Corrigendum: The Human Neonatal Gut Microbiome: A Brief Review (Front Pediatr, (2015), 3, (17), 10.3389/fped.2015.00017);The Human Neonatal Gut Microbiome: A Brief Review

Frontiers in Pediatrics

Volumn 3, Issue , 2015, Pages

  Gritz, Emily C ^a   Bhandari, Vineet ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

dysbiosis; microbiota; newborn; preterm; probiotics; gut; necrotizing enterocolitis; microbiome

Indexed keywords

EID: 85119043736     PISSN: None     EISSN: 22962360     Source Type: Journal    
DOI: 10.3389/fped.2015.00060     Document Type: Erratum

References (105)

1. Chen K Pachter L. Bioinformatics for whole-genome shotgun sequencing of microbial communities. PLoS Comput Biol (2005) 1:106–12.10.1371/journal.pcbi.001002416110337
2. Fricke WF. The more the merrier? Reduced fecal microbiota diversity in preterm infants treated with antibiotics. J Pediatr (2014) 165:8–10.10.1016/j.jpeds.2014.03.022
3. Berrington JE Stewart CJ Cummings SP Embleton ND. The neonatal bowel microbiome in health and infection. Curr Opin Infect Dis (2014) 27:236–43.10.1097/QCO.000000000000006124751892
4. Putignani L Del Chierico F Petrucca A Vernocchi P Dallapiccola B. The human gut microbiota: a dynamic interplay with the host from birth to senescence settled during childhood. Pediatr Res (2014) 76:2–10.10.1038/pr.2014.4924732106
5. Aagaard K Ma J Antony KM Ganu R Petrosino J Versalovic J. The placenta harbors a unique microbiome. Sci Transl Med (2014) 6:237ra65.10.1126/scitranslmed.300859924848255
6. Adlerberth I Wold AE. Establishment of the gut microbiota in Western infants. Acta Paediatr (2009) 98:229–38.10.1111/j.1651-2227.2008.01060.x19143664
7. Sood R Zehnder JL Druzin ML Brown PO. Gene expression patterns in human placenta. Proc Natl Acad Sci U S A (2006) 103:5478–83.10.1073/pnas.050803510316567644
8. Stout MJ Conlon B Landeau M Lee I Bower C Zhao Q et al. Identification of intracellular bacteria in the basal plate of the human placenta in term and preterm gestations. Am J Obstet Gynecol (2013) 208:.e1–7.10.1016/j.ajog.2013.01.01823333552
9. Madan JC Salari RC Saxena D Davidson L O’Toole GA Moore JH et al. Gut microbial colonisation in premature neonates predicts neonatal sepsis. Arch Dis child Fetal Neonatal Ed (2012) 97:F456–62.10.1136/fetalneonatal-2011-30137322562869
10. Ardissone AN de la Cruz DM Davis-Richardson AG Rechcigl KT Li N Drew JC et al. Meconium microbiome analysis identifies bacteria correlated with premature birth. PLoS One (2014) 9:e90784.10.1371/journal.pone.009078424614698
11. Chassard C de Wouters T Lacroix C. Probiotics tailored to the infant: a window of opportunity. Curr Opin Biotechnol (2014) 26:141–7.10.1016/j.copbio.2013.12.01224469588
12. Maynard CL Elson CO Hatton RD Weaver CT. Reciprocal interactions of the intestinal microbiota and immune system. Nature (2012) 489:231–41.10.1038/nature1155122972296
13. Eckburg PB Bik EM Bernstein CN Purdom E Dethlefsen L Sargent M et al. Diversity of the human intestinal microbial flora. Science (2005) 308:1635–8.10.1126/science.111059115831718
14. Madan JC Farzan SF Hibberd PL Karagas MR. Normal neonatal microbiome variation in relation to environmental factors, infection and allergy. Curr Opin Pediatr (2012) 24:753–9.10.1097/MOP.0b013e32835a1ac823111681
15. Di Mauro A Neu J Riezzo G Raimondi F Martinelli D Francavilla R et al. Gastrointestinal function development and microbiota. Ital J Pediatr (2013) 39:15.10.1186/1824-7288-39-15
16. Torrazza RM Neu J. The altered gut microbiome and necrotizing enterocolitis. Clin Perinatol (2013) 40:93–108.10.1016/j.clp.2012.12.00923415266
17. Scholtens PA Oozeer R Martin R Amor KB Knol J. The early settlers: intestinal microbiology in early life. Annu Rev Food Sci Technol (2012) 3:425–47.10.1146/annurev-food-022811-10112022224552
