A review of the source and function of microbiota in breast milk

Seminars in Reproductive Medicine

Volumn 32, Issue 1, 2014, Pages 68-73

  LaTuga, M Susan ^a   Stuebe, Alison ^b,c   Seed, Patrick C ^d  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c IL   (United States)

^d DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

enteromammary trafficking; immune function; mastitis

Indexed keywords

ANTIBIOTIC AGENT; INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 4; INTERLEUKIN 5; TUMOR NECROSIS FACTOR;

BACTERIAL TRANSMISSION; BREAST MILK; CHILD DEVELOPMENT; CHILD GROWTH; CYTOKINE RELEASE; HUMAN; MASTITIS; MICROFLORA; NONHUMAN; OBESITY; REGULATORY T LYMPHOCYTE; REVIEW; TH1 CELL; TH2 CELL; VERTICAL TRANSMISSION; ADULT; FEMALE; INFANT; INTESTINE; MICROBIOLOGY; NEWBORN; PHYSIOLOGY; PREGNANCY;

ADULT; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; INTESTINES; MASTITIS; MICROBIOTA; MILK, HUMAN; PREGNANCY;

EID: 84891787698     PISSN: 15268004     EISSN: 15264564     Source Type: Journal    
DOI: 10.1055/s-0033-1361824     Document Type: Review

References (66)

