Bioeng 1989; 28:329-342.
    • (1989) Biotechnol Bioeng , vol.28 , pp. 329-342
    • Tharakan, J.P.1    Chau, P.C.2
  • 35
    • 0019225745 scopus 로고
    • Microencapsulated islets as bioartificial endocrine pancreas
    • Lim F, Sun AM. Microencapsulated islets as bioartificial endocrine pancreas. Science 1980; 210:908-910.
    • (1980) Science , vol.210 , pp. 908-910
    • Lim, F.1    Sun, A.M.2
  • 36
    • 0142042610 scopus 로고
    • Use of cellular microencapsulation in large-scale production of monoclonal antibodies
    • Feder J, Tolbert WR, eds, Orlando:Academic Press
    • Rupp RG. Use of cellular microencapsulation in large-scale production of monoclonal antibodies. In: Feder J, Tolbert WR, eds. Large-Scale Mammalian Cell Culture. Orlando:Academic Press, 1985:19-38.
    • (1985) Large-Scale Mammalian Cell Culture , pp. 19-38
    • Rupp, R.G.1
  • 37
    • 0023569375 scopus 로고
    • Alginate-polylysine microcapsules of controlled membrane molecular weight cutoff for mammalian cell culture engineering
    • King GA, Kaugulis AJ, Faulkner P, Goosen MFA. Alginate-polylysine microcapsules of controlled membrane molecular weight cutoff for mammalian cell culture engineering. Biotechnol Prog 1987; 3:231-340.
    • (1987) Biotechnol Prog , vol.3 , pp. 231-340
    • King, G.A.1    Kaugulis, A.J.2    Faulkner, P.3    Goosen, M.F.A.4
  • 38
    • 0024034580 scopus 로고
    • Chitosan-alginate complex coacervate capsules; effects of calcium chloride, plasticizers, and polyelectrolytes on mechanical stability
    • Daly MM, Knorr D. Chitosan-alginate complex coacervate capsules; effects of calcium chloride, plasticizers, and polyelectrolytes on mechanical stability. Biotechnol Prog 1988; 4:76.
    • (1988) Biotechnol Prog , vol.4 , pp. 76
    • Daly, M.M.1    Knorr, D.2
  • 42
    • 84966167269 scopus 로고
    • Growth of anchorage dependent cells on macroporous microcarrier
    • Nilsson K, Buzsaky F, Mosbach K. Growth of anchorage dependent cells on macroporous microcarrier. Biotechnology 1986; 4:989-990.
    • (1986) Biotechnology , vol.4 , pp. 989-990
    • Nilsson, K.1    Buzsaky, F.2    Mosbach, K.3
  • 44
    • 0014661176 scopus 로고
    • Spin filter culture: The propagation of mammalian cells in suspension
    • Himmelfarb P, Thayer PS, Martin HE. Spin filter culture: the propagation of mammalian cells in suspension. Science 1969; 164:555-557.
    • (1969) Science , vol.164 , pp. 555-557
    • Himmelfarb, P.1    Thayer, P.S.2    Martin, H.E.3
  • 45
    • 0019785505 scopus 로고
    • Large scale rotating filter perfusion system for high density growth of mammalian suspension cultures
    • Tolbert WR, Feder J, Kimes RS. Large scale rotating filter perfusion system for high density growth of mammalian suspension cultures. In Vitro 1981; 17:885-890.
    • (1981) Vitro , vol.17 , pp. 885-890
    • Tolbert, W.R.1    Feder, J.2    Kimes, R.S.3
  • 46
    • 0030019157 scopus 로고    scopus 로고
    • Practical considerations in operation and scale-up of spin-filter based bioreactors for monoclonal antibody production
    • Deo YM, Mahadevan MD, Fuchs R. Practical considerations in operation and scale-up of spin-filter based bioreactors for monoclonal antibody production. Biotechnol Prog 1996; 12:57-64.