18. Biasucci G Rubini M Riboni S Morelli L Bessi E Retetangos C. Mode of delivery affects the bacterial community in the newborn gut. Early Hum Dev (2010) 86(Suppl 1):13–5.10.1016/j.earlhumdev.2010.01.00420133091
19. Jakobsson HE Abrahamsson TR Jenmalm MC Harris K Quince C Jernberg C et al. Decreased gut microbiota diversity, delayed Bacteroidetes colonisation and reduced Th1 responses in infants delivered by caesarean section. Gut (2014) 63:559–66.10.1136/gutjnl-2012-30324923926244
20. Salminen S Gibson GR McCartney AL Isolauri E. Influence of mode of delivery on gut microbiota composition in seven year old children. Gut (2004) 53:1388–9.10.1136/gut.2004.041640
21. Palmer C Bik EM DiGiulio DB Relman DA Brown PO. Development of the human infant intestinal microbiota. PLoS Biol (2007) 5:e177.10.1371/journal.pbio.005017717594176
22. Turroni F Peano C Pass DA Foroni E Severgnini M Claesson MJ et al. Diversity of bifidobacteria within the infant gut microbiota. PLoS One (2012) 7:e36957.10.1371/journal.pone.003695722606315
23. Penders J Thijs C Vink C Stelma FF Snijders B Kummeling I et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics (2006) 118:511–21.10.1542/peds.2005-282416882802
24. Eggesbo M Moen B Peddada S Baird D Rugtveit J Midtvedt T et al. Development of gut microbiota in infants not exposed to medical interventions. APMIS (2011) 119:17–35.10.1111/j.1600-0463.2010.02688.x21143523
25. Groer MW Luciano AA Dishaw LJ Ashmeade TL Miller E Gilbert JA. Development of the preterm infant gut microbiome: a research priority. Microbiome (2014) 2:38.10.1186/2049-2618-2-3825332768
26. Yatsunenko T Rey FE Manary MJ Trehan I Dominguez-Bello MG Contreras M et al. Human gut microbiome viewed across age and geography. Nature (2012) 486:222–7.10.1038/nature1105322699611
27. Jain N Walker WA. Diet and host-microbial crosstalk in postnatal intestinal immune homeostasis. Nat Rev Gastroenterol Hepatol (2014) 12(1):14–25.10.1038/nrgastro.2014.15325201040
28. Di Gioia D Aloisio I Mazzola G Biavati B. Bifidobacteria: their impact on gut microbiota composition and their applications as probiotics in infants. Appl Microbiol Biotechnol (2014) 98:563–77.10.1007/s00253-013-5405-924287935
29. Berrington JE Stewart CJ Embleton ND Cummings SP. Gut microbiota in preterm infants: assessment and relevance to health and disease. Arch Dis Child Fetal Neonatal Ed (2013) 98:F286–90.10.1136/archdischild-2012-302134
30. Dai D Walker WA. Protective nutrients and bacterial colonization in the immature human gut. Adv Pediatr (1999) 46:353–82.10645469
31. Oozeer R van Limpt K Ludwig T Ben Amor K Martin R Wind RD et al. Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides. Am J Clin Nutr (2013) 98:561s–71s.10.3945/ajcn.112.03889323824728
32. Musilova S Rada V Vlkova E Bunesova V. Beneficial effects of human milk oligosaccharides on gut microbiota. Benef Microbes (2014) 5:273–83.10.3920/BM2013.008024913838
33. Solís G de los Reyes-Gavilan CG Fernández N Margolles A Gueimonde M. Establishment and development of lactic acid bacteria and bifidobacteria microbiota in breast-milk and the infant gut. Anaerobe (2010) 16:307–10.10.1016/j.anaerobe.2010.02.00420176122
34. Civardi E Garofoli F Tzialla C Paolillo P Bollani L Stronati M. Microorganisms in human milk: lights and shadows. J Matern Fetal Neonatal Med (2013) 26(Suppl 2):30–4.10.3109/14767058.2013.82969324059550
35. Latuga MS Stuebe A Seed PC. A review of the source and function of microbiota in breast milk. Semin Reprod Med (2014) 32:68–73.10.1055/s-0033-136182424390923
36. Donnet-Hughes A Perez PF Dore J Leclerc M Levenez F Benyacoub J et al. Potential role of the intestinal microbiota of the mother in neonatal immune education. Proc Nutr Soc (2010) 69:407–15.10.1017/S002966511000189820633308