1. Han Y. W., Shen T., Chung P., Buhimschi I. A., Buhimschi C. S. Uncultivated bacteria as etiologic agents of intra-amniotic inflammation leading to preterm birth. J Clin Microbiol: 2009; 47 1 38 47
2. D'Onofrio A., Crawford J. M., Stewart E. J., et al. Siderophores from neighboring organisms promote the growth of uncultured bacteria. Chem Biol: 2010; 17 3 254 264
3. Costello E. K., Stagaman K., Dethlefsen L., Bohannan B. J., Relman D. A. The application of ecological theory toward an understanding of the human microbiome. Science: 2012; 336 6086 1255 1262
4. Grice E. A., Kong H. H., Conlan S., et al. NISC Comparative Sequencing Program. Topographical and temporal diversity of the human skin microbiome. Science: 2009; 324 5931 1190 1192
5. Gao Z., Tseng C. H., Pei Z., Blaser M. J. Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci U S A: 2007; 104 8 2927 2932 (Pubitemid 46327980)
6. Yatsunenko T., Rey F. E., Manary M. J., et al. Human gut microbiome viewed across age and geography. Nature: 2012; 486 7402 222 227
7. Gueimonde M., Laitinen K., Salminen S., Isolauri E. Breast milk: a source of bifidobacteria for infant gut development and maturation? Neonatology: 2007; 92 1 64 66 (Pubitemid 47013399)
8. Heikkilä M. P., Saris P. E. Inhibition of Staphylococcus aureus by the commensal bacteria of human milk. J Appl Microbiol: 2003; 95 3 471 478 (Pubitemid 37041078)
9. Tyson J. E., Edwards W. H., Rosenfeld A. M., Beer A. E. Collection methods and contamination of bank milk. Arch Dis Child: 1982; 57 5 396 398 (Pubitemid 12109261)
10. Hunt K. M., Foster J. A., Forney L. J., et al. Characterization of the diversity and temporal stability of bacterial communities in human milk. PLoS ONE: 2011; 6 6 e21313
11. Cabrera-Rubio R., Collado M. C., Laitinen K., Salminen S., Isolauri E., Mira A. The human milk microbiome changes over lactation and is shaped by maternal weight and mode of delivery. Am J Clin Nutr: 2012; 96 3 544 551
12. Thompson N., Pickler R. H., Munro C., Shotwell J. Contamination in expressed breast milk following breast cleansing. J Hum Lact: 1997; 13 2 127 130 (Pubitemid 127498662)
13. Palmer C., Bik E. M., DiGiulio D. B., Relman D. A., Brown P. O. Development of the human infant intestinal microbiota. PLoS Biol: 2007; 5 7 e177
14. Perez P. F., Doré J., Leclerc M., et al. Bacterial imprinting of the neonatal immune system: lessons from maternal cells? Pediatrics: 2007; 119 3 e724 e732 (Pubitemid 46407547)
15. Holmes A. V. Establishing successful breastfeeding in the newborn period. Pediatr Clin North Am: 2013; 60 1 147 168
16. Ramsay D. T., Kent J. C., Owens R. A., Hartmann P. E. Ultrasound imaging of milk ejection in the breast of lactating women. Pediatrics: 2004; 113 2 361 367 (Pubitemid 38177089)
17. Ramsay D. T., Mitoulas L. R., Kent J. C., Larsson M., Hartmann P. E. The use of ultrasound to characterize milk ejection in women using an electric breast pump. J Hum Lact: 2005; 21 4 421 428 (Pubitemid 41671765)
18. Lif Holgerson P., Harnevik L., Hernell O., Tanner A. C., Johansson I. Mode of birth delivery affects oral microbiota in infants. J Dent Res: 2011; 90 10 1183 1188
19. Stagg A. J., Hart A. L., Knight S. C., Kamm M. A. The dendritic cell: its role in intestinal inflammation and relationship with gut bacteria. Gut: 2003; 52 10 1522 1529 (Pubitemid 37176736)
20. Donnet-Hughes A., Perez P. F., Doré J., et al. Potential role of the intestinal microbiota of the mother in neonatal immune education. Proc Nutr Soc: 2010; 69 3 407 415
21. Turroni F., Peano C., Pass D. A., et al. Diversity of bifidobacteria within the infant gut microbiota. PLoS ONE: 2012; 7 5 e36957
22. Heath L., Conway S., Jones L., et al. Restriction of HIV-1 genotypes in breast milk does not account for the population transmission genetic bottleneck that occurs following transmission. PLoS ONE: 2010; 5 4 e10213
23. Gray R. R., Salemi M., Lowe A., et al. Multiple independent lineages of HIV-1 persist in breast milk and plasma. AIDS: 2011; 25 2 143 152
24. Wu G. D., Chen J., Hoffmann C., et al. Linking long-term dietary patterns with gut microbial enterotypes. Science: 2011; 334 6052 105 108