    • (1996) Biotechnol Prog , vol.12 , pp. 57-64
    • Deo, Y.M.1    Mahadevan, M.D.2    Fuchs, R.3
  • 47
    • 0027976952 scopus 로고
    • Scaleup of spinfilter perfusion bioreactor for mammalian cell retention
    • Yabannavar VM, Singh V, Connelly NV. Scaleup of spinfilter perfusion bioreactor for mammalian cell retention. Biotechnol Bioeng 1994; 43:159-164.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 159-164
    • Yabannavar, V.M.1    Singh, V.2    Connelly, N.V.3
  • 48
    • 11944254486 scopus 로고
    • Spin filter perfusion system for high density cell culture: Production of recombinant urinary type plasminogen activation in CHO cells
    • Avgerinos GC, Drapeau D, Socolow JS, Mao J, Hsiao K, Broeze RJ. Spin filter perfusion system for high density cell culture: production of recombinant urinary type plasminogen activation in CHO cells. Biotechnology 1990; 8:54-58.
    • (1990) Biotechnology , vol.8 , pp. 54-58
    • Avgerinos, G.C.1    Drapeau, D.2    Socolow, J.S.3    Mao, J.4    Hsiao, K.5    Broeze, R.J.6
  • 49
    • 0026737391 scopus 로고
    • Mammalian cell retention in a spinfilter perfusion bioreactor
    • Yabannavar VM, Singh V, Connelly NV. Mammalian cell retention in a spinfilter perfusion bioreactor. Biotechnol Bioeng 1992; 40:925-933.
    • (1992) Biotechnol Bioeng , vol.40 , pp. 925-933
    • Yabannavar, V.M.1    Singh, V.2    Connelly, N.V.3
  • 50
    • 0026173338 scopus 로고
    • Influence of the screen material on the fouling of spin filters
    • Esclade LRJ, Carrel S, Peringer P. Influence of the screen material on the fouling of spin filters. Biotechnol Bioeng 1991; 38:159-168.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 159-168
    • Esclade, L.R.J.1    Carrel, S.2    Peringer, P.3
  • 51
    • 0024521374 scopus 로고
    • Use of tangential flow filtration in perfusion propagation of hybridoma cells for production of monoclonal antibodies
    • Velez D, Miller L, Macmillan DJ. Use of tangential flow filtration in perfusion propagation of hybridoma cells for production of monoclonal antibodies. Biotechnol Bioeng 1989; 33:938-940.
    • (1989) Biotechnol Bioeng , vol.33 , pp. 938-940
    • Velez, D.1    Miller, L.2    Macmillan, D.J.3
  • 53
    • 0026417346 scopus 로고
    • Long-term perfusion culture of hybridoma: A “grow or die” cell cycle system
    • De la Broise D, Noiseux M, Lemieux R. Long-term perfusion culture of hybridoma: a “grow or die” cell cycle system. Biotechnol Bioeng 1991; 38:781-787.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 781-787
    • De la Broise, D.1    Noiseux, M.2    Lemieux, R.3
  • 54
    • 0027909737 scopus 로고
    • Monoclonal antibody productivity and the metabolic pattern of perfusion cultures under varying oxygen tensions
    • Shi Y, Ryu DDY, Park SH. Monoclonal antibody productivity and the metabolic pattern of perfusion cultures under varying oxygen tensions. Biotechnol Bioeng 1993; 42:430-439.
    • (1993) Biotechnol Bioeng , vol.42 , pp. 430-439
    • Shi, Y.1    Ryu, D.D.Y.2    Park, S.H.3
  • 55
    • 0027571696 scopus 로고
    • A comparison of oxygenation methods for high-density perfusion cultures of animal cells
    • S. Zhang Z, Handa-Corrigan A, Spier RE. A comparison of oxygenation methods for high-density perfusion cultures of animal cells. Biotechnol Bioeng 1993; 41:685-692.
    • (1993) Biotechnol Bioeng , vol.41 , pp. 685-692
    • Zhang, Z.S.1    Handa-Corrigan, A.2    Spier, R.E.3
  • 57
    • 0028414087 scopus 로고
    • Filtration-based perfusion of hybridoma cultures in protein-free medium: Reduction of membrane fouling by medium supplementation with DNase I
    • Mercille S, Johnson M, Lemieux R, Massie B. Filtration-based perfusion of hybridoma cultures in protein-free medium: reduction of membrane fouling by medium supplementation with DNase I. Biotechnol Bioeng 1994; 43:833-846.