37. Power SE O’Toole PW Stanton C Ross RP Fitzgerald GF. Intestinal microbiota, diet and health. Br J Nutr (2014) 111:387–402.10.1017/S0007114513002560
38. Gomez-Llorente C Plaza-Diaz J Aguilera M Munoz-Quezada S Bermudez-Brito M Peso-Echarri P et al. Three main factors define changes in fecal microbiota associated with feeding modality in infants. J Pediatr Gastroenterol Nutr (2013) 57:461–6.10.1097/MPG.0b013e31829d519a23752082
39. Jost T Lacroix C Braegger CP Chassard C. New insights in gut microbiota establishment in healthy breast fed neonates. PLoS One (2012) 7:e44595.10.1371/journal.pone.004459522957008
40. Piacentini G Peroni D Bessi E Morelli L. Molecular characterization of intestinal microbiota in infants fed with soymilk. J Pediatr Gastroenterol Nutr (2010) 51:71–6.10.1097/MPG.0b013e3181dc8b0220543718
41. Guaraldi F Salvatori G. Effect of breast and formula feeding on gut microbiota shaping in newborns. Front Cell Infect Microbiol (2012) 2:94.10.3389/fcimb.2012.00094
42. Mackie RI Sghir A Gaskins HR. Developmental microbial ecology of the neonatal gastrointestinal tract. Am J Clin Nutr (1999) 69:1035s–45s.10232646
43. Hascoet JM Hubert C Rochat F Legagneur H Gaga S Emady-Azar S et al. Effect of formula composition on the development of infant gut microbiota. J Pediatr Gastroenterol Nutr (2011) 52:756–62.10.1097/MPG.0b013e318210585021593648
44. Manco M. Gut microbiota and developmental programming of the brain: from evidence in behavioral endophenotypes to novel perspective in obesity. Front Cell Infect Microbiol (2012) 2:109.10.3389/fcimb.2012.00109
45. Hochberg Z Feil R Constancia M Fraga M Junien C Carel JC et al. Child health, developmental plasticity, and epigenetic programming. Endocr Rev (2011) 32:159–224.10.1210/er.2009-003920971919
46. Kalliomaki M Collado MC Salminen S Isolauri E. Early differences in fecal microbiota composition in children may predict overweight. Am J Clin Nutr (2008) 87:534–8.18326589
47. Ley RE Backhed F Turnbaugh P Lozupone CA Knight RD Gordon JI. Obesity alters gut microbial ecology. Proc Natl Acad Sci U S A (2005) 102:11070–5.10.1073/pnas.050497810216033867
48. Mischke M Plosch T. More than just a gut instinct-the potential interplay between a baby’s nutrition, its gut microbiome, and the epigenome. Am J Physiol (2013) 304:R1065–9.10.1152/ajpregu.00551.201223594611
49. Luoto R Kalliomaki M Laitinen K Delzenne NM Cani PD Salminen S et al. Initial dietary and microbiological environments deviate in normal-weight compared to overweight children at 10 years of age. J Pediatr Gastroenterol Nutr (2011) 52:90–5.10.1097/MPG.0b013e3181f3457f21150648
50. Gupta RW Tran L Norori J Ferris MJ Eren AM Taylor CM et al. Histamine-2 receptor blockers alter the fecal microbiota in premature infants. J Pediatr Gastroenterol Nutr (2013) 56:397–400.10.1097/MPG.0b013e318282a8c223254444
51. Stewart CJ Marrs EC Nelson A Lanyon C Perry JD Embleton ND et al. Development of the preterm gut microbiome in twins at risk of necrotising enterocolitis and sepsis. PLoS One (2013) 8:e73465.10.1371/journal.pone.007346524023682
52. Arboleya S Binetti A Salazar N Fernandez N Solis G Hernandez-Barranco A et al. Establishment and development of intestinal microbiota in preterm neonates. FEMS Microbiol Ecol (2012) 79:763–72.10.1111/j.1574-6941.2011.01261.x22126419
53. Butel MJ Suau A Campeotto F Magne F Aires J Ferraris L et al. Conditions of bifidobacterial colonization in preterm infants: a prospective analysis. J Pediatr Gastroenterol Nutr (2007) 44:577–82.10.1097/MPG.0b013e3180406b2017460489
54. La Rosa PS Warner BB Zhou Y Weinstock GM Sodergren E Hall-Moore CM et al. Patterned progression of bacterial populations in the premature infant gut. Proc Natl Acad Sci U S A (2014) 111:12522–7.10.1073/pnas.140949711125114261