25. Wu C. A., Paveglio S. A., Lingenheld E. G., Zhu L., Lefrançois L., Puddington L. Transmission of murine cytomegalovirus in breast milk: a model of natural infection in neonates. J Virol: 2011; 85 10 5115 5124
26. Vochem M., Hamprecht K., Jahn G., Speer C. P. Transmission of cytomegalovirus to preterm infants through breast milk. Pediatr Infect Dis J: 1998; 17 1 53 58 (Pubitemid 28086325)
27. Stagno S., Reynolds D. W., Pass R. F., Alford C. A. Breast milk and the risk of cytomegalovirus infection. N Engl J Med: 1980; 302 19 1073 1076 (Pubitemid 10123111)
28. Lanzieri T. M., Dollard S. C., Josephson C. D., Schmid D. S., Bialek S. R. Breast milk-acquired cytomegalovirus infection and disease in VLBW and premature infants. Pediatrics: 2013; 131 6 e1937 e1945
29. Ehlinger E. P., Webster E. M., Kang H. H., et al. Maternal cytomegalovirus-specific immune responses and symptomatic postnatal cytomegalovirus transmission in very low-birth-weight preterm infants. J Infect Dis: 2011; 204 11 1672 1682
30. Godfrey W. R., Spoden D. J., Ge Y. G., et al. Cord blood CD4(+)CD25(+)-derived T regulatory cell lines express FoxP3 protein and manifest potent suppressor function. Blood: 2005; 105 2 750 758 (Pubitemid 40070762)
31. Zhou L., Chong M. M., Littman D. R. Plasticity of CD4+ T cell lineage differentiation. Immunity: 2009; 30 5 646 655
32. Zhang B., Ohtsuka Y., Fujii T., et al. Immunological development of preterm infants in early infancy. Clin Exp Immunol: 2005; 140 1 92 96 (Pubitemid 40461077)
33. Stephens S., Brenner M. K., Duffy S. W., Lakhani P. K., Kennedy C. R., Farrant J. The effect of breast-feeding on proliferation by infant lymphocytes in vitro. Pediatr Res: 1986; 20 3 227 231 (Pubitemid 16164725)
34. Carver J. D., Pimentel B., Wiener D. A., Lowell N. E., Barness L. A. Infant feeding effects on flow cytometric analysis of blood. J Clin Lab Anal: 1991; 5 1 54 56
35. Tarcan A., Gürakan B., Tiker F., Ozbek N. Influence of feeding formula and breast milk fortifier on lymphocyte subsets in very low birth weight premature newborns. Biol Neonate: 2004; 86 1 22 28 (Pubitemid 39077606)
36. Donnet-Hughes A. Protective properties of human milk. In: Duggan D., ed. Nutrition in Pediatrics. 4th ed. Ontario, Canada Decker Publishing: 2008; 355 362
37. Spörri R., Reis e Sousa C. Inflammatory mediators are insufficient for full dendritic cell activation and promote expansion of CD4+ T cell populations lacking helper function. Nat Immunol: 2005; 6 2 163 170 (Pubitemid 40268197)
38. Hansen C. H., Nielsen D. S., Kverka M., et al. Patterns of early gut colonization shape future immune responses of the host. PLoS ONE: 2012; 7 3 e34043
39. M'Rabet L., Vos A. P., Boehm G., Garssen J. Breast-feeding and its role in early development of the immune system in infants: consequences for health later in life. J Nutr: 2008; 138 9 1782S 1790S
40. Arumugam M., Raes J., Pelletier E., et al. MetaHIT Consortium. Enterotypes of the human gut microbiome. Nature: 2011; 473 7346 174 180
41. Ward T. L., Hosid S., Ioshikhes I., Altosaar I. Human milk metagenome: a functional capacity analysis. BMC Microbiol: 2013; 13 116
42. Morowitz M. J., Denef V. J., Costello E. K., et al. Strain-resolved community genomic analysis of gut microbial colonization in a premature infant. Proc Natl Acad Sci U S A: 2011; 108 3 1128 1133
43. LaTuga M. S., Ellis J. C., Cotton C. M., et al. Beyond bacteria: a study of the enteric microbial consortium in extremely low birth weight infants. PLoS ONE: 2011; 6 12 e27858
44. Schwartz S., Friedberg I., Ivanov I. V., et al. A metagenomic study of diet-dependent interaction between gut microbiota and host in infants reveals differences in immune response. Genome Biol: 2012; 13 4 r32
45. Carlisle E. M., Poroyko V., Caplan M. S., Alverdy J., Morowitz M. J., Liu D. Murine gut microbiota and transcriptome are diet dependent. Ann Surg: 2013; 257 2 287 294
46. Hancock R. E., Scott M. G. The role of antimicrobial peptides in animal defenses. Proc Natl Acad Sci U S A: 2000; 97 16 8856 8861 (Pubitemid 30626637)