    • (1994) Biotechnol Bioeng , vol.43 , pp. 833-846
    • Mercille, S.1    Johnson, M.2    Lemieux, R.3    Massie, B.4
  • 59
    • 0005629620 scopus 로고    scopus 로고
    • Continuous cell culture using the ATF system
    • Furey J. Continuous cell culture using the ATF system. Genetic Eng News 2000; 20:52-53.
    • (2000) Genetic Eng News , vol.20 , pp. 52-53
    • Furey, J.1
  • 61
    • 0024847585 scopus 로고
    • High cell density perfusion culture of mouse-human hybridoma
    • Takazawa Y, Tokashiki M. High cell density perfusion culture of mouse-human hybridoma. Appl Microbiol Biotechnol 1989; 32:280-284.
    • (1989) Appl Microbiol Biotechnol , vol.32 , pp. 280-284
    • Takazawa, Y.1    Tokashiki, M.2
  • 62
    • 0026182458 scopus 로고
    • Comparison of culture methods for human-human hybridomas secreting anti-HBsAg human monoclonal antibodies
    • Shitani Y, Kohno Y-I, Sawada H, Kitano K. Comparison of culture methods for human-human hybridomas secreting anti-HBsAg human monoclonal antibodies. Cytotechnology 1991; 6:197-208.
    • (1991) Cytotechnology , vol.6 , pp. 197-208
    • Shitani, Y.1    Kohno, Y.-I.2    Sawada, H.3    Kitano, K.4
  • 63
    • 0026816607 scopus 로고
    • Selective recycle of viable animal cells by coupling of airlift reactor and cell settler
    • Hülscher M, Scheibler U, Onken U. Selective recycle of viable animal cells by coupling of airlift reactor and cell settler. Biotechnol Bioeng 1992; 39:442-446.
    • (1992) Biotechnol Bioeng , vol.39 , pp. 442-446
    • Hülscher, M.1    Scheibler, U.2    Onken, U.3
  • 64
    • 51149196803 scopus 로고
    • Sedimentation of blood corpuscles
    • Boycott AE. Sedimentation of blood corpuscles. Nature 1920; 104:532-534.
    • (1920) Nature , vol.104 , pp. 532-534
    • Boycott, A.E.1
  • 65
    • 0025514464 scopus 로고
    • Inclined sedimentation for selective retention of viable hybridomas in a continuous suspension bioreactor
    • Batt BC, Davis RH, Kompala DS. Inclined sedimentation for selective retention of viable hybridomas in a continuous suspension bioreactor. Biotechnol Prog 1990; 6:458-464.
    • (1990) Biotechnol Prog , vol.6 , pp. 458-464
    • Batt, B.C.1    Davis, R.H.2    Kompala, D.S.3
  • 66
    • 80053894786 scopus 로고
    • On-line removal of cells from continuous suspension culture
    • Spier RE, Griffiths JB, Meignier B, eds, Butterworth-Heinemann
    • Brown PC, Lane JC, Wininger MT, Chow R. On-line removal of cells from continuous suspension culture. In: Spier RE, Griffiths JB, Meignier B, eds. Production of Biologicals from Animal Cells in Culture. Butterworth-Heinemann, 1991:416-420.
    • (1991) Production of Biologicals from Animal Cells in Culture , pp. 416-420
    • Brown, P.C.1    Lane, J.C.2    Wininger, M.T.3    Chow, R.4
  • 68
    • 0013684225 scopus 로고
    • Lamellar clarifier- a new device for animal cell retention in perfusion culture systems
    • Spier RE, Griffiths JB, Berthold W, eds, Butterworth-Heinemann
    • Stevens J, Eickel S, Onken U. Lamellar clarifier- a new device for animal cell retention in perfusion culture systems. In: Spier RE, Griffiths JB, Berthold W, eds. Animal Cell Technology: Products of Today, Prospects for Tomorrow. Butterworth-Heinemann, 1994:234-239.