55. Panigrahi P. Probiotics and prebiotics in neonatal necrotizing enterocolitis: new opportunities for translational research. Pathophysiology (2014) 21:35–46.10.1016/j.pathophys.2013.11.01624594006
56. Fanaroff AA Korones SB Wright LL Verter J Poland RL Bauer CR et al. Incidence, presenting features, risk factors and significance of late onset septicemia in very low birth weight infants. The National Institute of Child Health and Human Development Neonatal Research Network. Pediatr Infect Dis J (1998) 17:593–8.10.1097/00006454-199807000-00004
57. Mai V Torrazza RM Ukhanova M Wang X Sun Y Li N et al. Distortions in development of intestinal microbiota associated with late onset sepsis in preterm infants. PLoS One (2013) 8:e52876.10.1371/journal.pone.005287623341915
58. Neu J. The microbiome and its impact on disease in the preterm patient. Curr Pediatr Rep (2013) 1:215–21.10.1007/s40124-013-0031-7
59. Carlisle EM Morowitz MJ. The intestinal microbiome and necrotizing enterocolitis. Curr Opin Pediatr (2013) 25:382–7.10.1097/MOP.0b013e3283600e9123657248
60. Grishin A Papillon S Bell B Wang J Ford HR. The role of the intestinal microbiota in the pathogenesis of necrotizing enterocolitis. Semin Pediatr Surg (2013) 22:69–75.10.1053/j.sempedsurg.2013.01.00223611609
61. Mai V Young CM Ukhanova M Wang X Sun Y Casella G et al. Fecal microbiota in premature infants prior to necrotizing enterocolitis. PLoS One (2011) 6:e20647.10.1371/journal.pone.0020647
62. Morrow AL Lagomarcino AJ Schibler KR Taft DH Yu Z Wang B et al. Early microbial and metabolomic signatures predict later onset of necrotizing enterocolitis in preterm infants. Microbiome (2013) 1:13.10.1186/2049-2618-1-1324450576
63. Smith B Bode S Skov TH Mirsepasi H Greisen G Krogfelt KA. Investigation of the early intestinal microflora in premature infants with/without necrotizing enterocolitis using two different methods. Pediatr Res (2012) 71:115–20.10.1038/pr.2011.122289859
64. Patel RM Denning PW. Therapeutic use of prebiotics, probiotics, and postbiotics to prevent necrotizing enterocolitis: what is the current evidence? Clin Perinatol (2013) 40:11–25.10.1016/j.clp.2012.12.00223415261
65. Indrio F Riezzo G Raimondi F Bisceglia M Cavallo L Francavilla R. Effects of probiotic and prebiotic on gastrointestinal motility in newborns. J Physiol Pharmacol (2009) 60(Suppl 6):27–31.
66. Indrio F Riezzo G Raimondi F Francavilla R Montagna O Valenzano ML et al. Prebiotics improve gastric motility and gastric electrical activity in preterm newborns. J Pediatr Gastroenterol Nutr (2009) 49:258–61.10.1097/MPG.0b013e3181926aec19561548
67. Mastromarino P Capobianco D Campagna G Laforgia N Drimaco P Dileone A et al. Correlation between lactoferrin and beneficial microbiota in breast milk and infant’s feces. Biometals (2014) 27:1077–86.10.1007/s10534-014-9762-324970346
68. Ofek Shlomai N Deshpande G Rao S Patole S. Probiotics for preterm neonates: what will it take to change clinical practice? Neonatology (2014) 105:64–70.10.1159/000354891
69. Mihatsch WA Braegger CP Decsi T Kolacek S Lanzinger H Mayer B et al. Critical systematic review of the level of evidence for routine use of probiotics for reduction of mortality and prevention of necrotizing enterocolitis and sepsis in preterm infants. Clin Nutr (2012) 31:6–15.10.1016/j.clnu.2011.09.00421996513
70. Wang Q Dong J Zhu Y. Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials. J Pediatr Surg (2012) 47:241–8.10.1016/j.jpedsurg.2011.09.06422244424
71. Deshpande G Rao S Patole S Bulsara M. Updated meta-analysis of probiotics for preventing necrotizing enterocolitis in preterm neonates. Pediatrics (2010) 125:921–30.10.1542/peds.2009-130120403939
72. AlFaleh K Anabrees J. Probiotics for prevention of necrotizing enterocolitis in preterm infants. Cochrane Database Syst Rev (2014) 4:CD005496.10.1002/14651858.CD005496.pub4
