Structural and molecular modelling studies reveal a new mechanism of action of chloroquine and hydroxychloroquine against SARS-CoV-2 infection

International Journal of Antimicrobial Agents

Volumn 55, Issue 5, 2020, Pages

  Fantini, Jacques ^a,b   Di Scala, Coralie ^c   Chahinian, Henri ^a,b   Yahi, Nouara ^a,b  

^a Aix Marseille University   (France)

^b AIX MARSEILLE UNIVERSITY   (France)

^c Turing Center for Living Systems CENTURI Aix Marseille University   (France)

Author keywords

Chloroquine; Coronavirus; Ganglioside; Pandemic; SARS CoV 2; Spike

Indexed keywords

AMINO ACID; CHLOROQUINE; GANGLIOSIDE; HYDROXYCHLOROQUINE; SIALIC ACID; VITRONECTIN; CORONAVIRUS SPIKE GLYCOPROTEIN; SPIKE PROTEIN, SARS-COV-2;

ANTIVIRAL ACTIVITY; ARTICLE; BINDING SITE; CORONAVIRUS DISEASE 2019; DRUG CONFORMATION; DRUG MECHANISM; DRUG STRUCTURE; DRUG TARGETING; HUMAN; MOLECULAR MODEL; PRIORITY JOURNAL; SEQUENCE ALIGNMENT; SEVERE ACUTE RESPIRATORY SYNDROME CORONAVIRUS 2; STRUCTURE ACTIVITY RELATION; AMINO ACID SEQUENCE; BETACORONAVIRUS; CHEMISTRY; CORONAVIRUS INFECTION; DRUG EFFECT; MOLECULARLY TARGETED THERAPY; PANDEMIC; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; SEQUENCE ANALYSIS; VIRUS PNEUMONIA;

AMINO ACID SEQUENCE; BETACORONAVIRUS; CHLOROQUINE; CORONAVIRUS INFECTIONS; HUMANS; HYDROXYCHLOROQUINE; MODELS, MOLECULAR; MOLECULAR TARGETED THERAPY; PANDEMICS; PNEUMONIA, VIRAL; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ANALYSIS, PROTEIN; SPIKE GLYCOPROTEIN, CORONAVIRUS;

EID: 85083054973     PISSN: 09248579     EISSN: 18727913     Source Type: Journal    
DOI: 10.1016/j.ijantimicag.2020.105960     Document Type: Article

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