    • (1994) Animal Cell Technology: Products of Today, Prospects for Tomorrow , pp. 234-239
    • Stevens, J.1    Eickel, S.2    Onken, U.3
  • 69
    • 85134934114 scopus 로고
    • Spier RE, Griffiths JB, Berthold W, eds. Animal Cell Technology: Products of Today, Prospects for Tomorrow. Butterworth-Heinemann
    • Thompson KJ, Wilson JS. A compact gravitational settling device for cell retention. In: Spier RE, Griffiths JB, Berthold W, eds. Animal Cell Technology: Products of Today, Prospects for Tomorrow. Butterworth-Heinemann, 1994:227-229.
    • (1994) A compact gravitational settling device for cell retention , pp. 227-229
    • Thompson, K.J.1    Wilson, J.S.2
  • 70
    • 0028387992 scopus 로고
    • Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant Chinese hamster ovary cells
    • Searles JA, Todd P, Kompala DS. Viable cell recycle with an inclined settler in the perfusion culture of suspended recombinant Chinese hamster ovary cells. Biotechnol Prog 1994; 10:198-206.
    • (1994) Biotechnol Prog , vol.10 , pp. 198-206
    • Searles, J.A.1    Todd, P.2    Kompala, D.S.3
  • 71
    • 12644282066 scopus 로고
    • Perfusion culture of suspended CHO cells employing inclined sedimentation
    • Spier RE, Griffiths JB, Berthold W, eds, Butterworth-Heinemann
    • Searles JA, Todd P, Kompala DS. Perfusion culture of suspended CHO cells employing inclined sedimentation. In: Spier RE, Griffiths JB, Berthold W, eds. Animal Cell Technology: Products of Today, Prospects for Tomorrow. Butterworth-Heinemann, 1994:240-242.
    • (1994) Animal Cell Technology: Products of Today, Prospects for Tomorrow , pp. 240-242
    • Searles, J.A.1    Todd, P.2    Kompala, D.S.3
  • 73
    • 0023418508 scopus 로고
    • Dense cultures of animal cells at the industrial scale
    • Tyo M, Spier, Raymond E. Dense cultures of animal cells at the industrial scale. Enzyme Microb Technol 1987; 9:514-520.
    • (1987) Enzyme Microb Technol , vol.9 , pp. 514-520
    • Tyo, M.1    Spier, R.E.2
  • 76
    • 0025428552 scopus 로고
    • High density culture of hybridoma cells using a perfusion culture vessel with external centrifuge
    • Tokashiki M, Arai T, Hamamoto K, Ishimaru K. High density culture of hybridoma cells using a perfusion culture vessel with external centrifuge. Cytotechnology 1990; 3:239-244.
    • (1990) Cytotechnology , vol.3 , pp. 239-244
    • Tokashiki, M.1    Arai, T.2    Hamamoto, K.3    Ishimaru, K.4
  • 77
    • 26744472683 scopus 로고
    • A novel perfusion system for the large-scale cultivation of animal cells based on a continuous flow centrifuge
    • Spier RE, Griffiths JB, MacDonald C, eds, Butterworth-Heinemann
    • Jäger V. A novel perfusion system for the large-scale cultivation of animal cells based on a continuous flow centrifuge. In: Spier RE, Griffiths JB, MacDonald C, eds. Animal Cell Technology: Developments, Processes & Products. Butterworth-Heinemann, 1992:397-402.
    • (1992) Animal Cell Technology: Developments, Processes & Products , pp. 397-402
    • Jäger, V.1
  • 79
    • 0026417565 scopus 로고
    • A novel continuous centrifugal bioreactor for high-density cultivation of mammalian and microbial cells
    • van Wie BJ, Broouns TM, Elliot ML, Davis WC. A novel continuous centrifugal bioreactor for high-density cultivation of mammalian and microbial cells. Biotechnol Bioeng 1991; 38:1190-1202.
    • (1991) Biotechnol Bioeng , vol.38 , pp. 1190-1202
    • van Wie, B.J.1    Broouns, T.M.2    Elliot, M.L.3    Davis, W.C.4
  • 80
    • 0030292728 scopus 로고    scopus 로고
    • Use of the centritech lab centrifuge for perfusion culture of hybridoma cells in protein-free medium
    • Johnson M, Lanthier S, Massie B, lefebvre G, Kamen AA. Use of the centritech lab centrifuge for perfusion culture of hybridoma cells in protein-free medium. Biotechnol Prog 1996; 12:855-864.