73. Janvier A Malo J Barrington KJ. Cohort study of probiotics in a North American neonatal intensive care unit. J Pediatr (2014) 164:980–5.10.1016/j.jpeds.2013.11.02524411521
74. Deshpande GC Rao SC Keil AD Patole SK. Evidence-based guidelines for use of probiotics in preterm neonates. BMC Med (2011) 9:92.10.1186/1741-7015-9-9221806843
75. Oncel MY Sari FN Arayici S Guzoglu N Erdeve O Uras N et al. Lactobacillus reuteri for the prevention of necrotising enterocolitis in very low birthweight infants: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed (2014) 99:F110–5.10.1136/archdischild-2013-30474524309022
76. Jacobs SE Tobin JM Opie GF Donath S Tabrizi SN Pirotta M et al. Probiotic effects on late-onset sepsis in very preterm infants: a randomized controlled trial. Pediatrics (2013) 132:1055–62.10.1542/peds.2013-133924249817
77. Serce O Benzer D Gursoy T Karatekin G Ovali F. Efficacy of Saccharomyces boulardii on necrotizing enterocolitis or sepsis in very low birth weight infants: a randomised controlled trial. Early Hum Dev (2013) 89:1033–6.10.1016/j.earlhumdev.2013.08.01324041815
78. Fernandez-Carrocera LA Solis-Herrera A Cabanillas-Ayon M Gallardo-Sarmiento RB Garcia-Perez CS Montano-Rodriguez R et al. Double-blind, randomised clinical assay to evaluate the efficacy of probiotics in preterm newborns weighing less than 1500 g in the prevention of necrotising enterocolitis. Arch Dis Child Fetal Neonatal Ed (2013) 98:F5–9.10.1136/archdischild-2011-30043522556209
79. Rojas MA Lozano JM Rojas MX Rodriguez VA Rondon MA Bastidas JA et al. Prophylactic probiotics to prevent death and nosocomial infection in preterm infants. Pediatrics (2012) 130:e1113–20.10.1542/peds.2011-3584
80. Al-Hosni M Duenas M Hawk M Stewart LA Borghese RA Cahoon M et al. Probiotics-supplemented feeding in extremely low-birth-weight infants. J Perinatol (2012) 32:253–9.10.1038/jp.2011.5121546942
81. Braga TD da Silva GA de Lira PI de Carvalho Lima M. Efficacy of Bifidobacterium breve and Lactobacillus casei oral supplementation on necrotizing enterocolitis in very-low-birth-weight preterm infants: a double-blind, randomized, controlled trial. Am J Clin Nutr (2011) 93:81–6.10.3945/ajcn.2010.2979920980486
82. Samanta M Sarkar M Ghosh P Ghosh J Sinha M Chatterjee S. Prophylactic probiotics for prevention of necrotizing enterocolitis in very low birth weight newborns. J Trop Pediatr (2009) 55:128–31.10.1093/tropej/fmn09118842610
83. Lin HC Hsu CH Chen HL Chung MY Hsu JF Lien RI et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight preterm infants: a multicenter, randomized, controlled trial. Pediatrics (2008) 122:693–700.10.1542/peds.2007-300718829790
84. Lin HC Su BH Chen AC Lin TW Tsai CH Yeh TF et al. Oral probiotics reduce the incidence and severity of necrotizing enterocolitis in very low birth weight infants. Pediatrics (2005) 115:1–4.10.1542/peds.2004-1463
85. Bin-Nun A Bromiker R Wilschanski M Kaplan M Rudensky B Caplan M et al. Oral probiotics prevent necrotizing enterocolitis in very low birth weight neonates. J Pediatr (2005) 147:192–6.10.1016/j.jpeds.2005.03.05416126048
86. de Champs C Maroncle N Balestrino D Rich C Forestier C. Persistence of colonization of intestinal mucosa by a probiotic strain, Lactobacillus casei subsp. rhamnosus Lcr35, after oral consumption. J Clin Microbiol (2003) 41:1270–3.10.1128/JCM.41.3.1270-1273.200312624065
87. Costa GN Marcelino-Guimaraes FC Vilas-Boas GT Matsuo T Miglioranza LH. Potential fate of ingested Lactobacillus plantarum and its occurrence in human feces. Appl Environ Microbiol (2014) 80:1013–9.10.1128/AEM.02588-1324271176
88. Parks DH Beiko RG. Identifying biologically relevant differences between metagenomic communities. Bioinformatics (2010) 26:715–21.10.1093/bioinformatics/btq04120130030