47. Berkes J., Viswanathan V. K., Savkovic S. D., Hecht G. Intestinal epithelial responses to enteric pathogens: effects on the tight junction barrier, ion transport, and inflammation. Gut: 2003; 52 3 439 451 (Pubitemid 36253638)
48. Bates J. M., Akerlund J., Mittge E., Guillemin K. Intestinal alkaline phosphatase detoxifies lipopolysaccharide and prevents inflammation in Zebrafish in response to the gut microbiota. Cell Host Microbe: 2007; 2 6 371 382 (Pubitemid 350215326)
49. Liedel J. L., Guo Y., Yu Y., et al. Mother's milk-induced Hsp70 expression preserves intestinal epithelial barrier function in an immature rat pup model. Pediatr Res: 2011; 69 5, Pt 1 395 400
50. Arvans D. L., Vavricka S. R., Ren H., et al. Luminal bacterial flora determines physiological expression of intestinal epithelial cytoprotective heat shock proteins 25 and 72. Am J Physiol Gastrointest Liver Physiol: 2005; 288 4 G696 G704 (Pubitemid 40388181)
51. Marcobal A., Barboza M., Sonnenburg E. D., et al. Bacteroides in the infant gut consume milk oligosaccharides via mucus-utilization pathways. Cell Host Microbe: 2011; 10 5 507 514
52. Hunt K. M., Preuss J., Nissan C., et al. Human milk oligosaccharides promote the growth of staphylococci. Appl Environ Microbiol: 2012; 78 14 4763 4770
53. Jantscher-Krenn E., Marx C., Bode L. Human milk oligosaccharides are differentially metabolised in neonatal rats. Br J Nutr: 2013; 110 4 640 650
54. Eiwegger T., Stahl B., Haidl P., et al. Prebiotic oligosaccharides: in vitro evidence for gastrointestinal epithelial transfer and immunomodulatory properties. Pediatr Allergy Immunol: 2010; 21 8 1179 1188
55. Husebye E., Hellström P. M., Midtvedt T. Intestinal microflora stimulates myoelectric activity of rat small intestine by promoting cyclic initiation and aboral propagation of migrating myoelectric complex. Dig Dis Sci: 1994; 39 5 946 956 (Pubitemid 24188834)
56. Husebye E., Hellström P. M., Sundler F., Chen J., Midtvedt T. Influence of microbial species on small intestinal myoelectric activity and transit in germ-free rats. Am J Physiol Gastrointest Liver Physiol: 2001; 280 3 G368 G380
57. Sudo N., Chida Y., Aiba Y., et al. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J Physiol: 2004; 558 Pt 1 263 275 (Pubitemid 39077406)
58. Bercik P., Denou E., Collins J., et al. The intestinal microbiota affect central levels of brain-derived neurotropic factor and behavior in mice. Gastroenterology: 2011; 141 2 599 609, e1-e3
59. World Health Organization Mastitis: Causes and Management. Geneva World Health Organization: 2000
60. Kvist L. J., Larsson B. W., Hall-Lord M. L., Steen A., Schalén C. The role of bacteria in lactational mastitis and some considerations of the use of antibiotic treatment. Int Breastfeed J: 2008; 3 6
61. Delgado S., Arroyo R., Martín R., Rodríguez J. M. PCR-DGGE assessment of the bacterial diversity of breast milk in women with lactational infectious mastitis. BMC Infect Dis: 2008; 8 51
62. Delgado S., Arroyo R., Jiménez E., et al. Staphylococcus epidermidis strains isolated from breast milk of women suffering infectious mastitis: potential virulence traits and resistance to antibiotics. BMC Microbiol: 2009; 9 82
63. Bouchard D. S., Rault L., Berkova N., Le Loir Y., Even S. Inhibition of Staphylococcus aureus invasion into bovine mammary epithelial cells by contact with live Lactobacillus casei. Appl Environ Microbiol: 2013; 79 3 877 885
64. Jones S. E., Versalovic J. Probiotic Lactobacillus reuteri biofilms produce antimicrobial and anti-inflammatory factors. BMC Microbiol: 2009; 9 35
65. Jiménez E., Fernández L., Maldonado A., et al. Oral administration of Lactobacillus strains isolated from breast milk as an alternative for the treatment of infectious mastitis during lactation. Appl Environ Microbiol: 2008; 74 15 4650 4655
66. Arroyo R., Martín V., Maldonado A., Jiménez E., Fernández L., Rodríguez J. M. Treatment of infectious mastitis during lactation: antibiotics versus oral administration of Lactobacilli isolated from breast milk. Clin Infect Dis: 2010; 50 12 1551 1558