    • (1996) Biotechnol Prog , vol.12 , pp. 855-864
    • Johnson, M.1    Lanthier, S.2    Massie, B.3    Lefebvre, G.4    Kamen, A.A.5
  • 81
    • 0037554319 scopus 로고
    • Evaluation of a cell separator in large-scale perfusion culture
    • Beuvery EC, Griffiths JB, Zeijlemaker WP, eds, Dordrecht, The Netherlands: Kluwer Academic Publishers
    • Björling T, Dudel U, Fenge C. Evaluation of a cell separator in large-scale perfusion culture. In: Beuvery EC, Griffiths JB, Zeijlemaker WP, eds. Animal Cell Technology:Developments Towards the 21st Century. Dordrecht, The Netherlands: Kluwer Academic Publishers, 1995:671-675.
    • (1995) Animal Cell Technology:Developments Towards the 21st Century , pp. 671-675
    • Björling, T.1    Dudel, U.2    Fenge, C.3
  • 84
    • 0038568397 scopus 로고    scopus 로고
    • Major trends in technologies for cell culture
    • Wrotnowski C. Major trends in technologies for cell culture. Gen Eng News 2000; 20:8-58.
    • (2000) Gen Eng News , vol.20 , pp. 8-58
    • Wrotnowski, C.1
  • 89
    • 0030175089 scopus 로고    scopus 로고
    • An investigation into the possible use of hydrocyclones for the removal of yeast from beer
    • Yuan H, Rickwood D, Smyth IC, Thew MT. An investigation into the possible use of hydrocyclones for the removal of yeast from beer. Bioseparation 1996; 6:159-163.
    • (1996) Bioseparation , vol.6 , pp. 159-163
    • Yuan, H.1    Rickwood, D.2    Smyth, I.C.3    Thew, M.T.4
  • 91
    • 85134903467 scopus 로고
    • Ramirez EGaOT, ed. Advances in Bioprocess Engineering. Dordrecht, The Netherlands: Kluwer Academic Press
    • Ozturk SS. Scale-up and optimization of high density cell culture bioreactors. In: Ramirez EGaOT, ed. Advances in Bioprocess Engineering. Dordrecht, The Netherlands: Kluwer Academic Press, 1994.
    • (1994) Scale-up and optimization of high density cell culture bioreactors
    • Ozturk, S.S.1
  • 93
    • 85134948406 scopus 로고
    • Fluidized-bed bioreactor perfusion culture for the production of therapeutic proteins
    • Spier RE, Griffiths JB, MacDonald C, eds, Butterworth-Heinemann
    • Runstadler PW, Tung AS, Ray NG. Fluidized-bed bioreactor perfusion culture for the production of therapeutic proteins. In: Spier RE, Griffiths JB, MacDonald C, eds. Animal Cell Technology:Developments, Process and Products. Butterworth-Heinemann, 1992:495-500.
    • (1992) Animal Cell Technology:Developments, Process and Products , pp. 495-500
    • Runstadler, P.W.1    Tung, A.S.2    Ray, N.G.3
  • 95
    • 0342547017 scopus 로고    scopus 로고
    • Real-time monitoring and control of glucose and lactate concentrations in a mammalian cell perfusion reactor
    • Ozturk SS, Thrift JC, Blackie JD, Naveh D. Real-time monitoring and control of glucose and lactate concentrations in a mammalian cell perfusion reactor. Biotechnol Bioeng 1997; 53:372-378.
    • (1997) Biotechnol Bioeng , vol.53 , pp. 372-378
    • Ozturk, S.S.1    Thrift, J.C.2    Blackie, J.D.3    Naveh, D.4
  • 96
    • 26844435824 scopus 로고
    • Evaluation and applications of optical cell density probes in mammalian cell bioreactors. Biotechnol
    • Wu P, Ozturk SS, Blackie JD, Thrift JC, Figueroa C, Naveh D. Evaluation and applications of optical cell density probes in mammalian cell bioreactors. Biotechnol. Bioeng 1995; 42:312-323.