89. Panigrahi P Parida S Pradhan L Mohapatra S Misra P Johnson J et al. Long-term colonization of a Lactobacillus plantarum synbiotic preparation in the neonatal gut. J Pediatr Gastroenterol Nutr (2008) 47:45–53.10.1097/MPG.0b013e31815a5f2c18607268
90. Tobin JM Garland SM Jacobs SE Pirotta M Tabrizi SN. Rapid assay to assess colonization patterns following in-vivo probiotic ingestion. BMC Res Notes (2013) 6:252.10.1186/1756-0500-6-25223830222
91. Kitajima H Sumida Y Tanaka R Yuki N Takayama H Fujimura M. Early administration of Bifidobacterium breve to preterm neonates: randomised control trial. Arch Dis Child (1997) 76:F101–7.10.1136/fn.76.2.F1019135288
92. Reuman PD Duckworth DH Smith KL Kagan R Bucciarelli RL Ayoub EM. Lack of effect of Lactobacillus on gastrointestinal bacterial colonization in premature infants. Pediatr Infect Dis (1986) 5:663–8.10.1097/00006454-198611000-000133099269
93. Agarwal R Sharma N Chaudhry R Deorari A Paul VK Gewolb IH et al. Effects of oral Lactobacillus GG on enteric microflora in low-birth-weight neonates. J Pediatr Gastroenterol Nutr (2003) 36:397–402.10.1097/00005176-200303000-0001912604982
94. Bennet R Nord CE Zetterstrom R. Transient colonization of the gut of newborn infants by orally administered bifidobacteria and lactobacilli. Acta Paediatrica (1992) 81:784–7.10.1111/j.1651-2227.1992.tb12103.x1421883
95. Collins MD Gibson GR. Probiotics, prebiotics, and synbiotics: approaches for modulating the microbial ecology of the gut. Am J Clin Nutr (1999) 69:1052s–7s.10232648
96. Martin R Nauta AJ Ben Amor K Knippels LM Knol J Garssen J. Early life: gut microbiota and immune development in infancy. Benef Microbes (2010) 1:367–82.10.3920/BM2010.002721831776
97. Garcia-Lafuente A Antolin M Guarner F Crespo E Malagelada JR. Modulation of colonic barrier function by the composition of the commensal flora in the rat. Gut (2001) 48:503–7.10.1136/gut.48.4.50311247894
98. Madsen K Cornish A Soper P McKaigney C Jijon H Yachimec C et al. Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology (2001) 121:580–91.10.1053/gast.2001.2722411522742
99. Parassol N Freitas M Thoreux K Dalmasso G Bourdet-Sicard R Rampal P. Lactobacillus casei DN-114 001 inhibits the increase in paracellular permeability of enteropathogenic Escherichia coli-infected T84 cells. Res Microbiol (2005) 156:256–62.10.1016/j.resmic.2004.09.01315748992
100. Karczewski J Troost FJ Konings I Dekker J Kleerebezem M Brummer RJ et al. Regulation of human epithelial tight junction proteins by Lactobacillus plantarum in vivo and protective effects on the epithelial barrier. Am J Physiol Gastrointest Liver Physiol (2010) 298:G851–9.10.1152/ajpgi.00327.200920224007
101. Smelt MJ de Haan BJ Bron PA van Swam I Meijerink M Wells JM et al. L. plantarum, L. salivarius, and L. lactis attenuate Th2 responses and increase Treg frequencies in healthy mice in a strain dependent manner. PLoS One (2012) 7:e47244.10.1371/journal.pone.004724423056616
102. Hempel S Newberry S Ruelaz A Wang Z Miles JN Suttorp MJ et al. Safety of probiotics used to reduce risk and prevent or treat disease. Evid Rep Technol Assess (2011) 1–645.23126627
103. Zbinden A Zbinden R Berger C Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology (2015) 107:56–9.10.1159/00036798525402825
104. Abrahamsson TR Rautava S Moore AM Neu J Sherman PM. The time for a confirmative necrotizing enterocolitis probiotics prevention trial in the extremely low birth weight infant in North America is now! J Pediatr (2014) 165:389–94.10.1016/j.jpeds.2014.05.012
105. Chan L-N Soltani H Hazlet TK. Probiotics for neonates: safety for prime time questioned without regulatory changes. J Pediatr (2015) 166(2):502.10.1016/j.jpeds.2014.10.04125477163