    • (1995) Bioeng , vol.42 , pp. 312-323
    • Wu, P.1    Ozturk, S.S.2    Blackie, J.D.3    Thrift, J.C.4    Figueroa, C.5    Naveh, D.6
  • 98
    • 0028121775 scopus 로고
    • High density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements
    • Kyung Y.-S, Peshwa MV, Gryte DM, Hu W.-S. High density culture of mammalian cells with dynamic perfusion based on on-line oxygen uptake rate measurements. Cytotechnology 1994; 14:183-190.
    • (1994) Cytotechnology , vol.14 , pp. 183-190
    • Kyung, Y.-S.1    Peshwa, M.V.2    Gryte, D.M.3    Hu, W.-S.4
  • 99
    • 26844534680 scopus 로고    scopus 로고
    • Real-time monitoring of mammalian cell fermentation for monoclonal antibodies using a computer controlled immunoDetection (BioCad=RPM) System
    • Ozturk SS, Blackie J, Thrift J, Naveh D. Real-time monitoring of mammalian cell fermentation for monoclonal antibodies using a computer controlled immunoDetection (BioCad=RPM) System. Biotechnol Bioeng 1996; 48:95-101.
    • (1996) Biotechnol Bioeng , vol.48 , pp. 95-101
    • Ozturk, S.S.1    Blackie, J.2    Thrift, J.3    Naveh, D.4
  • 100
    • 5444273568 scopus 로고    scopus 로고
    • Production of a secreted glycoprotein reporter from an inducible promoter system in a perfusion bioreactor
    • Lipscomb ML, Mowry MC, Kompala DS. Production of a secreted glycoprotein reporter from an inducible promoter system in a perfusion bioreactor. Biotechnol Prog 2004; 20:1402-1407.
    • (2004) Biotechnol Prog , vol.20 , pp. 1402-1407
    • Lipscomb, M.L.1    Mowry, M.C.2    Kompala, D.S.3
  • 101
    • 0034629011 scopus 로고    scopus 로고
    • A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures
    • Ducommun P, Ruffieux P, Furter M, Marison I, von Stockar U. A new method for on-line measurement of the volumetric oxygen uptake rate in membrane aerated animal cell cultures. J Biotechnol 2000; 78:139-147.
    • (2000) J Biotechnol , vol.78 , pp. 139-147
    • Ducommun, P.1    Ruffieux, P.2    Furter, M.3    Marison, I.4    von Stockar, U.5
  • 102
    • 0344507414 scopus 로고    scopus 로고
    • Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures
    • Ruffieux PA, von Stockar U, Marison IW. Measurement of volumetric (OUR) and determination of specific (qO2) oxygen uptake rates in animal cell cultures. J Biotechnol 1998; 63:85-95.
    • (1998) J Biotechnol , vol.63 , pp. 85-95
    • Ruffieux, P.A.1    von Stockar, U.2    Marison, I.W.3
  • 103
    • 0033527082 scopus 로고    scopus 로고
    • Effect of Temperature and Cell Density on the Respiration Rate of Different Cell Lines
    • Jorjani P, Ozturk SS. Effect of Temperature and Cell Density on the Respiration Rate of Different Cell Lines. Biotechnol Bioeng 1999; 349-356.
    • (1999) Biotechnol Bioeng , pp. 349-356
    • Jorjani, P.1    Ozturk, S.S.2
  • 104
    • 0028693803 scopus 로고
    • A direct computer control concept for mammalian cell fermentation processes
    • Buntemeyer H, Marzahl R, Lehmann J. A direct computer control concept for mammalian cell fermentation processes. Cytotechnology 1994; 15:271-279.
    • (1994) Cytotechnology , vol.15 , pp. 271-279
    • Buntemeyer, H.1    Marzahl, R.2    Lehmann, J.3
  • 105
    • 0030571206 scopus 로고    scopus 로고
    • Effects of elevated pCO2 and=or osmolality on the growth and recombinant tPA production of CHO cells
    • Kimura R, Miller WM. Effects of elevated pCO2 and=or osmolality on the growth and recombinant tPA production of CHO cells. Biotechnol Bioeng 1996; 52:152-160.
    • (1996) Biotechnol Bioeng , vol.52 , pp. 152-160
    • Kimura, R.1    Miller, W.M.2
  • 106


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